Zendol 50mg Capsule 10'S

Introduction About ZENDOL 50MG CAPSULE

ZENDOL 50MG CAPSULE contains Danazol which belongs to the group of medicines
called Androgens. It is used to manage endometriosis, severe cyclical mastalgia
(breast pain associated with hormonal variations), breast cysts, dysfunctional
uterine bleeding (bleeding from vagina other than that of menstrual cycle),
symptomatic gynecomastia, preoperative thinning of endometrium and hereditary
angioneurotic edema (painless swelling under the skin).

Endometriosis is defined as an illness where some of the tissues that line the
womb are found elsewhere in the body. Gynecomastia refers to an increase in the
amount of breast gland tissue in males, due to an imbalance of hormones estrogen
and testosterone.

Prior to the management, your doctor may want you to take several blood tests to
understand your existing condition.

Avoid consum
may cause nausea or breathlessness.

Before taking ZENDOL 50MG CAPSULE, inform your doctor if you have hormonal
cancer, blood clots, heart, liver or kidney problems or porphyria.

ZENDOL 50MG CAPSULE is not recommended for use among pregnant or breastfeeding
women, therefore consult your doctor before taking it.

Safety and effectiveness of ZENDOL 50MG CAPSULE in paediatric and elderly
patients have not been established.

The most common side effects of taking ZENDOL 50MG CAPSULE are weight gain,
bloating, nausea, vomiting, lethargy and headache. Consult your doctor if any of
the side effects worsen.

Uses Of ZENDOL 50MG CAPSULE

Manage:

• endometriosis
• severe cyclical mastalgia
• breast cysts
• dysfunctional uterine bleeding
• symptomatic gynecomastia
• preoperative thinning of endometrium
• hereditary angioneurotic edema

How ZENDOL 50MG CAPSULE Works

ZENDOL 50MG CAPSULE works by suppressing the secretion of gonadotropins (a group
hormones that stimulate the activity of the gonads) in both men and women,
leading to inhibition of testicular/ovarian function. In addition, it suppresses
gonadal function directly by inhibiting the enzymes involved in steroid hormone
synthesis.

How to use ZENDOL 50MG CAPSULE

Take ZENDOL 50MG CAPSULE as advised by your physician. Swallow the medicine with
a glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose and duration for you depending upon your age, body weight and
disease condition. Do not stop taking ZENDOL 50MG CAPSULE unless your doctor
advice you to stop.

Side Effects Of ZENDOL 50MG CAPSULE

Common

• weight gain
• bloating
• nausea, vomiting
• gastroenteritis
• joint pain, muscle spasm
• lethargy
• headache
• depression

Rare

Stop taking ZENDOL 50MG CAPSULE and contact your doctor immediately if you
experience any of the following side effects:

• allergic reaction (rash, difficulty swallowing or breathing, swelling of your lips, face, throat or tongue)
• signs of heart attack (pain or tightness in the chest, jaw or arm)
• severe headache and vomiting
• clitoris becomes larger
• blurred vision, problems with eyesight, difficulty wearing contact lenses
• liver problems that may cause the eyes or skin to go yellow (jaundice)
• pain in the liver or liver failure may cause a swollen abdomen, mental disorientation and confusion
• pain when moving arms or legs (this may be due to a blood clot)
• feeling weak together with numb arms or legs which you may not be able to move (stroke)
• bruising more easily, getting more infections than usual (signs of a blood problem)

How To Manage Side Effects

Headache:

Drink ample amount of water. Get adequate rest. Try to be relaxed and stress
free. Apply pain relieving balm on your forehead if necessary. Consult your
doctor if the symptom does not improve.

Nausea:

Take ZENDOL 50MG CAPSULE with or just after meals. Stick to simple meals. Avoid
eating oily or spicy foods. Consult your doctor if the symptom does not improve.

Vomiting:

Get adequate rest. Drink sufficient amount of fluids, especially water. Have
small sips if you feel sick. Eat when you feel hungry. Do not take any medicine
for vomiting without asking your doctor. Consult your doctor if the symptom gets
worse.

Warning & Precautions

!### Pregnancy

ZENDOL 50MG CAPSULE is not recommended for use in pregnant women. Consult your
doctor before taking it.

!### Breastfeeding

ZENDOL 50MG CAPSULE is not recommended for use in breastfeeding women. Consult
your doctor before taking it.

!### Driving and Using Machines

ZENDOL 50MG CAPSULE has no or negligible influence on the ability to drive and
use machines.

!### Alcohol

Avoid consum
nausea or breathlessness.

!### Kidney

ZENDOL 50MG CAPSULE is not recommended for use in patients with impaired kidney
function. Consult your doctor before taking ZENDOL 50MG CAPSULE.

!### Liver

ZENDOL 50MG CAPSULE is not recommended for use in patients with impaired liver
function. Consult your doctor before taking ZENDOL 50MG CAPSULE.

!### Allergy

Do not take ZENDOL 50MG CAPSULE if you are allergic to Danazol or any other
ingredients of this medicine.

!### Heart Disease

ZENDOL 50MG CAPSULE is not recommended for use in patients with impaired heart
function. It should be used with caution in patients with high blood pressure or
heart disease. Consult your doctor before taking ZENDOL 50MG CAPSULE.

Others

ZENDOL 50MG CAPSULE is not recommended for use if you:

• ever had blood clots (thrombosis)
• have porphyria (a rare inherited illness which affects your metabolism)
• have a type of cancer which is influenced by hormones
• have unusual vaginal bleeding which is unchecked by a doctor

Before taking ZENDOL 50MG CAPSULE, inform your doctor if you:

• have an illness which could be worsened by fluid retention
• have diabetes (high blood sugar levels)
• have epilepsy (fits)
• have polycythaemia (an illness in which the blood gets thicker)
• get migraines
• have cancer or possible breast cancer
• are about to have any procedure

Use in paediatrics:

Safety and effectiveness of ZENDOL 50MG CAPSULE in children has not been
established.

Use in geriatrics:

Safety and effectiveness of ZENDOL 50MG CAPSULE in elderly patients (aged above
65 years) has not been established.

Interactions

A. Drug-Drug interactions:

Before taking ZENDOL 50MG CAPSULE, inform your doctor if you are taking any of
the following medicines:

• steroids (used in oral contrace
• medicines used to lower blood cholesterol levels (Ex. simvastatin, atorvastatin)
• medicines used to manage fits (Ex. phenytoin, carbamazepine)
• medicines used to thin the blood (Ex. warfarin, clopidogrel)
• anaesthetics (used to manage pain during procedures) Ex. midazolam, propofol
• medicines used to stop the rejection of organs after a transplant (Ex. ciclosporin and tacrolimus)
• alpha calcidol (used for vitamin D deficiency and illness where there is lack of calcium in the blood)
• medicines used to lower blood sugar levels (Ex. metformin, glyburide)
• medicines used to manage high blood pressure (Ex. atenolol, diltiazem)
• medicines used to manage migraine (Ex. sumatriptan, rizatriptan)

Overdosage:

If you or anyone else accidentally take too much of ZENDOL 50MG CAPSULE, consult
your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Danazol
Pharmacological Category	:	Androgens
Therapeutic Indication	:	Hormonal issues
Dosage Forms	:	Tablet, Capsule

More Information

• Keep ZENDOL 50MG CAPSULE out of reach of children
• Store at room temperature

FAQs About ZENDOL 50MG CAPSULE

Can I become pregnant while taking ZENDOL 50MG CAPSULE?

It is important that you do not become pregnant while taking ZENDOL 50MG
CAPSULE. Start taking the medicine on the first day of your period and use
reliable contrace
conjunction with contrace
be used until your management with ZENDOL 50MG CAPSULE is finished.

What if I forget to take a dose ofZENDOL 50MG CAPSULE?

If you forget to take a dose of ZENDOL 50MG CAPSULE, take it as soon as you
remember and then continue your management as usual. Do not take the medicine
twice to make up for the forgotten dose.

Can I stop taking ZENDOL 50MG CAPSULE on my own?

Do not stop taking ZENDOL 50MG CAPSULE just because you feel better. Keep taking
the medicine until your doctor tells you to do so. If you stop taking it
randomly on your own, your illness may get worse.

Does ZENDOL 50MG CAPSULE cause weight gain?

Yes, ZENDOL 50MG CAPSULE causes androgenic side effects like weight gain.
Consult your doctor in case of any concerns. Do not take any other medicine
without informing your doctor.

Does ZENDOL 50MG CAPSULE cause menopause?

ZENDOL 50MG CAPSULE is an androgen and can thus exert the adverse effects of
androgens too, but since it inhibits Luteinizing hormone (LH) and Follicle
stimulating hormone (FSH) secretion, it can also elicit menopausal-like
symptoms. Consult your doctor for advice.

Should I be concerned if I am about to take any test while taking ZENDOL 50MG
CAPSULE?

If you are going to have any blood test, it is important to tell your doctor you
are taking ZENDOL 50MG CAPSULE. Taking ZENDOL 50MG CAPSULE may affect the
results of some blood tests like testosterone levels, liver and thyroid
function, fats, sugars and protein levels in your blood. Your doctor may take
regular blood tests to check your liver function and your blood levels.

Useful Diagnostic Tests

• Pelvic exam
• Ultrasound
• Magnetic resonance imaging (MRI)
• Mammography