INDIRAB Vaccine 0.5ml

Introduction About INDIRAB VACCINE

INDIRAB VACCINE contains Rabies Virus which belongs to the group of medicines
called Vaccines. It is used to manage rabies before exposure to rabies virus
(pre-exposure prophylaxis) or after exposure to rabies virus (post-exposure
prophylaxis) in all age groups. Rabies is an infection that can be transmitted
when a person is bitten, scratched or even just licked by an infected

INDIRAB VACCINE is not recommended for use if you have an acute illness with a
high fever. INDIRAB VACCINE should be used with caution in patients who has
history of allergy (such as asthma, hay fever). Consult your doctor before
receiving it.

INDIRAB VACCINE can be used in pregnant and breast-feeding women who have had or
are likely to have contact with the virus and also used for pre-exposure
prophylaxis. Consult your doctor before receiving it.

The most common side effects of receiving INDIRAB VACCINE are headache,
dizziness, rash, hives, general discomfort, fatigue, weakness and fever. Contact
your doctor if any of the symptoms worsen.

Uses Of INDIRAB VACCINE

• To manage rabies

How INDIRAB VACCINE Works

INDIRAB VACCINE contains a rabies virus that has been killed, which stimulates
the immune system (the body's natural defence system) to form antibodies against
rabies viruses. These antibodies protect from infections or diseases caused by
the rabies virus.

How to use INDIRAB VACCINE

INDIRAB VACCINE will be given to you only by a doctor or a nurse into a muscle
as an injection into a muscle (usually in the upper arm or in small children,
into the muscle of the thigh). Your doctor will decide the correct dose and
duration for you depending upon your age, body weight, previous vaccination
status and disease condition. Do not administer the medicine into the buttocks,
under the skin or into a blood vessel.

Side Effects Of INDIRAB VACCINE

Common

• headache, dizziness
• rash, hives
• general discomfort
• fatigue, weakness
• fever
• swollen glands
• decreased appetite
• nausea, vomiting, diarrhoea, stomach pain
• muscle pain, joint pain
• pain, redness, swelling, itching or bruising at the site of injection
• hardness of the skin at the site of injection

Rare

• tingling sensations
• sweating, chills

Stop receiving INDIRAB VACCINE and contact your doctor if you experience any of
the following side effects:

• signs of anaphylactic reactions (serious allergic reactions) such as shock (severe drop of blood pressure), itching, skin rash, swelling of face and/or neck, breathing difficulties, bluish discoloration of the tongue or lips, low blood pressure, rapid heart rate, weak pulse, skin coldness, dizziness and fainting

How To Manage Side Effects

Headache:

Rest and relax. Drink plenty of fluids such as water or ORS (Oral Rehydrating
Solution) and apply a pain-relieving balm on the head if necessary. Contact your
doctor if your headache did not improve.

Nausea and vomiting:

Receive INDIRAB VACCINE, with or just after a meal. Stick to simple meals. Avoid
eating oily or spicy food. Contact your doctor if your nausea and vomiting did
not improve.

Stomach pain:

Try to have smaller meals but take them frequently. Keep a heating pad on your
stomach. Do not self-manage and contact your doctor if the stomach pain did not
improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any machines
while you are feeling dizzy. Contact your doctor if your dizziness did not
improve.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated.
Do not take any medicine on your own to manage diarrhoea. Contact your doctor if
your diarrhoea did not improve.

Skin rash:

Avoid hot baths because hot water can irritate your skin further. Do not scratch
the affected area. Use sunscreen and wear protective clothing while going
outside. Use unscented moisturizers to soothe and hydrate the affected area.
Contact your doctor if the rashes worsen.

Warning & Precautions

!### Pregnancy

INDIRAB VACCINE can be used in pregnant women who have had or are likely to have
contact with the virus and also used for pre-exposure prophylaxis (before
exposure to rabies virus). Consult your doctor before receiving INDIRAB VACCINE.

!### Breastfeeding

INDIRAB VACCINE can be used in breast feeding women who have had or are likely
to have contact with the virus and also used for pre-exposure prophylaxis
(before exposure to rabies virus). Consult your doctor before receiving INDIRAB
VACCINE.

!### Allergy

INDIRAB VACCINE is not recommended for use if you are allergic to the rabies
vaccine or beta propiolactone or any of the other ingredients of this medicine.

!### Lungs

INDIRAB VACCINE should be used with caution in patients who has a history of
allergy (such as asthma). Consult your doctor before receiving INDIRAB VACCINE.

Others

INDIRAB VACCINE is not recommended for use if you:

• have an acute illness with a high fever that requires management

Before receiving INDIRAB VACCINE, inform your doctor if you:

• have history of any other reactions to the vaccine
• have any blood disorders that makes you bruise or bleed easily such as haemophilia or thrombocytopenia
• have poor immunity status
• have/has a severe allergy to egg or egg products or to polygeline, latex
• have/has a severe allergy to the antibiotics like neomycin, chlortetracycline or amphotericin B
• fainted with a previous injection of INDIRAB VACCINE
• has a history of allergies (such as hay fever)

Use in Paediatrics

INDIRAB VACCINE should be used with caution in children (below 1 year). Consult
your doctor before receiving INDIRAB VACCINE.

Interactions

A. Drug-Drug Interactions:

Before receiving INDIRAB VACCINE, inform your doctor, if you are taking any of
the following medicine:

• immunosuppressants (medicines that lower the body’s immune responses) such as corticosteroids Ex. dexamethasone, beclomethasone

Overdosage:

INDIRAB VACCINE will be given to you only by a doctor or nurse in a hospital and
so it is unlikely to receive an overdose. However, if you experience any unusual
symptoms, consult your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Rabies Vaccine
Pharmacological Category	:	Vaccine
Therapeutic Indication	:	Prevent Rabies
Dosage Forms	:	Injection

More Information

• Keep INDIRAB VACCINE out of the sight and reach of children
• Store INDIRAB VACCINE in a refrigerator (at 2°C to 8°C)

FAQs About INDIRAB VACCINE

Can I take other vaccines with INDIRAB VACCINE?

INDIRAB VACCINE can be given at the same time as other inactivated vaccines. A
different injection site will be used for each type of vaccine. Consult your
doctor before receiving INDIRAB VACCINE.

Can I receive INDIRAB VACCINE with fever?

INDIRAB VACCINE is generally not recommended for use in people who are ill, with
a high temperature or acute infection, the vaccination will be postponed until
you or your child have recovered.  Your doctor may still decide to give the
vaccine even if this applies to you or your child. This is because rabies is a
serious disease.

What side effects are seen with INDIRAB VACCINE?

The most common side effects of receiving INDIRAB VACCINE are headache,
dizziness, rash, hives, general discomfort, fatigue, weakness and fever. Contact
your doctor if any of the symptoms worsen.

Who should avoid using INDIRAB VACCINE?

INDIRAB VACCINE is not recommended for use if you have an acute illness with a
high fever that requires management or are allergic to rabies vaccine or beta
propiolactone or any of the other ingredients of this medicine. Consult your
doctor before receiving INDIRAB VACCINE.

How frequent should I receive INDIRAB VACCINE?

The pre-exposure immunisation course consists of 3 injections at Day 0, Day 7
and either Day 21 or Day 28. If you are at high risk of exposure to rabies, your
doctor will assess the need and plan further booster injections in line with
official guidance. Post-exposure prophylaxis should be initiated as early as
possible after suspected rabies exposure. Proper wound care must be done
immediately or as early as possible after exposure. It must be before
administration of rabies vaccine or rabies antibodies. Vaccine should be
administered on Day 0, Day 3, Day 7, Day 14 and Day 28 for Post-exposure
prophylaxis.

Useful Diagnostic Tests

• Fluorescent antibody test (FAT)
• Reverse transcriptase- polymerase chain reaction (RT-PCR)