Remtrex 50mg Injection 1's

Introduction About REMTREX 50MG INJECTION

REMTREX 50MG INJECTION contains Methotrexate, which belongs to the group of
medicines called Antimetabolites. REMTREX 50MG INJECTION is used to manage
active rheumatoid arthritis in adults. It is also used to manage polyarthritic
forms (characterized by the involvement of five or more joints), which are
severe, active, and idiopathic in nature and affect young people (Juvenile
Idiopathic Arthritis, or JIA). REMTREX 50MG INJECTION is also used to manage
psoriasis.

In addition, REMTREX 50MG INJECTION is also used to manage Crohn’s disease and
various cancers such as acute lymphocytic lymphoma, Non-Hodgkin’s Lymphoma,
breast cancer, cervical cancer, bladder cancer, etc.

Rheumatoid arthritis is an autoimmune and inflammatory disease, which means that
your immune system attacks healthy cells in your body by mistake, causing
inflammation (painful swelling) in the affected parts of the body. Psoriasis is
a skin condition characterized by itchy scales that is not responsive to
conventional managements such as phototherapy and retinoids. Crohn’s disease is
an inflammatory disease affecting the intestine.

Before getting REMTREX 50MG INJECTION administered, it is recommended to inform
the doctor about your medical and family history, including the list of
medicines (prescri
are being taken, before receiving REMTREX 50MG INJECTION.

Also, REMTREX 50MG INJECTION is not recommended for children less than the age
of 3, pregnant and nursing women, women planning pregnancy, those who drink huge
amounts of alcohol, and patients suffering from liver and kidney impairment.

Caution must be exercised by patients suffering from lung disorders, blood
disorders, and gastric disorders before receiving REMTREX 50MG INJECTION. Care
must be taken to avoid taking products containing caffeine, such as black tea,
coffee, and cold drinks, while receiving REMTREX 50MG INJECTION.

The common side effects that can be experienced after receiving REMTREX 50MG
INJECTION are headache, nausea, vomiting, dizziness, and altered levels of blood
cells. Consult a doctor if any of the above side effects worsen after receiving
REMTREX 50MG INJECTION.

Uses Of REMTREX 50MG INJECTION

It is used to manage:

• active rheumatoid arthritis (adults)
• severe arthritis occurring due to unknown reasons (idiopathic and juvenile, which is non-responsive to conventional painkillers)
• psoriasis
• Crohn’s disease
• polyarthritic forms
• cancer (acute lymphocytic lymphoma, meningeal leukemia) (a type of cancer of white blood cells in the ovary, breast, cervix, lungs, bones, and bladder

How REMTREX 50MG INJECTION Works

REMTREX 50MG INJECTION contains Methotrexate, a disease-modifying antirheumatic
drug (DMARDs) which interferes with the growth of those cells in the body that
reproduce quickly. As a result, the growth of those cells gets retarded, thus
serving as an anti-tumour agent. Also, REMTREX 50MG INJECTION decreases the
undesired reactions of the body’s own immune-defense mech
as an effective immunosuppressant. In addition, it also exhibits
anti-inflammatory effects, thereby reducing pain, swelling, and redness. As a
result, REMTREX 50MG INJECTION manages the symptoms associated with diseases
such as rheumatoid arthritis and psoriasis.

How to use REMTREX 50MG INJECTION

REMTREX 50MG INJECTION will be administered to you into a muscle
(intramuscularly) only by a doctor or a nurse. Your doctor will administer the
correct dose and duration for you depending on your age, body weight, and
disease condition.

Side Effects Of REMTREX 50MG INJECTION

Common

• loss of appetite
• nausea
• vomiting
• stomach pain
• inflammation and ulcers in the mouth and throat
• increase in the level of liver enzymes
• decreased count of white and red blood cells
• decreased count of platelets
• headache
• tiredness
• drowsiness
• inflammation of the lungs along with the production of a dry, non-productive cough and shortness of breath
• fever
• diarrhea (frequent loose stools)
• development of itching, rash, and reddening of the skin
• decreased resistance to infection

Uncommon

• confusion
• depression
• fits
• inflammation of blood vessels
• liver disorders
• diabetes
• sensitivity to light
• brown skin
• loss of hair
• increase in rheumatic nodules
• viral infection
• joint or muscle pain
• porous bones (osteoporosis)
• painful urination
• severe allergic reactions
• development of inflammation and ulcers (vagina)
• eating disorder resulting in high weight loss (anorexia)
• pain in the chest
• cough
• inability to pass urine (dysuria)
• nose bleeding
• development of fatty liver
• red eyes (conjunctivitis)
• disturbances in the level of electrolytes

Rare

• inflammation of the sac around the heart along with the accumulation of fluid in the sac around the heart
• severe vision disturbances
• mood fluctuations
• low blood pressure
• blood clots
• asthma (difficult breathing along with the production of wheezing sounds)
• changed colour of nails
• development of acne (pimples)
• development of red or purple spots due to vessel bleeding
• kidney problems
• defective formation of sperm
• menstruation disorders
• nodulosis (small tissue growth at the hands and elbows, on Achilles tendons)
• loss of libido or impotence
• chills and fever (without any detectable pathogen)
• immunosuppression
• decreased resistance to infection
• abnormal tissue cell changes
• metabolic disorders
• development of breasts in men
• tinnitus (ringing sensation in the ears)
• sweating
• inflammatory conditions of the heart
• thromboembolic complications
• plaque-like erosions on the skin
• inflammation of the pharynx and gingiva
• stress fracture

Stop receiving REMTREX 50MG INJECTION and consult your doctor immediately if you
experience any of the following:

• sudden (acute) bleeding from the lungs characterized by spitting and/or coughing blood
• general weakness of muscles, disturbance in the vision, changes in pattern of thinking, memory, and orientation that lead to confusion and changes in personality (progressive multifocal leukoencephalopathy)
• general illness along with a dry, irritating cough and shortness of breath, breathlessness during rest, pain in the chest, or fever, indicative of lung problems
• severe peeling and/or blisters on the skin
• unusual bleeding and the formation of bruises
• severe, frequent, loose stools (diarrhea)
• presence of ulcers in the mouth
• black or tar-like stools
• presence of blood in urine and stools
• yellowing of the skin and eyes
• increased thirst
• fits (convulsions)
• blurred and/or decreased vision
• redness, swelling of the hands, ankles, feet, lips, mouth, and throat, leading to difficulty swallowing and/or breathing
• feeling of fainting
• symptoms of infection such as fever, body ache, and sore throat
• severe headache along with stiffness in the neck, fever, nausea, and vomiting, indicative of inflamed membranes of the brain (acute ase
• severe skin rash such as blistering of skin indicative of Stevens Johnson syndrome or burned skin syndrome (toxic epidermal necrolysis/Lyell’s syndrome)

How To Manage Side Effects

!### Diarrhea

Stick to simple meals. Avoid eating heavily rich or spicy food. Drink an oral
rehydration solution to compensate for the loss of water and minerals. Stay
hydrated. Consult your doctor if it persists for a long time or worsens with
time.

!### Dizziness Or Drowsiness

Take an adequate amount of rest and sleep. Stay hydrated and replenish yourself
with electrolytes. Also, do not indulge in driving or using heavy machinery, as
it may prove to be dangerous.

Headache

Stay hydrated and take as much rest as possible. Stay away from bright lights
and loud sounds. Apply a pain-relieving balm to the forehead. If the headache
persists or worsens, consult your doctor.

!### Nausea And Vomiting

Stick to simple meals. Avoid eating heavily rich or spicy food. Stay hydrated.
Consult your doctor if it persists for a long time or worsens with time.

Warning & Precautions

!### Pregnancy

ContraindicatedREMTREX 50MG INJECTION is not recommended if you are pregnant and/or are
planning to become pregnant since it can be harmful to the foetus (growing baby)
and lead to various malformations. Consult your doctor before receiving REMTREX
50MG INJECTION.

!### Breastfeeding

ContraindicatedREMTREX 50MG INJECTION is not recommended if you are a nursing mother. Consult
your doctor before receiving REMTREX 50MG INJECTION.

!### Driving and Using Machines

ContraindicatedREMTREX 50MG INJECTION is not recommended if you feel tired and/or dizzy after
receiving the medicine. Consult your doctor prior to receiving REMTREX 50MG
INJECTION.

!### Alcohol

ContraindicatedREMTREX 50MG INJECTION is not recommended if you consume large amounts of
alcohol. Consult your doctor before receiving REMTREX 50MG INJECTION.

!### Kidney

ContraindicatedREMTREX 50MG INJECTION is not recommended if you are diagnosed with a severe
kidney disorder. Consult your doctor before receiving REMTREX 50MG INJECTION.

!### Liver

ContraindicatedREMTREX 50MG INJECTION is not recommended if you are diagnosed with a severe
liver disorder. Consult your doctor before receiving REMTREX 50MG INJECTION.

!### Allergy

ContraindicatedREMTREX 50MG INJECTION is not recommended if you are allergic to methotrexate
and/or any other constituent of REMTREX 50MG INJECTION. Consult your doctor
before receiving REMTREX 50MG INJECTION.

!### Lungs

Use with CautionREMTREX 50MG INJECTION is recommended to be received with caution if you have
issues with lung function and are diagnosed with ascites and pleural effusion.
Consult your doctor before receiving REMTREX 50MG INJECTION.

!### Use In Pediatrics

ContraindicatedREMTREX 50MG INJECTION is not recommended for children below the age of 3 years
due to a lack of safety data. If needed, your doctor will administer the right
dose depending on your child’s age, body weight, and disease condition. Consult
the doctor before receiving REMTREX 50MG INJECTION.

!### Use In Geriatrics

Use with CautionREMTREX 50MG INJECTION is recommended to be administered with caution and in a
lower dosage to elders due to diminished function of the liver and kidneys and
reduced folate levels in the blood in old age. Consult the doctor before
receiving REMTREX 50MG INJECTION.

Others

REMTREX 50MG INJECTION is not recommended for use if you:

• have blood disorders
• have an impaired immune system
• have a severe and/or existing infection (Ex. tuberculosis, HIV)
• have ulcers in the gastro-intestinal tract
• are receiving vaccinations containing live vaccines
• have bone marrow suppression
• have certain immunodeficiency syndromes
• have scheduled a surgery (which requires anesthesia)
• have ulcerative colitis characterized by bleeding from the bowel
• are malnourished

Before receiving REMTREX 50MG INJECTION, inform your doctor if you:

• have diabetes mellitus
• are overweight
• have a tooth infection, such as an abscess in a tooth
• have increased and/or unusual bleeding or bruising
• suffer folate deficiency of folate
• are receiving radiotherapy for various conditions, such as X-rays and UV-rays

Interactions

A. Drug-Drug Interactions:

Before receiving REMTREX 50MG INJECTION, inform your doctor if you are taking
any of the following medicines:

• other medicines used to manage rheumatoid arthritis and psoriasis (Ex. leflunomide, phenylbutazone, or amidopyrine)
• medicines used in organ transplantation (Ex. azathioprine)
• medicines used to manage skin conditions (Ex. retinoids)
• medicines used to manage fits (Ex. phenytoin)
• medicines used in cancer
• medicines used to induce sleep (Ex. barbiturates such as phenobarbitone)
• medicines used to induce calmness and relieve anxiety (Ex. tranquilizers such as diazepam)
• medicines used for oral contrace
• medicines used to manage gout (Ex. probenecid)
• medicines used to manage bacterial infections (Ex. amoxicillin)
• medicines used to manage malaria (Ex. pyrimethamine)
• medicines used to manage severe heartburn or ulcers (Ex. omeprazole)
• medicines used to manage asthma (Ex. theophylline)
• medicines used to suppress hyperactive immune system (Ex. diphenylhydantoin, amidopyrine derivatives)
• medicines used to manage various infections (Ex. pyrimethamine and cotrimoxazole)
• medicines used to manage increased cholesterol levels (Ex. Cholestyramine)
• medicines used to manage heart problems (Ex. Amiodarone)
• medicines used to manage diabetes (Ex. Metformin)

B. Drug-food interactions:

It is recommended to avoid the consum
as black tea, coffee, and soft drinks, to manage dehydration.

Overdosage:

REMTREX 50MG INJECTION will be administered only by a doctor or nurse in a
hospital, and so it is unlikely to receive an overdose. Contact your doctor
immediately.However, if you experience any unusual symptoms like an easy
tendency to bruise or bleed, nausea, vomiting, or feeling unusual weakness,
along with the development of mouth sores, black or bloody stools, coughing up
blood and vomiting that looks like coffee grounds, or decreased urination.

Synopsis

Drug	:	Methotrexate
Pharmacological Category	:	Anti-metabolites
Therapeutic Indication	:	Rheumatoid Arthritis, Psoriasis, Cancer
Dosage Forms	:	Injection, Gel, Capsule, Tablet

More Information

• Keep REMTREX 50MG INJECTION out of the reach and sight of children
• Store REMTREX 50MG INJECTION at a temperature below 25°C

FAQs About REMTREX 50MG INJECTION

Q: What is REMTREX 50MG INJECTION used for?

A: REMTREX 50MG INJECTION contains Methotrexate, which belongs to the group of
medicines called Antimetabolites. It is used to manage active rheumatoid
arthritis in adults. It is also used to manage polyarthritic forms
(characterized by the involvement of five or more joints), which are severe,
active, and idiopathic in nature and affect young people (Juvenile Idiopathic
Arthritis, or JIA). REMTREX 50MG INJECTION is also used to manage psoriasis,
which is a skin condition characterized by itchy scales that is not responsive
to conventional management such as phototherapy and retinoids.

Q: Can I receive REMTREX 50MG INJECTION during pregnancy?

A: REMTREX 50MG INJECTION is not recommended for use in pregnant women and/or in
women who are planning pregnancy because it can be harmful for the foetus (a
growing baby in the womb). Consult your doctor before receiving it.

Q: Can I receive REMTREX 50MG INJECTION if I am breastfeeding?

A: REMTREX 50MG INJECTION is not recommended for nursing mothers due to a lack
of safety data. Consult your doctor before receiving it.

Q: Can REMTREX 50MG INJECTION be received by children?

A: REMTREX 50MG INJECTION is not recommended to be received by children less
than 3 years of age. Consult your doctor before receiving REMTREX 50MG
INJECTION.

Q: Can REMTREX 50MG INJECTION be used by the elderly?

A: REMTREX 50MG INJECTION is recommended to be administered with caution and in
a lower dosage to elders due to diminished function of the liver and kidneys and
reduced folate levels in the blood in old age. Consult the doctor before
receiving it.

Q: Is there any specific food to avoid while receiving REMTREX 50MG INJECTION?

A: It is recommended to avoid the consum
such as black tea, coffee, and soft drinks, along with REMTREX 50MG INJECTION,
to manage dehydration.

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Liver Function Test (LFT)
• Kidney Function Test (KFT)