RIMACTANE 300mg Capsule 4's

Introduction About RIMACTANE 300MG CAPSULE

RIMACTANE 300MG CAPSULE contains Rifampicin which belongs to the group of
medicines called Antibacterial. It is used to manage bacterial infections such
as tuberculosis (affects the lungs), legionnaires disease (lung inflammation),
brucellosis (infection spreading from
lesions and nerve damage) and serious staphylococcal infections.

It also manages the infections caused by Haemophilus influenzae and Neisseria
meningitides (who are the carriers but do not show the symptoms), thereby
managing and managing the onset of flu and meningitis. The doctor may ask you to
take blood tests and liver function tests before starting management with
RIMACTANE 300MG CAPSULE. RIMACTANE 300MG CAPSULE is not recommended for use if
you have yellowing of the skin and eyes (jaundice).

Before taking RIMACTANE 300MG CAPSULE, it is recommended to inform your doctor
if you have liver, kidney problems, diabetes, are underweight or malnourished,
have a rare blood problem (porphyria), bleeding or a tendency to bruise easily.
Also, inform your doctor if symptoms of tuberculosis return or get worse, are
wearing contact lenses, are vitamin K deficient or have hypoprothrombinemia
(deficient clotting factor).

RIMACTANE 300MG CAPSULE is not recommended for use in pregnant and breastfeeding
women. RIMACTANE 300MG CAPSULE should be used with caution in children under 2
years of age and in elderly patients above 65 years of age. The most common side
effects seen are nausea, vomiting, chills, fever. Consult your doctor if
symptoms do not improve.

Uses Of RIMACTANE 300MG CAPSULE

RIMACTANE 300MG CAPSULE is used to manage:

• tuberculosis
• leprosy
• brucellosis
• legionnaires
• serious staphylococcal infections
• infections caused by Haemophilus influenzae (causes flu) and Neisseria meningitides (causes meningitis)

How RIMACTANE 300MG CAPSULE Works

RIMACTANE 300MG CAPSULE works by managing protein synthesis and interferes with
the enzymes present in the bacteria causing its death. This results in a
reduction in the count of infection-causing bacteria, thereby managing bacterial
infections.

How to use RIMACTANE 300MG CAPSULE

Take RIMACTANE 300MG CAPSULE as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine. It is recommended to
take RIMACTANE 300MG CAPSULE on an empty stomach. Your doctor will decide the
correct dose and duration for you depending on your age, body weight and disease
condition.

Side Effects Of RIMACTANE 300MG CAPSULE

Common

• headache, dizziness
• nausea and vomiting
• pyrexia (fever)
• chills
• thrombocytopenia with or without purpura (low platelet level)

Rare

Stop taking RIMACTANE 300MG CAPSULE and consult your doctor immediately if you
experience any of the following:

• allergic reactions such as swollen face, lips, tongue, throat causing difficulty in breathing and/or swallowing
• skin reactions characterized by fever, red colored circular patches on skin with central blisters along with skin peeling and ulcers on mouth, nose, throat and/or genitals, which may indicate Steven Johnson Syndrome and/or Toxic Epidermal Necrolysis
• severe watery, frequent loose stools and/or with presence of blood in it, along with weakness and/or fever
• flu- like symptoms along with the appearance of a rash which are widespread in nature, increased temperature and enlarged lymph nodes which are characteristic of DRESS (Drug Reaction with Eosinophilia and Systemic symptoms)
• development of purple spots and/or bruises on skin
• severe headache
• bleeding from various parts such as nose, ears, gums, throat
• tender and/or swollen stomach
• black tar-like stools
• loss of weight, decreased blood sugar levels (hypoglycemia), dehydration, disorientation (adrenal insufficiency)
• pain in abdomen along with increased blood pressure and rapid abnormal heartbeat, which may indicate Porphyria
• red and scaly rash which is widely spread on body with bumps under the skin along with fever (acute generalized exanthematous pustulosis (AGEP))
• altered amount of urine along with the presence of blood in it, feeling weak and drowsy (kidney problem)
• dark urine along pale stools and yellowing of skin and eyes (liver problem)
• return of the original symptoms and/or increase in the severity of pre-existing symptoms (Paradoxical Drug Reaction). ( associated with fever, swollen lymph nodes (lymphadenitis), breathlessness, cough, headaches, loss of appetite and weight loss)
• swollen blood vessels in the skin
• fever, chills, headache, dizziness and bone pain
• mental problems causing a change in personality, hallucinations and odd behavior (psychotic disorder)

How To Manage Side Effects

Nausea and Vomiting: Stick to simple meals. Avoid eating heavily rich
or spicy food. Stay hydrated. Consult your doctor if it persists for long or
worsens with time.

Headache:

Take some rest, in a quiet place and avoid using mobile phones and other
electronic devices for a while. Drinking water as inadequate hydration may
worsen your headache. If symptoms persist, contact your doctor.

Warning & Precautions

!### Pregnancy

RIMACTANE 300MG CAPSULEis not recommended for use in women who are pregnant
and/or planning pregnancy as it can affect the growth of your unborn baby and
may cause complications to the mother and baby after birth.

Also, RIMACTANE 300MG CAPSULE may result in the ineffectiveness of oral
contrace
coils are recommended. Always consult your doctor before taking RIMACTANE 300MG
CAPSULE.

!### Breastfeeding

RIMACTANE 300MG CAPSULE is not recommended to be taken by nursing women since it
may pass to the baby through mother’s milk. Consult your doctor before taking
RIMACTANE 300MG CAPSULE.

!### Driving and Using Machines

It is not recommended to drive and use heavy machinery after taking RIMACTANE
300MG CAPSULE as it might make you feel dizzy or faint. It is recommended to
take RIMACTANE 300MG CAPSULE only after consultation with the doctor.

!### Kidney

RIMACTANE 300MG CAPSULE must be taken with caution if you are diagnosed with any
kidney disease. Consult your doctor before taking RIMACTANE 300MG CAPSULE.

!### Liver

RIMACTANE 300MG CAPSULE must be taken caution if you are diagnosed with any
disease of the liver. Consult your doctor before taking RIMACTANE 300MG CAPSULE.

!### Allergy

It is not recommended to take RIMACTANE 300MG CAPSULE if you are allergic to
Rifampicin and/or any other drug present in RIMACTANE 300MG CAPSULE.

Others

RIMACTANE 300MG CAPSULE is not recommended for use if you:

• have yellowish tinge to eyes and skin which may be indicative of jaundice

Before taking RIMACTANE 300MG CAPSULE, inform your doctor if you:

• are diagnosed with diabetes (elevated level of sugar in blood)
• are underweight and/or malnourished
• are diagnosed with a blood disorder called Porphyria characterized by the appearance of purple colored rash on skin
• are prone to bleeding and/or bruising
• wear contact lenses
• have deficiency of Vitamin K
• if symptoms of tuberculosis return or get worse
• have hypoprothrombinemia (deficient clotting factor)

Use in Pediatrics: RIMACTANE 300MG CAPSULE must be taken in caution in
children below 2 years of age. Consult your doctor before taking it as they can
decide the correct and required dosage, frequency and strength of RIMACTANE
300MG CAPSULE based on age, disease condition and body weight of the child.

Use in Geriatrics: RIMACTANE 300MG CAPSULE must be taken in caution in
elderly patients (above the age of 65 years). Consult your doctor before taking
RIMACTANE 300MG CAPSULE.

Interactions

A. Drug-Drug Interactions:

Before taking RIMACTANE 300MG CAPSULE, inform your doctor if you are taking any
of the following medicine:

• medicines used to manage HIV infection (Ex. saquinavir, ritonavir)
• medicines used to manage indigestion such as antacids (Ex. aluminium hydroxide, magnesium carbonate)
• other medicines used to manage tuberculosis (Ex. P-Aminosalicylic Acid)
• medicines used to thin the blood (Ex. clopidrogel, warfarrin)
• medicines used to lower cholesterol (Ex. atorvastatin, rosuvastatin)
• medicines for heart problems or to control your heartbeat (Ex. atenolol, bisprolol), lower the blood pressure (Ex. diuretics like eplerenone)
• medicines used to manage thought disorders (Ex. antipsychotics like haloperidol), reduce anxiety (Ex. hypnotics-lorazepam), to induce sleep (Ex. barbiturates-phenobarbital), manage depression (Ex. amitriptyline)
• medicines used to manage epilepsy (Ex. phenytoin), disease of motor neurons (Ex. riluzole)
• medicines used to manage various viral infections (Ex. indinavir, telaprevir, amprenavir, nelfinavir, atazanavir, lopinavir, neviparine, daclatasvir, simeprevir, sofosbuvir and telaprevir)
• medicines used to manage fungal diseases (Ex. ketoconazole, clotrimazole), bacterial infections (Ex. amoxicillin, cephalosporin), tapeworm infections (Ex. praziquantel)
• medicines used to lower the immune system response (Ex. ciclosporin, tacrolimus, sirolimus)
• medicines used to manage pneumonia (Ex. atovaquone)
• medicines used for contrace
• medicines used to manage cancer (Ex. imatinib, irinotecan, ethinyloestradiol, levonorgestrel or dydrogesterone), for breast cancer or endometriosis (Ex. tamoxifen, gestrinone, toremifene)
• medicines used to manage thyroid gland problems (Ex. levothyroxine)
• medicines used to manage gout and other pains (Ex. aspirin, etoricoxib, codeine, morphine, fentanyl, pethidine, etoricoxib, aspirin and indomethacin)
• medicines used to manage inflammation in the body such as corticosteroids (Ex. hydrocortisone, betamethasone and prednisolone)
• medicines used during withdrawal from heroin (Ex. methadone)
• medicines used to manage diabetes (Ex. metformin)
• medicines used before surgery to relax the mind and body (Ex. halothane)
• medicines used for nausea (Ex. ondansetron, aprepitant)
• medicines used for malaria (Ex. quinine)
• medicines used to manage difficulty breathing and wheezing sound (Ex. theophylline)

Overdosage:

If you or anyone else accidentally took too much of RIMACTANE 300MG CAPSULE,
visit the nearby hospital or consult your doctor immediately. Signs and symptoms
of overdosage are feeling sick (nausea) along with vomiting and pain in abdomen,
increased itch (pruritus), headache and increased lethargy, feeling of
drowsiness, swelling of the face, eyes or eyelids, fast or uneven heartbeat,
dizziness, fits and heart attack.

Synopsis

Drug	:	Rifampicin
Pharmacological Category	:	Antibacterial
Therapeutic Indication	:	Bacterial infections
Dosage Forms	:	Syrup, Capsule, Tablet, Suspension

More Information

• Keep RIMACTANE 300MG CAPSULE out of reach of children
• Keep RIMACTANE 300MG CAPSULE away from heat
• Keep it below 25°C

FAQs About RIMACTANE 300MG CAPSULE

What is RIMACTANE 300MG CAPSULE used for? RIMACTANE 300MG CAPSULE is used
to manage bacterial infections such as tuberculosis (affects the lungs),
legionnaires disease (lung inflammation), brucellosis (infection spreading from

staphylococcal infections. It also manages the infections caused by Haemophilus
influenzae and Neisseria meningitides (who are the carriers but do not show the
symptoms), thereby managing and managing the onset of flu and meningitis.

How does RIMACTANE 300MG CAPSULE work? RIMACTANE 300MG CAPSULE works by
managing protein synthesis and interfering with the enzymes present in the
bacteria causing its death. This results in a reduction in the count of
infection-causing bacteria, thereby managing bacterial infections.

When should I not take RIMACTANE 300MG CAPSULE? RIMACTANE 300MG CAPSULE
is not recommended to be taken if you are allergic to Rifampicin and/or any
other constituent of RIMACTANE 300MG CAPSULE, have yellowish tinge to eyes and
skin which may be indicative of jaundice and/or are diagnosed with HIV
infection.

C
recommended to drive and use heavy machinery after taking RIMACTANE 300MG
CAPSULE as it might make you feel dizzy or faint. It is recommended to take
RIMACTANE 300MG CAPSULE only after consultation with the doctor.

Can RIMACTANE 300MG CAPSULE be takenwith Vitamin D? Taking RIMACTANE
300MG CAPSULE with Vitamin D will decrease the effect of Vitamin D. Inform your
doctor if you are taking this medicine as the dose will be adjusted accordingly.

Useful Diagnostic Tests

• Liver Function Test (LFT)
• Complete Blood Count (CBC)
• Blood Glucose Level