Lumerax 40mg Tablet 6'S

Introduction About LUMERAX 40MG TABLET

LUMERAX 40MG TABLET is a combination of Artemether and Lumefantrine which
belongs to the group of medicines called Antimalarials. It is used in infants,
children and adults for the management of acute uncomplicated malaria (mosquito
borne disease with symptoms of fever with chills, tiredness, nausea, vomiting,
stomach pain) caused by a parasite called plasmodium falciparum.

LUMERAX 40MG TABLET should be used with caution in patients with severe liver or
kidney problems or if the patient feels worse or unwell to eat and drink.

LUMERAX 40MG TABLET is not recommended for use in patients having severe type of
malarial infection affecting the lungs, kidney or brain, heart condition such as
changes in the heart rhythm, slow heartbeat or severe heart disease and low
levels of electrolytes such as potassium or magnesium in the blood.

LUMERAX 40MG TABLET is generally not recommended for use during the first
trimester of pregnancy and it should be used with caution during the second and
third trimester of pregnancy and breast-feeding women only if advised by the
doctor.

LUMERAX 40MG TABLET should be used with caution in children and your child’s
doctor may adjust the dose depending upon child’s age and body weight.

The most common side effects of taking LUMERAX 40MG TABLET are headache,
dizziness, vomiting, stomach pain, nausea, muscle pain and loss of appetite.
Consult your doctor if any of the side effects worsen.

Uses Of LUMERAX 40MG TABLET

• Manage acute uncomplicated malarial infections (caused by plasmodium falciparum) in infants, children and adults

How LUMERAX 40MG TABLET Works

LUMERAX 40MG TABLET effectively manages malarial infections, whereartemether
effectively kills the malarial parasites by binding to haem (part of molecules
that contains iron which is toxic to malarial parasites) which is produced
during the breakdown of haemoglobin. Lumefantrine works by binding to hemin
where it manages the formation of a toxic malarial pigment called hemozoin,
thereby it manages malarial infection. In addition to this artemether and
lumefantrine blocks nucleic acid and protein synthesis in parasite that damages
the parasitic cell membrane of plasmodium falciparum which leads to the death of
parasite. Thus, it helps in managing the malarial infection.

How to use LUMERAX 40MG TABLET

Take LUMERAX 40MG TABLET exactly as advised by your doctor.

For Tablet, Capsule: Swallow LUMERAX 40MG TABLET with a glass of water. This
medicine should be taken with food or drinks rich in fat such as milk. Crush the
medicine into powder if your child is unable to swallow the whole medicine.

For Dispersible Tablet: Disperse LUMERAX 40MG TABLET in the specified
quantity of water as mentioned in the label. Consume the mixture immediately
after reconstitution.

Your doctor will decide the correct dose and duration for you depending upon
your age, body weight and severity of the disease condition.

Side Effects Of LUMERAX 40MG TABLET

Common

• headache, dizziness
• nausea, vomiting
• stomach pain
• diarrhea
• muscle or joint pain
• difficulty to sleep
• loss of appetite
• cough
• fast heartbeat
• general weakness, tiredness
• involuntary muscle spasms
• abnormal walking (in children above 12 years)
• tingling sensation or numbness of hand and feet
• rashes or itching in the skin
• disturbance in heart rhythm (prolonged QTc interval)

Uncommon

• sleepiness
• decreased skin sensitivity
• inability to coordinate movements

Rare

• allergic reactions

Stop taking LUMERAX 40MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• swelling of the face, lips, tongue or throat with difficulty in breathing and swallowing
• skin condition with large fluid filled blisters (bullous eru

How To Manage Side Effects

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the forehead if required. Do not consume too much of
alcohol. Consult your doctor if the symptom does not improve.

Nausea and vomiting:

Stick to simple meals while taking this medicine. Avoid eating oily, fried or
spicy foods. Do not lie down or sleep immediately after eating. Consult your
doctor if the symptom does not improve.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals.
Keep a heat pad on your stomach. Do not self-manage on your own and consult your
doctor if the symptom does not improve.

Diarrhea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated.
Avoid taking any medicine on your own for managing diarrhea. Consult your doctor
if the symptom does not improve.

Tiredness:

Drink plenty of fluid and eat balanced diet and frequent meals. Do regular
minimal exercise and follow regular sleep schedule. Consult your doctor if the
symptom does not improve.

Warning & Precautions

!### Pregnancy

LUMERAX 40MG TABLET is generally not recommended for use during the first
trimester of pregnancy. It should be used with caution during second and third
trimester of pregnancy only if considered clearly necessary. Consult your doctor
before taking LUMERAX 40MG TABLET.

!### Breastfeeding

LUMERAX 40MG TABLET should be taken with caution in breast feeding women only if
considered clearly necessary. Consult your doctor before taking LUMERAX 40MG
TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if you experience dizziness, sleepiness or
weakness after taking LUMERAX 40MG TABLET.

!### Kidney

LUMERAX 40MG TABLET is not recommended for use in patients having severe type of
malarial infection affecting the kidneys. It should be taken with caution in
patients with severe kidney problems. Consult your doctor before taking LUMERAX
40MG TABLET.

!### Liver

LUMERAX 40MG TABLET should be taken with caution in patients with severe liver
problems. Consult your doctor before taking LUMERAX 40MG TABLET.

!### Allergy

Do not take LUMERAX 40MG TABLET if you are allergic to Artemether, Lumefantrine
or any other ingredients of this medicine.

!### Lungs

LUMERAX 40MG TABLET is not recommended for use in patients having malaria with
pulmonary edema or severe type of malarial infection affecting the lungs.
Consult your doctor before taking it.

!### Heart Disease

LUMERAX 40MG TABLET is not recommended for use in patients with severe heart
disease or with heart diseases such as slow heartbeat, changes in the rhythm or
rate of the heartbeat or family history of death due to heart problems or born
with heart problems. LUMERAX 40MG TABLET should be taken with caution in
patients with variations in ECG (prolongation of QTc interval). Consult doctor
before taking LUMERAX 40MG TABLET.

Others

LUMERAX 40MG TABLET is not recommended for use if you have:

• severe type of malarial infection that has affected the brain
• low levels of electrolytes such as potassium or magnesium in blood

Before taking LUMERAX 40MG TABLET, inform your doctor if you:

• infected with both the plasmodium falciparum and plasmodium vivax parasites
• feeling worse or if you feel too unwell to eat and drink

Use in pediatrics

LUMERAX 40MG TABLET should be given with caution in children as the dosages of
LUMERAX 40MG TABLET vary in children according to their body weight. So, consult
a paediatrician before you give this medicine to your child.

Use in geriatrics

LUMERAX 40MG TABLET can be used in elderly patients. However, consult your
doctor before taking this medicine.

Interactions

A. Drug – drug interactions:

Before taking LUMERAX 40MG TABLET, inform your doctor if you are taking any of
the following medicines:

• medicines used to manage heart rhythm problems (Ex. Flecainide, metoprolol)
• medicines used to manage depression (Ex. imipramine, amitriptyline, clomipramine, St. John’s wort)
• medicine used to manage leprosy or tuberculosis (Ex. rifampicin)
• medicines used to manage bacterial infections (EX.  fluroquinolones such as ciprofloxacin, levofloxacin, macrolide antibiotics like azithromycin, erythromycin)
• medicines used to manage fungal infection (Ex. ketoconazole, fluconazole, itraconazole)
• medicines used to manage allergy (Ex. terfenadine, astemizole)
• medicine used to manage stomach disturbance (Ex. cisapride)
• medicines used to manage fits (Ex. carbamazepine, phenytoin)
• medicines used to manage malaria (Ex.  atovaquone/progu
• medicines used to manage HIV infection (Ex. indinavir, ritonavir)
• medicine used to manage pregnancy (Ex. Ethinyl estradiol)

B. Drug – Food interactions

Drink grapefruit juice with caution while taking LUMERAX 40MG TABLET as it may
interact with this medicine.

Overdosage:

If you or anyone else accidentally take too much of LUMERAX 40MG TABLET, consult
your doctor immediately or visit a nearby hospital.

Synopsis

Drug	:	Artemether, Lumefantrine
Pharmacological Category	:	Antimalarials
Therapeutic Indication	:	Manages acute uncomplicated malaria
Dosage Forms	:	Tablet, Dispersible tablet, Injection, Syrup, Oral suspension, Dry Syrup

More Information

• Keep LUMERAX 40MG TABLET out of reach of children
• Store LUMERAX 40MG TABLET at room temperature

FAQs About LUMERAX 40MG TABLET

What is LUMERAX 40MG TABLET used for?

LUMERAX 40MG TABLET is used in infants, children and adults for the management
of acute uncomplicated malaria (mosquito born disease with symptoms of fever
with chills, tiredness, nausea, vomiting, stomach pain) caused by a parasite
called plasmodium falciparum.

Does LUMERAX 40MG TABLET helps to manage malaria?

LUMERAX 40MG TABLET is not used to manage malaria. It is only used to manage
malarial infection caused by a parasite called plasmodium falciparum. Consult
your doctor for advice before taking this medicine.

Is LUMERAX 40MG TABLET safe to use in pregnant women?

LUMERAX 40MG TABLET is generally not recommended for use during the first
trimester of pregnancy. It should be used with caution during second and third
trimester of pregnancy only if considered clearly necessary. Consult your doctor
before taking LUMERAX 40MG TABLET.

Can LUMERAX 40MG TABLET be used in patients with kidney problems?

LUMERAX 40MG TABLET is not recommended for use in patients having severe type of
malarial infection affecting the kidneys. It should be taken with caution in
patients with severe kidney problems. Consult your doctor before taking LUMERAX
40MG TABLET.

Does LUMERAX 40MG TABLET cause diarrhea?

Yes, LUMERAX 40MG TABLET may cause diarrhea in some individuals. To manage this
effect, drink lot of fluids such as water or fruit juices to keep yourself
hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult
your doctor if the symptom does not improve.

Useful Diagnostic Tests

• Peripheral Smear for Malaria