Endoxan Asta 200mg Injection 1's

Introduction About ENDOXAN ASTA 200MG INJECTION

ENDOXAN ASTA 200MG INJECTION contains Cyclophosphamide, which belongs to a group
of medicines called Cytotoxic agents or Anti-cancer agents. It is indicated for
malignant diseases in adults and children (such as malignant lymphomas,
Hodgkin’s disease, Non-Hodgkin’s lymphoma, lymphocytic lymphoma mixed-cell type
lymphoma, histiocytic lymphoma, Burkitt’s lymphoma, multiple myeloma, chronic
lymphocytic leukemia, chronic granulocytic leukemia, acute myelogenous and
monocytic leukemia, acute lymphoblastic leukemia, mycosis fungoides,
neuroblastoma, adenocarcinoma of the ovary, retinoblastoma, Ewing’s sarcoma,
breast cancer. It is also used for minimal change nephrotic syndrome in
children.

ENDOXAN ASTA 200MG INJECTION is not recommended for use in patients with acute
infections, bone-marrow aplasia, urinary tract infections like cystitis, acute
urothelial toxicity from cytotoxic chemotherapy or radiation therapy, urinary
outflow obstruction, or unmanageed infections. Before receiving ENDOXAN ASTA
200MG INJECTION inform your doctor if you are allergic or have anaphylactic
reactions, bone marrow suppression, neutropenic fever, serious infections,
severe immune suppression, concomitant chemotherapy and/or radiation therapy,
urinary tract and renal diseases, heart diseases, pneumonitis, pulmonary
fibrosis, pulmonary veno-occlusive disease, respiratory failure, pneumonitis and
secondary malignancies, veno-occlusive liver disease, SIADH (syndrome of
inappropriate secretion of antidiuretic hormone), rare hereditary problems of
fructose intolerance, galactose intolerance, glucose-galactose malabsor
Lapp lactase deficiency, sucrase-isomaltase insufficiency, adrenal
insufficiency, diabetes and poor general health.

ENDOXAN ASTA 200MG INJECTION is not recommended for use by pregnant women. It is
generally not recommended for use in breastfeeding women as it may pass through
the breast milk. ENDOXAN ASTA 200MG INJECTION should be used with caution in
children and adolescents. It should be used with caution in elderly patients.
The most common side effects of receiving ENDOXAN ASTA 200MG INJECTION are
nausea, vomiting, weight loss, alopecia, hematuria and leukopenia. Contact your
doctor if any of your symptoms gets worse or persists for a long duration.

Uses Of ENDOXAN ASTA 200MG INJECTION

It is used for:

• malignant diseases in adults and children
• minimal change nephrotic syndrome in children

How ENDOXAN ASTA 200MG INJECTION Works

ENDOXAN ASTA 200MG INJECTION works by interfering with the malignant cell growth
by cross-linking of cancer cells DNA. ENDOXAN ASTA 200MG INJECTION also
transfers alkyl groups to DNA during the process of cell division, thus managing
the normal synthesis of DNA. Therefore it works against the growth and
multiplication of cancer cells.

How to use ENDOXAN ASTA 200MG INJECTION

ENDOXAN ASTA 200MG INJECTION will be administered only by a doctor or a nurse
into a vein as an intravenous injection or infusion. Your doctor will decide the
correct dose and duration for you depending on your age, body weight and disease
condition.

Side Effects Of ENDOXAN ASTA 200MG INJECTION

Common

• nausea, vomiting
• weight loss
• alopecia (hair loss)
• hematuria
• leukopenia (decrease in white blood cells)

Uncommon

• diarrhea
• darkening of skin/fingernails
• stomatitis
• anorexia
• headache
• diaphoresis
• gonadal suppression
• hyperuricemia
• impaired wound healing
• amenorrhea, premature menopause

Rare

• Pain and redness at the injection site

Stop receiving ENDOXAN ASTA 200MG INJECTION and contact your doctor immediately
if you experience any of the following side effects:

• Allergic reactions such as anaphylaxis, swelling of the face, lips, ankles/legs causing shortness of breath
• Palpitations
• Weight gain, dizziness or loss of consciousness
• Signs of infection include fever, sore throat, cold and cough
• Signs of bleeding from gums, bruising and petechiae due to a decrease in platelet count
• Haematuria (blood in urine)

How To Manage Side Effects

!### Diarrhea

Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not
take any medicine on your own for managing diarrhea. Contact your doctor if the
symptom did not improve.

Headache

Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a
pain-relieving balm on the head if necessary. Do not consume alcohol. Contact
your doctor if the symptom did not improve.

!### Nausea And Vomiting

Take the medicine, with or just after a meal. Stick to simple meals. Avoid
eating oily or spicy food.

Warning & Precautions

!### Pregnancy

ContraindicatedENDOXAN ASTA 200MG INJECTION is generally not recommended for use in pregnant
women. Consult your doctor before receiving ENDOXAN ASTA 200MG INJECTION.

!### Breastfeeding

ContraindicatedENDOXAN ASTA 200MG INJECTION is generally not recommended for use in
breastfeeding women as it may pass through the breast milk. Consult your doctor
before receiving ENDOXAN ASTA 200MG INJECTION.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machinery if you feel dizziness, blurred vision, and
visual impairment after receiving ENDOXAN ASTA 200MG INJECTION.

!### Alcohol

Consult your doctorAvoid consum
increases nausea and vomiting caused by ENDOXAN ASTA 200MG INJECTION.

!### Kidney

Consult your doctorENDOXAN ASTA 200MG INJECTION is not recommended if you have kidney or bladder
problems as a result of previous chemotherapy or radiotherapy. It should be used
with caution in patients with kidney diseases. Contact your doctor before
receiving ENDOXAN ASTA 200MG INJECTION.

!### Liver

Use with CautionENDOXAN ASTA 200MG INJECTION should be used with caution in patients with liver
diseases. Contact your doctor before receiving ENDOXAN ASTA 200MG INJECTION.

Allergy

Use with CautionDo not receive ENDOXAN ASTA 200MG INJECTION if you are allergic to
Cyclophosphamide or any other ingredients of this medicine.

!### Lungs

Use with Caution[GBNEYWORD] should be used with caution in patients with lung diseases such as
pneumonia, pulmonary fibrosis, pulmonary venous-occlusive disease, respiratory
failure, and pneumonitis. Contact your doctor before receiving ENDOXAN ASTA
200MG INJECTION.

!### Heart Disease

Use with CautionENDOXAN ASTA 200MG INJECTION should be used with caution in patients with heart
disease such as myocarditis, myopericarditis, and pericardial effusion including
cardiac tamponade, congestive heart failure, ventricular arrhythmias. Contact
your doctor before receiving ENDOXAN ASTA 200MG INJECTION.

!### Use In Pediatrics

Use with CautionENDOXAN ASTA 200MG INJECTION should be used with caution in children. Contact
your doctor before receiving ENDOXAN ASTA 200MG INJECTION.

!### Use In Geriatrics

Use with CautionENDOXAN ASTA 200MG INJECTION should be used with caution in elderly patients
aged 65 years or above. Contact your doctor before receiving ENDOXAN ASTA 200MG
INJECTION.

Others

ENDOXAN ASTA 200MG INJECTION is not recommended for use if you have:

• acute infections
• bone-marrow aplasia
• urinary tract infection like cystitis
• acute urothelial toxicity from cytotoxic chemotherapy and radiation
• urinary outflow obstruction
• unmanageed infections

Before receiving ENDOXAN ASTA 200MG INJECTION, inform your doctor if you have:

• bone marrow suppression
• serious infections include pneumonia, bacterial, fungal, viral, protozoal, and parasitic infections
• severe immune suppression
• concomitant chemotherapy and/or radiation therapy
• urinary tract and renal diseases like haemorrhagic cystitis, pyelitis, urethritis, and hematuria
• urotoxicity such as bladder ulceration, necrosis, fibrosis, contracture
• urinary tract obstructions or active urinary tract infections
• secondary malignancies (urinary tract cancer, myelodysplasia, acute leukemias, lymphomas, thyroid cancer, sarcomas, and bladder cancer)
• veno-occlusive liver disease
• poor wound healing
• hyponatremia
• SIADH (syndrome of inappropriate secretion of antidiuretic hormone)
• rare hereditary problems of fructose intolerance, galactose intolerance, glucose-galactose malabsor
• diabetes

Interactions

A. Drug-Drug interactions:

Before receiving ENDOXAN ASTA 200MG INJECTION, inform your doctor if you are
taking any of the following medicine:

• Medicines used for cancer (Ex. paclitaxel, Busulfan, thiotepa)
• Depolarizing muscle relaxants Ex. succinylcholine (a medicine used in anaesthesia)
• Aprepitant
• Ciprofloxacin, chloramphenicol, sulfadiazine, sulfasalazine, sulfamethoxazole, Rifampin (medicines used to manage bacterial infections)
• Fluconazole, itraconazole, Amphotericin-B (medicines used for fungal infections)
• Prasugrel (medicines used to thin the blood)
• Allopurinol (medicines used for gout)
• Azathioprine (medicines used to reduce the activity of the immune system)
• Chloral hydrate (medicines used for insomnia)
• Medicines used to manage stomach ulcers (Ex. cimetidine)
• Disulfiram (medicines used for alcoholism)
• Glyceraldehyde (medicines used for warts)
• Protease inhibitors Ex. atazanavir, darunavir, Zidovudine (medicines used to manage viral infection)
• Ondansetron
• Medicines used to manage epilepsy or seizures (Ex. carbamazepine, phenobarbital, phenytoin)
• St. John’s wort (used for depression)
• Corticosteroids (medicines used for inflammation)
• Carbimazole (medicines used for an overactive thyroid)
• Medicines used for multiple sclerosis Ex. natalizumab
• Medicines used to manage high blood pressure (enalapril, thiazide diuretics such as hydrochlorothiazide or chlorthalidone)
• Amiodarone (medicines used to manage irregular heartbeat)
• Medicine used to increase white blood cell numbers after chemotherapy (Ex. GM-CSF, G-CSF)
• Indomethacin (medicines used to manage pain and inflammation)
• Etanercept (medicines used for rheumatoid arthritis)
• Metronidazole (medicines used for bacterial or protozoal infections)
• Bupropion (medicines used to manage depression)
• Digoxin, β-acetyl digoxin (medicines used for heart conditions)
• Vaccines Ex. BCG vaccine, anthrax vaccine (used to manage infections)
• Verapamil (medicines used to manage high blood pressure, angina or irregular heartbeat)
• Clozapine (medicines used to manage psychotic disorders)

Overdosage:

ENDOXAN ASTA 200MG INJECTION will be administered by your doctor or nurse, so it
is unlikely to cause an overdose, if you experience any unusual reactions,
consult your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Cyclophosphamide
Pharmacological Category	:	Alkylating agents
Therapeutic Indication	:	Malignant diseases, Minimal change nephrotic syndrome in children
Dosage Forms	:	Tablet, Injection, Infusion

More Information

• Keep ENDOXAN ASTA 200MG INJECTION out of the sight and reach from children
• Store ENDOXAN ASTA 200MG INJECTION at 2°C to 8°C

FAQs About ENDOXAN ASTA 200MG INJECTION

Q: How ENDOXAN ASTA 200MG INJECTION is given?

A: ENDOXAN ASTA 200MG INJECTION will be given to you only by a doctor or a nurse
into a vein as an intravenous injection or infusion. Your doctor will determine
the correct dose and duration for you depending on your age, body weight and
disease condition.

Q: Does ENDOXAN ASTA 200MG INJECTION cause hair loss?

A: Yes. ENDOXAN ASTA 200MG INJECTION may cause hair loss. Contact your doctor
before receiving ENDOXAN ASTA 200MG INJECTION.

Q: Can I receive ENDOXAN ASTA 200MG INJECTION during pregnancy?

A: No. ENDOXAN ASTA 200MG INJECTION is not recommended for use by pregnant
women. Contact your doctor before receiving ENDOXAN ASTA 200MG INJECTION.

Q: Does ENDOXAN ASTA 200MG INJECTION cause mouth ulcers?

A: Yes. ENDOXAN ASTA 200MG INJECTION causes mouth ulcers. Contact your doctor
before receiving ENDOXAN ASTA 200MG INJECTION.

Q: Can I receive vaccines while using ENDOXAN ASTA 200MG INJECTION?

A: No. Do not receive vaccines while using ENDOXAN ASTA 200MG INJECTION. Contact
your doctor before receiving ENDOXAN ASTA 200MG INJECTION.

Useful Diagnostic Tests

• Complete blood count
• Peripheral smear count
• Renal function test
• Liver function test
• Prothrombin time
• Triglycerides
• Urine albumin