Tenocruz Af 25Mg Tablet 30's

Introduction About TENOCRUZ AF 25MG TABLET

TENOCRUZ AF 25MG TABLET contains Tenofovir alafenamide which belongs to the
group of medicines called Anti-viral drugs. It is used to manage chronic
(long-term) hepatitis B infection in adolescents and adults (aged 12 years and
older). Hepatitis B is a virus that infects the liver, causes long-term
infection, and can result in liver damage. It can show symptoms like easy
tiredness, anxiety, lack of appetite, jaundice, fits and vomiting.

Before taking TENOCRUZ AF 25MG TABLET, inform your doctor if you have any liver
or kidney disease, hepatitis C or D (viral liver infection), HIV infection,
intolerance to some sugars. TENOCRUZ AF 25MG TABLET should be used with caution
in pregnant women and it is not recommended for use in breastfeeding women.

Prior to the management, your doctor may want you to take several blood tests to
understand your existing condition. During the management take precautions to
avoid sexual contact and spreading the infection to others.

TENOCRUZ AF 25MG TABLET is not recommended for use in children who are (younger
than 12 years of age or weighing less than 35 kgs) and it should be used with
caution in elderly patients (aged 65 years and above). The most common side
effects of taking TENOCRUZ AF 25MG TABLET are headache, diarrhoea, vomiting,
nausea, dizziness, stomach pain, joint pain, rash, itching and tiredness.
Consult your doctor if any of the side effect worsens

Uses Of TENOCRUZ AF 25MG TABLET

• Manage long-term hepatitis B infection

How TENOCRUZ AF 25MG TABLET Works

TENOCRUZ AF 25MG TABLET works by inhibiting an enzyme (viral polymerase),
causing chain termination, which in turn, inhibits DNA synthesis and viral
replication, thereby managing the virus to produce new viruses and stops the
infection from spreading.

How to use TENOCRUZ AF 25MG TABLET

Take TENOCRUZ AF 25MG TABLET as advised by your physician. Swallow the medicine
with a glass of water. Your doctor will decide the right dose and duration
depending upon your age, body weight and disease condition. Do not stop taking
TENOCRUZ AF 25MG TABLET unless your doctor advices to stop.

Side Effects Of TENOCRUZ AF 25MG TABLET

Common

• headache, dizziness
• diarrhoea, vomiting, nausea, stomach pain, feeling bloated, flatulence
• joint pain
• rash, itching
• tiredness

Uncommon

• swelling of the face, lips, throat or tongue (angioedema)
• hives (urticaria)
• increased liver enzyme in the blood

Rare

Stop taking TENOCRUZ AF 25MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• new onset or worsening of kidney impairment
• lactic acidosis (too much acid in the blood) (signs include weakness or tiredness than usual, unusual muscle pain, shortness of breath or fast breathing, stomach pain with nausea and vomiting, fast or abnormal heartbeat, cold or blue hands and feet, feeling dizzy or light-headedness)
• signs of severe liver problems (such as yellowing of skin or white of the eyes, dark tea-colored urine, light-colored stools, loss of appetite, stomach pain or nausea)

How To Manage Side Effects

!### Diarrhea

Drink lot of water or fruit juice to keep yourself hydrated. Avoid eating
high-fat or spicy foods. if symptoms does not show improvement consult your
doctor.

!### Dizziness Or Drowsiness

Lie down until dizziness is gone. Move slowly and carefully, do not hurry. Get
adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes,
alcohol, and drugs. If symptom does not show improvement, consult your doctor.

Headache

Drink ample amount of water. Get adequate rest. Try to be relaxed and stress
free. Apply pain relieving balm on your forehead if necessary. Consult your
doctor if the symptom does not show improvement.

!### Indigestion

Eat smaller and frequent meals and exercise regularly (walking). Limit the
intake of carbonated drinks. Avoid eating foods such as beans, lentils which
cause bloating. If the symptom does not show improvement, consult your doctor.

!### Nausea And Vomiting

Take TENOCRUZ AF 25MG TABLET with meals. Stick to simple meals. Avoid eating
oily, fried or spicy foods. Do not lay down or sleep immediately after eating.
If symptom does not show improvement, consult your doctor.

!### Stomach Pain

Try to rest and relax. Have smaller meals more frequently. Keep a heat pad. If
the symptom does not show improvement, consult your doctor.

Warning & Precautions

!### Pregnancy

Monitoring requiredTENOCRUZ AF 25MG TABLET should be used with caution during pregnancy only if
considered clearly necessary. Consult your doctor before taking TENOCRUZ AF 25MG
TABLET.

!### Breastfeeding

ContraindicatedTENOCRUZ AF 25MG TABLET is not recommended for use in breastfeeding women as the
medicine passes to baby through breast milk. Consult your doctor before taking
TENOCRUZ AF 25MG TABLET.

!### Driving and Using Machines

Use with CautionDo not drive or use any machines if you feel dizzy after taking TENOCRUZ AF 25MG
TABLET.

!### Kidney

Use with CautionTENOCRUZ AF 25MG TABLET should be used with caution in patients with kidney
disease or problems. Consult your doctor before taking TENOCRUZ AF 25MG TABLET.

!### Liver

Use with CautionTENOCRUZ AF 25MG TABLET should be used with caution in patients with history of
liver disease, including hepatitis C or D (viral liver infection that leads to
serious liver damage). Consult your doctor before taking TENOCRUZ AF 25MG
TABLET.

!### Allergy

ContraindicatedDo not take TENOCRUZ AF 25MG TABLET if you are allergic to Tenofovir alafenamide
or any other ingredients of this medicine.

!### Use In Pediatrics

ContraindicatedTENOCRUZ AF 25MG TABLET is not recommended for use in children who are (younger
than 12 years of age or weighing less than 35 kgs). Consult your child’s doctor
for advice.

!### Use In Geriatrics

Use with CautionTENOCRUZ AF 25MG TABLET should be used with caution in elderly patients (aged 65
years and above). Consult your doctor before taking TENOCRUZ AF 25MG TABLET.

Others

Before taking TENOCRUZ AF 25MG TABLET, inform your doctor if you have:

• HIV (human immunodeficiency virus) infection
• intolerance to some sugars

Interactions

A. Drug-Drug interactions:

Before taking TENOCRUZ AF 25MG TABLET, inform your doctor if you are taking any
of the following medicines:

• other medicines used to manage hepatitis B infection (Ex. tenofovir alafenamide, tenofovir disoproxil, adefovir dipivoxil)
• ritonavir or cobicistat boosted darunavir, lopinavir, atazanavir (used to manage HIV infection)
• medicines used to manage bacterial infections including tuberculosis (Ex. rifabutin, rifampicin, rifapentine)
• medicines used to manage fits (Ex. carbamazepine, oxcarbazepine, phenobarbital or phenytoin)
• St. John’s wort (herbal medicine for depression and anxiety)
• medicines used to manage fungal infections (Ex. ketoconazole or itraconazole)

Overdose:

If you or anyone else accidentally take too much of TENOCRUZ AF 25MG TABLET,
consult your doctor immediately or visit the nearby hospital due to increased
risk of side effects.

Synopsis

Drug	:	Tenofovir alafenamide
Pharmacological Category	:	Nucleotide Reverse Transcriptase Inhibitor (NtRTI)
Therapeutic Indication	:	Hepatitis B infection
Dosage Forms	:	Tablet

More Information

• Keep TENOCRUZ AF 25MG TABLET away from children
• Store at room temperature

FAQs About TENOCRUZ AF 25MG TABLET

Q: Can I pass hepatitis B infection to others while taking TENOCRUZ AF 25MG
TABLET?

A: Yes, you can still pass the infection to others while taking TENOCRUZ AF 25MG
TABLET. It does not reduce the risk of infecting others with hepatitis B through
sexual contact or blood contamination. Discuss the precautionary measures needed
with your doctor to avoid infecting others.

Q: What if I miss a dose of TENOCRUZ AF 25MG TABLET?

A: It is important not to miss a dose of TENOCRUZ AF 25MG TABLET but if you do,
take the next dose as soon as possible if you remember within 18 hours of
previous dose. Do not take the forgotten dose if you remember after 18 hours or
more of previous dose. Wait and take your next dose as per schedule.

Q: What if I vomit a dose of TENOCRUZ AF 25MG TABLET?

A: If you have vomited a dose of TENOCRUZ AF 25MG TABLET in less than 1 hour
after taking it, take another medicine. Do not take another dose if you vomit
the medicine more than 1 hour after taking it.

Q: Can I stop taking TENOCRUZ AF 25MG TABLET?

A: Do not stop taking TENOCRUZ AF 25MG TABLET without consulting your doctor, as
it may worsen your condition. It could be very serious if you already have any
liver problems. When you stop taking TENOCRUZ AF 25MG TABLET, your doctor will
monitor you for several months to check your infection. If you have any more
doubts regarding the use of this medicine, ask your doctor.

Q: Can TENOCRUZ AF 25MG TABLET be used in children?

A: No, TENOCRUZ AF 25MG TABLET is used for adults and not recommended for use in
children who are (younger than 12 years of age or weighing less than 35 kgs).
Child’s doctor will decide the correct dose or select a suitable alternative
therapy for your child.

Useful Diagnostic Tests

• Hepatitis B panel of blood tests
• Liver Function Test
• Complete Blood Count (CBC)