Sandimmun Neoral 100mg Capsule 50'S

Introduction About SANDIMMUN NEORAL 100MG CAPSULE

SANDIMMUN NEORAL 100MG CAPSULE contains Cyclosporine which belongs to the group
of medicines called Immunosuppressants. It is used to manage graft rejection in
patients undergoing transplantation of any organ, bone marrow or stem cells.

It can also be used to manage various auto-immune disease conditions such as
psoriasis, atopic dermatitis (or eczema), rheumatoid arthritis (joint
inflammation), nephrotic syndrome (a kidney disease) or eye inflammation (such
as endogenous uveitis, including Behçet's uveitis). It is mostly used in
combination with other immune suppressants (such as azathioprine) to achieve
maximum benefits.

Take SANDIMMUN NEORAL 100MG CAPSULE regularly as instructed by your doctor.
While undergoing therapy with SANDIMMUN NEORAL 100MG CAPSULE your doctor will
periodically monitor your blood pressure, blood cholesterol levels, liver and
kidney functions to avoid the risk of side effects.

Your doctor may also prescribe you blood tests and urine tests at regular
intervals to access the improvement in your health conditions. During management
with SANDIMMUN NEORAL 100MG CAPSULE, avoid exposing your skin towards direct
sunlight. Wear protective loose-fitting clothes and apply sunscreen while going
outdoors.

Before taking SANDIMMUN NEORAL 100MG CAPSULE inform your doctor if you have any
liver problems or any signs of infections (such as fever or sore throat). You
must also inform your doctor if you have hepatitis C infection, fits, low blood
magnesium levels, gout, alcohol dependence or if you are about to receive any
vaccinations as a precaution.

SANDIMMUN NEORAL 100MG CAPSULE is not recommended for use in patients with
severe uncontrollable infections, any types of cancer or severe high blood
pressure. Do not take SANDIMMUN NEORAL 100MG CAPSULE without consulting your
doctor if you are pregnant or breastfeeding.

Avoid consuming grapefruit or drinking grapefruit juice while taking SANDIMMUN
NEORAL 100MG CAPSULE as it may increase the risk of side effects. The most
common side effects of taking SANDIMMUN NEORAL 100MG CAPSULE are increase in
blood sugar levels, increase in blood cholesterol levels, increased blood
potassium levels, high blood pressure, headache, loss of appetite, acne, hot
flushes, tiredness, excessive facial hair and low blood magnesium levels in
blood. Consult your doctor if any of these side effects worsen.

Uses Of SANDIMMUN NEORAL 100MG CAPSULE

• Prevents graft rejection following organ transplantation
• Manage auto-immune skin diseases such as psoriasis or atopic dermatitis
• Manage rheumatoid arthritis (joint inflammation)
• Manage nephrotic syndrome (a kidney disease)
• Manage eye inflammation (such as endogenous uveitis, including Behçet's uveitis)

How SANDIMMUN NEORAL 100MG CAPSULE Works

SANDIMMUN NEORAL 100MG CAPSULE is an immunosuppressive agent. It works by
blocking the release of certain chemicals in the body (such as T-cells,
interleukins and cytokines) that triggers the immune response. This action
suppresses your body’s immune functions and enables your body to accept the
newly transplanted organ. It also stops the abnormal immune response in the body
and manages your body from attacking its own cells.

How to use SANDIMMUN NEORAL 100MG CAPSULE

Take SANDIMMUN NEORAL 100MG CAPSULE as directed by your physician. Swallow the
medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition. Do not stop taking
SANDIMMUN NEORAL 100MG CAPSULE without consulting your doctor.

Side Effects Of SANDIMMUN NEORAL 100MG CAPSULE

Common

• high blood pressure
• headache, shakiness
• nausea, vomiting, loss of appetite, stomach pain, diarrhoea
• acne, hot flushes, fever, tiredness
• excessive facial hair
• high blood cholesterol levels
• high blood sugar levels
• tingling sensation in the body
• muscle spasm, swollen gums
• high blood levels of uric acid or potassium
• low levels of magnesium in blood

Uncommon

• lack of sleep
• oedema, weight gain

Rare

• inflammation of the pancreas, severe upper stomach pain
• menstrual irregularities, breast enlargement in men

Stop taking SANDIMMUN NEORAL 100MG CAPSULE and contact your doctor immediately
if you experience any of the following side effects:

• signs of infections (such as fever or sore throat)
• signs of brain infection called progressive multifocal leukoencephalopathy (such as vision changes, loss of coordination, being clumsy, memory loss, problems in speaking or understanding, muscle weakness)
• brain problems (causing seizures, confusion, disorientation, lack of response, behavioural changes, agitation, sleeplessness, vision changes, paralysis, stiff neck, loss of coordination with or without unusual speech or eye movements)
• swelling at the back of the eye with blurred vision
• signs of liver problems (such as yellow skin and eyes, nausea, loss of appetite and dark urine)
• low urine output, kidney problems
• low level of red blood cells or platelets (causing pale skin, tiredness, breathlessness, having dark urine, bruising or bleeding with no obvious reasons, confusion, disorientation, being less alert and having kidney problems)

How To Manage Side Effects

Nausea or vomiting:

Try to take SANDIMMUN NEORAL 100MG CAPSULE with or just after meals. Stick to
simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea
worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

Warning & Precautions

!### Pregnancy

SANDIMMUN NEORAL 100MG CAPSULE is not recommended for use in pregnant women
unless considered necessary by the physician. Therefore, consult your doctor
before taking it.

!### Breastfeeding

SANDIMMUN NEORAL 100MG CAPSULE may pass through the breast milk. Therefore, it
is not recommended for use in breastfeeding woman. However, consult your doctor
before taking it.

!### Driving and Using Machines

Do not drive or operate any heavy tools or machines if your ability is affected
by SANDIMMUN NEORAL 100MG CAPSULE.

!### Alcohol

Avoid consum
might worsen your condition.

!### Kidney

SANDIMMUN NEORAL 100MG CAPSULE is not recommended for use in patients with other
kidney problems (except for nephrotic syndrome). Therefore, consult your doctor
before taking it.

!### Liver

SANDIMMUN NEORAL 100MG CAPSULE should be used with caution in patients with
liver problems (including Hepatitis C infection). Therefore, consult your doctor
before taking it.

!### Allergy

Talk to your doctor before taking SANDIMMUN NEORAL 100MG CAPSULE if you are
allergic to cyclosporine.

Others

SANDIMMUN NEORAL 100MG CAPSULE is not recommended for use if you:

• have severe infections in the body which is unable to control
• have any type of cancer
• have uncontrollably high blood pressure

Before taking SANDIMMUN NEORAL 100MG CAPSULE inform your doctor if you:

• have any signs of infection, such as fever or sore throat
• have low levels of magnesium in the body
• have high blood potassium levels
• have gout (joint pain caused due to fluid accumulation)
• are about to receive any vaccination
• have or ever had alcohol-related problems
• have epilepsy

Use in paediatrics:

SANDIMMUN NEORAL 100MG CAPSULE should only be used to manage nephrotic syndrome
in children. It is generally not recommended for managing graft rejection or for
managing other auto-immune disease condition apart from nephrotic syndrome in
children. Therefore, consult your doctor before taking it.

Use in geriatrics:

SANDIMMUN NEORAL 100MG CAPSULE should be used with caution in elderly patients.
Therefore, consult your doctor before taking it. Proper dose adjustments and
careful monitoring are required in such patients.

Interactions

A. Drug - Drug interactions:

Before taking SANDIMMUN NEORAL 100MG CAPSULE, inform your doctor if you are
taking any of the following medicines such as:

• St. John’s Wort (an herbal medicine used to manage depression)
• dabigatran etexilate (a medicine used to manage blood clots after surgery)
• bosentan or aliskiren (medicines used to manage high blood pressure)
• vaccines
• medicines that can increase blood potassium levels in the body (such as potassium supplements or potassium-sparing diuretics (Ex. amiloride, triamterene or spironolactone))
• methotrexate (a medicine used to manage cancer and severe rheumatoid arthritis)
• medicines used to manage bacterial infections (Ex. erythromycin, azithromycin, gentamycin, tobramycin, ciprofloxacin)
• medicines used to manage fungal infections (Ex. voriconazole, itraconazole, terbinafine, amphotericin B)
• medicines used for heart problems or high blood pressure (Ex. diltiazem, nicardipine, verapamil, digoxin, amiodarone)
• metoclopramide (a medicine used to stop nausea and vomiting)
• danazol (a medicine used to manage overgrowth in the uterus)
• oral contrace
• medicines used to manage gout (Ex. colchicine, allopurinol)
• medicines used to manage gallstones (Ex. ursodiol)
• medicines used to manage leukaemia and other cancers (Ex. imatinib, melphalan, etoposide, doxorubicin)
• barbiturates (used to reduce anxiety and to induce sleep) Ex. phenobarbital
• medicines used to manage epilepsy (Ex. carbamazepine, phenytoin, cannabidiol)
• octreotide (a medicine used to manage hormonal disorder, (acromegaly) and tumours)
• orlistat (a medicine that helps in weight loss)
• ticlopidine (a medicine used to manage blood clots due to platelet aggregation)
• other medicines used to supress immune system (Ex. everolimus, sirolimus, tacrolimus)
• medicine used to reduce pain and inflammation Ex. diclofenac
• medicines used to lower cholesterol levels (Ex. fenofibrate, atorvastatin, Fluvastatin)
• medicines used to manage tuberculosis (Ex. isoniazid, rifampicin)
• medicines used to manage HIV infections (Ex. acyclovir, ritonavir, nelfinavir, saquinavir, efavirenz, etravirine, nevirapine)
• medicines used to manage hepatitis C infection (Ex. telaprevir, boceprevir, the combination ombitasvir/paritaprevir/ritonavir with or without dasabuvir, elbasvir/grazoprevir and glecaprevir/pibrentasvir)
• medicines used to manage gastric problems (Ex. omeprazole, cimetidine, magnesium hydroxide, aluminum hydroxide)
• trimethoprim or cotrimoxazole (used to manage bacterial infections)
• corticosteroids (used to manage allergic or autoimmune diseases) Ex. prednisolone, methylprednisolone
• medicines used to manage diabetes (Ex. repaglinide)

B. Drug – food interactions

Avoid consuming grapes or grapefruit juice while taking SANDIMMUN NEORAL 100MG
CAPSULE as it may increase the risk of side effects.

Overdosage:

If you or anyone else accidentally took more SANDIMMUN NEORAL 100MG CAPSULE,
consult your doctor immediately or visit the nearby hospital. Symptoms of
overdosage might include vomiting, drowsiness, headache, fast heartbeat and
kidney damage.

Synopsis

Drug	:	Cyclosporine
Pharmacological Category	:	Calcineurin inhibitors
Therapeutic Indication	:	Graft rejection, Autoimmune diseases
Dosage Forms	:	Tablet, Capsule, Injection, Infusion, Oral Solution, Oral Suspension, Eye Drops, Ophthalmic Emulsion

More Information

• Keep SANDIMMUN NEORAL 100MG CAPSULE out of reach of children
• Store SANDIMMUN NEORAL 100MG CAPSULE at room temperature

FAQs About SANDIMMUN NEORAL 100MG CAPSULE

What is the use of SANDIMMUN NEORAL 100MG CAPSULE?

SANDIMMUN NEORAL 100MG CAPSULE is used to manage graft rejection in patients
undergoing transplantation of any organ, bone marrow or stem cells. It can also
be used to manage various auto-immune disease conditions such as psoriasis,
atopic dermatitis (or eczema), rheumatoid arthritis, nephrotic syndrome or eye
inflammation (such as endogenous uveitis, including Behçet's uveitis).

How SANDIMMUN NEORAL 100MG CAPSULE works?

SANDIMMUN NEORAL 100MG CAPSULE is an immunosuppressive agent. It works by
blocking the release of certain chemicals in the body (such as T-cells,
interleukins and cytokines) that triggers the immune response. This action
suppresses your body’s immune functions and enables your body to accept the
newly transplanted organ. It also stops the abnormal immune response in the body
and manages your body from attacking its own cells.

How to take SANDIMMUN NEORAL 100MG CAPSULE?

Take SANDIMMUN NEORAL 100MG CAPSULE as directed by your physician. Swallow the
medicine with a glass of water. Do not crush or chew the medicine.

Is SANDIMMUN NEORAL 100MG CAPSULE an antibiotic?

No. SANDIMMUN NEORAL 100MG CAPSULE is an immunosuppressive agent. It suppresses
your body’s immune functions and enables your body to accept the transplanted
organ. It also stops the abnormal immune response in the body and manages your
body from attacking its own cells.

What precautions must be followed while taking SANDIMMUN NEORAL 100MG
CAPSULE?

Before taking SANDIMMUN NEORAL 100MG CAPSULE inform your doctor if you have any
liver problems or any signs of infections (such as fever or sore throat). You
must also inform your doctor if you have hepatitis C infection, fits, low blood
magnesium levels, gout, alcohol dependence, severe uncontrollable infections,
any types of cancer, severe high blood pressure or if you are about to receive
any vaccinations as a precaution. Inform your doctor before taking SANDIMMUN
NEORAL 100MG CAPSULE if you are pregnant or breastfeeding.

How long should I take SANDIMMUN NEORAL 100MG CAPSULE?

You need to take SANDIMMUN NEORAL 100MG CAPSULE for the stipulated duration
prescribed by your doctor. Your doctor will decide the correct dose and duration
of therapy for you depending upon your age, body weight and disease condition.

What to do if I forgot to take a dose of SANDIMMUN NEORAL 100MG CAPSULE?

If you forgot to take a dose of SANDIMMUN NEORAL 100MG CAPSULE, take it as soon
as you remember. However, if it is time for the next dose of SANDIMMUN NEORAL
100MG CAPSULE, skip the missed dose and take the next one regularly. Do not take
a double dose of SANDIMMUN NEORAL 100MG CAPSULE to compensate the missed ones.

Is SANDIMMUN NEORAL 100MG CAPSULE safe?

The most common side effects of taking SANDIMMUN NEORAL 100MG CAPSULE are
increase in blood sugar levels, increase in blood cholesterol levels, increased
blood potassium levels, high blood pressure, headache, loss of appetite, acne,
hot flushes, tiredness, excessive facial hair and low blood magnesium levels in
blood. Consult your doctor if any of these side effects worsen.

Can I stop taking SANDIMMUN NEORAL 100MG CAPSULE without consulting your
doctor?

No. You should not stop taking SANDIMMUN NEORAL 100MG CAPSULE without consulting
your doctor because your body’s immune system may once again attempt to reject
the newly transplanted organ. Therefore, take SANDIMMUN NEORAL 100MG CAPSULE for
the stipulated duration recommended by your doctor to achieve maximum results.

What happens if I take too more of SANDIMMUN NEORAL 100MG CAPSULE?

If you or anyone else accidentally took more SANDIMMUN NEORAL 100MG CAPSULE,
consult your doctor immediately or visit the nearby hospital. Symptoms of
overdosage might include vomiting, drowsiness, headache, fast heartbeat and
kidney damage.

Can I use SANDIMMUN NEORAL 100MG CAPSULE if I suffer from kidney diseases?

SANDIMMUN NEORAL 100MG CAPSULE is not recommended for use in patients with other
kidney problems (except for nephrotic syndrome). Therefore, consult your doctor
before taking it.

Will taking a higher dose of SANDIMMUN NEORAL 100MG CAPSULE be more
effective?

No, taking a higher dose of SANDIMMUN NEORAL 100MG CAPSULE will not be effective
rather it can lead to toxicity. Always take the dose prescribed by your doctor.
If the prescribed dose is not effective for you, consult your doctor for advice.
Your doctor might increase the dose or suggest an alternative therapy.

Can I take medication for high blood pressure along with SANDIMMUN NEORAL
100MG CAPSULE?

It is not advisable to take medicines to control blood pressure while taking
SANDIMMUN NEORAL 100MG CAPSULE without consulting your doctor as they have known
interactions with SANDIMMUN NEORAL 100MG CAPSULE.

Can SANDIMMUN NEORAL 100MG CAPSULE be used in pregnant women?

SANDIMMUN NEORAL 100MG CAPSULE is not recommended for use in pregnant women
unless considered necessary by the physician. Therefore, consult your doctor
before taking it.

How much SANDIMMUN NEORAL 100MG CAPSULE should I take?

SANDIMMUN NEORAL 100MG CAPSULE should be used only under medical supervision.
Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body condition and severity of the disease condition.

Is SANDIMMUN NEORAL 100MG CAPSULE a steroid?

No. SANDIMMUN NEORAL 100MG CAPSULE is an immunosuppressive agent. It suppresses
your body’s immune functions and enables your body to accept the transplanted
organ. It also stops the abnormal immune response in the body and manages your
body from attacking its own cells.