P Cool Cream 20gm

Introduction About P COOL CREAM

P COOL CREAM contains Calamine, Lignocaine(lidocaine), and Phenylephrine which
belong to the group of medicines called antipruritic,  anaesthetics, and
sympathomimetic agents. P COOL CREAM is used in adults to relieve pain and
bleeding associated with piles, anal fissures, and haemorrhoids.

Piles (haemorrhoids) are tissue growth in and around the anus due to the
enlargement of veins in the lower anus or rectum, which leads to discomfort such
as pain, itching, blood in the stool, discomfort when pooping, etc. An anal
fissure is a tear or cracks in the lining of the anus or anal canal with
symptoms of severe pain while pooping, blood in the poop, etc.

P COOL CREAM is not recommended for use in areas of trauma (injury to the mucosa
due to chemical, physical, or thermal injury) or patients with hypersensitivity
to the ingredients. Before using P COOL CREAM, inform your doctor if you have
any heart diseases, increased blood pressure, diabetes, an enlarged prostate
gland, thyroid problems, etc.

P COOL CREAM should be used with caution in patients who are pregnant,
breastfeeding, elderly, or have children. Possible side effects of P COOL CREAM
are irritation, headache, rectal bleeding, anxiety, skin dryness, etc. Consult
your doctor if any of the symptoms are worsening.

Uses Of P COOL CREAM

It is used in adults to relieve pain and bleeding associated with:

• piles (tissue growth in and around the anus with discomfort, pain, blood in stool, itching etc)
• anal fissures (tear or crack in rectum or anus with blood in the mucus, pain during and after pooping)
• haemorrhoids

How P COOL CREAM Works

P COOL CREAM contains calamine, lignocaine (lidocaine), and phenylephrine.
Calamine relieves itching and soothes the skin. When applied to the skin, the
aqueous component of calamine lotion evaporates. The heat required for
evaporation is taken from the body, which gives a cooling effect at the site of
application.

Calamine has antibacterial properties, which help manage infections.
Phenylephrine is a decongestant that shrinks swollen blood vessels. Enlarged
blood vessels result in piles, so phenylephrine helps manage the symptoms of
burning, itching, and swelling associated with piles. Lidocaine blocks the pain
alerts from the nerves to the brain, thereby decreasing the feeling of pain.

How to use P COOL CREAM

Always use P COOL CREAM as directed by your physician. It is for external use
only. Do not use it on your eyes. Take a small amount of P COOL CREAM in a
fingercot. Insert it slowly into the anal opening and apply with gentle
rotation. You can also apply P COOL CREAM with a penta applicator.

For that, remove the cap of the tube and insert the Penta applicator into the
tube. Insert this into the anal opening. Push the medicine from behind slowly.
Remove the applicator and clean it after separating it from the tube. Do not
share your applicator with anyone else. Your doctor will determine the required
dose and duration of P COOL CREAM for you as per your age and disease condition.

Side Effects Of P COOL CREAM

Rare

Stop using P COOL CREAM and contact your doctor immediately if you notice any of
the symptoms:

• bluish discolouration of the skin (cyanosis), pallor, fatigue, weakness, headache, irregular heartbeat, muscle pain, metabolic acidosis, seizures, coma, and death. (Signs of methemoglobinemia– blood disorder)
• swelling of the mouth, lip, and throat with wheezing, and tightness in the chest or throat; trouble breathing, swallowing or talking (signs of angioedema)
• bleeding from the rectum or rectal pain
• rashes, hives, itching with red, swollen, blistered lesions or peeling skin with or without fever. (Signs of serious allergic reactions)

Warning & Precautions

!### Pregnancy

Use with CautionP COOL CREAM should be used with caution if you are pregnant, especially in
early pregnancy where organogenesis (development of the organ in baby) takes
place. Consult your doctor before using P COOL CREAM.

!### Breastfeeding

Use with CautionP COOL CREAM should be used with caution in breastfeeding women, as it may pass
through the breast milk. Consult your doctor before using P COOL CREAM.

!### Liver

Use with CautionP COOL CREAM should be used with caution in patients who suffer from serious
liver diseases as they are at risk of developing lidocaine toxicity. (Numbness,
dizziness, tongue paresthesia etc.) Consult your doctor before using P COOL
CREAM.

!### Allergy

ContraindicatedIf you are allergic to calamine, lignocaine (lidocaine), phenylephrine, or any
of the other ingredients in P COOL CREAM, do not use it. Consult your doctor
before using P COOL CREAM.

!### Lungs

Use with CautionP COOL CREAM should be used with caution in patients with pulmonary compromise
(deterioration in respiratory function with a high likelihood of rapid
progression to respiratory failure and death), as there is a higher chance of
getting methemoglobinemia. Consult your doctor before using P COOL CREAM.

!### Heart Disease

Use with CautionP COOL CREAM should be used with caution in patients suffering from heart
diseases and increased blood pressure. Consult your doctor before using P COOL
CREAM.

!### Use In Pediatrics

Use with CautionP COOL CREAM should be used with caution in children. Infants under 6 months of
age are at a higher risk of developing methemoglobinemia (bluish discolouration
of the skin, pallor, weakness, abnormal heart rate, comma etc.) while using P
COOL CREAM. Consult your doctor before using it.

!### Use In Geriatrics

Use with CautionP COOL CREAM should be used with caution in elderly people. Consult your doctor
before taking it.

Others

P COOL CREAM is not recommended to use in:

• areas of trauma(injury to mucosa due to chemical , physical or thermal injury), inflammation

Before using P COOL CREAM inform your doctor if you are having:

• weakened immune system and prone to infections often (immune compressive patients)
• diabetes
• thyroid diseases
• enlarged prostate gland with difficulty in urinating
• glucose-6-phosphate dehydrogenase deficiency
• congenital or idiopathic methemoglobinemia
• pseudocholinesterase deficiency
• weakness and illness

Interactions

A. Drug-Drug interaction:

Before using P COOL CREAM inform your doctor if you are taking the following
medicines:

• medicine used to manage infections (ex. dapsone, sulfonamides, nitrofurantoin, para-aminosalicylic acid)
• medicine used to manage malaria (ex. chlorquine, primaquine, quinine)
• medicine used to manage fits(ex. phenytoin, sodium valproate, phenobarbital)
• medicines used to manage cancer (ex. cyclophosphamide, flutamide, rasburicase, ifosfamide, hydroxyurea)
• medicines used to relieve pain (ex. local anaesthetics like benzocaine, lidocaine, bupivacaine, mepivacaine, tetracaine, prilocaine, procaine, articaine, ropivacaine and general anaesthetics like nitrous oxide)
• medicines used to manage heart problems (ex. nitroglycerin)
• medicines used to manage high blood pressure (nitroprusside, nitric oxide)
• medicine used to manage fever (ex. acetaminophen)
• medicine used to manage nausea and vomiting (ex. metoclopramide)
• medicine used to manage inflammatory bowel disease(ex. sulfasalazine)

Overdosage:

If you or anyone else accidentally use too much of P COOL CREAM, consult your
doctor or visit the nearby hospital.

Synopsis

Drug	:	Calamine, Lignocaine(lidocaine), Phenylephrine
Pharmacological Category	:	Antipruritic, Anaesthetics, Sympathomimetic agents
Therapeutic Indication	:	Used in adults to relieve pain and bleeding associated with piles, anal fissures, and haemorrhoids
Dosage Forms	:	Cream

More Information

• Keep P COOL CREAM out of reach of children
• Store at room temperature. (Below 25 degrees Celsius)

FAQs About P COOL CREAM

Q: What is P COOL CREAM used for?

A: P COOL CREAM is used in adults to relieve pain and bleeding associated with
piles, anal fissures, and haemorrhoids. Piles (haemorrhoids) are tissue growth
in and around the anus due to the enlargement of veins in the lower anus or
rectum, which leads to discomfort such as pain, itching, blood in the stool,
discomfort when pooping, etc. An anal fissure is a tear or cracks in the lining
of the anus or anal canal with symptoms of severe pain while pooping, blood in
the poop, etc. consult a doctor before using P COOL CREAM.

Q: What are the possible side effects of using P COOL CREAM?

A: Possible side effects of P COOL CREAM are irritation, headache, rectal
bleeding, anxiety, skin dryness, etc. Consult your doctor if any of the symptoms
are worsening.

Q: How does P COOL CREAM work?

A: P COOL CREAM contains calamine, lignocaine (lidocaine), and phenylephrine.
Calamine relieves itching and soothes the skin. When applied to the skin, the
aqueous component of calamine lotion evaporates. The heat required for
evaporation is taken from the body, which gives a cooling effect at the site of
application.

Calamine has antibacterial properties, which help manage infections.
Phenylephrine is a decongestant that shrinks swollen blood vessels. Enlarged
blood vessels result in piles, so phenylephrine helps manage the symptoms of
burning, itching, and swelling associated with piles. Lidocaine blocks the pain
alerts from the nerves to the brain, thereby decreasing the feeling of pain.

Q: How to use P COOL CREAM?

A: Always use P COOL CREAM as directed by your physician. It is for external use
only. Do not use it on your eyes. Avoid contact with the eyes, nose, and mouth.
Take a small amount of P COOL CREAM in a fingercot. Slowly insert it inside the
anal opening and apply it through gentle rotation. You can also apply P COOL
CREAM with a penta applicator.

For that, remove the cap of the tube and insert the Penta applicator into the
tube. Insert this into the anal opening. Push the medicine from behind slowly.
Remove the applicator and clean it after separating it from the tube. Do not
share your applicator with anyone else. Your doctor will determine the required
dose and duration of P COOL CREAM for you as per your age and disease condition.

Q: What are the ingredients of P COOL CREAM?

A: P COOL CREAM contains 5% w/w calamine, 3% w/w lignocaine (lidocaine), 0.1%
w/w phenylephrine, and 0.1% w/w chlorocresol as ingredients.

Q: Can I use P COOL CREAM if I am pregnant?

A: P COOL CREAM should be used with caution if you are pregnant, especially in
early pregnancy where organogenesis (the development of organs in the baby)
takes place. Consult your doctor before using P COOL CREAM.

Useful Diagnostic Tests

• Digital rectal examination
• Blood examination
• Stool culture