Myplat 360mg Tablet 10'S

INTRODUCTION ABOUT MYPLAT 360MG TABLET

MYPLAT 360MG TABLET contains Mycophenolate mofetil which belongs to the group of
medicines called Immunosuppressants. It is used to manage your body rejecting a
transplanted organ (such as kidney, heart, and liver). It is also given with
other medications such as corticosteroids and ciclosporin.

Your doctor will perform some regular blood tests to monitor any changes in your
body. MYPLAT 360MG TABLET may increases the risk of skin cancer. Limit your
exposure to sunlight and ultraviolet light by covering the exposed areas of skin
as much as possible and by applying sunscreen with a high protective factor.

MYPLAT 360MG TABLET can cause birth defects and miscarriage, hence it is
strictly not recommended for use in pregnant women and breastfeeding women.

MYPLAT 360MG TABLET is not recommended for use in children under 2 years of age.
Contact your doctor before taking.

MYPLAT 360MG TABLET should be used with caution in elderly patients aged 65
years or above. Contact your doctor before taking MYPLAT 360MG TABLET.

The most common side effects of taking MYPLAT 360MG TABLET are nausea, vomiting,
diarrhea, stomach pain, headache, high blood pressure, and low number of white
blood cells. Contact your doctor if the above side effects worsen.

USES OF MYPLAT 360MG TABLET

• Used to manage your body rejecting a transplanted organ (such as kidney, heart, and liver)

HOW MYPLAT 360MG TABLET WORKS

MYPLAT 360MG TABLET belongs to immunosuppressants which reduces the action of
the body's own defense system (the immune system) and manages rejection of the
transplanted organ.

DIRECTIONS FOR USE

Take MYPLAT 360MG TABLET as advised by your physician. Swallow the medicines
with a glass of water. Do not crush or chew the medicine. Your dosage will vary
depending on the type of transplant you received. Do not stop the medicine
suddenly without the concern of your doctor.

SIDE EFFECTS OF MYPLAT 360MG TABLET

COMMON

• decreased white blood cells
• decrease in calcium levels of blood
• abnormal potassium levels in the blood (high or low)
• raised uric acid levels in the blood
• high or low blood pressure
• anxiety
• diarrhoea
• joint or muscle pain
• tiredness, shortness of breath and pale skin (decrease in red blood cells)
• unexpected bleeding and bruising (decrease in blood platelets)
• hypomagnesemia (decrease in magnesium levels of blood)
• dizziness
• headache
• cough
• shortness of breath
• stomach pain, inflammation of the lining of the stomach, abdominal bloating, constipation, indigestion, flatulence, loose stools, nausea, vomiting
• tiredness
• fever
• change in liver and kidney function test results
• respiratory infection
• acne
• weakness
• swelling of hands, ankles, or feet
• itching

UNCOMMON

• fast heartbeat or irregular heartbeat
• fluid in the lungs
• presence of cyst in lymph
• trembling, difficulty in sleeping
• conjunctivitis, blurry vision
• bad breath, gas formation, intestinal blockage, ulcers on lips, heartburn, discoloration of tongue, dry mouth, inflammation of the gums
• loss of appetite
• wheezing
• blockage of salivary glands
• elevated lipid levels
• increase in blood glucose levels or blood cholesterol levels
• strange dreams, delusions
• pain, rigors
• inability to keep an erection
• cough, difficulty breathing, painful breathing
• fever, chills, nausea, vomiting, low body temperature, fast heartbeat

RARE

Stop taking MYPLAT 360MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• yellowish discoloration of skin and whites of eyes, nausea, loss of appetite and dark urine
• persistent cough or become breathlessness
• signs of infection such as fever, chills, sore throat, sweating, feeling tired, drowsy, or lack of energy
• blood vomit blood or blood in stools due stomach, or intestinal ulcer
• swelling of glands, development of a new skin growth or enlargement of an existing skin growth, or changes in an existing mole. may lead to development of cancer of the skin or lymph nodes
• rashes, swelling of face, lips, tongue or throat causing difficulty breathing

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink plenty of water and fruit juice to keep yourself hydrated. Contact your
doctor if the diarrhea did not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a
pain-relieving balm on the head if necessary. Do not consume alcohol. Contact
your doctor if the headache did not improve.

Nausea and Vomiting:

Take the medicine, with or just after a meal. Stick to simple meals. Avoid
eating oily or spicy food. Contact your doctor if nausea and vomiting did not
improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operate any machines
while you are feeling dizzy. Do not drink alcohol, as it can aggravate your
dizziness. Contact your doctor if the dizziness did not improve.

Stomach pain:

Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on
your stomach. Contact your doctor if the stomach pain did not improve.

WARNING & PRECAUTIONS

!### PREGNANCY

MYPLAT 360MG TABLET is not recommended for use in pregnant women. Inform your
doctor if you are planning to have a child before taking this medicine. Contact
your doctor before taking MYPLAT 360MG TABLET.

!### BREASTFEEDING

MYPLAT 360MG TABLET is generally not recommended for use in breastfeeding women,
hence small amounts of the medicine can pass into the mother’s milk. Contact
your doctor before taking MYPLAT 360MG TABLET.

!### DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel drowsiness, somnolence,
dizziness, tremor, low blood pressure, numb or confusion after taking MYPLAT
360MG TABLET.

!### KIDNEY

MYPLAT 360MG TABLET should be used with caution in patients with kidney
diseases. Contact your doctor before taking MYPLAT 360MG TABLET.

!### LIVER

MYPLAT 360MG TABLET should be used with caution in patients with liver diseases.
Contact your doctor before taking MYPLAT 360MG TABLET.

!### ALLERGY

Do not take MYPLAT 360MG TABLET if you are allergic (hypersensitive) to
Mycophenolate mofetil, or to some sugars such as lactose, galactose, or glucose
or to other ingredients of this medicine.

!### LUNGS

MYPLAT 360MG TABLET should be used with caution in patients with lung diseases.
Contact your doctor before taking MYPLAT 360MG TABLET.

!### HEART DISEASE

MYPLAT 360MG TABLET should be used with caution in patients with heart diseases.
Contact your doctor before taking MYPLAT 360MG TABLET.

OTHERS

MYPLAT 360MG TABLET is not recommended for use if you:

• have hereditary enzyme deficiency such as Lesch-Nyhan (neurogenetic disorder) and Kelley-Seegmiller syndrome (partial deficiency of the enzyme hypoxanthine gu

Before taking MYPLAT 360MG TABLET, inform your doctor if you:

• have any unexpected bruising (skin discoloration from a skin or tissue injury) or bleeding
• have digestive problems (such as a stomach ulcer)
• have a rare problem with your metabolism called phenylketonuria (hereditary condition that results in an accumulation of the phenylal
• are planning to get live vaccinations
• have Hepatitis B or C infections
• have skin cancer or lymphoma

Use in pediatrics:

MYPLAT 360MG TABLET is not recommended for use in children under the age of 2,
because there is limited information on its safety and effectiveness. Contact
your doctor before taking MYPLAT 360MG TABLET.

Use in geriatrics:

MYPLAT 360MG TABLET should be used with caution in elderly patients aged 65
years or above. Contact your doctor before taking MYPLAT 360MG TABLET.

INTERACTIONS

A. Drug-Drug interactions:

Before taking MYPLAT 360MG TABLET, inform your doctor if you are taking any of
the following medicine:

• azathioprine, tacrolimus, belatacept, cyclosporine A (suppress your immune system given after a transplant operation)
• cholestyramine (medicine used to manage high cholesterol)
• rifampicin (medicines used to manage infections such as TB)
• medicines used to manage ulcer problems (antacids such as aluminium hydroxide, magnesium hydroxide, sodium bicarbonate, calcium carbonate or proton pump inhibitors such as omeprazole, rabeprazole, pantoprazole)
• phosphate binders (used to reduce phosphate absor
• antibiotics (medicines used to manage bacterial infections) amoxicillin and clavul
• isavuconazole (medicine used to manage fungal infections)
• telmisartan (medicine used to manage high blood pressure)
• activated charcoal (used to manage digestive problems)
• acyclovir or ganciclovir (medicines used to manage viral infections)
• oral contrace
• probenecid (medicines used to manage gout)
• iron salts such as Ex. ferrous sulphate (medicines used to manage iron deficiency)

Overdosage:

If you or anyone else accidentally takes too much of MYPLAT 360MG TABLET,
consult your doctor immediately or visit the nearby hospital. Symptoms include
nausea, vomiting, diarrhea, and neutropenia.

SYNOPSIS

Drug	:	Mycophenolate mofetil
Pharmacological Category	:	Immunosuppressants
Therapeutic Indication	:	Prevents your body from rejecting a transplanted organ
Dosage Forms	:	Tablet, Capsule, Suspension, Oral suspension

MORE INFORMATION

• Keep MYPLAT 360MG TABLET out of the sight and reach of children
• Store MYPLAT 360MG TABLET below 30°C

FAQs ABOUT MYPLAT 360MG TABLET

What is MYPLAT 360MG TABLET used for?

MYPLAT 360MG TABLET is used to manage your body from rejecting an organ
transplant (such as kidney, heart, and liver). Contact your doctor before taking
MYPLAT 360MG TABLET.

Can I use MYPLAT 360MG TABLET in pregnancy?

No. MYPLAT 360MG TABLET is strictly not recommended for use in pregnant women
unless considered necessary. Contact your doctor before taking MYPLAT 360MG
TABLET.

Is MYPLAT 360MG TABLET safe?

Yes, MYPLAT 360MG TABLET is safe and well tolerated. Contact your doctor before
taking.

Can I use MYPLAT 360MG TABLET in children?

No, MYPLAT 360MG TABLET is not recommended for use in children under the age of
2, because there is limited information on its safety and effectiveness for
them. Contact your doctor before taking.

How MYPLAT 360MG TABLET work?

MYPLAT 360MG TABLET belongs to immunosuppressants which reduces the action of
the body's own defense system (the immune system) and manages rejection of the
transplanted organ.

Can I use MYPLAT 360MG TABLET while breast feeding?

No. MYPLAT 360MG TABLET is generally not recommended for use in breastfeeding
women, small amounts of the medicine can pass into the mother’s milk. Contact
your doctor before taking it.

REFERENCES

1. KD Tripathi. Immunosuppressant Drugs. Essentials of Medical Pharmacology.
   Seventh Edition,2013. Page - 883.

2. Jeffrey J Swigris, Amy L Olson, Aryeh Fischer, David A Lynch, Gregory P
   Cosgrove, Stephen K Frankel, Richard T Meehan, Kevin K Brown. Uses of
   Mycophenolate mofetil. National Institute of Health. NLM. National Centre for
   Biotechnology Information. . 2006. [Accessed on 16th July
   2022]

3. Novartis Pharma GmbH. Electronic Medicines Compendium (EMC); [Revised on July
   2021] [Accessed 16th July
   2022]

4. Roche Products Limited. Electronic Medicines Compendium (EMC); [Revised on
   January 2022] [Accessed 16th July
   2022]

5. Novartis Pharma GmbH. Electronic Medicines Compendium (EMC); [Revised on July
   2021] [Accessed 16th July
   2022]

6. Accord Healthcare B.V. Electronic Medicines Compendium (EMC); [Revised on Oct
   2020] [Accessed 16th July
   2022]

7. Roche Pharma AG. European Medical Agency. [Revised in Jan 2021] [Accessed on
   16th July
   2022]

8. Biocon. Mycophenolate mofetil. [Accessed on 16th July
   2022]

9.Hoffmann-La Roche Limited. Mycophenolate mofetil. [Revised on January 2022]
[Accessed 16th July
2022]

10. Mycophenolate mofetil. . [Accessed on 16th July
    2022]

USEFUL DIAGNOSTIC TESTS

• Complete blood count
• Liver function test
• Kidney function test