Zurig 80mg Tablet 30'S

Introduction About ZURIG 80MG TABLET

ZURIG 80MG TABLET contains Febuxostat, which belongs to a group of medicines
called Antigout agents. It is used in the management of gout (common and complex
form of arthritis that occurs when too much uric acid crystallises and deposits
in the joints, resulting in sudden, severe attacks of pain, swelling, redness
and tenderness in one or more joints, most often in the big toe). It is also
used to manage accumulation of high blood levels of uric acid in the blood.

Before taking ZURIG 80MG TABLET inform your doctor if you have any liver,
kidney, heart, thyroid problems and undergoing management for Lesch-Nyhan
syndrome. ZURIG 80MG TABLET is not recommended for use by pregnant women,
breastfeeding mothers, children, and adolescents. ZURIG 80MG TABLET should be
used with caution by elderly patients.

The common side effects of taking ZURIG 80MG TABLET are abnormal liver test
results, diarrhoea, headache, rash, nausea, increase in gout symptoms, localized
swelling due to retention of fluids in tissues (oedema). Consult your doctor
immediately if any of your symptoms gets worse.

Uses Of ZURIG 80MG TABLET

• Manage gout
• Prevents accumulation of high uric acid levels in the blood

How ZURIG 80MG TABLET Works

ZURIG 80MG TABLET works by blocking the action of enzyme called xanthine
oxidase, which is involved in the process of converting hypoxanthine into uric
acid (purine metabolism pathway). This type of action reduces high uric acid
level in gout and blood cancer patients undergoing chemotherapy management.

How to use ZURIG 80MG TABLET

Take ZURIG 80MG TABLET as advised by your physician. Swallow ZURIG 80MG TABLET
with a glass of water and do not chew or crush the medicine. Your doctor will
decide the correct dose and duration for you depending upon your age, body
weight.

Side Effects Of ZURIG 80MG TABLET

Common

• liver function test results appear abnormal
• diarrhea
• headache
• skin rash
• nausea
• exaggerated gout symptoms
• oedema

Uncommon

• decreased appetite
• signs of diabetes (blood sugar level changes, excessive thirst, increased blood fat levels and weight)
• loss of sex drive
• difficulty in sleeping
• sleepiness
• dizziness, numbness, tingling, reduced or altered sensation
• altered taste sensation, decreased sense of smell
• abnormal ECG, irregular or rapid heartbeats and palpitation
• hot flushes (e.g., redness of the face or neck), increased blood pressure
• cough, shortness of breath, chest discomfort or pain, inflammation of nasal passage and/or throat and bronchitis
• dry mouth, abdominal pain or wind, heartburn, constipation, vomiting, stomach discomfort
• skin itching, and small red or purple spots on the skin, covered with small confluent bumps, areas of redness and spots on the skin
• inflammation of joints usually accomp
• blood in the urine, abnormal frequent urination, abnormal urine tests (increased level of proteins in the urine)
• fatigue, chest pain, chest discomfort
• stones in gallbladder or bile ducts (cholelithiasis)
• increase thyroid stimulating hormone (TSH) level
• blood chemistry changes or abnormal amount of blood cells or platelets
• kidney stones
• erectile dysfunction

Rare

• nervousness
• feeling thirsty
• ringing sensation in the ears
• blurred vision, change in vision
• hair loss
• ulcers in mouth
• increased sweating
• weight decrease, increased appetite, or uncontrolled loss of appetite
• muscle and/or joint stiffness
• urgent need to urinate
• changes or decrease in urine amount due to inflamed kidneys
• inflamed liver, yellowing of the skin or liver damage
• increased level of creatine phosphokinase in blood
• sudden cardiac death

Stop taking ZURIG 80MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• signs of Stevens- Johnson syndrome/ toxic epidermal necrolysis (serious skin rashes characterized by formation of blisters and shedding of the skin and inner surfaces of mouth and genitals, painful ulcers in the mouth and/or genital areas, accomp
• muscle pain, tenderness, or weakness
• sings of drug reaction with eosinophilia and systemic symptoms (extensive skin rash in association with enlarged lymph nodes, liver enlargement, raising of the white cells count)

How To Manage Side Effects

Nausea or vomiting:

Take ZURIG 80MG TABLET with or just after meals. Stick to simple meals. Avoid
eating oil rich or spicy foods. If the symptom does not improve, contact your
doctor immediately.

Flatulence:

Eat smaller and more frequent meals. Eat and drink slowly, and exercise
regularly. If the symptom does not improve, contact your doctor immediately.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and
drink plenty of water. Exercise more regularly. If the symptom does not improve,
contact your doctor immediately.

Diarrhoea:

Drink lots of fluids, such as water or fruit juice, to keep yourself hydrated.
Do not consume any medicine on your own without consulting your doctor.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller and more
frequent meals. Keep a heating pad on your stomach. If the symptom does not
improve, contact your doctor immediately.

Warning & Precautions

!### Pregnancy

ZURIG 80MG TABLET is generally not recommended for use by pregnant women.
Consult your doctor before taking the medicine.

!### Breastfeeding

ZURIG 80MG TABLET is generally not recommended for use by breastfeeding women as
it may pass through the breast milk. Consult your doctor before taking it.

!### Driving and Using Machines

Do not drive or operate any machines if you feel dizzy, sleepy, blurred vision
and numbness or tingling sensation after taking ZURIG 80MG TABLET.

!### Kidney

ZURIG 80MG TABLET should be used with caution in patients with having or have
had kidney disease. Consult your doctor for advice before taking ZURIG 80MG
TABLET.

!### Liver

ZURIG 80MG TABLET should be used with caution in patients who have or had liver
disease or liver function test abnormalities. Consult your doctor for advice
before taking ZURIG 80MG TABLET.

!### Allergy

ZURIG 80MG TABLET is not recommended for use if you are allergic to febuxostat.
It should also be used with caution in patients having history of serious
allergic reaction to Allopurinol.

!### Heart Disease

ZURIG 80MG TABLET should be used with caution in patients having or have had
heart failure or heart problems or stroke. Consult your doctor for advice before
taking ZURIG 80MG TABLET.

Others

Before taking ZURIG 80MG TABLET, inform your doctor if you:

• are being managed for Lesch-Nyhan syndrome
• have thyroid problems

Use in Paediatrics:

ZURIG 80MG TABLET is generally not recommended for use in children and
adolescents (under 18 years of age). Consult your doctor before taking ZURIG
80MG TABLET.

Use in Geriatrics:

ZURIG 80MG TABLET should be used with caution in elderly patients. Consult your
doctor for advice before taking ZURIG 80MG TABLET.

Interactions

A. Drug-Drug Interactions:

Before taking ZURIG 80MG TABLET, inform your doctor if you are taking any of the
following medicine:

• mercaptopurine (used to manage cancer)
• azathioprine (used to reduce immune response)
• theophylline (used to manage asthma)

Overdosage:

If you or anyone else accidentally takes too much of ZURIG 80MG TABLET, consult
your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Febuxostat
Pharmacological Category	:	Xanthine oxidase inhibitors
Therapeutic Indication	:	Gout, blood cancer patients undergoing chemotherapy
Dosage Forms	:	Tablet

More Information

• Keep the medicine out of reach from children
• Store ZURIG 80MG TABLET at room temperature

FAQs About ZURIG 80MG TABLET

What is ZURIG 80MG TABLET used for?

ZURIG 80MG TABLET is used in adults to manage gout (form of arthritis that occur
when too much uric acid crystallises and deposits in the joints) and used to
manage high blood levels of uric acid in blood cancer patients receiving
chemotherapy.

What are the side effects of ZURIG 80MG TABLET?

ZURIG 80MG TABLET can commonly cause side effects such as abnormal liver
function test results, diarrhea, headache, skin rash, nausea, exaggerated gout
symptoms and oedema. If you feel any of these getting worse, please consult your
doctor immediately.

Does ZURIG 80MG TABLET reduce uric acid levels?

Yes, ZURIG 80MG TABLET works by blocking the action of an enzyme called xanthine
oxidase, which is involved in the process of converting hypoxanthine into uric
acid (purine metabolism pathway). This type of action reduces high uric acid
levels in gout and blood cancer patients undergoing chemotherapy management.

What happens if I stop taking ZURIG 80MG TABLET?

Once you are prescribed ZURIG 80MG TABLET it is very important that you do not
stop taking it unless advised by your doctor or unless side effects develop. If
ZURIG 80MG TABLET management is stopped, there is a high risk that your gout may
worsen. You should continue to take it even if you do not have symptoms.

Is ZURIG 80MG TABLET good for kidney?

No, ZURIG 80MG TABLET might affect the function of the kidney, resulting in
kidney stones, changes in the amount of urine, abnormally frequent urination,
and an increased level of proteins in the urine). If you experience any of these
symptoms while taking ZURIG 80MG TABLET, please consult your doctor immediately.