Terlistat 1mg Injection 10ml

Introduction About TERLISTAT 1MG INJECTION

TERLISTAT 1MG INJECTION contains Terlipressin which belongs to the group of
medicines called Vasopressin Analogues. It is used for the management of
bleeding oesophageal varices (bleeding from dilated veins in the food pipe
leading to your stomach).

Bleeding oesophageal varices occur when swollen veins (varices) in your lower
food pipe rupture and bleed. During TERLISTAT 1MG INJECTION management, your
doctor may want you to take several blood tests to monitor side effects.

Before receiving TERLISTAT 1MG INJECTION, inform your doctor if you have any
heart or kidney problems, se
limbs. TERLISTAT 1MG INJECTION should be used in pregnant women only if your
doctor finds it necessary and should be used in breastfeeding women only after
discussing the potential risk to your baby.

TERLISTAT 1MG INJECTION is not recommended for use in children and adolescents
due to lack of experience. The most common side effects of receiving TERLISTAT
1MG INJECTION are headache, temporary stomach pain or diarrhea, pale face or
skin, stomach cramps in women, etc. Contact your doctor if any of the symptoms
get worse over time.

Uses Of TERLISTAT 1MG INJECTION

• Manage bleeding oesophageal varices

How TERLISTAT 1MG INJECTION Works

TERLISTAT 1MG INJECTIONreduces bleeding by releasing substance called lysine
vasopressin that acts on the walls of the blood vessels and constricts them,
thus decreasing the blood flow to the affected veins.

How to use TERLISTAT 1MG INJECTION

TERLISTAT 1MG INJECTION will be given to you only by a doctor or a nurse into a
vein as an intravenous infusion. Your doctor will decide the correct dose and
duration of management depending upon your age, body weight and disease
condition.

Side Effects Of TERLISTAT 1MG INJECTION

Common

• very slow heart rate, high or low blood pressure
• signs in ECG showing insufficient blood supply in the heart vessels
• insufficient blood supply in arms, legs and skin
• paleness of face or skin
• headache
• temporary stomach cramps or diarrhoea
• abdominal cramps in women

Uncommon

• chest pain, rapid rise in blood pressure, heart attack, throbbing sensation
• skin or lips becoming bluish
• hot flushes, heart failure
• excess fluid on the lungs, breathlessness due to spasm in the bronchial muscles
• temporary nausea or vomiting
• inflammation of the lymph vessels
• reduced blood supply to the intestines
• uterine cramps, reduced blood flow to the uterus
• too little sodium in the blood if not monitored

Rare

• breathlessness

Stop receiving TERLISTAT 1MG INJECTION and contact your doctor immediately if
you experience any of the following side effects:

• severe breathlessness due to an asthma attack
• severe trouble with or stopping breathing
• severe pain in the chest, severe and persistent irregular heartbeats
• locally dead skin (necrosis)
• convulsions (fits)
• kidney failure

How To Manage Side Effects

Diarrhea:

Drink lots of fluids, such as water or fruit juice for hydration. Do not consume
any medicine on your own without asking your doctor. If symptom persists,
contact your doctor.

Stomach pain:

Try to rest and relax. Try to have smaller and frequent meals. Keep a heat pad
on your stomach. If symptom persists, contact your doctor.

Headache:

Try to take rest in a quiet dark room. Don’t involve yourself in exertive
activities. Apply a pain-relieving balm on your forehead. If symptom persists,
contact your doctor.

Warning & Precautions

!### Pregnancy

TERLISTAT 1MG INJECTION should be used in pregnant women only if considered
clearly necessary. Consult your doctor for advice.

!### Breastfeeding

TERLISTAT 1MG INJECTION should be used in breastfeeding women only after
discussing the potential risk to your baby. Consult your doctor for advice.

!### Driving and Using Machines

It is not studied whether TERLISTAT 1MG INJECTION affects the ability to drive
and use machines. Consult your doctor if you feel any side effect during
management with TERLISTAT 1MG INJECTION that may stop you from driving or using
machines.

!### Kidney

TERLISTAT 1MG INJECTION should be taken with caution in patients with impaired
kidney function. Consult your doctor for advice.

!### Liver

No dose adjustment of TERLISTAT 1MG INJECTION is required in patients with liver
failure. Consult your doctor for advice.

!### Allergy

Do not receive TERLISTAT 1MG INJECTION if you are allergic to Terlipressin or
any of the other ingredients of this medicine.

!### Lungs

TERLISTAT 1MG INJECTION should be used with caution in patients having bronchial
asthma or other conditions that affect your breathing. Consult your doctor for
advice.

!### Heart Disease

TERLISTAT 1MG INJECTION should be used in caution in patients having
uncontrolled high blood pressure, insufficient blood circulation in the heart
vessels (Ex. angina), arteriosclerosis (hardening of the arteries), irregular
heartbeats or in those who previously had a heart attack. Consult your doctor
for advice.

Others

Before receiving TERLISTAT 1MG INJECTION, inform your doctor if you have:

• a severe infection called se
• poor blood circulation to your brain (Ex. stroke) or to your legs (peripheral vascular disease)
• disturbances in electrolyte levels in your blood
• decreased amount of fluid in your circulation or have already lost a large amount of blood

Use in Paediatrics:

TERLISTAT 1MG INJECTION is not recommended for use in children and adolescents
due to lack of experience. Consult your child’s doctor for advice.

Use in Geriatrics:

TERLISTAT 1MG INJECTION should be used with caution in elderly patients (aged
above 70 years). Consult your doctor for advice.

Interactions

A. Drug - Drug interactions:

Before receiving TERLISTAT 1MG INJECTION, inform your doctor if you are taking
any of the following medicines:

• medicines used to lower high blood pressure (Ex. atenolol, sotalol, furosemide, spironolactone)
• medicines used to induce anaesthesia (Ex. sufent
• medicines used to manage irregular beating of the heart (Ex. quinidine, procainamide, disopyramide, amiodarone, ibutilide, dofetilide)
• erythromycin (used to manage bacterial infections)
• medicines used to manage allergies (Ex. chlorphenamine, promethazine)
• certain medicines used to manage depression (Ex. nortriptyline, amitriptyline)

Overdosage:

TERLISTAT 1MG INJECTION will be administered to you only by a doctor or a nurse
in a hospital and so it is unlikely to receive an overdose. However, consult
your doctor or nurse if you experience any unusual symptoms.

Synopsis

Drug	:	Terlipressin
Pharmacological Category	:	Vasopressin Analogue
Therapeutic Indication	:	Bleeding oesophageal varices
Dosage Forms	:	Injection

More Information

• Keep TERLISTAT 1MG INJECTION out of reach of children
• Store in a refrigerator at 2-8°C

FAQs About TERLISTAT 1MG INJECTION

Is TERLISTAT 1MG INJECTION safe for use during pregnancy?

TERLISTAT 1MG INJECTION should only be used during pregnancy if it is necessary
to manage your condition. If you are pregnant, think you may be pregnant or are
planning for a baby, contact your doctor before receiving it.

What if I miss a dose of TERLISTAT 1MG INJECTION?

Please stick to the prescribed schedule as agreed with your doctor for o
efficacy of TERLISTAT 1MG INJECTION management. Tell your doctor whenever you
forget to receive any dose.

Is TERLISTAT 1MG INJECTION suitable for children?

TERLISTAT 1MG INJECTION is not recommended for use in children and adolescents
due to lack of experience. Consult your child’s doctor for advice. The doctor
will advise a proper dose or select a suitable alternative management for your
child.

Can TERLISTAT 1MG INJECTION be stopped?

Continue receiving TERLISTAT 1MG INJECTION until your doctor tells you to stop,
unless you experience any unwanted effects, worsening of your condition or any
new symptoms. Contact your doctor in such case.

Can I take other medicines with TERLISTAT 1MG INJECTION?

Before receiving TERLISTAT 1MG INJECTION, inform your doctor if you are taking,
have taken or are going to take any other medicine, including prescri
the counter or any herbal product, as these might lead to serious side effects
by interacting with each other.

Useful Diagnostic Tests

• GI endoscopy