SHUBHOPRINE 50MG TABLET 14'S

Introduction About SHUBHOPRINE 50MG TABLET 14'S

SHUBHOPRINE 50MG TABLET 14'S contains Azathioprine which belongs to the group of
medicines called Immunosuppressants. Azathioprine is used to help the body to
accept a kidney, liver, heart, lung, or pancreas transplant.

It is also used for severe rheumatoid arthritis, inflammation of the gut, and to
manage some diseases where the immune system is reacting against its own body
(autoimmune disease) including severe inflammatory diseases of the liver,
arteries, skin, and some blood disorders.

SHUBHOPRINE 50MG TABLET 14'S is not recommended to use when allergic to
Azathioprine, mercaptopurine (a medicine used to manage leukemia, a cancer of
the white blood cells), or any of the other ingredients of this medicine.

SHUBHOPRINE 50MG TABLET 14'S is not recommended to use in pregnant or intend to
become pregnant and breastfeeding women. Consult your doctor for advice before
taking the medicine.

The most common side effects of taking SHUBHOPRINE 50MG TABLET 14'S are low
white blood cell levels in your blood tests, which may cause an infection and
nausea (feeling sick). Consult your doctor for advice if any of the above side
effects worsen or persist for a longer duration.

Uses Of SHUBHOPRINE 50MG TABLET 14'S

It is used to:

• prevent organ rejection in transplant patients (kidney, liver, heart, lung, or pancreas)
• manage rheumatoid arthritis
• manage systemic lupus erythematosus

How SHUBHOPRINE 50MG TABLET 14'S Works

SHUBHOPRINE 50MG TABLET 14'S belongs to immunosuppressants which reduces the
action of body's own defense system (the immune system) and manages rejection of
the transplanted organ. It also blocks the action of certain chemical messengers
that are responsible for inflammation, swelling, and redness associated with
certain joint diseases.

How to use SHUBHOPRINE 50MG TABLET 14'S

Take SHUBHOPRINE 50MG TABLET 14'S as advised by your physician. Swallow the
SHUBHOPRINE 50MG TABLET 14'S with a glass of water. Do not crush or chew the
medicine. Your doctor will decide the correct dose and duration for you
depending upon your age, body weight, and disease condition.

Side Effects Of SHUBHOPRINE 50MG TABLET 14'S

Common

• infections
• reduction in the number of  blood platelets
• increases the risk of bleeding or bruising
• decrease in red blood cells in the blood (anemia)
• nausea, vomiting
• loss of appetite
• increased infections in patients with bowel inflammation
• decrease in the number of the white blood cells in patients with rheumatoid arthritis
• liver disease
• inflammation of the pancreas, which causes severe pain in the back and abdomen

Uncommon

• blood disorder after transplant surgery
• foul-smelling in the stools which are bulky, loose, and greasy
• hair loss
• liver problems in patients with rheumatoid arthritis

Rare

• stomach ulcers (which can bleed) and disease which may cause heartburn, vomiting, general discomfort in the stomach
• bowel problems leading to diarrhea, abdominal pain, and constipation
• blood and bone marrow disorders
• exposure to sunlight can cause skin discoloration or a rash
• different types of cancers including blood, lymph, and skin cancers

Stop taking SHUBHOPRINE 50MG TABLET 14'S and contact your doctor immediately if
you experience any of the following side effects:

• tiredness, dizziness, nausea, vomiting, diarrhea, or abdominal pain
• swelling of the eyelids, face, or lips
• redness of the skin nodules or a skin rash
• pain in muscles or joints
• sudden wheeziness, coughing, or difficulty in breathing
• increased temperature, or other signs of an infection such as sore mouth, sore throat, urinary problems, or chest infection causing breathlessness and cough
• problems with liver, signs include skin or whites of eyes turn yellow (jaundice)
• rash (increased pink,  red, or purple lumps which are sore to touch), particularly on your hands, arms, fingers, face, and neck, which may also be accomp

How To Manage Side Effects

Nausea or Vomiting:

Take this medicine with, or just after meals. Stick to simple meals. Avoid
eating oil-rich or spicy foods.

Constipation:

Eat plenty of fiber-rich foods such as fresh fruits, vegetables, and cereals,
and drink plenty of water. Exercise more regularly.

Warning & Precautions

!### Pregnancy

SHUBHOPRINE 50MG TABLET 14'S is not recommended for use in pregnant women unless
considered clearly necessary. Consult your doctor before taking it.

!### Breastfeeding

SHUBHOPRINE 50MG TABLET 14'S is not recommended for use in breastfeeding women
as it may pass through the breast milk. Consult your doctor before taking it.

!### Driving and Using Machines

Do not drive or operate any machines if you feel dizzy after taking SHUBHOPRINE
50MG TABLET 14'S. Consult your doctor before taking it.

!### Alcohol

Avoid consum
your doctor before taking it.

!### Kidney

SHUBHOPRINE 50MG TABLET 14'S should be taken with caution in patients with
kidney problems. Consult your doctor before taking.

!### Liver

SHUBHOPRINE 50MG TABLET 14'S is not recommended for use in patients with severe
liver disease. Consult your doctor before taking.

!### Allergy

Do not take SHUBHOPRINE 50MG TABLET 14'S, if you are allergic to Azathioprine or
6-mercaptopurine or any of the other ingredients of this medicine.

Others

SHUBHOPRINE 50MG TABLET 14'S is not recommended for use if you have:

• severe infection
• severe bone marrow disease
• metabolic abnormality called Lesch-Nyhan syndrome

Before taking SHUBHOPRINE 50MG TABLET 14'S, inform your doctor if you:

• ever suffered from chickenpox or shingles
• have TPMT or NUDT15 deficiency
• have higher risk of infections
• have hair loss
• have tumors, including skin cancer
• have lymphoproliferative disorders
• have Macrophage Activation Syndrome (excessive activation of white blood cells associated with inflammation) causes certain types of arthritis
• have increased risk of developing lymphoma
• have hepatosplenic T-cell lymphoma (HSTCL), a rare type of T-cell lymphoma
• have Crohn's disease or ulcerative colitis
• have severe leukopenia, thrombocytopenia, anemias including macrocytic anemia, and/or pancytopenia

Use in pediatrics:

Safety and efficacy of SHUBHOPRINE 50MG TABLET 14'S in pediatric patients have
not been established. Consult your doctor before taking it.

Use in geriatrics:

SHUBHOPRINE 50MG TABLET 14'S should be used with caution in elderly patients.
Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

• medicines used to manage viral infections (Ex. ribavirin)
• immunosuppressants (Ex. ciclosporin, methotrexate, tacrolimus)
• medicines to manage cancer (Ex. Doxorubicin)
• allopurinol, oxipurinol or thiopurinol, or other xanthine oxidase inhibitors, such as febuxostat (for gout or kidney stones)
• cimetidine (for gut or stomach ulcers)
• furosemide (water medicine )
• penicillamine (used for rheumatoid arthritis)
• anticoagulants such as warfarin or acenocoumarol (used to thin the blood)
• captopril (used for blood pressure or heart failure)
• indomethacin (an anti-inflammatory)
• co-trimoxazole (an antibiotic)
• infliximab, mesalazine, olsalazine, sulfasalazine, or balsalazide (used to manage ulcerative colitis or Crohn’s disease)

Overdosage:

If you or anyone else accidentally takes too much of SHUBHOPRINE 50MG TABLET
14'S, consult your doctor immediately or visit the nearby hospital. Symptoms of
overdose include nausea, vomiting and diarrhea, and lack of white blood cells
which may cause frequent infections such as fever, severe chills, sore throat or
mouth ulcers, disturbances of your liver function, bruising, and bleeding.

Synopsis

Drug	:	Azathioprine
Pharmacological Category	:	Immunosuppressants
Therapeutic Indication	:	Prevention of organ rejection in transplant patients, Management of Rheumatoid arthritis
Dosage Forms	:	Tablet

More Information

• Keep SHUBHOPRINE 50MG TABLET 14'S reach out of children
• Store at room temperature

FAQs About SHUBHOPRINE 50MG TABLET 14'S

Does SHUBHOPRINE 50MG TABLET 14'S increase the chance of infections?

It may cause leukopenia (decreased number of white blood cells) and hence makes
more susce
infections such as fever, sore throat, breathlessness, jaundice, unexplained
bleeding, or bruising.

Is SHUBHOPRINE 50MG TABLET 14'S safe to take during pregnancy?

No, it is not safe to take SHUBHOPRINE 50MG TABLET 14'S during pregnancy.
Consult your doctor before taking it.

IsSHUBHOPRINE 50MG TABLET 14'S can be stopped at any time?

No. Do not stop taking SHUBHOPRINE 50MG TABLET 14'S without consulting your
doctor as you may need to take it indefinitely to help stop transplant
rejection.

How long do I need to take SHUBHOPRINE 50MG TABLET 14'S?

The duration varies from person to person as it is prescribed depending upon the
patient’s medical condition.

What should I do if I forget a dose of SHUBHOPRINE 50MG TABLET 14'S?

If you miss a dose of SHUBHOPRINE 50MG TABLET 14'S, take the dose as soon as you
remember it. Do not take a double dose to make up for a missed one.

Is breastfeeding safe during SHUBHOPRINE 50MG TABLET 14'S management?

No, breastfeeding should be avoided, while taking this medicine, since it may
harm the baby and cause serious side effects. Consult your doctor before taking.

Useful Diagnostic Tests

• Rheumatoid Factor - Agglutination
• Rheumatoid Factor - Turbidometry
• Rheumatoid Factor IgG Antibody