VIR 250mg Injection 5ml

Introduction About VIR 250MG INJECTION

VIR 250MG INJECTION contains Acyclovir, which belongs to the group of medicines
called Antivirals. It is used for the management of varicella zoster infections
(an infection caused by the varicella-zoster virus and symptoms include an itchy
rash with small, fluid-filled blisters) and herpes encephalitis caused by the
Herpes Simplex Virus in neonates and adults. Symptoms include headaches, fevers,
drowsiness, hyperactivity and general weakness).

Herpes simplex infections and severe initial genital herpes (a common sexually
transmitted infection caused by the herpes simplex virus) in patients with a
weakened immune system, prophylaxis of Herpes simplex infections in
immunodeficient patients and management of Herpes simplex infections in the
neonates and infants up to three months of age.

Before receiving VIR 250MG INJECTION inform your doctor if you have kidney
problems. VIR 250MG INJECTION should be used with caution among pregnant or
breastfeeding women, therefore consult your doctor before receiving it. The most
common side effects after receiving VIR 250MG INJECTION are headache, dizziness,
feeling or being sick, diarrhea, stomach pain and rashes. Contact your doctor if
the symptom gets worse or persists.

Uses Of VIR 250MG INJECTION

• Manage and manages herpes infections
• Manage chickenpox and shingles

How VIR 250MG INJECTION Works

VIR 250MG INJECTION works by killing or stopping the growth of viruses (herpes
virus). It has a higher affinity for viral DNA cells than human DNA cells and
incorporates into the viral DNA and causes DNA chain termination and
inactivation, leading to the death of cells.

How to use VIR 250MG INJECTION

VIR 250MG INJECTION will be given to you only by a doctor or a nurse into a vein
as an intravenous infusion. Your doctor will decide the correct dose and
duration for you depending on your age, body weight and disease condition.

Side Effects Of VIR 250MG INJECTION

Common

• nausea and vomiting
• allergic reactions such as rashes, itchy, sensitivity to light
• swelling, redness, tenderness or pain at the site of injection
• elevated liver enzymes
• increase in blood urea and creatinine

Uncommon

• anaemia, leukopenia, thrombocytopenia
• rashes include photosensitivity, urticaria, pruritus
• nosebleeds and bruises easily due to a decrease in blood platelets
• fatigue, decreased energy, weakness, dyspnoea (shortness of breath), fainting, palpitations, pale skin due to anaemia
• risk of infections due to falling in white blood cells

Rare

Stop taking VIR 250MG INJECTION and contact your doctor immediately if you
experience any of the following side effects:

• severe allergic reactions such as erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria and tissue necrosis
• encephalopathy changes characterized by lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures or coma
• signs of liver problems such as hepatitis, hyperbilirubinemia, jaundice (yellowing of the skin and the whites of the eyes)

How To Manage Side Effects

Nausea or vomiting:

Take this medicine with or just after meals. Avoid eating oily or spicy foods.
If the symptom does not improve, contact your doctor immediately.

Itchy skin:

Try to use an unscented moisturiser. If the symptom does not improve, contact
your doctor immediately.

Warning & Precautions

!### Pregnancy

VIR 250MG INJECTION is generally not recommended for use in pregnant women
unless considered necessary. Consult your doctor before receiving VIR 250MG
INJECTION.

!### Breastfeeding

VIR 250MG INJECTION is not recommended for use in breastfeeding women as it may
pass through the breast milk. Consult your doctor before receiving VIR 250MG
INJECTION.

!### Driving and Using Machines

Do not drive or operate any machines if you have confusion, hallucinations,
agitation, tremors and drowsiness after receiving VIR 250MG INJECTION.

!### Kidney

VIR 250MG INJECTION should be used with caution in patients with kidney
diseases. Consult your doctor before receiving VIR 250MG INJECTION.

!### Allergy

Do not receive VIR 250MG INJECTION if you are allergic to Acyclovir or
valacyclovir or any other ingredients of this medicine.

Others

Before receiving VIR 250MG INJECTION, inform your doctor:

• if you have a low resistance to disease (immune deficiency)
• dehydration
• low sodium diet

Use in pediatrics:

NA

Use in geriatrics:

VIR 250MG INJECTION should be used with caution in elderly patients (aged above
75 years). Consult your doctor before receiving it.

Interactions

A. Drug-Drug interactions:

Before receiving VIR 250MG INJECTION, inform your doctor if you are taking any
of the following medicine:

• probenecid (a medicine used to manage gout)
• cimetidine (a medicine used to manage stomach ulcers)
• drugs acting on the immune system (Ex. mycophenolate mofetil, cyclosporine and tacrolimus)
• lithium (a medicine used to manage bipolar disorder)
• theophylline (a medicine used to manage breathing disorders)

B. Drug - Food interaction:

NA

Overdosage:

VIR 250MG INJECTION will be administered to you only by a doctor or a nurse in a
hospital, so it is unlikely to receive an overdose. However, consult your doctor
or nurse if you experience any unusual symptoms.

Synopsis

Drug	:	Acyclovir
Pharmacological Category	:	Antivirals
Therapeutic Indication	:	Chickenpox, shingles, herpes simplex virus
Dosage Forms	:	Tablet, Suspension, Syrup, Infusion, Injection, Cream, Ointment, Eye- ointment

More Information

• Keep VIR 250MG INJECTION out of the sight and reach from children
• Store VIR 250MG INJECTION below 25°C

FAQs About VIR 250MG INJECTION

Can I take VIR 250MG INJECTION for chicken pox?

Yes. VIR 250MG INJECTION is effective for chickenpox in adults and
immunocompromised children, causing more rapid resolution of the illness and
fewer complications. Consult your doctor before receiving it.

Can VIR 250MG INJECTION cause hair loss?

Yes. VIR 250MG INJECTION may cause hair loss. If you experience any side
effects. Consult your doctor before receiving it.

Can I take VIR 250MG INJECTION with alcohol?

No. Taking VIR 250MG INJECTION with alcohol may lead to unwanted effects such as
confusion, hallucinations, agitation, tremors and drowsiness. Consult your
doctor before receiving it.

Can VIR 250MG INJECTION cause tremors?

Yes. VIR 250MG INJECTION can cause tremors. However, it does not affect every
individual. Try to rest and relax. If your symptom worsens, please consult your
doctor before receiving it.

Does VIR 250MG INJECTION cause hallucinations?

Yes. VIR 250MG INJECTION can cause hallucinations. Try to rest and relax.
Meditation and breathing exercises can work. If your symptom worsens, please
consult your doctor.

Useful Diagnostic Tests

• Herpes Simplex Virus 1 DNA PCR
• Herpes Simplex Virus 1 IgG
• Herpes Simplex Virus 2 DNA PCR
• Herpes Simplex Virus 2 IgG
• Herpes Simplex Virus 2 IgM
• Varicella Zoster IgG
• Varicella Zoster IgM