METHYLGON Injection 1ml

Introduction About METHYLGON INJECTION

METHYLGON INJECTION contains Methylergometrine which belongs to a group of
medicines called Ergot alkaloids. METHYLGON INJECTION is used in the routine
management of uterine atony (inability of the uterus to contract sufficiently
during and after childbirth), haemorrhage and subinvolution of the uterus
(delayed return of enlarged uterus to normal size) following delivery of
placenta.

METHYLGON INJECTION is also used to control uterine haemorrhage (heavy/unusual
bleeding from uterus) following delivery of anterior shoulder of the foetus
(childbirth).

METHYLGON INJECTION is not recommended for use in patients allergic to
Methylergometrine. It is also not recommended for use in patients with high
blood pressure, and/or toxemia (blood poisoning due to local bacterial
infection).

Before receiving METHYLGON INJECTION, inform your doctor if you are a smoker,
and/or have high cholesterol, obesity, diabetes, heart problems (such as
coronary artery disease), kidney problems (such as impaired renal function),
and/or liver problems (such as impaired hepatic function).

METHYLGON INJECTION is generally not recommended for use during pregnancy and in
breast feeding women. The medicine should be received with caution in elderly
women (aged above 65 years) after consulting the doctor.

The most common side effect of receiving METHYLGON INJECTION is hypertension
associated with seizure, and/or headache. Consult your doctor if the side effect
worsens.

Uses Of METHYLGON INJECTION

• Helps in the routine management of uterine atony, haemorrhage and subinvolution of the uterus following delivery of placenta
• Helps to control uterine haemorrhage following delivery of anterior shoulder of the foetus (childbirth)

How METHYLGON INJECTION Works

METHYLGON INJECTION works by causing sustained contractions of uterine smooth
muscles by acting directly on the uterine smooth muscle which leads to
compression of blood vessels resulting in controlled/reduced blood loss
following childbirth.

How to use METHYLGON INJECTION

METHYLGON INJECTION will be given to you only by a doctor or a nurse as an
intravenous or intramuscular injection. Your doctor will decide the correct dose
and duration for you depending upon your age, body weight and disease condition.

Side Effects Of METHYLGON INJECTION

Common

• hypertension associated with seizure, and/or headache

Rare

• chest pain, fast/rapid/slow heart rate, coronary arterial spasm (sudden tightening of arteries of heart), heart attack
• vasoconstriction, vasospasm (narrowing of brain blood vessel)
• shortness of breath
• hematuria (blood in urine)
• thrombophlebitis (inflammation of a vein)
• hallucinations, dizziness
• leg cramps, ringing in ears, nasal congestion
• diarrhoea
• diaphoresis (sweating at a usual degree)
• rash
• foul taste
• signs of anaphylaxis reaction (life threatening allergic reaction) such as red itchy welts, low blood pressure, wheezing, and/or trouble in breathing

How To Manage Side Effects

Diarrhoea:

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on
your own to manage diarrhea. Consult and inform your doctor if the symptom
worsens.

Rash:

Do not scratch the affected area. Wear protective clothing while going outdoors.
Regularly moisturize your skin. Consult and inform your doctor if the symptom
gets worse.

Dizziness:

Try to rest and get enough sleep. Try to avoid driving or operating any tools or
machines while you feel dizzy. Limit consum
dizziness. Consult and inform your doctor if the symptom worsens.

Warning & Precautions

!### Pregnancy

METHYLGON INJECTION is generally not recommended for use during pregnancy.
Consult your doctor before receiving METHYLGON INJECTION.

!### Breastfeeding

METHYLGON INJECTION is generally not recommended for use in breast feeding women
since the medicine may pass through breast milk. Consult your doctor before
receiving METHYLGON INJECTION.

!### Kidney

METHYLGON INJECTION should be used with caution in patients with kidney problems
such as impaired renal function. Consult your doctor before receiving the
medicine.

!### Liver

METHYLGON INJECTION should be used with caution in patients with liver problems
such as impaired hepatic function. Consult your doctor before receiving the
medicine.

!### Allergy

Do not receive METHYLGON INJECTION if you are allergic to Methylergometrine,
and/or any other ingredients of this medicine.

!### Heart Disease

METHYLGON INJECTION should be used with caution in patients with heart problems
such as coronary artery disease. Consult your doctor before receiving the
medicine.

Others

METHYLGON INJECTION is not recommended for use if you:

• have high blood pressure
• suffer from toxemia (blood poisoning due to local bacterial infection)

Before receiving METHYLGON INJECTION, inform your doctor if you:

• are a smoker
• suffer from high cholesterol, obesity, diabetes
• have obliterative vascular disease (gradual narrowing of arterial blood vessel), and/or suffer from sepsis (life threatening complication of an infection)
• are in second stage of labor

Use in Geriatrics:

METHYLGON INJECTION should be used with caution in elderly patients (aged 65
years and above). Consult your doctor before receiving the medicine.

Interactions

A. Drug-Drug interactions:

Before receiving METHYLGON INJECTION, inform your doctor if you are taking any
of the following medicine:

• macrolide antibiotics (medicines used to manage bacterial infections) such as erythromycin, troleandomycin, clarithromycin
• HIV protease/reverse transcriptase inhibitors (medicines used to manage HIV) Ex. atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, nevirapine
• nefazodone, fluoxetine, fluvoxamine (medicines used to manage depression)
• fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, clotrimazole (medicines used to manage fungal disease)
• zileuton (used to manage asthma)
• rifampicin (used to manage infections)
• beta-blockers (used to manage high blood pressure) Ex. acebutolol, atenolol
• aesthetics (medicines used for the induction and maintenance of general anaesthesia) Ex. halothan, methoxyfluran
• glyceryl trinitrate (used to manage angina)
• prostaglandins (used to induce labor/abortion and manage postpartum haemorrhage)

B. Drug-Food interaction:

Grapefruit/or its juice may interact with this medicine and lead to unwanted
side effects. Consult your doctor before taking any grapefruit products.

Overdosage:

METHYLGON INJECTION will be administered to you only by a doctor or a nurse in a
hospital, and so it is unlikely to receive an overdose. However, consult your
doctor or nurse if you experience any unusual symptoms such as nausea, vomiting,
oliguria (low urine output), abdominal pain, numbness, tingling of the
extremities, rise in blood pressure, low blood pressure, respiratory depression,
hypothermia (dangerous drop in body temperature), convulsions, and/or coma.

Synopsis

Drug	:	Methylergometrine
Pharmacological Category	:	Ergot alkaloid
Therapeutic Indication	:	Routine management of uterine atony, haemorrhage and subinvolution of the uterus (following delivery of placenta), Control uterine haemorrhage following childbirth
Dosage Forms	:	Tablet, Injection

More Information

• Keep METHYLGON INJECTION out of reach of children
• Store at room temperature

FAQs About METHYLGON INJECTION

What is METHYLGON INJECTION used for?

METHYLGON INJECTION is used in the routine management of uterine atony
(inability of the uterus to contract sufficiently during and after childbirth),
haemorrhage and subinvolution of the uterus (delayed return of enlarged uterus
to normal size) following delivery of placenta. It is also used to control
uterine haemorrhage (heavy/unusual bleeding from uterus) following delivery of
anterior shoulder of the foetus (childbirth).

How METHYLGON INJECTION works?

METHYLGON INJECTION works by causing sustained contractions of uterine smooth
muscles by acting directly on the uterine smooth muscle which leads to
compression of blood vessels resulting in controlled/reduced blood loss
following childbirth.

How METHYLGON INJECTION is administered?

METHYLGON INJECTION will be given to you only by a doctor or a nurse as an
intravenous or intramuscular injection. Your doctor will decide the correct dose
and duration for you depending upon your age, body weight and disease condition.

What are the most common side effects of taking METHYLGON INJECTION?

The most common side effect of receiving METHYLGON INJECTION is hypertension
associated with seizure, and/or headache. Consult your doctor if the side effect
worsens.

Can METHYLGON INJECTION be used in pregnant and breastfeeding women?

No, METHYLGON INJECTION is not recommended for use in pregnant and breastfeeding
women. Consult your doctor before receiving the medicine.

Useful Diagnostic Tests

• Activated Partial Thromboplastin Time
• Complete Blood Count
• Prothrombin Time
• Thrombin Time