Nitrest CR 12.5mg Tablet 10'S

Introduction About NITREST CR 12.5MG TABLET

NITREST CR 12.5MG TABLET contains Zolpidem, which belongs to the group of
medicines known as Hypnotics. It is used in the short-term management of
insomnia (sleeping disorder) in adults (above 18 years of age). The person with
insomnia problems may have difficulty in sleeping, staying awake, or staying
asleep, waking up too early etc.

NITREST CR 12.5MG TABLET is not recommended for use in patients who have or had
myasthenia gravis (muscle weakness), severe liver diseases, severe breathing
problems, sleep apnoea (serious breathing problem while sleeping), psychosis
(mental illness), somnambulism (sleepwalking) or abnormal behaviours after
taking hypnotic medication in past.

NITREST CR 12.5MG TABLET should be used with caution in patients suffering from
any heart problems which include irregular heartbeat, depression, or any other
mental illness, in patients suffering from kidney disease, and in patients who
have a history of alcohol and drug abuse.

NITREST CR 12.5MG TABLET is not recommended for use by pregnant and
breastfeeding women. NITREST CR 12.5MG TABLET is not recommended for use in
children below 18 years of age. NITREST CR 12.5MG TABLET should be used with
caution in elderly patients above age 65 years. The common side effects of
taking NITREST CR 12.5MG TABLET are impaired memory, hallucinations, sleeping
problems that might get worse, headache, nightmares, nausea, vomiting, feeling
drowsy during the day, etc. Consult your doctor immediately if any of your side
effects get worse or if you experience abnormal behaviour or develop suicidal
thoughts.

Uses Of NITREST CR 12.5MG TABLET

• Short-term management of Insomnia (sleeping disorder)

How NITREST CR 12.5MG TABLET Works

NITREST CR 12.5MG TABLET helps to manage insomnia. It works by increasing the
level of a chemical in the brain called GABA, which blocks or slows down the
activity of the brain to induce a calming effect.

How to use NITREST CR 12.5MG TABLET

Take NITREST CR 12.5MG TABLET as advised by your doctor. Do not crush or chew
the medicine while consuming it with water. Your doctor will decide the correct
dosage, and duration of the management for you depending on your age, body
weight and disease condition.

Side Effects Of NITREST CR 12.5MG TABLET

Common

• feeling sleepy, dizzy or drowsy
• headache and fatigue or agitation
• poor memory, strange behaviour
• hallucinations, nightmares, depression
• sleeping problems might get worse
• diarrhoea, nausea, vomiting
• abdominal pain
• back pain
• respiratory infections

Uncommon

• excessive sweating
• restlessness, aggressive behaviour, confusion, irritation
• euphoria
• sleepwalking
• lack of concentration, speech problems
• itching or skin rash
• tremor
• blurred vision or double vision
• muscle pain, muscle spasms, weak muscles, neck pain
• change in appetite
• burning or creeping on skin, tingling, pricking, burning sensation, numbness
• changes in liver function tests

Rare

• less awareness of surroundings
• falling injuries (in elderly patients)
• changes in sexual drive
• urticaria
• itchy skin
• visual impairment
• delusions
• cholestasis (a liver condition in which the flow of bile from the liver is stopped
• signs include jaundice, rash, fever, or dark-coloured urine
• infection or injury to liver signs includes skin, eyes discoloration, pain in the abdomen, bloating, severe itching, pale or bloody stools, weakness, nausea, loss of appetite
• changes  the way you walk

Stop taking NITREST CR 12.5MG TABLET and consult your doctor immediately in case
you experience any of the following:

• severe allergic reaction such as rash, itching, hives or urticaria, breathing difficulty and swallowing, swelling in throat, tongue, lips, and face

How To Manage Side Effects

Itchy skin:

Avoid taking hot showers as they can irritate the skin. Do not scratch the
affected area. Use sunscreen and protective clothing when going outdoors or use
unscented moisturizers to soothe and hydrate the skin. Contact your doctor if
the itching persists.

Headache:

Take rest and relax. Apply a pain-relieving balm on the head if needed. Contact
your doctor if your headache does not improve.

Dizziness or drowsiness:

Try to rest and relax. Get enough sleep. Avoid driving or operating machinery if
you feel drowsiness or dizziness. Avoid alcohol consum
dizziness or drowsiness. Contact your doctor if your dizziness or drowsiness
worsens.

Stomach pain:

Try to rest and relax. Eat small meals but take them frequently. Keep a heating
pad on your stomach. Contact your doctor if the stomach pain does not improve.

Diarrhoea:

Drink plenty of water or fruit juices to keep yourself hydrated. Don’t take any
medicine on your own to manage diarrhoea. Contact your doctor if the diarrhoea
gets worse.

Warning & Precautions

!### Pregnancy

NITREST CR 12.5MG TABLET is not recommended for use by pregnant women as it may
harm the development of the baby. Such birth defects include cleft lip, cleft
palate, reduced foetal movement and foetal heart rate variability, muscle
weakness, low body temperature (hypothermia), difficulty feeding and breathing
problems (respiratory depression). Consult your doctor before taking NITREST CR
12.5MG TABLET.

!### Breastfeeding

NITREST CR 12.5MG TABLET is not recommended for use by breastfeeding women as it
may pass through breast milk. Consult your doctor before taking NITREST CR
12.5MG TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if your feel dizzy, drowsy, sleepy,
confused, blurring of vision, or less alert after taking NITREST CR 12.5MG
TABLET. Consult your doctor for advice.

!### Alcohol

Do not consume alcohol while taking NITREST CR 12.5MG TABLET as it can cause
difficulty in breathing or walking, or put you in a very deep sleep. Consult
your doctor before taking NITREST CR 12.5MG TABLET.

!### Kidney

NITREST CR 12.5MG TABLET should be used with caution in patients suffering from
kidney disease. Consult your doctor before taking NITREST CR 12.5MG TABLET.

!### Liver

NITREST CR 12.5MG TABLET is not recommended for use in patients with severe
liver disease. Consult your doctor before taking NITREST CR 12.5MG TABLET.

!### Allergy

Do not take NITREST CR 12.5MG TABLET if you are allergic to Zopiclone or lactose
or other lactose other ingredients in the medicine.

!### Lungs

NITREST CR 12.5MG TABLET is not recommended for use in patients suffering from
sleep apnoea (severe breathing disorder in sleep) and in patients with severe
respiratory disorders or breathing difficulties. Consult your doctor before
taking NITREST CR 12.5MG TABLET.

!### Heart Disease

NITREST CR 12.5MG TABLET should be used with caution in patients suffering from
heart diseases including slow or uneven heartbeat. Consult your doctor before
taking NITREST CR 12.5MG TABLET.

Others

NITREST CR 12.5MG TABLET is not recommended for use if you have:

• myasthenia gravis (muscle weakness)
• mental illness or psychosis or depression

Before taking NITREST CR 12.5MG TABLET, inform your doctor if you have:

• depression and any other mental illness
• drug abuse
• plans to take a blood test to check liver function
• thoughts of harming or killing yourself
• fits

Use in paediatrics:

NITREST CR 12.5MG TABLET is not recommended for use in children below 18 years
of age. Consult your doctor before taking NITREST CR 12.5MG TABLET.

Use in geriatrics:

NITREST CR 12.5MG TABLET should be used with caution in patients more than 65
years of age. Consult your doctor before taking NITREST CR 12.5MG TABLET.

Interactions

A. Drug-Drug interactions:

Before taking NITREST CR 12.5MG TABLET, inform your doctor if you are taking any
of the following medicine:

• antipsychotics such as clozapine, haloperidol, and chlorpromazine (medicines used to manage mental illness)
• antidepressants such as sertraline, venlafaxine, fluoxetine, bupropion, and desipramine (medicines used to manage depression)
• antiepile
• anaesthetics (medicines used to cause numbness or awareness)
• chlorphenamine, and promethazine (medicines used to manage hay fever or allergies)
• medicines used to induce calm or reduce anxiety or for managing sleep problems (hypnotics) Ex. diazepam, alprazolam, etc
• St. John’s Wort (a medicine used to manage depression and mood swings)
• skeletal muscle relaxants Ex. baclofen (a medicine used to relax muscles)
• opioids such as codeine, methadone, tramadol, pethidine, oxycodone, and morphine (medicines used for severe pain and cough)
• rifampicin (a medicine used to manage tuberculosis)
• ketoconazole, and itraconazole (medicines used to manage fungal infections)
• clarithromycin, erythromycin, ciprofloxacin (medicines used to manage bacterial infections)
• ritonavir (medicines used to manage HIV infection)
• fluvoxamine (medicines used to manage obsessive-compulsive disorder)

Overdosage:

If you or anybody else accidentally take too much NITREST CR 12.5MG TABLET,
consult your doctor or visit the nearest hospital immediately. Symptoms of
overdose are drowsiness, confusion, sleeping deeply and possibly falling into a
coma.

Synopsis

Drug	:	Zolpidem
Pharmacological Category	:	Hypnotic
Therapeutic Indication	:	Manages Insomnia
Dosage Forms	:	Tablet

More Information

• Keep NITREST CR 12.5MG TABLET out of reach from children
• Store at room temperature below 25°C

FAQs About NITREST CR 12.5MG TABLET

Can I take NITREST CR 12.5MG TABLET every night?

Always take NITREST CR 12.5MG TABLET as recommended by your doctor. It can be
taken before going to bed. Your doctor will decide the correct dosage and
duration for you depending on your age, body weight, and severity of your
condition.

Can NITREST CR 12.5MG TABLET affect my blood test results?

Yes, NITREST CR 12.5MG TABLET can affect your blood sugar levels. Always inform
your doctor about the medication you are taking, before taking any blood tests.

Can NITREST CR 12.5MG TABLET induce abnormal behaviour and suicidal
thoughts?

Yes, NITREST CR 12.5MG TABLET can cause abnormal behaviour and develop suicidal
thoughts. Consult your doctor immediately if you develop any behavioural or
mental abnormalities.

What are the side effects caused by NITREST CR 12.5MG TABLET?

NITREST CR 12.5MG TABLET may cause some side effects such as poor memory,
hallucinations, sleeping problems might get worse, headaches, nightmares,
nausea, vomiting, feeling drowsy during the day etc. Consult your doctor
immediately if any of your side effects get worse.

Is NITREST CR 12.5MG TABLET a sleeping pill?

Yes, NITREST CR 12.5MG TABLET is used to induce sleep. It helps to manage
patients suffering from insomnia. However, consult your doctor before taking
NITREST CR 12.5MG TABLET.

Can NITREST CR 12.5MG TABLET cause memory loss?

Yes, NITREST CR 12.5MG TABLET may cause memory loss and difficulty to
concentrate. Contact your doctor if you get any symptoms.