Stritosar 100mg Injection 5ml

Introduction About STRITOSAR 100MG INJECTION

STRITOSAR 100MG INJECTION contains Irinotecan which belongs to the group of
medicines called Anticancer agents. It is used to manage advanced or metastatic
colorectal cancer (cancers of colon and rectum). It can also be used to manage
colorectal cancer among patients whose disease has recurred or progressed
following initial chemotherapy with 5-Fluorouracil.

STRITOSAR 100MG INJECTION is mostly used in combination with other anticancer
medicines to achieve better results. Before receiving STRITOSAR 100MG INJECTION
inform your doctor if you have hypertension or any other heart problems.

You must also inform your doctor if you have high blood cholesterol levels,
elevated bilirubin levels in the blood or any inflammation in the gut as a
precaution. STRITOSAR 100MG INJECTION is not recommended for use in pregnant or
breastfeeding women as it may harm the growing baby.

Both men and women of childbearing potential must use a suitable contrace
method to avoid pregnancy while undergoing therapy with this medicine. Men may
seek advice on sperm preservation, if necessary, prior to the therapy with this
medicine.

STRITOSAR 100MG INJECTION may cause severe nausea, vomiting and diarrhea. To
manage this, your doctor will prescribe a suitable anti-emetic and antidiarrheal
medicines along with this medicine. However, inform your doctor immediately if
these side effects worsen.

Other most common side effects of receiving STRITOSAR 100MG INJECTION are
stomach pain mouth ulcers, hair loss, tiredness, weakness, increased infections,
increased bleeding tendency and difficulty in passing stools. Consult your
doctor if any of these side effects trouble you.

Uses Of STRITOSAR 100MG INJECTION

• Manage advanced or metastatic cancers of colon or rectum

How STRITOSAR 100MG INJECTION Works

STRITOSAR 100MG INJECTION is an anticancer medication. It works by blocking the
actions of certain enzymes (DNA-Topoisomerase-1) within the cells which is
required for the cells to grow and multiply. As a result, it manages abnormal
cell division and slows down the growth and spread of cancer cells within the
body.

How to use STRITOSAR 100MG INJECTION

STRITOSAR 100MG INJECTION will be given to you only by a doctor or a nurse into
the vein (as an intravenous infusion).

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition.

Side Effects Of STRITOSAR 100MG INJECTION

Common

• low RBC count causing anemia, tiredness and pale skin
• increased infections
• loss of appetite
• hair loss
• nausea, vomiting, stomach pain
• mouth ulcers
• tiredness, weakness
• increased bleeding tendency due to low blood platelet counts
• difficulty in passing stools

Contact your doctor immediately if you experience any of the following side
effects after receiving STRITOSAR 100MG INJECTION:

• severe infections causing fever due to low WBC count in blood
• severe diarrhoea, vomiting or nausea
• signs of acute cholinergic syndrome (such as runny nose, increased saliva, excess tears in the eyes, sweating, flushing, stomach cramps and diarrhoea)
• signs of lung problems (such as new or worsening cough, trouble breathing, and fever)
• signs of blood clot formation in the body (such as chest pain, shortness of breath, or swelling, pain, redness, or warmth in an arm or leg)
• severe stomach pain with bloating and difficulty in passing stools
• severe pain, redness and swelling at the injection site

How To Manage Side Effects

!### Mouth Ulcers

Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on
the affected areas of the mouth if required. Consult your doctor if the symptom
did not improve.

!### Nausea And Vomiting

Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if
the symptoms are worsening.

Warning & Precautions

!### Pregnancy

ContraindicatedSTRITOSAR 100MG INJECTION is not recommended for use in pregnant women as it may
cause harm to the growing baby. Therefore, inform your doctor before receiving
it. Women of childbearing potential must use a suitable contrace
avoid pregnancy during the management and for at least 6 months after the last
dose.

!### Breastfeeding

ContraindicatedSTRITOSAR 100MG INJECTION is not recommended for use in women who are
breastfeeding. Therefore, consult your doctor before receiving it.

!### Driving and Using Machines

Use with CautionSTRITOSAR 100MG INJECTION may cause dizziness and vision problem during the
first 24 hours after receiving it. Therefore, do not drive or handle any heavy
tools or machines if your ability is affected by this medicine.

!### Allergy

ContraindicatedTalk to your doctor before receiving STRITOSAR 100MG INJECTION if you are
allergic to Irinotecan.

!### Heart Disease

Use with CautionSTRITOSAR 100MG INJECTION should be used with caution in patients with
hypertension or any other heart diseases. Therefore, inform your doctor before
receiving it.

!### Use In Pediatrics

Consult your doctorThe safety and efficacy of STRITOSAR 100MG INJECTION have not been established
in children and adolescents (aged below 18 years). Therefore, consult your
doctor before receiving it.

!### Use In Geriatrics

Use with CautionSTRITOSAR 100MG INJECTION should be used with caution in elderly patients (aged
65 years or above). Therefore, consult your doctor before receiving it.

Others

STRITOSAR 100MG INJECTION is not recommended for use if you:

• have any inflammation in the bowel for a prolonged period
• have any obstructions or block in the gut
• have elevated bilirubin levels in the blood
• have severe bone marrow failure
• are in a poor general condition
• are taking an herbal medicine called St. John’s Wort for mental illnesses
• recently got vaccinated with a live attenuated vaccine (Ex. vaccine for chicken pox, shingles, measles, mumps, rubella, tuberculosis, rotavirus, influenza)

Inform your doctor, before receiving STRITOSAR 100MG INJECTION, if you:

• have Gilbert’s syndrome (an inherited condition that causes elevated bilirubin levels and jaundice)
• have a habit of smoking
• have high blood cholesterol levels
• are scheduled for any surgeries (including minor dental surgeries)

Interactions

A. Drug-Drug interactions:

Inform your physician, before receiving STRITOSAR 100MG INJECTION, if you are
taking any of the following medicines such as:

• medicines used for blood thinning (such as aspirin, warfarin)

• medicines used to manage epilepsy (such as carbamazepine, phenobarbital, phenytoin and fosphenytoin)

• medicines used to manage fungal infections (such as ketoconazole, itraconazole, voriconazole and Posaconazole)

• medicines used to manage bacterial infection (such as erythromycin, clarithromycin, and telithromycine)

• medicines used to manage tuberculosis (Ex. rifampicin and rifabutin)

• St. John's Wort (a herbal dietary supplement used to manage mental illnesses)

• live attenuated vaccines (such as vaccine for chicken pox, shingles, measles, mumps, rubella, tuberculosis, rotavirus, influenza)

• medicines used to manage HIV infection (such as ritonavir, amprenavir, fosamprenavir, indinavir, nelfinavir, atazanavir, and others)

• medicines used to suppress your body’s immune system and to manage transplant rejection (such as cyclosporine and tacrolimus)

• other medicines used to manage cancer (such as regorafenib, crizotinib, idelalisib, apalutamide, 5-fluorouracil/folinic acid, bevacizumab and cetuximab)

• medicines used for relaxing muscles during surgeries (Ex. suxamethonium)

• laxatives (used to soften stools) such as lactulose

Overdosage:

STRITOSAR 100MG INJECTION will be administered to you only by a doctor or a
nurse in a hospital, and so it is unlikely to receive an overdose. However,
consult your doctor if you experience any unusual symptoms.

Synopsis

Drug	:	Irinotecan
Pharmacological Category	:	Topoisomerase-1 Inhibitors
Therapeutic Indication	:	Colorectal cancer
Dosage Forms	:	Injection

More Information

• Keep STRITOSAR 100MG INJECTION out of reach of children
• Store STRITOSAR 100MG INJECTION at room temperature

FAQs About STRITOSAR 100MG INJECTION

Q: What is the use of STRITOSAR 100MG INJECTION?A: STRITOSAR 100MG INJECTION It is used to manage advanced or metastatic
colorectal cancer (cancers of colon and rectum).

Q: Will men managed with STRITOSAR 100MG INJECTION be able to father a
child?A: No studies have shown that STRITOSAR 100MG INJECTION may affect
fertility. However, talk to your doctor about the possible risk with this
medicine and the o
STRITOSAR 100MG INJECTION.

Q: How STRITOSAR 100MG INJECTION works?A: STRITOSAR 100MG INJECTION is an anticancer medication. It works by
blocking the actions of certain enzymes (DNA-Topoisomerase-1) within the cells
which is required for cells to grow and multiply. As a result, it manages
abnormal cell division and slows down the growth and spread of cancer cells
within the body.

Q: How STRITOSAR 100MG INJECTION is administered?A: STRITOSAR 100MG INJECTION will be given to you only by a doctor or a
nurse into the vein (as an intravenous infusion).

Q: What are the most common side effects of receiving STRITOSAR 100MG
INJECTION?A: The most common side effects of receiving STRITOSAR 100MG INJECTION are
nausea, vomiting, diarrhea, stomach pain mouth ulcers, hair loss, tiredness,
weakness, increased infections, increased bleeding tendency and difficulty in
passing stools. Consult your doctor if any of these side effects trouble you.

Q: Will the use of STRITOSAR 100MG INJECTION cause infertility?A: No studies have shown that STRITOSAR 100MG INJECTION may affect
fertility. However, consult your doctor for advice.

Q: Can STRITOSAR 100MG INJECTION manage cancer?A: The manage rate of cancer depends upon the severity of the disease.
However, STRITOSAR 100MG INJECTION acts by managing the abnormal growth and
multiplication of cancer cells in the body, which may help in managing cancer
completely.

Q: Can the use of STRITOSAR 100MG INJECTION cause hair loss?A: Hair loss is one of the common side effects of receiving STRITOSAR 100MG
INJECTION. If it bothers you, consult your doctor for advice. This side effect
usually disappears, and new hair starts regrowing once the therapy with this
medicine stops completely.

Q: Can the use of STRITOSAR 100MG INJECTION cause mouth ulcers?A: Mouth ulcers are one of the common side effects of receiving STRITOSAR
100MG INJECTION. Avoid eating spicy foods. Drink plenty of water. Apply a
pain-relieving gel on the affected areas of the mouth if required. Consult your
doctor if the symptom did not improve.

Q: Is STRITOSAR 100MG INJECTION a chemo drug?A: Yes. STRITOSAR 100MG INJECTION contains a medicine called irinotecan
which is a chemotherapeutic agent. It stops abnormal growth and multiplication
of cancer cells in the body.

Q: What happens if I stop receiving STRITOSAR 100MG INJECTION?A: No. Do not stop receiving STRITOSAR 100MG INJECTION without consulting
your doctor as it may make your symptoms reappear. Therefore, take STRITOSAR
100MG INJECTION as advised by your doctor for the stipulated duration.

Q: Can STRITOSAR 100MG INJECTION be used during pregnancy?A: STRITOSAR 100MG INJECTION is not recommended for use in pregnant women as
it may cause harm to the growing baby. Therefore, inform your doctor before
receiving it.

Q: Can the use of STRITOSAR 100MG INJECTION make me feel tired?A: Yes. STRITOSAR 100MG INJECTION may make you feel tired easily. This is
because, it reduces the levels of red blood cells in your blood and may make you
anaemic. Consult your doctor if you experience tiredness after receiving
STRITOSAR 100MG INJECTION. Tiredness can also occur if you have any pre-existing
disease conditions such as liver or kidney impairment while taking this
medicine.

Q: How to control nausea caused due to STRITOSAR 100MG INJECTION?A: Generally, anticancer medicines are associated with uncontrollable nausea
and vomiting. To avoid this, your doctor would prescribe a suitable medicine to
control them along with STRITOSAR 100MG INJECTION. If not, consult your doctor
for a suitable anti-emetic medicine. Do not self-manage nausea.