Methastar 0.125mg Tablet 10'S

Introduction About METHASTAR 0.125MG TABLET

METHASTAR 0.125MG TABLET contains Methylergometrine which belongs to a group of
medicines called Ergot alkaloids. METHASTAR 0.125MG TABLET is used in the
routine management of uterine atony (inability of the uterus to contract
sufficiently during and after childbirth), haemorrhage and subinvolution of the
uterus (delayed return of enlarged uterus to normal size) following delivery of
placenta.

METHASTAR 0.125MG TABLET is also used to control uterine haemorrhage
(heavy/unusual bleeding from uterus) following delivery of anterior shoulder of
the foetus (childbirth).

METHASTAR 0.125MG TABLET is not recommended for use in patients allergic to
Methylergometrine. It is also not recommended for use in patients with high
blood pressure, and/or toxemia (blood poisoning due to local bacterial
infection).

Before taking METHASTAR 0.125MG TABLET, inform your doctor if you are a smoker,
and/or have high cholesterol, obesity, diabetes, heart problems (such as
coronary artery disease), kidney problems (such as impaired renal function),
and/or liver problems (such as impaired hepatic function).

METHASTAR 0.125MG TABLET is generally not recommended for use during pregnancy
and in breast feeding women. The medicine should be taken with caution in
elderly women (aged above 65 years) after consulting the doctor.

The most common side effect of taking METHASTAR 0.125MG TABLET is hypertension
associated with seizure, and/or headache. Consult your doctor if the side effect
worsens.

Uses Of METHASTAR 0.125MG TABLET

• Helps in the routine management of uterine atony, haemorrhage and subinvolution of the uterus following delivery of placenta
• Helps to control uterine haemorrhage following delivery of anterior shoulder of the foetus (childbirth)

How METHASTAR 0.125MG TABLET Works

METHASTAR 0.125MG TABLET works by causing sustained contractions of uterine
smooth muscles by acting directly on the uterine smooth muscle which leads to
compression of blood vessels resulting in controlled/reduced blood loss
following childbirth.

How to use METHASTAR 0.125MG TABLET

Take METHASTAR 0.125MG TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine. Your doctor will
decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Side Effects Of METHASTAR 0.125MG TABLET

Common

• hypertension associated with seizure, and/or headache

Rare

• chest pain, fast/rapid/slow heart rate, coronary arterial spasm (sudden tightening of arteries of heart), heart attack
• vasoconstriction, vasospasm (narrowing of brain blood vessel)
• shortness of breath
• hematuria (blood in urine)
• thrombophlebitis (inflammation of a vein)
• hallucinations, dizziness
• leg cramps, ringing in ears, nasal congestion
• diarrhoea
• diaphoresis (sweating at a usual degree)
• rash
• foul taste
• signs of anaphylaxis reaction (life threatening allergic reaction) such as red itchy welts, low blood pressure, wheezing, and/or trouble in breathing

How To Manage Side Effects

Diarrhoea:

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on
your own to manage diarrhea. Consult and inform your doctor if the symptom
worsens.

Rash:

Do not scratch the affected area. Wear protective clothing while going outdoors.
Regularly moisturize your skin. Consult and inform your doctor if the symptom
gets worse.

Dizziness:

Try to rest and get enough sleep. Try to avoid driving or operating any tools or
machines while you feel dizzy. Limit consum
dizziness. Consult and inform your doctor if the symptom worsens.

Warning & Precautions

!### Pregnancy

METHASTAR 0.125MG TABLET is generally not recommended for use during pregnancy.
Consult your doctor before taking METHASTAR 0.125MG TABLET.

!### Breastfeeding

METHASTAR 0.125MG TABLET is generally not recommended for use in breast feeding
women since the medicine may pass through breast milk. Consult your doctor
before taking METHASTAR 0.125MG TABLET.

!### Kidney

METHASTAR 0.125MG TABLET should be used with caution in patients with kidney
problems such as impaired renal function. Consult your doctor before taking the
medicine.

!### Liver

METHASTAR 0.125MG TABLET should be used with caution in patients with liver
problems such as impaired hepatic function. Consult your doctor before taking
the medicine.

!### Allergy

Do not take METHASTAR 0.125MG TABLET if you are allergic to Methylergometrine,
and/or any other ingredients of this medicine.

!### Heart Disease

METHASTAR 0.125MG TABLET should be used with caution in patients with heart
problems such as coronary artery disease. Consult your doctor before taking the
medicine.

Others

METHASTAR 0.125MG TABLET is not recommended for use if you:

• have high blood pressure
• suffer from toxemia (blood poisoning due to local bacterial infection)

Before taking METHASTAR 0.125MG TABLET, inform your doctor if you:

• are a smoker
• suffer from high cholesterol, obesity, diabetes
• have obliterative vascular disease (gradual narrowing of arterial blood vessel), and/or suffer from sepsis (life threatening complication of an infection)
• are in second stage of labor

Use in Geriatrics:

METHASTAR 0.125MG TABLET should be used with caution in elderly patients (aged
65 years and above). Consult your doctor before taking the medicine.

Interactions

A. Drug-Drug interactions:

Before taking METHASTAR 0.125MG TABLET, inform your doctor if you are taking any
of the following medicine:

• macrolide antibiotics (medicines used to manage bacterial infections) such as erythromycin, troleandomycin, clarithromycin
• HIV protease/reverse transcriptase inhibitors (medicines used to manage HIV) Ex. atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, nevirapine
• nefazodone, fluoxetine, fluvoxamine (medicines used to manage depression)
• fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, clotrimazole (medicines used to manage fungal disease)
• zileuton (used to manage asthma)
• rifampicin (used to manage infections)
• beta-blockers (used to manage high blood pressure) Ex. acebutolol, atenolol
• aesthetics (medicines used for the induction and maintenance of general anaesthesia) Ex. halothan, methoxyfluran
• glyceryl trinitrate (used to manage angina)
• prostaglandins (used to induce labor/abortion and manage postpartum haemorrhage)

B. Drug-Food interaction:

Grapefruit/or its juice may interact with this medicine and lead to unwanted
side effects. Consult your doctor before taking any grapefruit products.

Overdosage:

If you or anyone else accidentally take too much of METHASTAR 0.125MG TABLET,
consult your doctor immediately or visit the nearby hospital. Symptoms of
overdose are nausea, vomiting, oliguria (low urine output), abdominal pain,
numbness, tingling of the extremities, rise in blood pressure, low blood
pressure, respiratory depression, hypothermia (dangerous drop in body
temperature), convulsions, and/or coma.

Synopsis

Drug	:	Methylergometrine
Pharmacological Category	:	Ergot alkaloid
Therapeutic Indication	:	Routine management of uterine atony, haemorrhage and subinvolution of the uterus (following delivery of placenta), Control uterine haemorrhage following childbirth
Dosage Forms	:	Tablet, Injection

More Information

• Keep METHASTAR 0.125MG TABLET out of reach of children
• Do not store METHASTAR 0.125MG TABLET above 30°C

FAQs About METHASTAR 0.125MG TABLET

What is METHASTAR 0.125MG TABLET used for?

METHASTAR 0.125MG TABLET is used in the routine management of uterine atony
(inability of the uterus to contract sufficiently during and after childbirth),
haemorrhage and subinvolution of the uterus (delayed return of enlarged uterus
to normal size) following delivery of placenta. It is also used to control
uterine haemorrhage (heavy/unusual bleeding from uterus) following delivery of
anterior shoulder of the foetus (childbirth).

How METHASTAR 0.125MG TABLET works?

METHASTAR 0.125MG TABLET works by causing sustained contractions of uterine
smooth muscles by acting directly on the uterine smooth muscle which leads to
compression of blood vessels resulting in controlled/reduced blood loss
following childbirth.

How to take METHASTAR 0.125MG TABLET?

Take METHASTAR 0.125MG TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine. Your doctor will
decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

What are the most common side effects of taking METHASTAR 0.125MG TABLET?

The most common side effect of taking METHASTAR 0.125MG TABLET is hypertension
associated with seizure, and/or headache. Consult your doctor if the side effect
worsens.

Can METHASTAR 0.125MG TABLET be used in pregnant and breastfeeding women?

No, METHASTAR 0.125MG TABLET is not recommended for use in pregnant and
breastfeeding women. Consult your doctor before taking the medicine.

Useful Diagnostic Tests

• Activated Partial Thromboplastin Time
• Complete Blood Count
• Prothrombin Time
• Thrombin Time