Kinaplat 100mg Infusion 50ml

Introduction About KINAPLAT 100MG INFUSION

KINAPLAT 100MG INFUSION contains Oxaliplatin which belongs to the group of
medicine called Anticancer drugs. It is used to manage cancers of the colon
and/or rectum. It is highly used in combination with other anti-cancer medicines
(such as 5-flurouracil and folinic acid) as an adjunct to manage stage III colon
cancer after removing the primary tumour. It can also be used to manage
metastatic colorectal cancer (cancer of colon and rectum that has been spread to
other parts of the body).

Before receiving KINAPLAT 100MG INFUSION inform your doctor if you have any
liver, kidney or heart problems. You must also inform your doctor if you have
low white blood count in your blood or recently received or planning to receive
any vaccination in the upcoming days.

KINAPLAT 100MG INFUSION is not recommended for use in pregnant or breastfeeding
women and in children aged below 18 years. Men and women receiving KINAPLAT
100MG INFUSION must use a suitable contrace
undergoing therapy with KINAPLAT 100MG INFUSION.

The most common side effects of receiving KINAPLAT 100MG INFUSION are tingling
and numbness of body parts, abnormal sensation in the throat, nausea, vomiting,
stomach pain, headache, dizziness, tiredness, weight loss, changes in taste,
skin rash, hair loss, mouth ulcers and low blood calcium levels. Contact your
doctor if any of these side effect worsens.

Uses Of KINAPLAT 100MG INFUSION

It is used to manage:

• Colon cancer (stage III)
• Metastatic colorectal cancer

How KINAPLAT 100MG INFUSION Works

KINAPLAT 100MG INFUSION is an anticancer medication. It works by damaging the
DNA (genetic material) of the cancer cells. As a result, it reduces abnormal
growth and multiplication of cancer cells in the body.

How to use KINAPLAT 100MG INFUSION

KINAPLAT 100MG INFUSION will be given to you only by a doctor or a nurse into a
vein (as an intravenous infusion).

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition.

Side Effects Of KINAPLAT 100MG INFUSION

Common

• nerve pain, tingling and numbness of body parts
• abnormal sensation in the throat, problems in breathing
• diarrhea, nausea, vomiting, constipation, stomach pain
• indigestion, heartburn, hiccups
• low blood counts (causing bleeding, anemia and increased infections)
• injections site reactions (pain and discomfort)
• fever, shakiness, headache, dizziness, tiredness, body pains
• weight loss, lack of appetite
• changes in taste, nasal bleeds
• skin rash, itching, flaky skin, hair loss, flushing
• nail disorder, increased sweating
• joint pain
• passing little or no urine
• high blood pressure
• depression and lack of sleep
• low blood calcium levels
• neck stiffness

Uncommon

• nervousness

Rare

• loss of hearing

Contact your doctor immediately if you experience any of the following side
effects after receiving KINAPLAT 100MG INFUSION:

• signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
• mouth ulcers (oral sores)
• low platelet count in blood causing excessive unusual bruising
• dry cough, difficulty in breathing and crackling sounds
• sepsis (blood infections)
• low WBC count causing fever or flu-like symptoms
• signs of blood clots in lungs (chest pain, difficulty in breathing, coughing up blood)
• blockage or swelling in the intestines
• problems in hearing, ringing sound in the ears and spinning sensation
• severe persistent diarrhea and vomiting
• short-term vision loss
• signs of reversible posterior leukoencephalopathy syndrome (a nerve disorder causing headache, altered mental functioning, seizures and abnormal vision from blurriness to vision loss)
• signs of Haemolytic-uraemic syndrome (such as extreme tiredness, low RBC count, shortness of breath, low platelet count, abnormal bruising, passing little or no urine)
• inflammation of the lungs
• pain in upper abdomen and back with nausea and vomiting
• vascular disorders of the liver (symptoms include abdominal pain and swelling, weight gain and tissue swelling of the feet, ankles or other parts of the body)
• bleeding in the gut causing bloody stools or vomits

How To Manage Side Effects

Skin rash:

Avoid hot showers because hot water can irritate your skin further. Do not
scratch the affected area. Use protective clothing when going outdoors.
Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Consult your doctor if your
dizziness worsens.

Nausea and Vomiting:

Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea
worsens, consult your doctor for advice.

Mouth ulcers:

Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on
the affected areas of the mouth if required. Consult your doctor if the symptom
did not improve.

Diarrhoea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid
taking any medicine on your own to manage diarrhoea and consult your doctor if
the symptom gets worse.

Constipation:

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and
drink plenty of water. Try doing exercise regularly (going for a daily walk or
run). If this does not help, inform your doctor for receiving alternate
managements for constipation.

Warning & Precautions

!### Pregnancy

KINAPLAT 100MG INFUSION is generally not recommended for use in pregnant women.
However, consult your doctor before receiving it. Women of childbearing
potential must use a suitable contrace
therapy with KINAPLAT 100MG INFUSION and until 4 months after stopping the
therapy. If you accidentally became pregnant while receiving KINAPLAT 100MG
INFUSION, inform your doctor immediately.

!### Breastfeeding

KINAPLAT 100MG INFUSION is not recommended for use in women who are
breastfeeding. Therefore, consult your doctor before receiving it.

!### Driving and Using Machines

Do not drive or operate any machines if your ability is affected by KINAPLAT
100MG INFUSION.

!### Kidney

KINAPLAT 100MG INFUSION is not recommended to use in patients with severe kidney
problems. It should be used with caution in patients with mild to moderate
kidney problems. Therefore, consult your doctor before receiving it.

!### Liver

KINAPLAT 100MG INFUSION should be used with caution in patients with liver
problems. Therefore, consult your doctor before receiving it.

!### Allergy

Talk to your doctor before receiving KINAPLAT 100MG INFUSION if you are allergic
to Oxaliplatin or to any other platinum-based anticancer medicines (such as
carboplatin, cisplatin).

!### Heart Disease

KINAPLAT 100MG INFUSION should be used with caution in patients with heart
problems (such as prolongation of the QT interval, an irregular heartbeat). It
should also be used with caution in patients having a family history of heart
problems. Therefore, consult your doctor before receiving it.

Others

KINAPLAT 100MG INFUSION is not recommended for use if you have:

• reduced number of blood cells
• tingling and numbness in the fingers and/or toes
• difficulty in performing delicate tasks (such as buttoning clothes)

Inform your doctor, before receiving KINAPLAT 100MG INFUSION, if you:

• recently received any vaccine or plan to receive any vaccines

Use in pediatrics:

KINAPLAT 100MG INFUSION is generally not recommended for use in children and
adolescents (under 18 years of age). Therefore, consult your doctor before
receiving it.

Use in geriatrics:

KINAPLAT 100MG INFUSION should be used with caution in elderly patients (aged 65
years or above). Therefore, consult your doctor before receiving it.

Interactions

A. Drug-Drug interactions:

Inform your physician, before receiving KINAPLAT 100MG INFUSION, if you are
taking any of the following medicines such as:

• other medicines used to manage cancer (Ex. 5-fluorouracil, paclitaxel)
• medicines used as antibiotics (Ex. erythromycin)
• medicines used to relieve pain (Ex. salicylates)
• medicines used for vomiting (Ex. gr
• medicines used to manage epilepsy (Ex. sodium valproate)
• live or attenuated vaccines (Ex. yellow fever vaccine)

Overdosage:

KINAPLAT 100MG INFUSION will be administered to you only by a doctor or a nurse
in a hospital and so it is unlikely to receive an overdose. However, consult
your doctor if you experience any unusual symptoms.

Synopsis

Drug	:	Oxaliplatin
Pharmacological Category	:	Platinum-based chemotherapy agent
Therapeutic Indication	:	Colorectal cancer
Dosage Forms	:	Injection, Infusion

More Information

• Keep KINAPLAT 100MG INFUSION out of reach of children
• Store KINAPLAT 100MG INFUSION below 25°C

FAQs About KINAPLAT 100MG INFUSION

What KINAPLAT 100MG INFUSION is used for?

KINAPLAT 100MG INFUSION is used to manage colorectal cancer. It can also be used
to manage metastatic colorectal cancer and can be used an adjunct to manage
stage III colon cancer after removing the primary tumour.

How KINAPLAT 100MG INFUSION works on my body?

KINAPLAT 100MG INFUSION is an anti-cancer medicine. It works by damaging the
genetic material (DNA) of the cancer cells. As a result, it reduces abnormal
growth and multiplication of cancer cells in the body.

Can KINAPLAT 100MG INFUSION manage cancer?

The manage rate of cancer depends upon the severity of the disease. However,
KINAPLAT 100MG INFUSION acts by managing the abnormal growth and multiplication
of cancer cells in the body, which may help in managing cancer completely.

Can the use of KINAPLAT 100MG INFUSION cause hair loss?

Hair loss is one of the common side effects of receiving KINAPLAT 100MG
INFUSION. If it bothers you, consult your doctor for advice.

Can the use of KINAPLAT 100MG INFUSION cause mouth ulcers?

Mouth ulcers are one of the common side effects of receiving KINAPLAT 100MG
INFUSION. Avoid eating spicy foods. Drink plenty of water. Apply a
pain-relieving gel on the affected areas of the mouth if required. Consult your
doctor if the symptom did not improve.

Can KINAPLAT 100MG INFUSION be used in children?

KINAPLAT 100MG INFUSION should not be used in children aged below 18 years.
Therefore, consult your doctor before receiving it.

Is KINAPLAT 100MG INFUSION a chemo drug?

Yes. KINAPLAT 100MG INFUSION contains a medicine called oxaliplatin which is a
platinum-based chemotherapeutic agent. It stops abnormal growth and
multiplication of cancer cells in the body.

What precautions must be followed while taking KINAPLAT 100MG INFUSION?

Before taking KINAPLAT 100MG INFUSION inform your doctor if you have any liver,
kidney or heart problems. Inform your doctor before receiving KINAPLAT 100MG
INFUSION if you are a pregnant or a breastfeeding woman. Men and women receiving
KINAPLAT 100MG INFUSION must use a suitable contrace
pregnancy while undergoing therapy with KINAPLAT 100MG INFUSION.

What happens if I stop receiving KINAPLAT 100MG INFUSION?

No. Do not stop receiving KINAPLAT 100MG INFUSION without consulting your doctor
as it may make your symptoms reappear. Therefore, take KINAPLAT 100MG INFUSION
as advised by your doctor for the stipulated duration.

Can KINAPLAT 100MG INFUSION be used during pregnancy?

KINAPLAT 100MG INFUSION is generally not recommended for use in pregnant women.
If you accidentally became pregnant while receiving KINAPLAT 100MG INFUSION,
inform your doctor immediately.

Can the use of KINAPLAT 100MG INFUSION make me feel tired?

Yes. KINAPLAT 100MG INFUSION may make you feel tired easily. This is because, it
reduces the levels of red blood cells in your blood and may make you anaemic.
Consult your doctor if you experience tiredness after receiving KINAPLAT 100MG
INFUSION. Tiredness can also occur if you have any pre-existing disease
conditions such as liver or kidney impairment while taking this medicine.

Can I drive a car after receivingKINAPLAT 100MG INFUSION?

KINAPLAT 100MG INFUSION may make you feel tired or dizzy. Therefore, do not
drive or operate any heavy tools or machines if your ability is affected by
KINAPLAT 100MG INFUSION.

How KINAPLAT 100MG INFUSION is administered?

KINAPLAT 100MG INFUSION will be given to you only by a doctor or a nurse into a
vein (as an intravenous infusion).

How to control nausea caused due to KINAPLAT 100MG INFUSION?

Generally, anticancer medicines are associated with uncontrollable nausea and
vomiting. To avoid this, your doctor would prescribe a suitable medicine to
control them along with KINAPLAT 100MG INFUSION. If not, consult your doctor for
a suitable anti-emetic medicine. Do not self-manage nausea.

What are the side effects of receiving KINAPLAT 100MG INFUSION?

The most common side effects of receiving KINAPLAT 100MG INFUSION are tingling
and numbness of body parts, abnormal sensation in the throat, nausea, vomiting,
stomach pain, headache, dizziness, tiredness, weight loss, changes in taste,
skin rash, hair loss, mouth ulcers and low blood calcium levels. Contact your
doctor if any of these side effect worsens.

Who should avoid taking KINAPLAT 100MG INFUSION?

KINAPLAT 100MG INFUSION is not recommended for use if you are allergic to
oxaliplatin. It is also not recommended for use in pregnant or breastfeeding
women and in children (aged below 18 years).

IsKINAPLAT 100MG INFUSION safe to use in kidney disease?

KINAPLAT 100MG INFUSION should be used with caution in patients with kidney
problems. Your doctor will access your health condition and suggest a suitable
dose for you.

Can the use of KINAPLAT 100MG INFUSION affect the liver?

Yes. KINAPLAT 100MG INFUSION may affect the way your liver work. It can elevate
the levels of certain liver enzymes in your body. Therefore, it should be used
with caution in patients with liver problems. Consult your doctor before taking
it.

Useful Diagnostic Tests

• Complete Blood Count