Pemaxam 500mg Injection 1'S

Introduction About PEMAXAM 500MG INJECTION

PEMAXAM 500MG INJECTION contains Pemetrexed which belongs to the group of
medicines called Anticancer agents. It is used to manage advanced stages of
non-small cell lung cancer (NSCLC). It can be used as a management o
control cancer progression in patients who have failed to respond adequately to
conventional therapies.

PEMAXAM 500MG INJECTION is also used to manage malignant cancer of pleural
membrane (a protective layer surrounding the lungs), called as pleural
mesothelioma. It is mostly used in combination with other anti-cancer medicines
(such as cisplatin, carboplatin) to achieve better results.

Before receiving PEMAXAM 500MG INJECTION inform your doctor if you have any
lung, liver, kidney or heart problems or a previous history of the same. You
must also inform your doctor if you have fluid accumulation in the lungs or
recently received or planning to receive any radiation therapy or vaccination in
the upcoming days as a precaution.

PEMAXAM 500MG INJECTION is not recommended for use in pregnant or breastfeeding
women and in children aged below 18 years. Men and women receiving PEMAXAM 500MG
INJECTION must use a suitable contrace
undergoing therapy with PEMAXAM 500MG INJECTION and for until 6 months after
stopping the therapy.

The most common side effects of receiving PEMAXAM 500MG INJECTION are increased
infections, sore throat, nausea, vomiting, stomach pain, dizziness, tiredness,
weight loss, changes in taste, skin rash, hair loss and mouth ulcers. Contact
your doctor if any of these side effect worsens.

Uses Of PEMAXAM 500MG INJECTION

• Manage advanced non-small cell lung cancer (NSCLC)
• Manage malignant pleural mesothelioma (cancer of the protective layer of the lungs)

How PEMAXAM 500MG INJECTION Works

PEMAXAM 500MG INJECTION is an anticancer medication. It works by blocking the
activity of certain enzymes (Ex. dihydrofolate reductase, thymidylate synthase
etc.) in the body that may help cancer cells to grow and multiply. As a result,
it reduces abnormal growth and multiplication of cancer cells in the body.

How to use PEMAXAM 500MG INJECTION

PEMAXAM 500MG INJECTION will be given to you only by a doctor or a nurse into a
vein (as an intravenous infusion).

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition.

Side Effects Of PEMAXAM 500MG INJECTION

Common

• infections, fever, sore throat
• hair loss
• nausea, vomiting, loss of appetite
• stomach pain, indigestion, constipation, diarrhea
• mouth ulcers (pain, redness, swelling on the mouth)
• tiredness, dehydration, dizziness
• skin rash (marks may resemble bull’s eye)
• flaky skin, loss of sensation on the skin, increased skin pigmentation
• changes in taste
• muscle weakness or wasting, unsteady movements
• eye inflammation, dry eyes, eye swelling, eye irritation, tearing
• irregular heartbeat
• increase in liver and kidney enzymes
• swelling of body parts
• inflammation of the gut

Uncommon

• rectal inflammation or bleeding
• inflammation and redness of esophagus

Rare

Contact your doctor immediately if you experience any of the following side
effects after receiving PEMAXAM 500MG INJECTION:

• fever, increased infections, sepsis (infections of the blood)
• chest pain, fast heart rate
• inflammation of the mouth with pain, redness and swelling
• signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing)
• severe skin reactions with blistering and peeling of skin, burning or prickling sensation or fever
• signs of low RBC in blood (tiredness, pale skin, fainting, breathlessness)
• increased tendency to bleed (such as bleeding gums, bleeding from the nose or mouth)
• unexpected bruising
• signs of blood clot in lungs (such as breathlessness, heavy chest pain or cough with bloody sputum)

How To Manage Side Effects

Skin rash:

Avoid hot showers because hot water can irritate your skin further. Do not
scratch the affected area. Use protective clothing when going outdoors.
Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Consult your doctor if your
dizziness worsens.

Nausea and Vomiting:

Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea
worsens, consult your doctor for advice

Mouth ulcers:

Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on
the affected areas of the mouth if required. Consult your doctor if the symptom
did not improve

Diarrhoea

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid
taking any medicine on your own to manage diarrhoea and consult your doctor if
the symptom gets worse.

Constipation

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and
drink plenty of water. Try doing exercise regularly (going for a daily walk or
run). If this does not help, inform your doctor for receiving alternate
managements for constipation.

Warning & Precautions

!### Pregnancy

PEMAXAM 500MG INJECTION is generally not recommended for use in pregnant women
due to increased risk of side effects. Women of childbearing potential must use
a suitable contrace
PEMAXAM 500MG INJECTION. If you accidentally became pregnant while receiving
PEMAXAM 500MG INJECTION, inform your doctor immediately.

!### Breastfeeding

PEMAXAM 500MG INJECTION is generally not recommended for use in breastfeeding
women as it may pass through breast milk. Therefore, consult your doctor before
receiving it.

!### Driving and Using Machines

Do not drive or operate any machines if you feel tired after receiving PEMAXAM
500MG INJECTION.

!### Kidney

PEMAXAM 500MG INJECTION should be used with caution in patients with kidney
problems. It should also be used with caution in patients who has a previous
history of kidney problems. Therefore, consult your doctor before receiving it.

!### Liver

PEMAXAM 500MG INJECTION should be used with caution in patients with liver
problems. Therefore, consult your doctor before receiving it.

!### Allergy

Do not receive PEMAXAM 500MG INJECTION if you are allergic to pemetrexed or to
any of the other ingredients of the medicines.

!### Lungs

PEMAXAM 500MG INJECTION should be used with caution in patients with fluid
accumulation around the lungs. Therefore, consult your doctor before receiving
it.

!### Heart Disease

PEMAXAM 500MG INJECTION should be used with caution in patients with heart
problems. It should also be used with caution in patients who has a previous
history of heart problems. Therefore, consult your doctor before receiving it.

Others

Before receiving PEMAXAM 500MG INJECTION inform your doctor if you:

• have had or are going to take radiation therapy
• have been recently vaccinated

Use in pediatrics:

PEMAXAM 500MG INJECTION is generally not recommended for use in children and
adolescents (under 18 years of age) due to lack of safety data. Therefore,
consult your doctor before receiving it.

Use in geriatrics:

PEMAXAM 500MG INJECTION should be used with caution in elderly patients (aged 65
years and above). Consult your doctor before receiving it.

Interactions

A. Drug-Drug interactions:

Before receiving PEMAXAM 500MG INJECTION inform your doctor if you are taking
any of the following medicine:

• medicines used to manage pain and inflammation (Ex. ibuprofen)
• live or attenuated vaccines (Ex. yellow fever vaccine)

Overdosage:

PEMAXAM 500MG INJECTION will be administered to you only by a doctor or nurse in
a hospital, and so it is unlikely to receive an overdose. However, consult your
physician or nurse if you experience any unusual symptoms.

Synopsis

Drug	:	Pemetrexed
Pharmacological Category	:	Folate Antagonists
Therapeutic Indication	:	Advanced non-small cell lung cancer
Dosage Forms	:	Injection

More Information

• Keep PEMAXAM 500MG INJECTION out of reach of children
• Store PEMAXAM 500MG INJECTION at room temperature

FAQs About PEMAXAM 500MG INJECTION

What PEMAXAM 500MG INJECTION is used for?

PEMAXAM 500MG INJECTION is used to manage advanced non-small cell lung cancer.
It can also be used to manage metastatic cancer of pleural membrane (a
protective layer surrounding the lungs), called as pleural mesothelioma

How PEMAXAM 500MG INJECTION works on my body?

PEMAXAM 500MG INJECTION is an anticancer medication. It works by blocking the
activity of certain enzymes (Ex. dihydrofolate reductase, thymidylate synthase
etc.) in the body that may help cancer cells to grow and multiply. As a result,
it reduces abnormal growth and multiplication of cancer cells in the body.

Can PEMAXAM 500MG INJECTION manage cancer?

The manage rate of cancer depends upon the severity of the disease. However,
PEMAXAM 500MG INJECTION acts by managing the abnormal growth and multiplication
of cancer cells in the body, which may help in managing cancer completely.

Can the use of PEMAXAM 500MG INJECTION cause hair loss?

Hair loss is one of the common side effects of receiving PEMAXAM 500MG
INJECTION. If it bothers you, consult your doctor for advice.

Can the use of PEMAXAM 500MG INJECTION cause mouth ulcers?

Mouth ulcers are one of the common side effects of receiving PEMAXAM 500MG
INJECTION. Avoid eating spicy foods. Drink plenty of water. Apply a
pain-relieving gel on the affected areas of the mouth if required. Consult your
doctor if the symptom did not improve

Can PEMAXAM 500MG INJECTION be used in children?

PEMAXAM 500MG INJECTION should not be used in children aged below 18 years.
Therefore, consult your doctor before receiving it.

Is PEMAXAM 500MG INJECTION a chemo drug?

Yes. PEMAXAM 500MG INJECTION contains a medicine called pemetrexed which is a
chemotherapeutic agent. It stops abnormal growth and multiplication of cancer
cells in the body.

What precautions must be followed while taking PEMAXAM 500MG INJECTION?

Before taking PEMAXAM 500MG INJECTION inform your doctor if you have any lung,
liver, kidney or heart problems. You must also inform your doctor if you have
fluid accumulation in the lungs or recently received or planning to receive any
radiation therapy or vaccination in the upcoming days as a precaution. Inform
your doctor before receiving PEMAXAM 500MG INJECTION if you are a pregnant or a
breastfeeding woman. Men and women receiving PEMAXAM 500MG INJECTION must use a
suitable contrace
PEMAXAM 500MG INJECTION.

What happens if I stop receiving PEMAXAM 500MG INJECTION?

No. Do not stop receiving PEMAXAM 500MG INJECTION without consulting your doctor
as it may make your symptoms reappear. Therefore, take PEMAXAM 500MG INJECTION
as advised by your doctor for the stipulated duration.

Can PEMAXAM 500MG INJECTION be used during pregnancy?

PEMAXAM 500MG INJECTION is generally not recommended for use in pregnant women.
If you accidentally became pregnant while receiving PEMAXAM 500MG INJECTION,
inform your doctor immediately.

Can the use of PEMAXAM 500MG INJECTION make me feel tired?

Yes. PEMAXAM 500MG INJECTION may make you feel tired easily. This is because, it
reduces the levels of red blood cells in your blood and may make you anemic.
Consult your doctor if you experience tiredness after receiving PEMAXAM 500MG
INJECTION. Tiredness can also occur if you have any pre-existing disease
conditions such as liver or kidney impairment while taking this medicine.

Can I drive a car after receivingPEMAXAM 500MG INJECTION?

PEMAXAM 500MG INJECTION may make you feel tired or dizzy. Therefore, do not
drive or operate any heavy tools or machines if your ability is affected by
PEMAXAM 500MG INJECTION.

How PEMAXAM 500MG INJECTION is administered?

PEMAXAM 500MG INJECTION will be given to you only by a doctor or a nurse into a
vein (as an intravenous infusion).

How to control nausea caused due to PEMAXAM 500MG INJECTION?

Generally, anticancer medicines are associated with uncontrollable nausea and
vomiting. To avoid this, your doctor would prescribe a suitable medicine to
control them along with PEMAXAM 500MG INJECTION. If not, consult your doctor for
a suitable anti-emetic medicine. Do not self-manage nausea.

What are the side effects of receiving PEMAXAM 500MG INJECTION?

The most common side effects of receiving PEMAXAM 500MG INJECTION are increased
infections, sore throat, nausea, vomiting, stomach pain, dizziness, tiredness,
weight loss, changes in taste, skin rash, hair loss and mouth ulcers. Contact
your doctor if any of these side effect worsens.

Who should avoid taking PEMAXAM 500MG INJECTION?

PEMAXAM 500MG INJECTION is not recommended for use if you are allergic to
pemetrexed. It is also not recommended for use in pregnant or breastfeeding
women and in children (aged below 18 years).

IsPEMAXAM 500MG INJECTION safe to use in kidney disease?

PEMAXAM 500MG INJECTION should be used with caution in patients with kidney
problems. Your doctor will access your health condition and suggest a suitable
dose for you.

Can the use of PEMAXAM 500MG INJECTION affect the liver?

Yes. PEMAXAM 500MG INJECTION may affect the way your liver work. It can elevate
the levels of certain liver enzymes in your body. Therefore, it should be used
with caution in patients with liver problems. Consult your doctor before taking
it.