Cytogem 1gm Injection 1's

Introduction About CYTOGEM 1GM INJECTION

CYTOGEM 1GM INJECTION contains Gemcitabine which belongs to the group of
medicines called Antimetabolites. CYTOGEM 1GM INJECTION is used in the
management of non-small cell lung cancer (alone or combined with cisplatin),
pancreatic cancer, breast cancer (with paclitaxel), ovarian cancer (with
carboplatin) and bladder cancer (with cisplatin).

Cancer is a disease in which there is uncontrollable growth of some of the
body’s cells that spread to other parts of the body. During CYTOGEM 1GM
INJECTION management, your doctor might ask you to take certain blood tests to
check your blood cell count, kidney function or liver function.

Avoid drinking alcohol during CYTOGEM 1GM INJECTION management as it can make
you feel sleepy. Before receiving CYTOGEM 1GM INJECTION, inform your doctor if
you had or are going to have radiotherapy, have been vaccinated recently or if
you have any liver, kidney or heart diseases.

CYTOGEM 1GM INJECTION is not recommended for use in pregnant women,
breastfeeding women, children and adolescents (under 18 years of age). Consult
your doctor before receiving it.

The most common side effects of receiving CYTOGEM 1GM INJECTION are vomiting,
constipation, hair loss, poor appetite, headache, insomnia, cough, itching,
sweating, etc. Contact your doctor if any of the symptoms or side effects bother
you.

Uses Of CYTOGEM 1GM INJECTION

Used in the management of:

• non-small cell lung cancer (alone or with cisplatin)
• pancreatic cancer
• breast cancer (with paclitaxel)
• ovarian cancer (with carboplatin)
• bladder cancer (with cisplatin)

How CYTOGEM 1GM INJECTION Works

CYTOGEM 1GM INJECTION kills the dividing cancer cells by inhibition of their DNA
(hereditary material) synthesis.

How to use CYTOGEM 1GM INJECTION

CYTOGEM 1GM INJECTION will be given to you only by a doctor or a nurse into a
vein as an intravenous infusion. Your doctor will decide the correct dose and
duration for you depending upon your age, body weight and surface area and
disease condition.

Side Effects Of CYTOGEM 1GM INJECTION

Common

• vomiting, nausea, constipation, diarrhoea
• hair loss
• liver problems
• blood or protein in urine, abnormal urine test
• swollen ankles, fingers, feet, face
• poor appetite
• headache
• insomnia, sleepiness
• cough, runny nose
• itching, sweating
• muscle or back pain
• fever, weakness, chills, infections

Uncommon

• scarring of air sacs of the lungs
• wheezing
• scarring of the lungs seen as abnormal chest X ray/scan
• heart, kidney or liver failure
• stroke

Rare

• low blood pressure
• skin scaling, ulceration or blistering
• skin sloughing and severe blistering
• injection site reactions
• radiation recall (a skin rash like severe sunburn which can occur on skin that has been exposed to radiotherapy in the past)
• fluid in the lungs
• radiation toxicity (scarring of the air sacs of the lung related to radiation therapy)
• gangrene of fingers or toes
• inflammation of the blood vessels

Stop receiving CYTOGEM 1GM INJECTION and contact your doctor immediately if you
experience any of the following side effects:

• allergic reactions (mild to moderate skin rash, fever, itching)
• low haemoglobin (tiredness, feeling faint, easy breathlessness, paleness)
• low platelet count (bleeding from the gums, nose or mouth, any bleeding that would not stop, reddish or pinkish urine, unexpected bruising)
• low white blood cell count with fever, sweating or other signs of infection
• stomatitis (pain, redness, swelling, mouth ulcers)
• mild breathing trouble
• irregular heartbeat
• capillary leak syndrome (generalised swelling, shortness of breath, weight gain due to fluid leakage from small blood vessels into tissues)
• posterior reversible encephalopathy syndrome (headache with vision changes, confusion, seizures or fits)
• thrombotic microangiopathy and haemolytic uraemic syndrome (extreme tiredness and weakness, bruises, low or no urine output, signs of infection)

How To Manage Side Effects

Nausea:

Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to
simple meals. Avoid eating oily or spicy foods. If symptom persists, contact
your doctor.

Vomiting:

Get adequate rest. Drink lots of fluids, especially water. Have small sips if
you feel sick. Eat when you feel like it – no need to eat or avoid any specific
foods. If symptom persists, contact your doctor.

Diarrhea:

Drink fluids such as water or fruit juices so that you are sufficiently
hydrated. If symptom persists, contact your doctor.

Constipation:

Have plenty of fiber rich foods like fresh fruits, vegetables, cereals and drink
ample amount of water. Exercise more regularly. If symptom persists, contact
your doctor.

Poor appetite:

Eat when you are hungry. Eat smaller meals more often than usual. Snack only
when you're hungry. Eat a protein-rich or other healthy snack such as dried
fruit and nuts. If symptom persists, contact your doctor.

Headache:

Drink plenty of water and get adequate rest. Try to be relaxed and stress free.
Take medicine for headache after asking your doctor. If symptom persists,
contact your doctor.

Skin rash:

Avoid hot showers to manage further irritation of skin. Do not scratch the
affected area. Use protective clothing when going outdoors. Regularly moisturize
your skin. If symptom persists, contact your doctor.

Warning & Precautions

!### Pregnancy

CYTOGEM 1GM INJECTION is not recommended for use in pregnancy. Consult your
doctor before receiving it.

!### Breastfeeding

CYTOGEM 1GM INJECTION is not recommended for use in breastfeeding women. Consult
your doctor before receiving it.

!### Driving and Using Machines

Do not drive or operate any machines if you feel sleepy after receiving CYTOGEM
1GM INJECTION.

!### Alcohol

Do not consume alcohol during the management with CYTOGEM 1GM INJECTION as it
can make you feel sleepy.

!### Kidney

CYTOGEM 1GM INJECTION should be used with caution in patients who had or have
any kidney diseases. Contact your doctor before receiving it.

!### Liver

CYTOGEM 1GM INJECTION should be used with caution in patients who had or have
any liver diseases. Contact your doctor before receiving it.

!### Allergy

Do not receive CYTOGEM 1GM INJECTION if you are allergic to gemcitabine or any
of the other ingredients of this medicine.

!### Heart Disease

CYTOGEM 1GM INJECTION should be used with caution in patients who had or have
any heart or vascular diseases. Contact your doctor before receiving it.

Others

Before receiving CYTOGEM 1GM INJECTION, inform your doctor if you:

• had or are about to have radiotherapy
• have been vaccinated recently

Use in paediatrics:

CYTOGEM 1GM INJECTION is not recommended for use in children and adolescents
(under 18 years of age) due to insufficient data on safety and efficacy. Consult
your child’s doctor for advice.

Use in geriatrics:

No dose adjustment of CYTOGEM 1GM INJECTION is required for elderly patients,
however, consult your doctor before receiving it.

Interactions

A. Drug - Drug interactions:

Before receiving CYTOGEM 1GM INJECTION, inform your doctor if you are taking,
have taken or might take any other medicine, including prescri
non-prescri

Overdosage:

CYTOGEM 1GM INJECTION will be administered to you only by a doctor or a nurse in
a hospital and so it is unlikely to receive an overdose. However, consult your
doctor or nurse if you experience anything unusual.

Synopsis

Drug	:	Gemcitabine
Pharmacological Category	:	Pyrimidine antagonists
Therapeutic Indication	:	Cancer management
Dosage Forms	:	Injection

More Information

• Keep CYTOGEM 1GM INJECTION out of reach of children
• Store CYTOGEM 1GM INJECTION between 25°C

FAQs About CYTOGEM 1GM INJECTION

Can CYTOGEM 1GM INJECTION cause hearing loss?

According to some studies, CYTOGEM 1GM INJECTION is ototoxic, which means it can
cause hearing or balance problems. Consult your doctor if you experience any
problems with hearing during this management.

How long do I need to take CYTOGEM 1GM INJECTION?

You usually have CYTOGEM 1GM INJECTION as a course of several cycles of
management. This means that you receive the medicine and then rest to allow your
body to recover. Usually, a cycle of CYTOGEM 1GM INJECTION is over 3 to 4 weeks
(21 to 28 days), but your doctor will determine the duration of management
according to your condition.

Is it safe to have a baby during management with CYTOGEM 1GM INJECTION?

For women, CYTOGEM 1GM INJECTION is not recommended for use if you are pregnant
or planning for a baby. Men are advised not to father a child during and up to 6
months after management with CYTOGEM 1GM INJECTION. You may want to seek
counselling on sperm storage before starting your management. Consult your
doctor for advice.

Can I receive CYTOGEM 1GM INJECTION if I got recently vaccinated?

Before receiving CYTOGEM 1GM INJECTION, inform your doctor if you recently got
vaccinated as it can affect the number of blood cells that are tested during
this management. Consult your doctor for advice.

Can I drive a car during management with CYTOGEM 1GM INJECTION?

CYTOGEM 1GM INJECTION may make you feel sleepy, especially if you have consumed
any alcohol. Do not drive a car until you are sure that this management has not
made you feel sleepy. Consult your doctor if you feel any side effect during
management with CYTOGEM 1GM INJECTION that may stop you from driving or using
machines.

Useful Diagnostic Tests

• Complete Blood Count (CBC)