Pyralfin AL 80/480mg Tablet 6'S

Introduction About PYRALFIN AL 80/480MG TABLET

PYRALFIN AL 80/480MG TABLET is a combination of Artemether and Lumefantrine
which belongs to the group of medicines called Antimalarials. It is used in
infants, children and adults for the management of acute uncomplicated malaria
(mosquito borne disease with symptoms of fever with chills, tiredness, nausea,
vomiting, stomach pain) caused by a parasite called plasmodium falciparum.

PYRALFIN AL 80/480MG TABLET should be used with caution in patients with severe
liver or kidney problems or if the patient feels worse or unwell to eat and
drink.

PYRALFIN AL 80/480MG TABLET is not recommended for use in patients having severe
type of malarial infection affecting the lungs, kidney or brain, heart condition
such as changes in the heart rhythm, slow heartbeat or severe heart disease and
low levels of electrolytes such as potassium or magnesium in the blood.

PYRALFIN AL 80/480MG TABLET is generally not recommended for use during the
first trimester of pregnancy and it should be used with caution during the
second and third trimester of pregnancy and breast-feeding women only if advised
by the doctor.

PYRALFIN AL 80/480MG TABLET should be used with caution in children and your
child’s doctor may adjust the dose depending upon child’s age and body weight.

The most common side effects of taking PYRALFIN AL 80/480MG TABLET are headache,
dizziness, vomiting, stomach pain, nausea, muscle pain and loss of appetite.
Consult your doctor if any of the side effects worsen.

Uses Of PYRALFIN AL 80/480MG TABLET

• Manage acute uncomplicated malarial infections (caused by plasmodium falciparum) in infants, children and adults

How PYRALFIN AL 80/480MG TABLET Works

PYRALFIN AL 80/480MG TABLET effectively manages malarial infections,
whereartemether effectively kills the malarial parasites by binding to haem
(part of molecules that contains iron which is toxic to malarial parasites)
which is produced during the breakdown of haemoglobin. Lumefantrine works by
binding to hemin where it manages the formation of a toxic malarial pigment
called hemozoin, thereby it manages malarial infection. In addition to this
artemether and lumefantrine blocks nucleic acid and protein synthesis in
parasite that damages the parasitic cell membrane of plasmodium falciparum which
leads to the death of parasite. Thus, it helps in managing the malarial
infection.

How to use PYRALFIN AL 80/480MG TABLET

Take PYRALFIN AL 80/480MG TABLET exactly as advised by your doctor.

For Tablet, Capsule: Swallow PYRALFIN AL 80/480MG TABLET with a glass of
water. This medicine should be taken with food or drinks rich in fat such as
milk. Crush the medicine into powder if your child is unable to swallow the
whole medicine.

For Dispersible Tablet: Disperse PYRALFIN AL 80/480MG TABLET in the
specified quantity of water as mentioned in the label. Consume the mixture
immediately after reconstitution.

Your doctor will decide the correct dose and duration for you depending upon
your age, body weight and severity of the disease condition.

Side Effects Of PYRALFIN AL 80/480MG TABLET

Common

• headache, dizziness
• nausea, vomiting
• stomach pain
• diarrhea
• muscle or joint pain
• difficulty to sleep
• loss of appetite
• cough
• fast heartbeat
• general weakness, tiredness
• involuntary muscle spasms
• abnormal walking (in children above 12 years)
• tingling sensation or numbness of hand and feet
• rashes or itching in the skin
• disturbance in heart rhythm (prolonged QTc interval)

Uncommon

• sleepiness
• decreased skin sensitivity
• inability to coordinate movements

Rare

• allergic reactions

Stop taking PYRALFIN AL 80/480MG TABLET and contact your doctor immediately if
you experience any of the following side effects:

• swelling of the face, lips, tongue or throat with difficulty in breathing and swallowing
• skin condition with large fluid filled blisters (bullous eru

How To Manage Side Effects

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the forehead if required. Do not consume too much of
alcohol. Consult your doctor if the symptom does not improve.

Nausea and vomiting:

Stick to simple meals while taking this medicine. Avoid eating oily, fried or
spicy foods. Do not lie down or sleep immediately after eating. Consult your
doctor if the symptom does not improve.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals.
Keep a heat pad on your stomach. Do not self-manage on your own and consult your
doctor if the symptom does not improve.

Diarrhea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated.
Avoid taking any medicine on your own for managing diarrhea. Consult your doctor
if the symptom does not improve.

Tiredness:

Drink plenty of fluid and eat balanced diet and frequent meals. Do regular
minimal exercise and follow regular sleep schedule. Consult your doctor if the
symptom does not improve.

Warning & Precautions

!### Pregnancy

PYRALFIN AL 80/480MG TABLET is generally not recommended for use during the
first trimester of pregnancy. It should be used with caution during second and
third trimester of pregnancy only if considered clearly necessary. Consult your
doctor before taking PYRALFIN AL 80/480MG TABLET.

!### Breastfeeding

PYRALFIN AL 80/480MG TABLET should be taken with caution in breast feeding women
only if considered clearly necessary. Consult your doctor before taking PYRALFIN
AL 80/480MG TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if you experience dizziness, sleepiness or
weakness after taking PYRALFIN AL 80/480MG TABLET.

!### Kidney

PYRALFIN AL 80/480MG TABLET is not recommended for use in patients having severe
type of malarial infection affecting the kidneys. It should be taken with
caution in patients with severe kidney problems. Consult your doctor before
taking PYRALFIN AL 80/480MG TABLET.

!### Liver

PYRALFIN AL 80/480MG TABLET should be taken with caution in patients with severe
liver problems. Consult your doctor before taking PYRALFIN AL 80/480MG TABLET.

!### Allergy

Do not take PYRALFIN AL 80/480MG TABLET if you are allergic to Artemether,
Lumefantrine or any other ingredients of this medicine.

!### Lungs

PYRALFIN AL 80/480MG TABLET is not recommended for use in patients having
malaria with pulmonary edema or severe type of malarial infection affecting the
lungs. Consult your doctor before taking it.

!### Heart Disease

PYRALFIN AL 80/480MG TABLET is not recommended for use in patients with severe
heart disease or with heart diseases such as slow heartbeat, changes in the
rhythm or rate of the heartbeat or family history of death due to heart problems
or born with heart problems. PYRALFIN AL 80/480MG TABLET should be taken with
caution in patients with variations in ECG (prolongation of QTc interval).
Consult doctor before taking PYRALFIN AL 80/480MG TABLET.

Others

PYRALFIN AL 80/480MG TABLET is not recommended for use if you have:

• severe type of malarial infection that has affected the brain
• low levels of electrolytes such as potassium or magnesium in blood

Before taking PYRALFIN AL 80/480MG TABLET, inform your doctor if you:

• infected with both the plasmodium falciparum and plasmodium vivax parasites
• feeling worse or if you feel too unwell to eat and drink

Use in pediatrics

PYRALFIN AL 80/480MG TABLET should be given with caution in children as the
dosages of PYRALFIN AL 80/480MG TABLET vary in children according to their body
weight. So, consult a paediatrician before you give this medicine to your child.

Use in geriatrics

PYRALFIN AL 80/480MG TABLET can be used in elderly patients. However, consult
your doctor before taking this medicine.

Interactions

A. Drug – drug interactions:

Before taking PYRALFIN AL 80/480MG TABLET, inform your doctor if you are taking
any of the following medicines:

• medicines used to manage heart rhythm problems (Ex. Flecainide, metoprolol)
• medicines used to manage depression (Ex. imipramine, amitriptyline, clomipramine, St. John’s wort)
• medicine used to manage leprosy or tuberculosis (Ex. rifampicin)
• medicines used to manage bacterial infections (EX.  fluroquinolones such as ciprofloxacin, levofloxacin, macrolide antibiotics like azithromycin, erythromycin)
• medicines used to manage fungal infection (Ex. ketoconazole, fluconazole, itraconazole)
• medicines used to manage allergy (Ex. terfenadine, astemizole)
• medicine used to manage stomach disturbance (Ex. cisapride)
• medicines used to manage fits (Ex. carbamazepine, phenytoin)
• medicines used to manage malaria (Ex.  atovaquone/progu
• medicines used to manage HIV infection (Ex. indinavir, ritonavir)
• medicine used to manage pregnancy (Ex. Ethinyl estradiol)

B. Drug – Food interactions

Drink grapefruit juice with caution while taking PYRALFIN AL 80/480MG TABLET as
it may interact with this medicine.

Overdosage:

If you or anyone else accidentally take too much of PYRALFIN AL 80/480MG TABLET,
consult your doctor immediately or visit a nearby hospital.

Synopsis

Drug	:	Artemether, Lumefantrine
Pharmacological Category	:	Antimalarials
Therapeutic Indication	:	Manages acute uncomplicated malaria
Dosage Forms	:	Tablet, Dispersible tablet, Injection, Syrup, Oral suspension, Dry Syrup

More Information

• Keep PYRALFIN AL 80/480MG TABLET out of reach of children
• Store PYRALFIN AL 80/480MG TABLET at room temperature

FAQs About PYRALFIN AL 80/480MG TABLET

What is PYRALFIN AL 80/480MG TABLET used for?

PYRALFIN AL 80/480MG TABLET is used in infants, children and adults for the
management of acute uncomplicated malaria (mosquito born disease with symptoms
of fever with chills, tiredness, nausea, vomiting, stomach pain) caused by a
parasite called plasmodium falciparum.

Does PYRALFIN AL 80/480MG TABLET helps to manage malaria?

PYRALFIN AL 80/480MG TABLET is not used to manage malaria. It is only used to
manage malarial infection caused by a parasite called plasmodium falciparum.
Consult your doctor for advice before taking this medicine.

Is PYRALFIN AL 80/480MG TABLET safe to use in pregnant women?

PYRALFIN AL 80/480MG TABLET is generally not recommended for use during the
first trimester of pregnancy. It should be used with caution during second and
third trimester of pregnancy only if considered clearly necessary. Consult your
doctor before taking PYRALFIN AL 80/480MG TABLET.

Can PYRALFIN AL 80/480MG TABLET be used in patients with kidney problems?

PYRALFIN AL 80/480MG TABLET is not recommended for use in patients having severe
type of malarial infection affecting the kidneys. It should be taken with
caution in patients with severe kidney problems. Consult your doctor before
taking PYRALFIN AL 80/480MG TABLET.

Does PYRALFIN AL 80/480MG TABLET cause diarrhea?

Yes, PYRALFIN AL 80/480MG TABLET may cause diarrhea in some individuals. To
manage this effect, drink lot of fluids such as water or fruit juices to keep
yourself hydrated. Avoid taking any medicine on your own for managing diarrhea.
Consult your doctor if the symptom does not improve.

Useful Diagnostic Tests

• Peripheral Smear for Malaria