Parxin 250mg Tablet 10'S

Introduction About PARXIN 250MG TABLET

PARXIN 250MG TABLET contains Chloramphenicol which belongs to the group of
medicine called Antibiotics. It is used to manage typhoid fever and other
dangerous infections where other antibiotics are not effective.

Typhoid fever is a bacterial infection that can spread throughout the body,
affecting many organs, without proper management, it can cause serious
complications and can be fatal.

During the therapy your doctor might recommend you for routine blood tests to
monitor in case of prolong use of this medicine, as chloramphenicol can damage
blood cells.

Pregnant and breastfeeding women should consult their doctor before taking this
medicine.

Before taking this medicine inform your doctor if you have blood, bone marrow
disease, liver or kidney problems, high blood pressure. Consult your doctor for
advice.

The common side effects are anaemia, dark coloured urine, sore throat and fever,
unusual bleeding or bruising, difficulty in breathing, headache, nausea and
vomiting, burning, numbness and tingling in the arms. Consult your doctor if any
of the above side effects worsen or persists for a longer duration.

Uses Of PARXIN 250MG TABLET

It is used to manage:

• typhoid fever
• other severe bacterial infections where other antibiotics are not effective

How PARXIN 250MG TABLET Works

Chloramphenicol is a semi-synthetic antibiotic. It diffuses through the
bacterial cell wall and binds to the ribosome of the bacteria, thereby managing
the formation of bacterial protein consequently leading to inhibition of cell
growth and cell lysis, resulting in suppressing the growth of bacteria.

How to use PARXIN 250MG TABLET

Always take this medicine as directed by your physician. Swallow the medicine as
a whole with a plenty of water and do not crush or chew the medicine. Your
doctor will decide the correct dose for you depending upon your age, body weight
and disease condition.

Side Effects Of PARXIN 250MG TABLET

Common

• anaemia
• dark coloured urine
• sore throat
• fever
• difficulty in breathing
• headache
• nausea and vomiting
• diarrhoea
• bloating
• tiredness
• thirst
• burning
• numbness
• tingling in the arms and feet
• swelling of face, lips, eyelids, tongue, hands and feet
• depression

Rare

Stop taking and contact your doctor immediately, if you have:

• difficulty breathing or swallowing, swelling of the face, lips, tongue or throat, severe itching of the skin, with a red rash or raised lumps, blistering of the mouth, eyes or genital region, patchy areas of rash, peeling skin, severe, persistent or bloody diarrhoea
• drowsiness, feeling faint, sudden loss of consciousness, shortness of breath, nausea, vomiting
• unusual or increased bleeding or bruising
• fever, sore throat, mouth ulcers, repeated infections or infections
• feeling tired, breathless and looking pale
• sudden loss or blurring of vision, loss of colour vision, eye pain which worsens with eye movement
• ringing in the ears or temporary hearing loss, head-spins (vertigo), dizziness

How To Manage Side Effects

Nausea and Vomiting:

Try to take this medicine with or just after a meal or a snack. Stick to simple
meals. Avoid eating rich or spicy food.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated.
Avoid taking any medicine on your own for managing diarrhoea. Consult your
doctor if the symptom did not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the head if required. Do not consume too much of alcohol.
Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines while you are feeling dizzy. Do not consume too much of alcohol, as it
can aggravate your dizziness. Consult your doctor if the symptom did not
improve.

Skin rash:

Avoid hot showers because hot water can irritate your skin further. Do not
scratch the affected area. Use protective clothing when going outdoors.
Regularly moisturize your skin. Consult your doctor if the symptom did not
improve.

Warning & Precautions

!### Pregnancy

PARXIN 250MG TABLET is not recommended for use in pregnant women. Consult your
doctor before taking this medicine.

!### Breastfeeding

PARXIN 250MG TABLET is not recommended for use in breastfeeding women. Consult
your doctor before taking this medicine.

!### Kidney

PARXIN 250MG TABLET should be used with caution in patients suffering from
kidney problems. Consult your doctor before taking this medicine.

!### Liver

PARXIN 250MG TABLET should be used with caution in patients suffering from liver
problems. Consult your doctor before taking this medicine.

!### Allergy

Do not take this medicine if you are allergic (hypersensitive) to
Chloramphenicol or any ingredients of this medicine.

Others

PARXIN 250MG TABLET is not recommended if you:

• have recently been vaccinated
• have porphyria (metabolism disorder which causes abdominal pains and mental disorder)
• have minor infection

Use in pediatrics:

PARXIN 250MG TABLET is not recommended for use in children. Consult your doctor
before taking this medicine.

Use in geriatrics:

PARXIN 250MG TABLET should be used with caution in elderly patients. Consult
your doctor before taking this medicine.

Interactions

A. Drug - Drug interactions:

Inform your physician if you are taking:

• Paracetamol (used to manage fever, pain)
• medicines that thin the blood such as warfarin
• antidiabetics such as gliclazide (used to manage diabetes)
• medicines that may suppress the bone marrow such as carbamazepine, penicillamine
• sulphonamide, phenylbutazone
• medicines to manage cancer
• clozapine, flupentixol, fluphenazine, procainamide (used to psychotic disorders)
• co-trimoxazole, penicillin or rifampicin, azithromycin, erythromycin (used to manage infection)
• phenytoin (used for epilepsy)
• barbiturates such as phenobarbitone
• immunosuppressants such as ciclosporin or tacrolimus
• vitamin B12 (hydroxocobalamin)
• oral contrace
• carbimazole, propylthiouracil (used to manage over-active thyroid disease)
• anti-retroviral medicines that manage HIV infection such as zidovudine
• pantoprazole, rabeprazole
• calcium channel blocker such as amlodipine, verapamil
• azole antifungals such as fluconazole, ketoconazole
• lidocaine, quinidine (used to manage heart problems)
• citalopram, sertraline
• sildenafil, vardenafil and avanafil
• atorvastatin (used to manage cholesterol levels)

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your
doctor immediately.

Synopsis

Drug	:	Chloramphenicol
Pharmacological Category	:	Antibiotics
Therapeutic Indication	:	Typhoid fever, Severe infections
Dosage Forms	:	Tablet, Capsule, Drops, Eye Drops, Eye Ointment, Injection, Syrup, Suspension, Caplet, Aplicap

More Information

• Keep out of reach of children
• Store at room temperature

FAQs About PARXIN 250MG TABLET

DoesPARXIN 250MG TABLETused to relieve pain?

No,PARXIN 250MG TABLETnot a pain killer. It only manages bacterial infections
and provides relief from symptoms of infection.

Is it safe to usePARXIN 250MG TABLETfor longer duration of time?

Use PARXIN 250MG TABLET only as prescribed by the doctor. Do not use for longer
durations. Consult your doctor if your condition does not improve despite using
this medicine for a week or if it worsens.

Can I stop takingPARXIN 250MG TABLETwhen I feel better?

No, do not stop taking PARXIN 250MG TABLETand complete the entire course of
management even if you start feeling better or else you may experience
management failure and the increased risk of recurrence of the infection.

Can the use ofPARXIN 250MG TABLETcause diarrhoea?

Yes, the use of PARXIN 250MG TABLETmay cause diarrhoea along with the desired
effect, but not everyone gets them. It is an antibiotic that kills both good and
bad bacteria, when good bacteria present in the intestine gets destroyed and it
may cause diarrhoea. If you are experiencing severe diarrhoea, talk to the
doctor about it.

What if my condition does not improve after takingPARXIN 250MG
TABLET?

Talk to the doctor if your condition does not improve, even after taking PARXIN
250MG TABLET. If needed your doctor will provide an alternate medicine.

Useful Diagnostic Tests

• Complete Blood Count
• Peripheral Smear Examination