Zunata 60mg Injection 1'S

Introduction About ZUNATA 60MG INJECTION

ZUNATA 60MG INJECTION contains Artesunate which belongs to the group of
medicines called Antimalarials. It is used for the management of severe malaria
including cerebral malaria in adult and paediatric patients. Also, it can also
be used against quinine resistance.

Malaria is mosquito-borne acute febrile disease caused by a protozoan named
Plasmodium falciparum. It is characterized by symptoms such as high fever,
chills, sweating, headache, muscle pain, nausea, vomiting, body aches, weakness,
agitation, confusion, fainting on standing up and anaemia (reduced red blood
cell count). Cerebral malaria is the most severe neurological complication of
Plasmodium falciparum malaria which may also cause coma.

ZUNATA 60MG INJECTION is not recommended for use if you have previous history of
allergic reactions to artesunate or artemisinin derivatives. Before receiving
ZUNATA 60MG INJECTION inform your doctor if you liver or kidney problems or any
other problems.

ZUNATA 60MG INJECTION is not recommended for use during first trimester of
pregnancy. It should be used with caution in breastfeeding women. Consult your
doctor before receiving ZUNATA 60MG INJECTION.

ZUNATA 60MG INJECTION should be used with caution in children. Consult your
child’s doctor for advice before administration of ZUNATA 60MG INJECTION to your
child.

The most common side effects associated with the use of ZUNATA 60MG INJECTION
are dizziness, light-headedness, headache, rash, hair loss, taste alteration
(metallic/bitter taste), nausea, vomiting, abdominal pain and diarrhoea. Inform
your doctor if any of these side effects bothers you.

Uses Of ZUNATA 60MG INJECTION

• Manage severe malaria including cerebral malaria

How ZUNATA 60MG INJECTION Works

ZUNATA 60MG INJECTION helps in managing malaria where Artesunate works by
transforming into a metabolite and binds with iron component of blood and forms
free radicals which inhibit the synthesis of protein and nucleic acid in
Plasmodium parasites and manages it from invading red blood cells, thus managing
the malaria effectively.

How to use ZUNATA 60MG INJECTION

ZUNATA 60MG INJECTION will be given to you only by a doctor or a nurse
intravenously (into the vein) or intramuscularly (into the muscle). Your doctor
will decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Side Effects Of ZUNATA 60MG INJECTION

Common

• dizziness, light-headedness
• tinnitus (with or without reduced hearing capability)
• headache, insomnia
• rash
• hair loss
• taste alteration (metallic/ bitter taste)
• nausea, vomiting, abdominal pain, loss of appetite and diarrhoea
• cough or nasal symptoms
• joint pain, muscle disorders
• fatigue, malaise, fever
• pain at injection site

Uncommon

• rhythm and conduction disorders
• hypersensitivity

Rare

• arterial ischemia, hypertensive retinopathy
• inflammation of pancreas
• hepatitis, calculous cholecystitis

Stop receiving ZUNATA 60MG INJECTION and inform your doctor if you experience
any of the following side effects:

• severe allergic reactions such as urticaria or generalized rash, shortness of breath, low blood pressure

How To Manage Side Effects

Nausea or vomiting:

Stick to simple meals while receiving this medicine. Avoid eating oily, fried or
spicy foods. Do not lie down or sleep immediately after eating. If the symptom
does not improve, inform your doctor.

Stomach pain:

Take rest to relax yourself. Try to have smaller and frequent meals. Keep a heat
pad on your stomach. In case of no improvement, inform your doctor.

Diarrhoea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated.
Inform your doctor if the symptom does not improve.

Headache:

Rest and relax. Consume plenty of fluids such as water and electrolytes. Apply a
pain-relieving balm on the forehead if necessary. Inform your doctor if the
symptom worsens.

Skin rash:

Avoid hot showers because hot water can irritate the skin. Do not scratch the
affected area. Use moisturizers to relax and hydrate the affected skin area.
Inform your doctor if the symptom worsens.

Warning & Precautions

!### Pregnancy

ZUNATA 60MG INJECTION is not recommended for use during first trimester of
pregnancy. Consult your doctor before receiving ZUNATA 60MG INJECTION.

!### Breastfeeding

ZUNATA 60MG INJECTION should be used with caution in breastfeeding women.
Consult your doctor before receiving ZUNATA 60MG INJECTION.

!### Kidney

No dose adjustment is needed for patients with kidney impairment. Consult your
doctor before receiving ZUNATA 60MG INJECTION.

!### Liver

No dose adjustment is needed for patients with liver impairment. Consult your
doctor before receiving ZUNATA 60MG INJECTION.

!### Allergy

Do not receive ZUNATA 60MG INJECTION if you are allergic to artesunate or
artemisinin derivatives or any other ingredients of this medicine.

Others

Use in Paediatrics

ZUNATA 60MG INJECTION should be used with caution in children. Consult your
child’s doctor for advice before administration of ZUNATA 60MG INJECTION to your
child.

Interactions

A. Drug-Drug Interactions

Before receiving ZUNATA 60MG INJECTION, inform your doctor, if you are taking
any of the following medicines:

• nevirapine or ritonavir (medicines used to manage HIV infection)
• rifampin (used to manage tuberculosis)
• carbamazepine, phenytoin (medicines used to manage fits)
• axitinib, vandet
• diclofenac (used to manage pain)

Overdosage:

ZUNATA 60MG INJECTION will be given to you only by a doctor or nurse in a
hospital, and so it is unlikely to receive an overdose. In case of overdose you
may experience seizures, dark stools, low levels of blood cells and multiorgan
failure.

Synopsis

Drug	:	Artesunate
Pharmacological Category	:	Artemisinin derivative
Therapeutic Indication	:	Severe malaria including falciparum malaria, cerebral malaria
Dosage Forms	:	Injection, Infusion, Tablet

More Information

• Store at room temperature

FAQs About ZUNATA 60MG INJECTION

What is ZUNATA 60MG INJECTION used for?

ZUNATA 60MG INJECTION is used for the management of severe malaria including
cerebral malaria in adult and paediatric patients. It can also be used against
quinine resistant strains of P. falciparum. Consult your doctor before receiving
ZUNATA 60MG INJECTION.

Who should avoid receiving ZUNATA 60MG INJECTION?

Do not receive ZUNATA 60MG INJECTION if you are allergic to artesunate or
artemisinin derivatives. It is not recommended for use during first trimester of
pregnancy. Consult your doctor before receiving ZUNATA 60MG INJECTION.

Is ZUNATA 60MG INJECTION safe to use in children?

ZUNATA 60MG INJECTION should be used with caution in children and adolescents
(aged 18 years or below) as it may cause postartemisinin-delayed hemolysis
(PADH). Consult your child’s doctor for advice before administration of ZUNATA
60MG INJECTION to your child.

Is ZUNATA 60MG INJECTION safe to use in pregnant and breastfeeding women?

ZUNATA 60MG INJECTION is not recommended for use during first trimester of
pregnancy. It should be used with caution in breastfeeding women as it may pass
through milk in very small quantities. Consult your doctor before receiving
ZUNATA 60MG INJECTION.

How doesZUNATA 60MG INJECTION work?

ZUNATA 60MG INJECTION helps in managing malaria where Artesunate works by
transforming into a metabolite and binds with iron component of blood and forms
free radicals which inhibit the synthesis of protein and nucleic acid in
Plasmodium parasites and manages it from invading red blood cells, thus managing
the malaria effectively.

What is the method of receivingZUNATA 60MG INJECTION?

ZUNATA 60MG INJECTION will be given to you only by a doctor or a nurse
intravenously (into the vein) or intramuscularly (into the muscle). Your doctor
will decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Useful Diagnostic Tests

• Malarial Falciparum & Vivax Antigen
• Malarial Parasite Identification
• Peripheral Smear for Malaria
• Liver function test