TRUTAZ 4.5gm Injection 1's

Introduction About TRUTAZ 4.5GM INJECTION

TRUTAZ 4.5GM INJECTION is a combination of Piperacillin and Tazobactam which
belongs to the group of medicines called Antibiotics. It is used to manage
several bacterial infections such as lower respiratory tract infections such as
pneumonia, acute bacterial exacerbation causing breathing difficulties, urinary
tract infections, pyelonephritis, skin infections, abdominal, biliary tract
infections and female pelvic infections such as postpartum endometritis or
pelvic inflammatory disease, bacteraemia, and bacterial meningitis in infants
and children.

It is also used along with other antibacterial agents in the management of
neutropenic caused by bacterial infection.

Pneumonia is an infection which causes inflammation in the air sac producing
cough with phlegm and shortness of breath. Pyelonephritis is a urinary tract
infection affecting the urinary bladder later gets spreads to the kidneys.
Bacteraemia is an infectious condition indicating presence of bacteria in the
blood stream.

Bacterial meningitis is an infection caused by bacteria in the region
surrounding the brain. Neutropenic is low levels of neutrophils (a type of white
blood cells) in our body.

Kindly inform your doctor or your health-care professional before any laboratory
tests as TRUTAZ 4.5GM INJECTION will interact with medical investigations.
Inform your doctor if you are allergic to any antibiotics or other medicines.

TRUTAZ 4.5GM INJECTION should not be used in patients allergic to penicillin
antibiotics, cephalosporin, and other beta-lactam antibiotics.

TRUTAZ 4.5GM INJECTION should be used with caution in patients with pre-existing
diarrhoea, low potassium levels, kidney, and liver diseases.

Avoid concomitant use of other aminoglycoside antibiotics and vancomycin along
with this medicine.

TRUTAZ 4.5GM INJECTION should be used with caution in pregnant and
breast-feeding women.TRUTAZ 4.5GM INJECTION should be used with caution in
children above 2 months and in elderly people. Your doctor will administer the
right dose depends on your child’s age, body weight and severity of the
infection.

The common side effects of TRUTAZ 4.5GM INJECTION are diarrhoea, yeast
infection, headache, sleeplessness, stomach pain, vomiting, nausea,
constipation, skin rash, itching, fever, and injection site reaction.

Uses Of TRUTAZ 4.5GM INJECTION

It is used to manage the following infections:

• intra-abdominal infection such as appendicitis and peritonitis
• skin and skin structure infection such as cutaneous abscesses, cellulitis, diabetic foot
• female pelvic infections such as postpartum endometritis or pelvic inflammatory disease
• lower respiratory tract infection such as community-acquired pneumonia, and ventilator-associated pneumonia
• bacterial se

How TRUTAZ 4.5GM INJECTION Works

TRUTAZ 4.5GM INJECTION works by destroying the bacterial growth responsible for
causing infections. Piperacillin works by interru
by binding with the enzymes responsible for cell wall synthesis. This binding
causes defects in the cell wall leading to cell death causing death of the
org
(beta- lactamases) that protect the org
anti-bacterial actions when given alone so it’s always used in combination with
other antibiotics. Thus, both the substances works by managing cell growth and
function inhibiting bacterial growth.

How to use TRUTAZ 4.5GM INJECTION

TRUTAZ 4.5GM INJECTION will be administered into the vein (intravenously) by
your doctor or nurse. Your doctor will administer the correct dose and duration
for you depending upon your age, body weight and disease condition.

Side Effects Of TRUTAZ 4.5GM INJECTION

Common

• diarrhoea
• yeast infection
• headache
• sleeplessness
• stomach pain, vomiting, nausea, constipation
• skin rash, itching
• fever, injection site reaction

Uncommon

• low blood pressure
• inflammation of the veins
• skin redness, skin lesions
• joint and muscle pain
• chills
• hypokalaemia, breathing difficulty
• abnormal lab investigations

Rare

• lack of white blood cells (agranulocytosis), bleeding nose
• serious infection of colon
• inflammation of inner lining of mouth
• peeling of skin

Contact your immediately if you experience any of the following side effects
after receiving TRUTAZ 4.5GM INJECTION

• serious skin rashes appear as reddish target-like spots or circular patches often with blisters,) ulcers in mouth, throat, nose, extremities, genitals red and swollen eyes (Stevens-Johnson syndrome, dermatitis bullous, dermatitis exfoliative, toxic epidermal necrolysis)
• a potentially fatal allergic condition (drug reaction with eosinophilia and systemic symptoms) involving skin and other organs such as the kidney and liver
• skin condition (acute generalised exanthemata’s pustulosis) symptoms include numerous tiny fluids filled blisters with swollen and reddened skin
• swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing or trouble breathing (angioedema)
• yellowing of the eyes or skin (jaundice)
• convulsions
• decrease in blood cells
• severe diarrhoea with fever

How To Manage Side Effects

!### Diarrhea

Drinking plenty of water and other electrolyte balanced fluids. Make sure to
hydrate throughout the day. Do not consume any medicine on your own without
consulting your doctor. If the symptom does not improve, contact your doctor.

Headache

Take some rest, in a quiet place avoid using user mobile phones and other
electronic devices for a while. Drink enough amount of water, dehydration may
lead you to develop a headache. If the symptom does not improve, contact your
doctor.

!### Injection Site Reactions

Try using warm water compress to reduce swelling. Keeping the affected area
elevated can help reduce the swelling. Not applying pressure to the affected
area will help reducing pain and managing further damage.

!### Nausea And Vomiting

Drink clear or ice-cold drinks. Eat light, bland foods. Avoid fried, greasy, or
sweet foods.  Eat slowly and eat smaller, more frequent meals, drinking
gradually larger amounts of clear liquids, avoid solid food until the vomiting
episode has passed, take rest. If the symptom does not improve, contact your
doctor.

!### Stomach Pain

Some diet and lifestyle changes can help with stomach pain. Eat smaller portions
of meal. Chew your food well and eat slowly. Avoid foods that cause gas or
indigestion. Avoid consum

Warning & Precautions

!### Pregnancy

Use with CautionTRUTAZ 4.5GM INJECTION should be used with caution in pregnant women. Consult
your doctor before receiving the medicine.

!### Breastfeeding

Use with CautionTRUTAZ 4.5GM INJECTION should be used with caution in breast-feeding women.
Consult your doctor before receiving the medicine.

!### Driving and Using Machines

Use with CautionDo not drive or handle heavy machines if you experience dizziness, drowsiness,
tired, or if you have blurred vision while receiving TRUTAZ 4.5GM INJECTION.

!### Alcohol

ContraindicatedConsum
INJECTION.

!### Kidney

Use with CautionTRUTAZ 4.5GM INJECTION should be used with caution in patients with kidney
diseases and patients on haemodialysis. Consult your doctor before receiving the
medicine.

!### Liver

Use with CautionTRUTAZ 4.5GM INJECTION should be used with caution in patients with liver
diseases and patients with abnormal liver tests.Consult your doctor before
receiving the medicine.

!### Allergy

ContraindicatedDo not receive TRUTAZ 4.5GM INJECTION if you are allergic to Piperacillin or
Tazobactam or to any other ingredients of this medicine.

!### Lungs

Use with CautionTRUTAZ 4.5GM INJECTION should be used with caution in patients with
community-acquired pneumonia andventilator-associated pneumonia. Consult your
doctor before receiving the medicine.

!### Use In Pediatrics

Use with CautionTRUTAZ 4.5GM INJECTION should be used with caution in children above 2 months of
age. Your doctor will administer the right dose depends on your child’s age,
body weight and disease condition. Consult your doctor before receiving the
medicine.

!### Use In Geriatrics

Use with CautionTRUTAZ 4.5GM INJECTION should be used with caution in elder patients (above 65
years of age). Consult your doctor before receiving the medicine.

Others

Before receiving this medicine inform your doctor if you:

• are suffering from diarrhoea
• have low levels of potassium

Interactions

A. Drug-Drug interactions:

Before receiving TRUTAZ 4.5GM INJECTION, inform your doctor if you are taking
any of the following medicine:

• other antibiotics used to manage bacterial infections (Ex. gentamycin, streptomycin, neomycin, amikacin, vancomycin)
• medicine used to manage gout (Ex. Probenecid)
• medicine used as muscle relaxants during surgery (Ex. vecuronium)
• medicines used to manage blood clots (Ex. heparin, warfarin, aspirin)
• methotrexate (used to manage cancer, arthritis, or psoriasis)
• medicines reducing potassium levels (Ex. furosemide)

Overdosage:

It is unlikely to receive overdose since it will be administered by the doctor
or nurse. If you experience any unusual side effects, consult your doctor
immediately. Symptoms of overdose may occur such as nausea, vomiting, diarrhoea,
neuromuscular disorders and convulsions.

Synopsis

Drug	:	Piperacillin, Tazobactam
Pharmacological Category	:	Beta-lactam antibiotics, Beta-lactamase inhibitors
Therapeutic Indication	:	Bacterial infections
Dosage Forms	:	Injection

More Information

• Keep TRUTAZ 4.5GM INJECTION out of reach of children
• Store at room temperature

FAQs About TRUTAZ 4.5GM INJECTION

Q: Will TRUTAZ 4.5GM INJECTION manage different bacterial infections?

A: Yes, TRUTAZ 4.5GM INJECTION is used in cases of serious infections of chest,
urinary system and blood along with others.

Q: Can TRUTAZ 4.5GM INJECTION be used in children?

A: Yes, it is safe to use TRUTAZ 4.5GM INJECTION in children above 2 months of
age, dose adjustments are necessary while used in children. Your doctor will
administer the correct dose for your child depending on your child’s age, body
weight and disease condition.

Q: How will TRUTAZ 4.5GM INJECTION manage my infection?

A: TRUTAZ 4.5GM INJECTION works by destroying the bacterial growth responsible
for causing infections. Piperacillin works by interru
formation by binding with the enzymes responsible for cell wall synthesis. This
binding causes defects in the cell wall leading to cell death causing death of
the org
enzymes (beta- lactamases) that protect the org
produces less anti-bacterial actions when given alone so it’s always used in
combination with other antibiotics. Thus, both the substances works by managing
cell growth and function inhibiting bacterial growth.

Q:How long will TRUTAZ 4.5GM INJECTION take to manage bacterial
infections?

A: TRUTAZ 4.5GM INJECTION will start working once it is injected in the blood
stream. It will work faster compared with oral antibiotics as it is injected
directly into the blood stream. However full course of antibiotic should be
given to obtain its efficacy. Your doctor will decide the dose adjustments and
termination of the medicine depending upon your health condition.