Tranesma Plus 250mg Tablet 10'S

Introduction About TRANESMA PLUS 250MG TABLET

TRANESMA PLUS 250MG TABLET contains Tranexamic Acid which belongs to the group
of medicines called Antifibrinolytics. It is used in the management of bleeding
in conditions such as heavy menstrual bleeding in women, bleeding inside the
digestive system (Ex. inflammatory bowel disease), bleeding from the nose, blood
in urine (not caused by the kidney (renal parenchyma)), control bleeding after
dental extraction in patients with coagulopathies and after cervix surgery.

TRANESMA PLUS 250MG TABLET is not recommended for use in patients with blood
clotting disorder or consum
disorder, irregular menstrual cycle, acquired disturbances of color vision,
venous or arterial thrombosis, active thromboembolic diseases such as deep vein
thrombosis, pulmonary embolism and cerebral thrombosis, subarachnoid hemorrhage
and blood in urine during periods.

Before taking TRANESMA PLUS 250MG TABLET, inform your doctor if you had or have
changes in normal bleeding pattern, family history of endometrial cancer,
abnormal bleeding between periods, bleeding during or after sexual intercourse,
premenstrual pain, lower abdominal pain, bleeding after menopause, are at risk
of having a blood clot, diabetic, overweight, polycystic ovary syndrome (PCOS).

TRANESMA PLUS 250MG TABLET should be used with caution in pregnant and
breast-feeding women only if clearly advised by the doctor. Consult your doctor
before taking TRANESMA PLUS 250MG TABLET. Your doctor may recommend you to take
relevant tests to understand your existing condition.

Safety and effectiveness of TRANESMA PLUS 250MG TABLET in children and
adolescents below 18 years of age has not been established yet and it is not
recommended for use in elderly women after menopause (stoppage of periods).

The most common side effects of taking TRANESMA PLUS 250MG TABLET are nausea,
vomiting, diarrhea, headache, tiredness and stomach pain. Consult your doctor
immediately if any of the side effect worsens.

Uses Of TRANESMA PLUS 250MG TABLET

It is used to manage bleeding in conditions such as:

• heavy menstrual bleeding in women
• bleeding from the nose
• bleeding inside the digestive system (gastrointestinal system, Ex. inflammatory bowel disease))
• blood in urine (not caused by the kidney (renal parenchyma))
• bleeding after undergoing surgery (such as dental extraction in patients with coagulopathies, cervix surgery)

How TRANESMA PLUS 250MG TABLET Works

TRANESMA PLUS 250MG TABLET manages bleeding by blocking the plasminogen from
binding with fibrin which results in bleeding. As a result, it manages and
controls bleeding associated with various conditions.

How to use TRANESMA PLUS 250MG TABLET

Take TRANESMA PLUS 250MG TABLET as directed by your physician. Swallow the
medicine as a whole and do not crush or chew the medicine. Do not take this
medicine before your period has started as it will not work properly. Your
doctor will decide the correct dose, duration and frequency of TRANESMA PLUS
250MG TABLET for you depending upon age, weight and disease conditions.

Side Effects Of TRANESMA PLUS 250MG TABLET

Common

• nausea, vomiting
• diarrhea, stomach pain
• headache
• sinus and nasal symptoms
• back, muscle or joint pain
• muscle cramps
• migraine
• anemia
• tiredness

Uncommon

• allergic skin reactions

Rare

• thromboembolic events (blood clot in vein)
• vision disturbances
• giddiness

Stop taking TRANESMA PLUS 250MG TABLET and contact your doctor immediately if
you experience any of the following side effects:

• impaired vision (especially color), blood clot in the eye
• itchy, red or swollen skin
• serious blood clots
• pain or feelings of heaviness in the chest
• pain or swelling in the arms or legs
• sudden shortness of breath, fainting
• coughing up blood

How To Manage Side Effects

Nausea or vomiting:

Stick to simple meals while taking this medicine. Avoid eating oily rich, fried
or spicy foods. Do not lie down or sleep immediately after eating. Consult your
doctor if the symptom does not improve.

Diarrhoea:

Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating
high-fat or spicy foods. Try to avoid taking any medicine on your own to manage
diarrhea and consult your doctor if the symptom gets worse.

Headache:

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to
be relaxed and stress free. Apply pain relieving balm on your forehead if
necessary. Consult your doctor if the symptom does not improve.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller meals more
frequently. Keep a heat pad on your stomach. If the symptom does not improve,
consult your doctor.

Warning & Precautions

!### Pregnancy

TRANESMA PLUS 250MG TABLET should be used with caution in pregnant women only if
considered clearly necessary. Inform your doctor immediately if you become
pregnant or think you may be pregnant before using TRANESMA PLUS 250MG TABLET.

!### Breastfeeding

TRANESMA PLUS 250MG TABLET should be used with caution in breastfeeding women
only if advised by the doctor as it may pass through the breast milk. Consult
your doctor before taking TRANESMA PLUS 250MG TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if you experience dizziness after taking
TRANESMA PLUS 250MG TABLET.

!### Kidney

TRANESMA PLUS 250MG TABLET is not recommended for use in patients with severe
kidney impairment.  TRANESMA PLUS 250MG TABLET should be used with caution in
patients with mild to moderate kidney impairment and your doctor may adjust the
dose depending upon kidney function. Consult your doctor for advice before
taking TRANESMA PLUS 250MG TABLET.

!### Liver

No dose adjustment is required in patients with hepatic impairment. Consult your
doctor for advice.

!### Allergy

Do not take TRANESMA PLUS 250MG TABLET if you are allergic to Tranexamic Acid or
any other ingredients of this medicine.

!### Lungs

TRANESMA PLUS 250MG TABLET is not recommended for use in patients with pulmonary
embolism (arteries of the lungs are blocked by clot). Consult your doctor before
taking TRANESMA PLUS 250MG TABLET.

Others

TRANESMA PLUS 250MG TABLET is not recommended for use if you:

• have a blood clotting disorder (consum
• have history of fits or seizure disorder
• have an irregular menstrual cycle
• have acquired disturbances of color vision
• have history of venous or arterial thrombosis (blood clot in artery/veins)
• have deep vein thrombosis, cerebral thrombosis (blood clot of cerebral vein in brain)
• have subarachnoid hemorrhage (bleeding in space between brain and tissue covering the brain)
• have blood in urine between periods

Before taking TRANESMA PLUS 250MG TABLET inform your physician if you:

• have changes in normal bleeding pattern
• have family history of endometrial cancer
• have abnormal bleeding between the periods
• have bleeding during or after sexual intercourse
• have premenstrual pain or lower abdominal pain
• have bleeding after menopause
• have obstruction of the urinary tract
• are at a risk for the formation of a blood clot
• are diabetic
• are overweight
• have polycystic ovary syndrome (PCOS)

Use in pediatrics:

Safety and effectiveness of TRANESMA PLUS 250MG TABLET in children and
adolescents below 18 years of age has not been established yet. Consult your
child’s doctor for advice.

Use in geriatrics:

TRANESMA PLUS 250MG TABLET is not recommended for use in elderly women after
menopause (stoppage of periods). Consult your doctor before taking TRANESMA PLUS
250MG TABLET.

Interactions

A. Drug-Drug interactions:

Before taking TRANESMA PLUS 250MG TABLET inform your doctor if you are taking
any of the following medicines:

• Ethinyl estradiol, levonorgestrel (oral contrace
• estrogen (used to manage hormone disorder)
• streptokinase, reteplase, tenecteplase (used to a breakdown blood clots)
• tamoxifen (used to manage breast cancer)
• trans-retinoic acid (used to manage acne)
• factor IX complex concentrates (used to stop bleeding)

Overdosage:

If you or anyone else accidentally takes too much of TRANESMA PLUS 250MG TABLET,
contact your doctor immediately or visit a nearby hospital immediately.
Overdosage symptoms of TRANESMA PLUS 250MG TABLET are headache, nausea,
vomiting, diarrhea, abnormal blood pressure, impaired vision, abnormal mental
status, skin rashes, dizziness and fits or seizures.

Synopsis

Drug	:	Tranexamic Acid
Pharmacological Category	:	Antifibrinolytics
Therapeutic Indication	:	Prevent and manages bleeding in various conditions
Dosage Forms	:	Tablet, Gel, Injection

More Information

• Keep out of reach from children
• Store at room temperature

FAQs About TRANESMA PLUS 250MG TABLET

Is TRANESMA PLUS 250MG TABLET safe for use in patients with impaired kidney
function?

TRANESMA PLUS 250MG TABLET is not recommended for use in patients with severe
kidney impairment.  TRANESMA PLUS 250MG TABLET should be used with caution in
patients with mild to moderate kidney impairment and your doctor may adjust the
dose depending upon kidney function. Consult your doctor for advice before
taking TRANESMA PLUS 250MG TABLET.

Does TRANESMA PLUS 250MG TABLET cause loose stools?

TRANESMA PLUS 250MG TABLET can cause side effects such as loose stools. To
manage this effect, drink lot of fluids, such as water to keep yourself
hydrated. Avoid eating high-fat or spicy foods. Try to avoid taking any medicine
on your own to manage diarrhea and consult your doctor if the symptom gets
worse.

Is TRANESMA PLUS 250MG TABLET used for heavy menstrual bleeding?

TRANESMA PLUS 250MG TABLET is used only when your periods are regular to control
heavy menstrual bleeding. It reduces the amount of blood lost during your period
but may not help other symptoms such as period pain. Do not take this medicine
if your periods are not heavy. Consult your doctor before taking TRANESMA PLUS
250MG TABLET.

What are the common side effects of TRANESMA PLUS 250MG TABLET?

The most common side effects of taking TRANESMA PLUS 250MG TABLET are nausea,
vomiting, diarrhea, headache, tiredness, muscle cramps, migraine, anemia (lack
of red blood cells), stomach pain, sinus and nasal symptoms. Consult your doctor
immediately if any of the side effect worsens.

Can TRANESMA PLUS 250MG TABLET be used in pregnant women?

TRANESMA PLUS 250MG TABLET should be used with caution in pregnant women only if
clearly advised by the doctor. Inform your doctor immediately if you become
pregnant or think you may be pregnant before taking TRANESMA PLUS 250MG TABLET.

Useful Diagnostic Tests

• Complete blood count
• kidney function test
• Bleeding time/clotting time
• Urine analysis