MEDPROL 4mg Tablet 10's

INTRODUCTION ABOUT MEDPROL 4MG TABLET

MEDPROL 4MG TABLET contains Methylprednisolone which belongs to the group of
medicines called Corticosteroids. It is used to manage problematic conditions of
the adrenal glands (such as adrenal insufficiency, congenital adrenal
hyperplasia and nonsuppurative thyroiditis).

It can also be used to manage various inflammatory auto-immune disease
conditions affecting the bones and joints (Ex. rheumatoid arthritis, ankylosing
spondylitis), skin and collagen (Ex. systemic lupus erythematosus, psoriasis),
eyes (Ex. o
tuberculosis), blood or blood vessels (Ex. leukaemia), bowel and gut (Ex.
Crohn’s disease and ulcerative colitis) and brain (Ex. tuberculous meningitis).

It is also indicated in the management of drug induced hypersensitivity
reactions and in other allergic reactions (such as atopic dermatitis, allergic
conjunctivitis and allergic rhinitis). It also helps in management of graft
rejection following organ transplantation and increases urine output or reduces
protein loss in urine among patients having kidney problems (such as nephrotic
syndrome).

Take MEDPROL 4MG TABLET as advised by your physician. Do not stop taking MEDPROL
4MG TABLET or reduce the dose of methylprednisolone without consulting your
doctor as it may lead to unpleasant withdrawal symptoms, especially if you are
taking higher dose of methylprednisolone.

Before taking MEDPROL 4MG TABLET inform your doctor if you any viral infections,
or any liver, kidney or heart problems. You must also inform your doctor if you
have hypertension, diabetes, thyroid deficiency, glaucoma, skin problem, gut
inflammation, muscle problems, osteoporosis, any types of tumors or cancer in
the body, depression or any other forms of mental illness.

MEDPROL 4MG TABLET should be used in pregnant or breastfeeding women only if it
is considered necessary by the physician. Avoid drinking grapefruit juice or
eating grapefruit while taking MEDPROL 4MG TABLET as it may lead to unwanted
side effects.

The most common side effects of taking MEDPROL 4MG TABLET are high blood
pressure, swelling of body parts, muscle cramps or weakness, skin thinning,
feeling sad or depressed and slowed growth in children. Consult your doctor if
any of these side effect worsens.

You must also inform your doctor if you experience severe depression with
suicidal thoughts or severe stomach pain with blood-stained stools or vomit.

USES OF MEDPROL 4MG TABLET

It is used to manage the following disease conditions:

• adrenal insufficiency and its associated conditions
• bone and joint problems (Ex. rheumatoid arthritis, ankylosing spondylitis)
• skin and collagen disorders (Ex. systemic lupus erythematosus, psoriasis)
• eye problems (Ex. o
• respiratory tract diseases (Ex. asthma, tuberculosis)
• blood cancer (leukemia), lymph cancer (lymphoma)
• problems of bowel and gut (Ex. Crohn’s disease and ulcerative colitis)
• brain problems (Ex. tuberculous meningitis)
• drug induced hypersensitivity reactions
• allergic reactions (such as atopic dermatitis, allergic conjunctivitis and allergic rhinitis)

It can also:

• prevent graft rejection following organ transplantation
• improve urine output or reduces protein loss in urine among patients having nephrotic syndrome

HOW MEDPROL 4MG TABLET WORKS

MEDPROL 4MG TABLET is a corticosteroid medicine with anti-inflammatory and
immune suppressant properties. It boosts your body with sufficient
corticosteroid levels (cortisol, aldosterone) during deficient conditions and
helps your body to function properly.

It also reduces the release of certain chemicals (prostaglandins) in the body
that causes inflammation. It manages graft rejection by suppressing the immune
functions and protects your kidney from damage in patients with kidney problems.

DIRECTIONS FOR USE

Take MEDPROL 4MG TABLET as advised by your physician. Swallow the medicine with
a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition. Do not stop taking
MEDPROL 4MG TABLET without consulting your doctor.

SIDE EFFECTS OF MEDPROL 4MG TABLET

COMMON

• high blood pressure (causing headache, or a general feeling of being unwell)
• swelling of body parts
• muscle cramps, weakness or wasting
• cataract, blurred vision
• slowed growth in children
• moon shaped face (Cushingoid facies)
• feeling sad, mood changes, m
• problems in sleeping
• difficulty in thinking, confusion, loss of memory, hallucinations
• fear or frightening thoughts
• acne, poor wound healing
• skin thinning

Contact your doctor immediately if you experience any of the following side
effects while undergoing therapy with MEDPROL 4MG TABLET:

• signs of allergic reaction (such as skin rash, itching, blistering and peeling of the skin, swelling of the face, lips, mouth, throat which may lead to breathing difficulties)
• signs of bleeding in the gut (such as stomach pain which radiates until your back, bleeding from the anus, black or blood-stained stools, blood in vomit)
• increased infections causing fever or a general feeling of being unwell
• signs of flare up of a previous tuberculosis infection (such as coughing blood or pain in the chest)
• signs of pancreatitis (inflammation of pancreas causing severe stomach pain and vomiting)
• signs of blood clot in lungs (such as sharp chest pain, shortness of breath, coughing up blood)
• signs of increased pressure within the skull (such as severe headaches with vomiting, lack of energy and drowsiness) usually occurs once therapy is stopped
• thrombophlebitis (blood clots in vein supplying the legs causing leg pain, swelling, redness and tenderness)
• feeling depressed, suicidal thoughts
• blurred vision or other visual disturbances

HOW TO MANAGE SIDE EFFECTS

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

WARNING & PRECAUTIONS

!### PREGNANCY

Monitoring requiredMEDPROL 4MG TABLET should be used in pregnant women only if it is considered
necessary by the physician. Therefore, inform your doctor before taking MEDPROL
4MG TABLET if you are pregnant, think you may be pregnant or planning to have a
baby.

!### BREASTFEEDING

Monitoring requiredMEDPROL 4MG TABLET should be used in breastfeeding women only if it is
considered necessary by the physician. Therefore, inform your doctor before
taking it.

!### DRIVING AND USING MACHINES

Use with CautionDo not drive or operate any heavy tools or machines if you experience dizziness
after taking MEDPROL 4MG TABLET.

!### ALCOHOL

Consult your doctorAvoid consum
feel drowsier.

!### KIDNEY

Use with CautionMEDPROL 4MG TABLET should be used with caution in patients with kidney diseases.
Therefore, consult your doctor before taking it.

!### LIVER

Use with CautionMEDPROL 4MG TABLET should be used with caution in patients with liver diseases.
Therefore, consult your doctor before taking it.

!### ALLERGY

ContraindicatedDo not take MEDPROL 4MG TABLET if you are allergic to Methylprednisolone.

!### LUNGS

ContraindicatedMEDPROL 4MG TABLET is not recommended for use in patients with fungal infection
of the lungs. Therefore, consult your doctor before taking it.

!### HEART DISEASE

Use with CautionMEDPROL 4MG TABLET should be used with caution in patients with heart problems
(such as recent heart attack or heart failure). Therefore, consult your doctor
before taking it.

!### USE IN PEDIATRICS

Monitoring requiredMEDPROL 4MG TABLET should be used in children and adolescents (aged below 18
years) only if prescribed by the physician. Therefore, consult your doctor for
advice before taking it.

!### USE IN GERIATRICS

Use with CautionMEDPROL 4MG TABLET should be used with caution in elderly patients (aged 65
years or above). Therefore, consult your doctor before taking it.

OTHERS

MEDPROL 4MG TABLET is not recommended for use if you:

• have serious unmanageed fungal infections (Ex. infection of lungs or esophagus)
• got vaccinated recently or scheduled for any upcoming vaccinations

Before taking MEDPROL 4MG TABLET, inform your doctor if you:

• have or had been in contact with someone who has chickenpox, measles or shingles
• have or ever had severe depression or bipolar disorder
• have a family history of mental illness
• have diabetes or a family history of diabetes
• have fits
• have or have a family history of glaucoma
• have viral or fungal infections of the eyes
• have hypertension (high blood pressure)
• have underactive thyroid gland (hypothyroidism)
• have inflammation of pancreatitis or gut lining (peritonium)
• have scleroderma (an autoimmune disorder causing skin tightness, cold extremities, joint pain and heart burn)
• have Kaposi’s sarcoma (a type of skin cancer)
• have any muscle problems (Ex. myasthenia gravis)
• have osteoporosis (brittle bones)
• have pheochromocytoma (a rare tumor of the adrenal glands)
• have skin abscess
• have stomach ulcer or other serious stomach or intestinal problems
• have thrombophlebitis (clots in veins)
• have or had tuberculosis
• have Cushing’s disease
• have brain injury due to trauma
• have any unusual stress
• are scheduled for any upcoming surgery (including dental surgery)

INTERACTIONS

A. Drug - Drug interactions:

Before taking MEDPROL 4MG TABLET, inform your doctor if you are taking any of
the following medicines such as:

• acetazolamide (a medicine used to manage glaucoma or edema)
• aminoglutethimide or cyclophosphamide (used for managing cancer)
• anticoagulants (used for blood thinning) such as acenocoumarol, phenindione and warfarin
• anti-cholinergic medicines used to manage myasthenia gravis (such as distigmine and neostigmine)
• medicines used to manage bacterial infections (Ex. isoniazid, erythromycin, clarithromycin and troleandomycin)
• medicines used to manage diabetes (Ex. metformin, glipizide)
• aprepitant or fosaprepitant (used to manage nausea and vomiting)
• non-steroidal anti-inflammatory medicines (used for fever and pain relief) such as aspirin, ibuprofen
• medicines used to manage epilepsy (such as carbamazepine, phenytoin and primidone)
• carbenoxolone and cimetidine (used to manage stomach ulcer and acid reflux)
• ciclosporin, tacrolimus (medicines used to suppress immune function and to manage graft rejection)
• medicines used to manage chest pain, hypertension or irregular heartbeat (such as digoxin, diltiazem or mibefradil)
• oral contrace
• medicines used to manage HIV infection (such as ritonavir, indinavir, cobicistat)
• medicines used to manage fungal infection (such as ketoconazole, amphotericin B, itraconazole)
• muscle relaxants (Ex. pancuronium or vecuronium)
• diuretics (used to manage edema and hypertension) Ex. furosemide, chlorothiazide, hydrochlorothiazide
• medicines used to manage asthma (such as aminophylline, salmeterol, formoterol)
• rifampicin and rifabutin (used to manage tuberculosis)
• live vaccines

B. Drug - Food interaction:

Avoid drinking grapefruit juice or eating grapefruit while taking MEDPROL 4MG
TABLET as it may lead to unwanted side effects.

Overdosage:

If you or anyone else accidentally took more MEDPROL 4MG TABLET, consult your
doctor immediately or visit the nearby hospital straight away.

SYNOPSIS

Drug	:	Methylprednisolone
Pharmacological Category	:	Synthetic Glucocorticoids
Therapeutic Indication	:	Adrenal insufficiency, Auto Immune Disease, Allergic reactions, Manage graft rejection, Proteinuria
Dosage Forms	:	Tablet, Injection, Cream

MORE INFORMATION

• Keep MEDPROL 4MG TABLET out of reach of children
• Store MEDPROL 4MG TABLET at room temperature

FAQs ABOUT MEDPROL 4MG TABLET

Q: What is MEDPROL 4MG TABLET used for?

A: MEDPROL 4MG TABLET is a corticosteroid medicine used to manage adrenal
insufficiency. It can also be used to manage drug induced hypersensitivity
reactions, allergic reactions and various inflammatory auto-immune disease
conditions affecting the skin, collagen, bones and joints, brain, gut, eyes etc.
It also helps in management of graft rejection following organ transplantation
and increases urine output among patients having kidney problems.

Q: How to take MEDPROL 4MG TABLET?

A: Swallow MEDPROL 4MG TABLET with a glass of water. Do not crush or chew the
medicine.

Q: Is MEDPROL 4MG TABLET a steroid?

A: Yes. MEDPROL 4MG TABLET is synthetic corticosteroid used to manage problems
of adrenal gland and various allergic, hypersensitivity and inflammatory
autoimmune disease conditions.

Q: What are the most common side effects of MEDPROL 4MG TABLET?

A: The most common side effects of taking MEDPROL 4MG TABLET are high blood
pressure, swelling of body parts, muscle cramps or weakness, skin thinning,
feeling sad or depressed and slowed growth in children. Consult your doctor if
any of these side effect worsens.

Q: Can MEDPROL 4MG TABLET make you feel high?

A: Yes. MEDPROL 4MG TABLET may make you feel high. Such symptoms may disappear
once the therapy has been stopped. However, consult your doctor if it bothers
you.

Q: How does MEDPROL 4MG TABLET works?

A: MEDPROL 4MG TABLET boosts your body with sufficient corticosteroid levels and
helps your body to function properly. It also reduces the release of certain
chemicals in the body that causes inflammation. It also manages graft rejection
by suppressing the immune functions and protects your kidney from damage in
patients with kidney problems.

Q: How long will it take for MEDPROL 4MG TABLET to control my disease?

A: The time taken by MEDPROL 4MG TABLET to control the disease may vary from
person-to-person depending upon the dose of methylprednisolone administered and
disease severity.

Q: Is MEDPROL 4MG TABLET safe to use in diabetic patients?

A: MEDPROL 4MG TABLET may alter the blood sugar levels in your body. Therefore,
it is necessary to inform your doctor if you have diabetes before taking MEDPROL
4MG TABLET as a precaution.

Q: Who should not take MEDPROL 4MG TABLET?

A: MEDPROL 4MG TABLET is not recommended for use in patients with serious fungal
infections. It is also not suitable for use in patients who got vaccinated
recently.

Q: Can I take a higher dose of MEDPROL 4MG TABLET?

A: No. It is not safe to take a higher dose of MEDPROL 4MG TABLET without
consulting your doctor. If the prescribed dose is less effective for you, kindly
consult your doctor for a suitable high dose or for an alternative therapy.

Q: Can I take MEDPROL 4MG TABLET daily?

A: Your doctor will evaluate your health condition and suggests whether can you
take MEDPROL 4MG TABLET every day or not.

Q: Can I stop taking MEDPROL 4MG TABLET once by pain reduces?

A: Take MEDPROL 4MG TABLET for the stipulated duration recommended by your
doctor to achieve maximum results. Do not stop taking MEDPROL 4MG TABLET or
reduce the dose of methylprednisolone without consulting your doctor, as sudden
cessation of the therapy may lead to unpleasant withdrawal symptoms such as skin
itchiness, fever, headache, muscle pain, joint pain, runny nose, tiredness or
weight loss, especially if you are taking higher dose of methylprednisolone.

Q: Can MEDPROL 4MG TABLET be used in children?

A: MEDPROL 4MG TABLET should be used in children and adolescents (aged below 18
years) only if prescribed by the physician. Therefore, consult your doctor for
advice before taking it.

Q: What to do if I forgot to take a dose of MEDPROL 4MG TABLET?

A: If you forgot to take a dose of MEDPROL 4MG TABLET, take it as soon as you
remember. However, if it is time for the next dose of MEDPROL 4MG TABLET, skip
the missed dose and take the next one regularly. Do not take a double dose of
MEDPROL 4MG TABLET to compensate the missed ones

Q: Will MEDPROL 4MG TABLET alter the effects of birth control pills?

A: MEDPROL 4MG TABLET may reduce the effects of birth control pills. Therefore,
try to avoid taking birth control pills along with MEDPROL 4MG TABLET. Consult
your doctor for advice.

Q: Can MEDPROL 4MG TABLET be used in pregnant women?

A: MEDPROL 4MG TABLET should be used in pregnant women only if it is considered
necessary by the physician. Therefore, inform your doctor before taking MEDPROL
4MG TABLET if you are pregnant, think you may be pregnant or planning to have a
baby.

REFERENCES

1. KD. Tripathi. Corticosteroids. Essentials of medical pharmacology. Eighth
   Edition. 2019. Page – 313.

2. Antonio Ocejo, Ricardo Correa. Methylprednisolone. StatPearls. NIH. National
   Library of Medicine. National Center for Biotechnology Information. [Revised in
   December 2021]. [Accessed on 8th October
   2022]

3. Jicheng Lv, MD, Hong Zhang, PhD, Muh Geot Wong, PhD. Effect of Oral
   Methylprednisolone on Clinical Outcomes in Patients with IgA Nephropathy: The
   TESTING Randomized Clinical Trial. JAMA Network. August 2017. [Accessed on 8th
   October 2022]

4. Pfizer Italia S.r.l. Electronic Medicines Compendium (EMC). [Revised in
   November 2018] [Accessed on 8th October
   2022]

5. Pfizer Italia S.r.l. Electronic Medicines Compendium (EMC). [Revised in
   November 2018] [Accessed on 8th October
   2022]

6. Methylprednisolone. Pfizer. [Revised in February 2019] [Accessed on 8th
   October 2022]

7. Central Drugs Standard Control Org
   [Revised in September 2009]. [Accessed on 8th October 2022]

8. Predniwel 8. Leeford Healthcare Ltd. [Accessed on 8th October 2022]

USEFUL DIAGNOSTIC TESTS

• Absolute Eosinophil Count
• Anti-Nuclear Antibody
• Anti-ds-DNA Antibody
• Anti-ds-DNA Antibody-IFA
• Peripheral Smear Examination
• Total IgE