ROPIN 0.20% INJECTION 50ML

Introduction About ROPIN 0.20% INJECTION 50ML

ROPIN 0.20% INJECTION 50ML contains Ropivacaine which belongs to the group of
medicines called Local Anaesthetics. It is used in children and adults of all
ages for acute pain management. It numbs (anaesthetises) parts of the body Ex.
after surgery.

ROPIN 0.20% INJECTION 50ML is not recommended for use in patients suffering from
hypovolemia (decreased volume of blood). Consult your doctor before receiving
it.

ROPIN 0.20% INJECTION 50ML should be used with caution in patients suffering
from lung, liver, kidney, heart diseases, porphyria (a blood disorder). Consult
your doctor before receiving it.

ROPIN 0.20% INJECTION 50ML should be used during pregnancy only if clearly
necessary and inform your doctor if you are breast feeding as it is not known
whether this medicine passes into breast milk.

ROPIN 0.20% INJECTION 50ML should be used with caution in new-born and children
below 12 years of age and in elderly patients above 65 years of age. Consult
your doctor before receiving it.

The most common side effects of receiving ROPIN 0.20% INJECTION 50ML are low
blood pressure causing dizziness or light-headedness, nausea. Contact your
doctor if any of the symptoms worsen.

Uses Of ROPIN 0.20% INJECTION 50ML

• For acute pain management in children and adults of all ages
• To numbs (anaesthetises) parts of the body Ex. after surgery

How ROPIN 0.20% INJECTION 50ML Works

ROPIN 0.20% INJECTION 50ML works by stopping the nerves from being able to pass
pain messages to the brain. Thus ROPIN 0.20% INJECTION 50ML will stop you
feeling pain, heat or cold in where it is used however you may still have other
feelings like pressure or touch.

How to use ROPIN 0.20% INJECTION 50ML

ROPIN 0.20% INJECTION 50ML will be given to you only by a doctor as an injection
or as an infusion into the region or near to the body part that needs to be
numbed or as an epidural injection (into the area around the spinal cord). Your
doctor will decide the exact dose and duration of management depending upon the
type of pain relief you need, age, body weight and condition.

Side Effects Of ROPIN 0.20% INJECTION 50ML

Common

• low blood pressure causing dizziness, light-headedness
• nausea, vomiting
• difficulty in passing urine
• high blood pressure
• back pain
• fever or chills
• slow or fast heartbeat (bradycardia, tachycardia)
• pins and needles
• headache

Uncommon

• anxiety
• breathing difficulties
• hypothermia (low body temperature)
• fainting
• seizures
• numbness of the lips, tongue and around the mouth
• hearing problems
• visual problems
• problems with your speech,
• stiff muscles and trembling

Rare

• heart attack (cardiac arrest)
• arrhythmias (uneven heartbeat)
• damaged nerves

Stop receiving ROPIN 0.20% INJECTION 50ML and consult your doctor immediately in
case you experience:

• serious allergic reactions (such as anaphylaxis) include sudden onset of rash, itching or hives, swelling of the face, lips, tongue or other parts of the body causing shortness of breath, wheezing or difficulty breathing
• signs and symptoms of methemoglobinemia include pale, grey or blue-coloured skin, headache, rapid heart rate, shortness of breath, light-headedness and fatigue

How To Manage Side Effects

Headache:

Rest and relax. Drink plenty of fluids such as water or ORS (Oral Rehydrating
Solution) and apply a pain-relieving balm on the head if necessary. Contact your
doctor if the headache did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any machines
while you are feeling dizzy. Contact your doctor if your dizziness did not
improve.

Nausea and vomiting:

Receive the medicine, with or just after a meal. Stick to simple meals. Avoid
eating oily or spicy food. Contact your doctor if your nausea and vomiting did
not improve.

Warning & Precautions

!### Pregnancy

ROPIN 0.20% INJECTION 50ML should be used during pregnancy only if clearly
necessary. Contact your doctor before receiving it.

ROPIN 0.20% INJECTION 50ML is not recommended for use in the neck of the womb to
relieve pain during childbirth.

!### Breastfeeding

If you are breastfeeding, ask your doctor for advice as it is not known whether
this medicine passes into breast milk.

!### Driving and Using Machines

ROPIN 0.20% INJECTION 50ML can make you feel sleepy and affect your action
reaction speed. Do not drive or operate machines until the next day after
receiving ROPIN 0.20% INJECTION 50ML.

!### Kidney

ROPIN 0.20% INJECTION 50ML should be used with caution in patients suffering
from kidney diseases and requires dose adjustment. Consult your doctor before
receiving it.

!### Liver

ROPIN 0.20% INJECTION 50ML should be used with caution in patients suffering
from liver diseases and requires dose adjustment. Consult your doctor before
receiving it.

!### Allergy

Do not receive ROPIN 0.20% INJECTION 50ML if you are allergic to ropivacaine or
to other local anaesthetics such as lidocaine, bupivacaine or any of the other
ingredients of this medicine.

!### Lungs

ROPIN 0.20% INJECTION 50ML should be used with caution in patients suffering
from lung diseases. Consult your doctor before receiving it.

!### Heart Disease

ROPIN 0.20% INJECTION 50ML should be used with caution in patients suffering
from heart diseases and requires dose adjustment. Consult your doctor before
receiving it.

Others

ROPIN 0.20% INJECTION 50ML is not recommended for use if you:

• have hypovolemia (decreased volume of blood)

Before receiving ROPIN 0.20% INJECTION 50ML inform your doctor if you:

• have a rare blood disorder called porphyria or family history of porphyria
• have glucose-6phosphate dehydrogenase deficiency (hereditary disorder that affects red blood cells)
• have congenital or idiopathic methemoglobinemia (condition affects red blood cells)

Use in paediatrics:

ROPIN 0.20% INJECTION 50ML should be used with caution in new-born and children
below 12 years of age. Consult your doctor before receiving it.

Use in geriatrics:

ROPIN 0.20% INJECTION 50ML should be used with caution in elderly patients above
65 years of age. Consult your doctor before receiving it.

Interactions

A. Drug-Drug interactions:

Before receiving ROPIN 0.20% INJECTION 50ML, inform your doctor if you are
taking any of the following medicine:

• morphine, codeine (medicines used to manage severe pain)
• local anaesthetics such as bupivacaine, articaine, benzocaine, prilocaine, procaine, mepivacaine, tetracaine (medicines which induce numbness in a specific part of the body)
• mexiletine, lidocaine, amiodarone (medicines used for management of irregular heartbeat)
• fluvoxamine, imipramine (medicines used for management of depression)
• ketoconazole (used for fungal infections)
• nitric oxide, nitro-glycerine, nitroprusside (medicines used to manage high blood pressure and heart diseases)
• nitrous oxide (a medicine used in general anaesthesia or to manage severe pain)
• phenobarbital, phenytoin, sodium valproate (medicines used to manage fits)
• acetaminophen (a medicine used to manage fever and pain)
• metoclopramide (used for management nausea and vomiting)
• sulfasalazine (used for management inflammatory bowel disease)
• antineoplastic agents Ex. cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase (medicines used to manage cancer)
• chloroquine, primaquine, quinine (medicines used to manage malaria)
• enoxacin, sulphonamides like silver sulphadiazine (used to manage bacterial infections)
• dapsone (used to manage leprosy)
• nitrofurantoin (used to manage urinary tract infections)
• para-amino salicylic acid (used to manage tuberculosis)
• theophylline (used to manage asthma)

Overdosage:

ROPIN 0.20% INJECTION 50ML will be administered to you only by a doctor in a
hospital and so it is unlikely to receive an overdose. However, consult your
doctor or nurse if you experience any unusual symptoms such as dizziness or
light headedness, numbness of lips, tongue, around the mouth, hearing problems,
visual problems, problems with your speech, muscle twitching, tremors,
trembling, fits and loss of consciousness.

More Information

• Keep ROPIN 0.20% INJECTION 50ML out of reach of children
• Store ROPIN 0.20% INJECTION 50ML below 30°C

FAQs About ROPIN 0.20% INJECTION 50ML

What is ROPIN 0.20% INJECTION 50ML used for?

ROPIN 0.20% INJECTION 50ML is used in children and adults for all ages for acute
pain management. It numbs (anaesthetises) parts of the body Ex. after surgery.
Contact your doctor before receiving it.

Can ROPIN 0.20% INJECTION 50ML cause permanent loss of sensation?

No, ROPIN 0.20% INJECTION 50ML does not cause permanent loss of sensation. It
gives pain relief for 5-6 hours. Contact your doctor if you experience pins and
needles sensation or decreased sensation in the skin.

Is it safe to use ROPIN 0.20% INJECTION 50ML in pregnancy?

ROPIN 0.20% INJECTION 50ML should be used during pregnancy only if clearly
necessary and it is not recommended for use into the neck of the womb to relieve
pain during childbirth. Contact your doctor before receiving it.

How long does ROPIN 0.20% INJECTION 50ML take to work?

ROPIN 0.20% INJECTION 50ML will start producing the effect of numbness within a
few minutes of administration and its effect lasts for 2-6 hours when ROPIN
0.20% INJECTION 50ML is used for pain management or to numb the body part.

Does ROPIN 0.20% INJECTION 50ML cause hypotension?

Yes, hypotension or low blood pressure (causing light-headedness, dizziness) is
the most common side effect seen after administration of ROPIN 0.20% INJECTION
50ML. Contact your doctor if any of the symptoms are worse.

Useful Diagnostic Tests

• Electrocardiogram (ECG)
• Kidney function test