ENDOGOLIX 150 Tablet 10's

Introduction About ENDOGOLIX 150 TABLET

ENDOGOLIX 150 TABLET is indicated for the management of moderate to severe pain
associated with endometriosis. It contains a medicine called Elagolix which
works by blocking the action of gonadotropin-releasing hormone (GnRH), reducing
estrogen levels and thereby decreasing inflammation and pain caused by
endometrial tissue outside the uterus.

Unlike traditional hormonal treatments, Elagolix offers rapid symptom relief and
a customizable dosing regimen, making it a preferred choice for women seeking
non-surgical management of endometriosis-related discomfort.

Patients should take Elagolix at the same time each day, with or without food,
and use non-hormonal contrace
fertility. Long-term use should be carefully monitored due to the risk of bone
mineral density loss.

Elagolix provides a convenient and effective alternative to surgery or
injectable hormone therapies for endometriosis management. It reduces pain and
improves quality of life, allowing women to manage their symptoms while
maintaining daily activities.

However, caution is advised for those with osteoporosis, mood disorders, liver
disease, or pregnancy, and interactions with certain medications should be
assessed before use. Regular follow-ups with a doctor are essential to ensure
safe and o

Uses Of ENDOGOLIX 150 TABLET

• Management of moderate to severe pain associated with endometriosis

Benefits of ENDOGOLIX 150 TABLET

• Effective Pain Relief: Helps reduce pelvic pain, menstrual cramps, and pain during intercourse (dyspareunia) by lowering estrogen levels.
• Rapid Symptom Control: Starts working within a few weeks, providing faster relief compared to other hormonal treatments.
• Flexible Dosing O
• Non-Surgical O
• Short-Term, Reversible Effects: Unlike surgical removal of ovaries, Elagolix allows temporary estrogen suppression, and normal hormone levels return after stopping the medication.
• Convenient Oral Therapy: Taken as a simple daily tablet, with or without food, for ease of use.

While Elagolix is effective for symptom relief, it is important to monitor bone
health and discuss long-term treatment plans with a doctor.

How ENDOGOLIX 150 TABLET Works

ENDOGOLIX 150 TABLET works by blocking a hormone called gonadotropin-releasing
hormone (GnRH) in the brain. GnRH normally signals the body to produce estrogen
and progesterone, hormones that regulate the menstrual cycle.

By partially blocking this signal, Elagolix lowers estrogen levels, which helps
reduce the growth and activity of endometrial tissue. This, in turn, relieves
pain and other symptoms associated with endometriosis. However, since estrogen
is important for bone health, long-term use of Elagolix may lead to bone density
loss.

How to use ENDOGOLIX 150 TABLET

How To Take ENDOGOLIX 150 TABLET?

1. Confirm Pregnancy Status: Ensure you are not pregnant before starting ENDOGOLIX 150 TABLET. If starting during your menstrual cycle, begin within the first 7 days of your period.
2. Dosage Timing: Take Elagolix at the same time each day, with or without food, to maintain consistent drug levels in your body.
3. Use the Lowest Effective Dose: Your doctor will determine the best dosage based on the severity of your symptoms and treatment goals.
4. Duration of Use: Do not exceed the prescribed duration, as long-term use may lead to bone density loss.

Recommended Dosage:

• For Normal Liver Function or Mild Hepatic Impairment:
  • 150 mg once daily for up to 24 months
  • 200 mg twice daily for up to 6 months (if you have dyspareunia or severe symptoms)
• For Moderate Hepatic Impairment:
  • 150 mg once daily for up to 6 months

Additional Considerations:

• Use non-hormonal contrace
• If you experience severe side effects, such as mood changes or unusual bleeding, contact your doctor immediately.
• Follow up with your doctor regularly to monitor bone health and treatment effectiveness.

What if I forgot to take ENDOGOLIX 150 TABLET

If you miss a dose, take it as soon as you remember on the same day. If it's
almost time for the next dose, skip the missed one and continue your regular
schedule. Do not take extra doses to make up for a missed one.

Side Effects Of ENDOGOLIX 150 TABLET

Like all medicines, ENDOGOLIX 150 TABLET may cause certain side effects,
although not everybody gets them.

Common Side Effects of ENDOGOLIX 150 TABLET:

• hot flushes and night sweats
• headache, nausea
• insomnia (lack of sleep)
• amenorrhea (lack of periods)
• anxiety,
• joint pain, bone weakness

When To Seek Medical Attention?

Stop taking ENDOGOLIX 150 TABLET and inform your doctor immediately if you
experience any of the following side effects such as:

• depression-related adverse reactions
• mood changes

Warning & Precautions

!### Pregnancy

ContraindicatedENDOGOLIX 150 TABLET is contraindicated during pregnancy, as early exposure may
increase the risk of early pregnancy loss. If you become pregnant while taking
this medicine, discontinue use immediately and consult your doctor.

!### Breastfeeding

Consult your doctorThe presence of Elagolix in human milk, its effects on the breastfed child, or
its impact on milk production are not well understood. Therefore, it's advisable
to weigh the benefits of breastfeeding against the potential risks of taking
ENDOGOLIX 150 TABLET while nursing.

!### Driving and Using Machines

Use with CautionENDOGOLIX 150 TABLET may cause side effects such as dizziness, fatigue, or mood
changes, which can impair your ability to drive or operate heavy machinery. If
you experience these symptoms, refrain from such activities and discuss them
with your doctor.

!### Alcohol

Consult your doctorWhile there are no specific warnings against alcohol consum
150 TABLET, combining alcohol with medications can potentially exacerbate side
effects like dizziness or liver strain. It is prudent to limit or avoid alcohol
while on this medication.

!### Kidney

Consult your doctorNo dosage adjustment of Elagolix is required in women with any degree of renal
impairment or end-stage renal disease, including those on dialysis.

!### Liver

Consult your doctorENDOGOLIX 150 TABLET is not recommended for use in patients with severe hepatic
(liver) impairment due to the risk of bone loss. For those with moderate hepatic
impairment, a reduced dosage may be necessary. Always inform your doctor of any
existing liver conditions before starting therapy.

!### Allergy

ContraindicatedInform your doctor about any known allergies, especially to medications. If you
experience signs of an allergic reaction, such as rash, itching, swelling, or
difficulty breathing, seek medical attention promptly.

!### Use In Pediatrics

ContraindicatedENDOGOLIX 150 TABLET is not recommended for use in children and adolescents
under 18 years of age, as its safety and effectiveness have not been established
in this age group. Since Elagolix affects hormone levels and bone mineral
density, it may interfere with normal growth and bone development in younger
patients.

!### Use In Geriatrics

ContraindicatedENDOGOLIX 150 TABLET is not indicated for use in elderly patients (65 years and
older), as endometriosis is a condition that primarily affects women of
reproductive age. Additionally, older adults may have a higher risk of bone
loss, liver impairment, or drug interactions, making Elagolix unsuitable for
routine use in this population.

Other Warnings for ENDOGOLIX 150 TABLET

Before taking ENDOGOLIX 150 TABLET, inform your doctor if you have:

• Bone loss
• Reduced ability to recognise pregnant
• Suicidal ideation and mood disorders
• Hepatic transaminase elevations
• Estrogen-Containing Contrace

Who should not take ENDOGOLIX 150 TABLET

ENDOGOLIX 150 TABLET is not recommended for use in patients with:

• Known history of osteoporosis, as it can increase the risk of fractures
• Pregnancy

Drug - Drug interaction

• CYP3A Substrates: Elagolix may decrease plasma concentrations of drugs that are substrates of CYP3A (e.g, digoxin), as it is a weak to moderate inducer of this enzyme.
• P-glycoprotein (P-gp) Substrates: Elagolix may increase plasma concentrations of drugs that are substrates of P-gp (e.g., digoxin) because it inhibits this efflux transporter.
• Hormonal Contrace

More Information

Storage

• Store in a cool, dry place protected from light and moisture at a temperature not exceeding 30°C.
• Keep out of reach of children.

FAQs About ENDOGOLIX 150 TABLET

Q: What is ENDOGOLIX 150 TABLET used for?

A: ENDOGOLIX 150 TABLET is used to manage moderate to severe pain associated
with endometriosis, including pelvic pain, menstrual cramps, and pain during
intercourse (dyspareunia).

Q: How does ENDOGOLIX 150 TABLET work?

A: ENDOGOLIX 150 TABLET blocks gonadotropin-releasing hormone (GnRH) in the
brain, reducing estrogen levels, which helps decrease inflammation and pain
caused by endometrial tissue outside the uterus.

Q: How should I take ENDOGOLIX 150 TABLET?

A: Take ENDOGOLIX 150 TABLET at the same time each day, with or without food.
Follow your doctor’s dosage instructions carefully, as the duration of use is
limited.

Q: How long does it take for ENDOGOLIX 150 TABLET to start working?

A: Many women notice pain relief within a few weeks of starting management, but
individual responses may vary.

Q: What are the common side effects of ENDOGOLIX 150 TABLET?

A: Possible side effects include hot flashes, headache, nausea, mood changes,
irregular periods, and decreased bone mineral density with prolonged use.

Q: Can I take ENDOGOLIX 150 TABLET if I am pregnant or planning pregnancy?

A: No, Elagolix should not be used during pregnancy as it may cause early
pregnancy loss. Use non-hormonal contrace
one week after stopping therapy.

Q: Can Elagolix affect my bone health?

A: Yes, long-term use can lead to bone mineral density loss, which may not be
fully reversible. This is why its use is limited to 6-24 months depending on the
dosage.

Q: Are there any drug interactions with ENDOGOLIX 150 TABLET?

A: Yes, ENDOGOLIX 150 TABLET can interact with medications like oral
contrace
antidepressants. Always inform your doctor about all medicines you are taking.

Q: Can I drink alcohol while taking ENDOGOLIX 150 TABLET?

A: There are no specific restrictions, but alcohol may increase the risk of side
effects like dizziness, fatigue, or liver strain. It is best to limit or avoid
alcohol consum

Q: What should I do if I miss a dose of ENDOGOLIX 150 TABLET?

A: Take the missed dose as soon as you remember on the same day. If it's almost
time for your next dose, skip the missed one and continue your regular schedule.
Do not take extra doses to make up for the missed one.

Useful Diagnostic Tests

• Estrogen/Progesterone Receptor (ER/PR)
• Female Hormones Package
• Female Hormones Profile