SILECTONE 100 Tablet 10's

Introduction About SILECTONE 100 TABLET

SILECTONE 100 TABLET contains Spironolactone which belongs to the group of
medicines called Diuretics. It is used to manage fluid accumulation in the
tissues due to heart disorders and in the abdominal cavity, severe heart failure
(NYHA III-IV), and certain kidney disorders.

SILECTONE 100 TABLET is also used to manage high blood pressure along with a
salt-free diet and diuretics. It can also be used to diagnose and manage Conn’s
disease (a disorder in which excess levels of aldosterone is produced in the
adrenal cortex).

Fluid regularly drains into body tissues from the blood. When this fluid isn’t
removed from the tissue, fluid retention (edema) occurs, causing symptoms like
swelling and aching of affected body parts such as feet, ankles, or hands.

Prior to the management, your doctor may want you to take several tests to
understand your existing condition.

Avoid consum
taking SILECTONE 100 TABLET, inform your doctor if you have any liver, heart, or
kidney problems, or low sodium and high potassium levels.

SILECTONE 100 TABLET is not recommended for use among pregnant women. It should
be used in breastfeeding women only if specifically directed by your doctor,
therefore consult your doctor before taking it.

SILECTONE 100 TABLET is not recommended for use in children with moderate to
severe kidney disease. It should be used with caution in elderly patients
especially in patients having kidney diseases. Consult with your doctor.

The most common side effects of taking SILECTONE 100 TABLET are enlarged breasts
in men, headache, indigestion, diarrhea, extreme tiredness, and drowsiness.
Contact your doctor if any of the symptoms worsen.

Uses Of SILECTONE 100 TABLET

Manages,

• fluid accumulation
• severe heart failure (NYHA III-IV)
• certain kidney disorders
• high blood pressure along with a salt-free diet and diuretics
• Conn’s disease

How SILECTONE 100 TABLET Works

SILECTONE 100 TABLET works by competitively binding to receptors at the
aldosterone-dependent sodium-potassium exchange site in the kidney tubules,
causing increased amounts of sodium and water to be excreted, while retaining
potassium.

How to use SILECTONE 100 TABLET

Take SILECTONE 100 TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine. Your doctor will
decide the correct dose and duration for you depending upon your age, body
weight and disease condition. Do not stop taking SILECTONE 100 TABLET unless
your doctor advises you to stop.

Side Effects Of SILECTONE 100 TABLET

Common

• high blood potassium levels
• headache
• indigestion, diarrhea
• reduced libido
• erectile dysfunction, impotence, enlargement of breasts (men)
• breast disorders, tenderness of the breasts, menstrual disorders, deepening of the voice, changes in vaginal secretions, absence of periods, post-menopausal bleeding (women)
• extreme tiredness, drowsiness
• low sodium levels
• nausea, vomiting
• weakness, lethargy, sensations of tickling, itching, or tingling
• general weakness

Uncommon

• acidity of the blood in patients with liver problems
• confusion
• rash, hives, redness, darkness, generalised itchiness of the skin
• muscle or leg cramps
• raised serum creatinine levels

Rare

• lack of white blood cells (sudden high fever, severe throat pain, mouth ulcers), platelet deficiency (bruises, tendency to bleed)
• allergic reactions
• dehydration, porphyria, temporary increase in nitrogen levels in the blood and urine, high blood uric acid levels, which may lead to gout attacks
• paralysis, inability to voluntarily move your limbs

Stop taking SILECTONE 100 TABLET and contact your doctor immediately if you
experience any of the following side effects:

• low blood pressure
• worsening of kidney function
• low blood levels of magnesium, calcium, or chloride
• high blood sugar levels

How To Manage Side Effects

Diarrhea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do
not consume any medicine on your own without consulting your doctor. Ask for
your doctor’s advice if diarrhea doesn’t improve.

Nausea:

Take SILECTONE 100 TABLET with or after meals. Stick to simple meals while
taking this medicine. Avoid eating rich or spicy food. Do not take any
medication on your own. Ask for your doctor’s advice if nausea doesn’t improve.

Headache:

Try to take rest and don’t involve yourself in exertive activities. Rest in a
quiet and dark room. Apply a pain-relieving balm on your forehead. Ask for your
doctor’s advice if headache doesn’t improve

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, oily, or
sweet foods. Avoid carbonated drinks. Ask for your doctor’s advice if vomiting
doesn’t improve.

Warning & Precautions

!### Pregnancy

SILECTONE 100 TABLET is not recommended for use in pregnant women. Consult your
doctor before taking it.

!### Breastfeeding

SILECTONE 100 TABLET should be used in breastfeeding women only if specifically
directed by your doctor. Consult your doctor before taking it.

!### Driving and Using Machines

Do not drive or operate any machines if you experience dizziness, headache, or
confusion after taking SILECTONE 100 TABLET.

!### Alcohol

Avoid consum

!### Kidney

SILECTONE 100 TABLET is not recommended for use in patients with severely
impaired kidney function or a sudden or rapidly worsening kidney disease,
including those in which no urine, or very little urine, is being produced. It
should be used with caution in patients with other kidney disorders like severe
renal dysfunction. Consult your doctor before taking SILECTONE 100 TABLET.

!### Liver

SILECTONE 100 TABLET should be used with caution in patients with severe liver
disorders. Consult your doctor before taking it.

!### Allergy

Do not take SILECTONE 100 TABLET if you are allergic to Spironolactone.

Others

SILECTONE 100 TABLET is not recommended for use if you:

• have low blood sodium levels
• have high blood potassium levels or associated conditions
• have Adison’s disease (your adrenal gland doesn’t produce sufficient hormones)

Use in pediatrics:

SILECTONE 100 TABLET is not recommended for use in children with moderate to
severe kidney disease. It should be used with caution in children with
hypertension. They should be managed under guidance of a paediatrician. Consult
your child’s doctor before giving SILECTONE 100 TABLET to your child.

Use in geriatrics:

SILECTONE 100 TABLET should be used with caution in elderly patients, especially
those with kidney impairment. Consult your doctor before taking it.

Interactions

A. Drug - Drug interactions:

Before taking SILECTONE 100 TABLET, inform your doctor if you are taking any of
the following medicine:

• medicines used to reduce high blood pressure (Ex. enalapril, lisinopril, valsartan, entolinium, mecamylamine, furosemide, chlorthalidone, eplerenone)
• medicines used to relieve pain (Ex. aspirin, ibuprofen)
• potassium supplements
• medicines used to manage blood clots (Ex. heparin, LMW heparin)
• medicines used to stop blood coagulation (Ex. rivaroxaban, dabigatran)
• noradrenaline (used to produce a stimulant effect on a particular part of the nervous system)
• lithium (used to manage depression)
• digoxin (used to manage heart insufficiency)
• medicines used to induce sleep (Ex. phenobarbital, pentobarbital)
• medicines used to manage severe pain (Ex. codeine, morphine)
• cholestyramine (used to reduce high blood cholesterol levels)
• medicines used to manage different fits (Ex. corticosteroids, ACTH)
• ammonium chloride (used to manage cough with mucous)
• ciclosporin (used after organ transplant to manage rejection)
• medicines used to manage infections (Ex. trimethoprim, trimethoprim-sulfamethoxazole)
• abiraterone (used to manage prostate cancer)

B. Drug - Food interaction:

Avoid having foods rich in potassium while taking SILECTONE 100 TABLET.

Overdosage:

If you or anyone else accidentally take too much of SILECTONE 100 TABLET,
consult your doctor immediately or visit the nearby hospital. Symptoms of
overdose include nausea, vomiting, drowsiness, confusion, skin rash or diarrhea.

Synopsis

Drug	:	Spironolactone
Pharmacological Category	:	Potassium-sparing diuretic
Therapeutic Indication	:	Fluid retention, Hypertension, Heart failure, Kidney disorders, Conn’s disease
Dosage Forms	:	Tablet

More Information

• Keep SILECTONE 100 TABLET out of reach of children
• Store SILECTONE 100 TABLET at a temperature below 25°C

FAQs About SILECTONE 100 TABLET

Can SILECTONE 100 TABLET be used in children?

SILECTONE 100 TABLET is not recommended for use in children with moderate to
severe kidney disease. It should be used with caution in children with
hypertension. They should be managed under guidance of a paediatrician. Your
doctor will decide the correct dose or select a suitable alternative therapy for
your child.

CanSILECTONE 100 TABLETcause erectile dysfunction?

Erectile dysfunction is an uncommon side effect of SILECTONE 100 TABLET. Consult
your physician if you have trouble getting an erection or related symptoms.

Is SILECTONE 100 TABLET safe to use in pregnancy?

SILECTONE 100 TABLET is not recommended for use in pregnant women. So before
taking SILECTONE 100 TABLET, inform your doctor if you are pregnant, think you
might be pregnant, or planning to get pregnant.

Can I stop taking SILECTONE 100 TABLET?

Do not stop taking SILECTONE 100 TABLET unless your doctor advises you to stop.
Your original symptoms may return if you stop taking it suddenly. Ask for your
doctor’s advice if you wish to discontinue taking SILECTONE 100 TABLET.

Can SILECTONE 100 TABLET be crushed?

SILECTONE 100 TABLET should be generally swallowed wholly with a glass of water,
but to make it easier for children to take, the medicine may first be ground or
crushed and then mixed in a glass of water by stirring. If you have any further
doubts regarding use of SILECTONE 100 TABLET, contact your doctor.

What if I forget to take a dose ofSILECTONE 100 TABLET?

If you forget to take a dose of SILECTONE 100 TABLET, take it as soon as you
remember, and then continue your management as usual. Do not take the medicine
twice to make up for the forgotten dose. If you have any further doubts
regarding use of SILECTONE 100 TABLET, contact your doctor.

Useful Diagnostic Tests

• Complete Blood Count (CBC)
• ECG
• Serum electrolyte test