RIZAMELT 5mg Oral Disintegrating Strips 1's

Introduction About RIZAMELT 5MG ORAL DISINTEGRATING STRIPS

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS contains Rizatriptan which belongs to
the group of medicines called Selective serotonin 5-hydroxytryptamine receptor
agonist. RIZAMELT 5MG ORAL DISINTEGRATING STRIPS is used in adults to manage
headache phase of migraine attack.

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS is not recommended for use in patients
allergic to Rizatriptan. It is also not recommended for use in patients
suffering from moderate/mild/severe high blood pressure (which is not controlled
by medication), stroke, peripheral vascular disease (condition marked by
blockage of blood vessels), heart problems (such as heart attack, angina),
and/or severe kidney/liver problems.

Before taking RIZAMELT 5MG ORAL DISINTEGRATING STRIPS, inform your doctor if you
have diabetes, family history of heart disease, headache (associated with
dizziness, difficulty in walking, lack of coordination), short lived symptoms
(such as chest pain, tightness), and/or mild to moderate kidney/liver problems.

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS should be used with caution during
pregnancy and in women planning for pregnancy only if it is clearly necessary as
it is not known whether the medicine can cause harm to the unborn baby. It is
also used with caution in breastfeeding women only if it is clearly necessary.
Breastfeeding mothers should avoid nursing the child for next 24 hours after
taking the medicine since it may cause unwanted effects in the nursing child.

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS is not recommended for use in children
and adolescents (aged below 18 years) and is advised to be used with caution in
elderly patients (aged 65 years/above) after consulting the doctor.

The most common side effects of taking RIZAMELT 5MG ORAL DISINTEGRATING STRIPS
are tingling sensation of hands/feet, headache, sleeplessness, dry mouth,
nausea, vomiting, and/or diarrhea. Consult your doctor if any of these symptoms
worsens.

Uses Of RIZAMELT 5MG ORAL DISINTEGRATING STRIPS

• Manage headache experienced during migraine attack in adult patients

How RIZAMELT 5MG ORAL DISINTEGRATING STRIPS Works

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS works by constricting the blood vessels
that surround the brain which results in reduced swelling in the blood vessels
thus providing relief from headache that occurs in migraine attack in affected
individuals.

How to use RIZAMELT 5MG ORAL DISINTEGRATING STRIPS

Tablet

Take RIZAMELT 5MG ORAL DISINTEGRATING STRIPS as advised by your physician.
Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration for you depending upon
your age, body weight and disease condition.

Oral Disintegrating Tablet / Mouth Dissolving Tablet:

Take RIZAMELT 5MG ORAL DISINTEGRATING STRIPS as advised by your physician. Place
RIZAMELT 5MG ORAL DISINTEGRATING STRIPS inside your mouth and allow it to
dissolve completely. Do not swallow or chew the medicine. Your doctor will
decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Side Effects Of RIZAMELT 5MG ORAL DISINTEGRATING STRIPS

Common

• tingling sensation of hands/feet, headache, decreased sensitivity of skin, decreased mental sharpness
• sleeplessness
• fast/irregular heartbeat
• flushing
• throat discomfort, dry mouth, nausea, vomiting, diarrhea, indigestion
• feeling of heaviness in parts of the body, neck pain, stiffness
• pain in abdomen/chest

Uncommon

• bad taste in mouth
• ataxia (unsteadiness while walking), dizziness, tremor, fainting
• blurred vision
• confusion, nervousness
• high blood pressure
• thirst, sweating
• rash, itching, and/or red itchy welts
• swelling of face/lips/tongue, and/or throat
• feeling of tightness in parts of the body, muscle weakness
• changes in the rhythm/rate of the heartbeat
• very fast heartbeat
• facial pain, muscle pain

Rare

• wheezing
• allergic reaction
• anaphylaxis (sudden life-threatening allergic reaction)
• stroke (especially in patients with risk factors for heart and blood vessel disease)
• slow heartbeat.

Stop taking RIZAMELT 5MG ORAL DISINTEGRATING STRIPS and consult your doctor
immediately if you experience any of the following:

• signs of an allergic reaction such as swelling of the face/lips/tongue, shortness of breath, rash, itching, and/or red itchy welts
• signs of serotonin syndrome (serious drug reaction) such as agitation/restlessness, sleeplessness, confusion, and/or dilated pupils
• heart attack
• signs of stroke (condition that occurs due to poor blood supply to brain) such as sudden numbness/weakness in face/arm/leg, trouble speaking, dizziness, and/or loss of balance

How To Manage Side Effects

Headache:

If RIZAMELT 5MG ORAL DISINTEGRATING STRIPS causes headache, then take rest and
drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to
recommend a painkiller. Headaches should usually go away after the first week of
taking RIZAMELT 5MG ORAL DISINTEGRATING STRIPS. If it lasts more than a week or
severe, inform your doctor.

Dry mouth and thirst:

Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip
balm if your lips are dry. Brush your teeth twice a day and use mouthwash.
Consult and inform your doctor if the symptom gets worse.

Nausea and vomiting:

Take RIZAMELT 5MG ORAL DISINTEGRATING STRIPS with or just after a meal. Stick to
simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks.
Avoid drinking too much liquid along with your meals, drink slowly in between
meals. Inform your doctor if the condition worsens.

Diarrhea:

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on
your own to manage diarrhea. Consult and inform your doctor if the symptom
worsens.

Indigestion:

Try to have smaller and more frequent meals and drink slowly. Reduce consum
of coffee, cola, tea, or alcohol and lose weight if you are obese.  Try to avoid
smoking and don’t have rich, fatty or spicy foods. Consult your doctor and
inform if the symptom does not improve.

Dizziness:

Try to rest and get enough sleep. Try to avoid driving or operating any tools or
machines while you feel dizzy. Limit consum
dizziness. Consult and inform your doctor if the symptom worsens.

Rashes:

Do not scratch the affected area. Wear protective clothing while going outdoors.
Regularly moisturize your skin. Consult and inform your doctor if the symptom
gets worse.

Warning & Precautions

!### Pregnancy

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS should be used with caution during
pregnancy and in women planning for pregnancy only if it is clearly necessary as
it is not known whether the medicine can cause harm to the unborn baby. Consult
your doctor before taking the medicine.

!### Breastfeeding

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS should be used with caution in
breastfeeding women only if it is clearly necessary. Breastfeeding mothers
should avoid nursing the child for next 24 hours after taking the medicine.
Consult your doctor before taking RIZAMELT 5MG ORAL DISINTEGRATING STRIPS.

!### Driving and Using Machines

Do not drive/operate machines if you feel dizzy/sleepy after taking RIZAMELT 5MG
ORAL DISINTEGRATING STRIPS. Consult your doctor before taking the medicine.

!### Kidney

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS is not recommended for use in patients
with severe kidney problems. It should be used with caution in patients with
mild to moderate kidney problems. Consult your doctor before taking RIZAMELT 5MG
ORAL DISINTEGRATING STRIPS.

!### Liver

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS is not recommended for use in patients
with severe liver problems. It should be used with caution in patients with mild
to moderate liver problems. Consult your doctor before taking RIZAMELT 5MG ORAL
DISINTEGRATING STRIPS.

!### Allergy

Do not take RIZAMELT 5MG ORAL DISINTEGRATING STRIPS if you are allergic to
Rizatriptan, and/or any other ingredients of this medicine.

!### Heart Disease

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS is not recommended for use in patients
with heart problems such as heart attack, angina. It should be used with caution
in patients with other heart problems such as bundle branch block. Consult your
doctor before taking RIZAMELT 5MG ORAL DISINTEGRATING STRIPS.

Others

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS is not recommended for use if you:

• have moderately/mild/severe high blood pressure which is not controlled by medication
• have had a stroke
• suffer from peripheral vascular disease (condition marked by blockage of blood vessels).

Before taking RIZAMELT 5MG ORAL DISINTEGRATING STRIPS, inform your doctor if
you:

• have diabetes
• are a smoker
• have a family history of heart disease
• are a man aged above 40 years or women in postmenopausal phase
• suffer from headache associated with dizziness, difficulty in walking, lack of coordination, and/or weakness in the leg and arm
• have had short lived symptoms such as chest pain, tightness.

Use in Pediatrics:

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS is not recommended for use in children
and adolescents (aged below 18 years). Consult your doctor before taking the
medicine.

Use in Geriatrics:

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS should be used with caution in elderly
patients (aged 65 years/above). Consult your doctor before taking the medicine.

Interactions

A. Drug-Drug Interactions

Before taking RIZAMELT 5MG ORAL DISINTEGRATING STRIPS, inform your doctor if you
are taking any of the following medicine:

• other triptans (medicines used to manage migraine) Ex. ergotamine, dihydro-ergotamine, sumatriptan, naratriptan or zolmitriptan
• medicines used to manage depression such as selective serotonin reuptake inhibitors (SSRIs) (Ex.sertraline, escitalopram oxalate, uoxetine),  serotonin noradrenaline reuptake inhibitors (SNRIs) (Ex. venlafaxine, and duloxetine), monoamine oxidase (MAO) inhibitors (Ex. moclobemide, phenelzine, tranylcypromine, pargyline)
• medicines used to manage bacterial infections (Ex. linezolid)
• propranolol (used to manage heart problems, anxiety)
• methysergide (used to manage migraine)

Overdosage:

If you or anyone else accidentally takes too much of RIZAMELT 5MG ORAL
DISINTEGRATING STRIPS, visit the nearby hospital or consult your doctor
immediately. Symptoms of overdose are dizziness, drowsiness, vomiting, fainting,
and/or slow heart rate.

Synopsis

Drug	:	Rizatriptan
Pharmacological Category	:	Selective serotonin 5-HT1B/1D receptor agonists
Therapeutic Indication	:	Headache in migraine
Dosage Forms	:	Tablet, Oral Disintegration Tablets

More Information

• Keep RIZAMELT 5MG ORAL DISINTEGRATING STRIPS out of sight and reach of children
• Do not store RIZAMELT 5MG ORAL DISINTEGRATING STRIPS above 30°C

FAQs About RIZAMELT 5MG ORAL DISINTEGRATING STRIPS

What is RIZAMELT 5MG ORAL DISINTEGRATING STRIPS and why it is used?

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS contains Rizatriptan which belongs to
the group of medicines called Selective serotonin 5-hydroxytryptamine receptor
agonist. It is generally used to manage headache phase of migraine attack in
adult patients.

What are the common side effects of RIZAMELT 5MG ORAL DISINTEGRATING STRIPS?

The most common side effects of taking RIZAMELT 5MG ORAL DISINTEGRATING STRIPS
are tingling sensation of hands/feet, headache, sleeplessness, dry mouth,
nausea, vomiting, and/or diarrhea. Consult your doctor if any of these symptoms
worsens.

Can RIZAMELT 5MG ORAL DISINTEGRATING STRIPS be used in pregnant and
breastfeeding women?

Yes, RIZAMELT 5MG ORAL DISINTEGRATING STRIPS can be used but with caution in
pregnant and breastfeeding women only if necessary since it is not known whether
the medicine can cause harm to the unborn baby/nursing child. Consult your
doctor before taking the medicine.

How RIZAMELT 5MG ORAL DISINTEGRATING STRIPS works?

RIZAMELT 5MG ORAL DISINTEGRATING STRIPS works by constricting the blood vessels
that surround the brain which results in reduced swelling in the blood vessels
thus providing relief from headache that occurs in migraine attack in affected
individuals.

What happens if RIZAMELT 5MG ORAL DISINTEGRATING STRIPS is taken more than its
required dosage?

If you or anyone else accidentally takes too much of RIZAMELT 5MG ORAL
DISINTEGRATING STRIPS, visit the nearby hospital or consult your doctor
immediately. Symptoms of overdose are dizziness, drowsiness, vomiting, fainting,
and/or slow heart rate.