Lntrio 20mg Tablet 10'S

Introduction About LNTRIO 20MG TABLET

LNTRIO 20MG TABLET is a combination of Chlorthalidone, Cilnidipine
andTelmisartan which belongs to the group of medicines called Antihypertensive
drugs. It is used to manage essential hypertension in adults. High blood
pressure that is not caused by any other condition is called essential
hypertension. Symptoms of essential hypertension include early morning
headaches, nosebleeds, irregular heartbeat, vision changes, buzzing in the ears,
fatigue (feeling overtiredness), nausea, vomiting, confusion, anxiety, chest
pain and muscle tremors (shakiness).

LNTRIO 20MG TABLET is not recommended for use in patients with liver, kidney and
heart disease. LNTRIO 20MG TABLET is not recommended in early pregnancy and must
not be taken when more than 3 months pregnant, as it may cause serious harm to
the baby if used after 3 months of pregnancy. LNTRIO 20MG TABLET is not suitable
for use by breastfeeding women. LNTRIO 20MG TABLET is not recommended for use in
children and adolescents (under 18 years of age). Consult your doctor before
taking this medicine.

LNTRIO 20MG TABLET and it should be used with caution in elderly patients. The
most common side effects of taking LNTRIO 20MG TABLET are dizziness, nausea,
headache, constipation, fever and chills. Consult your doctor if the
above-mentioned symptoms are not improving.

Uses Of LNTRIO 20MG TABLET

• Manage essential hypertension (high blood pressure) in adults
• Lowers the risk of stroke and heart attack

How LNTRIO 20MG TABLET Works

LNTRIO 20MG TABLET effectively reduces the blood pressure where Chlorthalidone
acts by enhancing the excretion of sodium (which is necessary for constriction
of blood vessels) and water from the body causing blood vessels to relax and
Cilnidipine makes the blood vessels relax and thus lowers the blood pressure by
blocking the calcium entry in blood vessels which is necessary for the smooth
muscle contraction. Telmisartan acts by blocking the effects of Angiotensin II
(a substance produced in your body which causes the narrowing of blood vessels).

How to use LNTRIO 20MG TABLET

Take LNTRIO 20MG TABLET as advised by your physician. Swallow this medicine, do
not crush or chew the medicine. The correct dosage and duration of medicine to
be taken will be prescribed by your doctor depending on your age, body weight
and disease condition.

Side Effects Of LNTRIO 20MG TABLET

Common

• low blood pressure

Uncommon

• signs of urinary tract infection (bladder pain, foul smell, cloudy urine, frequent urination)
• signs of upper respiratory tract infection (sore throat, inflamed sinuses, common cold)
• anemia
• insomnia
• depression
• fainting
• feeling of spinning (vertigo)
• slow heart rate
• cough
• low blood pressure while standing up from a sitting position
• shortness of breath
• abdominal pain, abdominal discomfort, bloating
• diarrhea
• vomiting
• itching
• increased sweating
• drug rash
• back pain
• muscle cramps, muscle pain
• chest pain
• feeling of weakness

Rare

• signs of high eosinophil count in blood (fever, night sweats, swelling, weakness)
• signs of low platelet count (easy bleeding or bruising)
• severe allergic reaction (anaphylactic reaction)
• allergic reaction (Ex. rash, itching, wheezing, rapid swelling of the face and mucosa (angioedema)
• low sugar level in the blood (in diabetic patients)
• feeling anxious
• sleepiness
• impaired vision
• fast heartbeat (tachycardia)
• dry mouth, dysgeusia (impaired sense of taste)
• eczema (a skin condition with der, red, itchy, irritated skin)
• pain in joints(arthralgia), extremities, tendon
• flu-like-illness
• severe pain in joints, joint stiffness, slurred speech

Stop taking LNTRIO 20MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• sepsis (the body's life-threatening response to infection which can lead to death and organ failure)
• angioedema (rapid swelling of the skin and mucosa)

How To Manage Side Effects

Vomiting:

Take this medicine with or just after meals. Stick to simple meals. Avoid eating
oil-rich or spicy foods, sugary snacks and drinks. Avoid drinking too much
liquid along with your meals, drink slowly in between meals. Consult your doctor
if your symptom does not improve.

Diarrhea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do
not consume any medicine on your own without consulting your doctor.

Stomach pain:

Try to rest and relax. Try to have smaller and more frequent meals. Keep a
heating pad on your stomach. If the symptom does not improve, contact your
doctor.

Dizziness:

When you feel dizzy, lie or sit down immediately. if you're experiencing a
severe episode of vertigo, lie in a dark and quiet place with your eyes closed.
Vehicle driving should be avoided if you experience frequent dizziness without
warning. Talk to your doctor if the symptom worsens.

Skin rash:

Try to avoid hot showers because they may cause skin irritation. Avoid frequent
contact and rubbing over the affected area. Use sunscreen and protective
clothing when outdoors. If this symptom does not get better, speak to a doctor.

Warning & Precautions

!### Pregnancy

LNTRIO 20MG TABLET is not recommended in early pregnancy and must not be taken
when more than 3 months pregnant, as it may cause serious harm to the baby if
used after 3 months of pregnancy. Consult your doctor for advice.

!### Breastfeeding

LNTRIO 20MG TABLET is not recommended for use in breastfeeding women as it may
pass through the breast milk to the baby. Your doctor may choose another
management especially if you want to breastfeed when your baby is a new born or
born prematurely. Consult your doctor for advice before taking LNTRIO 20MG
TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if you feel dizzy or tired after taking
LNTRIO 20MG TABLET. Consult your doctor before taking LNTRIO 20MG TABLET.

!### Alcohol

Avoid alcohol consum
TABLET.

!### Kidney

LNTRIO 20MG TABLET is not recommended for use in patients with kidney failure.
It should be taken with caution in patients with kidney disease, kidney artery
stenosis (narrowing of blood vessels to one or both the kidneys) and kidney
transplant. Consult your doctor before taking LNTRIO 20MG TABLET.

!### Liver

LNTRIO 20MG TABLET is not recommended for use in patients with liver failure or
severe liver problems such as cholestasis or biliary obstruction (flow of bile
from the liver stops or slows) and it should be used with caution in patients
having progressive liver disease. Consult your doctor before taking LNTRIO 20MG
TABLET.

!### Allergy

LNTRIO 20MG TABLET is not recommended for use if you are allergic to
Chlorthalidone, Cilnidipine or Telmisartan.

!### Heart Disease

LNTRIO 20MG TABLET is not recommended for use in patients with cardiogenic shock
heart cannot pump sufficient blood to other organs), myocardial infarction
(heart attack), acute unstable angina and aortic stenosis (blocked blood supply
in the heart) and taken with caution in patients with low blood pressure (due to
dehydration problems, low-salt intake, diarrhoea or vomiting). Consult your
doctor for advice.

Others

LNTRIO 20MG TABLET is not recommended for use if you:

• decreased levels of potassium and sodium (hypokalaemia, hyponatraemia) and increased levels of calcium and urea (hypercalcaemia, hyperuricaemia)
• gout or uric acid calculi
• addison’s disease

Before taking LNTRIO 20MG TABLET, inform your doctor if you have:

• diabetes
• low blood pressure
• signs of high potassium in the body (muscle weakness or numbness in limbs, irregular or fast heartbeat)
• signs of raised aldosterone levels (extreme thirst, muscle spasms)

Use in pediatrics:

LNTRIO 20MG TABLET is not recommended for use in children and adolescents (under
18 years of age). Consult your doctor before taking this medicine.

Use in geriatrics:

LNTRIO 20MG TABLET is used with caution in elderly patients of 65years and above
with regular monitoring. Before taking LNTRIO 20MG TABLET, consult your doctor.

Interactions

A. Drug-Drug interactions:

• digoxin (a medicine used to manage heart failure and abnormal heart rhythm)
• cimetidine (a medicine used for stomach ulcers)
• rifampicin (a medicine used to manage tuberculosis)
• itraconazole, miconazole (medicines used to manage fungal infections)
• angiotensin-converting enzyme inhibitors used to manage high blood pressure (Ex. enalapril, lisinopril, ramipril)
• aliskiren (a medicine used to manage high blood pressure)
• medicines containing lithium (used to manage some types of depression)
• medicines that may increase blood potassium levels such as salt substitutes containing potassium, potassium-sparing diuretics (Ex. amiloride, spironolactone)
• non-steroidal anti-inflammatory drugs - medicines used to manage pain and inflammation (Ex. aspirin, ibuprofen)
• heparin (a medicine used to manage blood clots)
• immunosuppressive agents such as ciclosporin or tacrolimus (used to manage organ rejection after transplant)
• antibiotic trimethoprim (a medicine used to manage urinary tract infections)
• diuretics such as furosemide, hydrochlorothiazide (used to manage oedema or high blood pressure)
• corticosteroids such as dexamethasone, hydrocortisone which are involved in stress, immune response
• baclofen (a medicine used for muscle spasms)
• amifostine (a medicine used in cancer chemotherapy)
• barbiturates (medicine that acts as a central nervous system depressant) such as phenobarbital, pentobarbital
• antidepressants such as citalopram, fluoxetine and paroxetine (a medicine used to manage depression)
• narcotics such as morphine and codeine (a medicine used to manage moderate to severe pain)

B. Drug - Food interaction:

Avoid drinking grapefruit juice while taking LNTRIO 20MG TABLET as it may
increase the levels of this medication in the body.

Overdosage:

If you or anyone else accidentally take too much of LNTRIO 20MG TABLET, consult
your doctor immediately or visit the nearby hospital as it may increase the risk
of side effects. Signs and symptoms of overdosage include low blood pressure,
dizziness, nausea, sleepiness, elevated creatinine levels, sudden kidney
failure, electrolyte disturbances associated with cardiac arrhythmias (irregular
heartbeat) and muscle stiffness.

Synopsis

Drug	:	Chlorthalidone, Cilnidipine, Telmisartan
Pharmacological Category	:	Diuretics, Calcium Channel Blockers, Angiotensin II receptor antagonist
Therapeutic Indication	:	High Blood Pressure
Dosage Forms	:	Tablet

More Information

• Keep LNTRIO 20MG TABLET out of reach from children
• Store at a temperature not exceeding 30°C

FAQs About LNTRIO 20MG TABLET

What is LNTRIO 20MG TABLET and why is it given?

LNTRIO 20MG TABLET is used to manage essential hypertension (blood pressure not
caused by any other condition called essential hypertension) in adults.

Is LNTRIO 20MG TABLET safe for pregnant women?

LNTRIO 20MG TABLET is not recommended in early pregnancy and must not be taken
when more than 3 months pregnant, as it may cause serious harm to the baby if
used after 3 months of pregnancy. Consult your doctor for advice.

Can LNTRIO 20MG TABLET cause anxiety?

Yes. LNTRIO 20MG TABLET may make you feel anxious. However, it does not affect
every individual. Try to rest and relax. Meditation and breathing exercises can
work. If your symptom worsens, please consult your doctor.

Can LNTRIO 20MG TABLET be given to children?

LNTRIO 20MG TABLET is not recommended for use in children and adolescents (under
18 years of age). Consult your doctor before taking this medicine.

What precautions do I need to follow while taking LNTRIO 20MG TABLET?

Patients taking LNTRIO 20MG TABLET must inform their doctor about their
pre-existing disease conditions like kidney, heart or liver problems. Consult
your doctor immediately if you experience any unusual symptoms after taking
LNTRIO 20MG TABLET.

Useful Diagnostic Tests

• Kidney function test
• Serum electrolyte test