NINTIB 150 Capsule 10's

Introduction About NINTIB 150 CAPSULE

NINTIB 150 CAPSULE contains Ninted
called Kinase inhibitors. It is used to manage idiopathic pulmonary fibrosis
(IPF), chronic fibrosing interstitial lung diseases (ILDs) with a progressive
phenotype, slowing the rate of decline in pulmonary function in patients with
systemic sclerosis-associated interstitial lung disease (SSc-ILD). It is used in
combination with docetaxel in adult patients for the management of locally
advanced metastatic or recurrent non-small cell lung cancer (NSCLC) of
adenocarcinoma tumor histology after first line chemotherapy.

Idiopathic Pulmonary Fibrosis (IPF) is a chronic lung disorder in which the
lungs become scarred and breathing becomes increasingly difficult. Symptoms
include shortness of breath, persistent dry cough, tiredness, loss of appetite,
weight loss, rounded and swollen fingertips (clubbed fingers).

Before taking NINTIB 150 CAPSULE inform your doctor if you have liver, heart or
bleeding problems, history of blood clots or had a recent surgery in stomach.
NINTIB 150 CAPSULE is not recommended for use in pregnant women unless advised
by your doctor and it is not recommended for use in breastfeeding women as it
may pass through breast milk. Before starting management with NINTIB 150
CAPSULE, your doctor may want you to take several blood tests to understand your
existing condition.

NINTIB 150 CAPSULE should be used with caution in elderly patients (aged 65
years and above). The most common side effects of taking NINTIB 150 CAPSULE are
diarrhoea, nausea, vomiting, stomach pain, loss of appetite, headache, weight
loss and high blood pressure. Consult your doctor if any of the symptom worsens.

Uses Of NINTIB 150 CAPSULE

• Manage idiopathic pulmonary fibrosis (IPF)
• Manage chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype
• To slow the rate of decline in pulmonary function in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD)

How NINTIB 150 CAPSULE Works

NINTIB 150 CAPSULE is a tyrosine kinase inhibitor (TKI) which works by blocking
the enzymes in cells of the lungs called tyrosine kinases. Blocking these
enzymes helps to decrease fibrous tissue formation in the lungs, thereby stops
the symptoms of lung disease getting worse.

How to use NINTIB 150 CAPSULE

Take NINTIB 150 CAPSULE as advised by your physician. Swallow the medicine with
a glass of water. Do not crush, chew, or open the medicine. Your doctor will
decide the correct dose and duration for you based upon your age, body weight
and disease condition. Do not stop taking NINTIB 150 CAPSULE unless your doctor
advises you to stop.

Side Effects Of NINTIB 150 CAPSULE

Common

• diarrhoea
• nausea, vomiting
• stomach pain
• liver problems
• decreased appetite
• headache
• weight loss
• high blood pressure

Rare

Stop taking NINTIB 150 CAPSULE and contact your doctor immediately if you
experience any of the following side effects:

• severe liver problems symptoms such as yellowing of your skin or white part of your eyes (jaundice), dark or brown (tea colored) urine, pain on the upper right side of your stomach area (abdomen), bleeding or bruising more easily than normal, feeling tired, or loss of appetite
• severe diarrhoea, nausea and vomiting
• signs of heart attack such as chest pain or pressure, pain in arms, back, neck or jaw, or shortness of breath
• signs of stroke such as numbness or weakness on one side of your body, trouble talking, headache or dizziness
• signs of bleeding problem such as unusual bleeding, bruising, or wounds that do not heal
• signs of tear in stomach or intestinal wall (perforation) such as pain or swelling in stomach area
• signs of increased protein in urine (proteinuria) such as foamy urine, swelling of the hands, arms, legs, or feet or sudden weight gain

How To Manage Side Effects

!### Diarrhea

Drink lot of fluids, such as water to keep yourself hydrated. Try to avoid
taking any medicine on your own to manage diarrhea and consult your doctor if
the symptom gets worse.

Headache

Drink ample amount of water. Get adequate rest. Try to be relaxed and stress
free. Do not strain your eyes by watching screen for long time. Apply pain
relieving balm on your forehead if necessary. Consult your doctor if the symptom
gets worse.

!### Loss Of Appetite

Eat when you are hungry. Eat smaller meals more often than usual. Snack only
when you're hungry. Eat a nutritious snack which is rich in calories and
protein, such as dried fruit and nuts. Consult your doctor if the symptom does
not improve.

!### Nausea And Vomiting

Try to take NINTIB 150 CAPSULE with or just after a meal or a snack. Stick to
simple meals. Avoid eating oily, fried or spicy foods. Consult your doctor if
the symptom gets worse.

!### Stomach Pain

Try to rest and relax. Eat and drink slowly or try to have smaller meals more
frequently. Keep a heat pad on your stomach. If the stomach pain does not
improve, consult your doctor.

Warning & Precautions

!### Pregnancy

Monitoring requiredNINTIB 150 CAPSULE is not recommended for use in pregnant women unless
considered clearly necessary. Consult your doctor before taking it.

!### Breastfeeding

ContraindicatedNINTIB 150 CAPSULE is not recommended for use in breastfeeding women as it may
pass through breast milk. Consult your doctor before taking it.

!### Liver

Use with CautionNINTIB 150 CAPSULE should be taken with caution in patients with liver problems.
Consult your doctor before taking it.

!### Allergy

ContraindicatedDo not take NINTIB 150 CAPSULE if you are allergic to Ninted
other ingredients of this medicine.

!### Heart Disease

Use with CautionNINTIB 150 CAPSULE should be taken with caution in patients with heart problems.
Consult your doctor before taking it.

!### Use In Pediatrics

Consult your doctorThere is no proper information regarding the use of this medicine in children.
Consult child’s doctor for advice

!### Use In Geriatrics

Use with CautionNINTIB 150 CAPSULE should be used with caution in elderly patients (aged 65
years and above). Consult your doctor before taking NINTIB 150 CAPSULE.

Others

Before taking NINTIB 150 CAPSULE inform your doctor if you:

• have history of blood clots
• have bleeding problem or a family history of bleeding problem
• had recent surgery in stomach (abdominal) area
• are a smoker

Interactions

A. Drug - Drug interactions:

Before taking NINTIB 150 CAPSULE inform your doctor if you are taking any of the
following medicines:

• st. john’s wort (used to manage depression)
• laxatives such as bisacodyl, stool softeners such as lactulose (used to manage constipation)
• other medicines or dietary supplements (used to manage diarrhoea)
• blood thinners such as warfarin (used to manage or manage blood clots)
• aspirin (used to manage fever and pain)

Overdosage:

If you or anyone else accidentally take too much of NINTIB 150 CAPSULE, consult
your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Ninted
Pharmacological Category	:	Tyrosine Kinase Inhibitor
Therapeutic Indication	:	Idiopathic pulmonary fibrosis (IPF), Chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype, slows the rate of decline in pulmonary function in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD)
Dosage Forms	:	Capsule

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More Information

• Keep NINTIB 150 CAPSULE out of reach of children
• Store at room temperature

FAQs About NINTIB 150 CAPSULE

Q: Can I take NINTIB 150 CAPSULE during pregnancy?

A: NINTIB 150 CAPSULE is not recommended for use in pregnant women unless
clearly advised by your doctor. Consult your doctor before taking NINTIB 150
CAPSULE if you are pregnant or planning to get pregnant.

Q: What to do If I forget to take a dose of NINTIB 150 CAPSULE?

A: You should take NINTIB 150 CAPSULE immediately when you remember. If it is
time for your next dose skip the missed dose and follow your regular dose
schedule. Do not double the dose to match up your missed dose.

Q: Can I stop taking NINTIB 150 CAPSULE on my own?

A: Do not stop taking NINTIB 150 CAPSULE unless your doctor advises you to stop.
Remember that it works to slow the decline in lung function only for as long as
you keep taking it. If you stop taking NINTIB 150 CAPSULE suddenly it worsens
the lung function and increases the risk of life-threatening complications.

Q: What are the common side effects of NINTIB 150 CAPSULE?

A: The common side effects of taking NINTIB 150 CAPSULE are diarrhoea, nausea,
vomiting, stomach pain, loss of appetite, headache, weight loss, altered liver
enzymes and high blood pressure. Consult your doctor if any of the side effect
worsens.

Q: IsNINTIB 150 CAPSULE safe to use in patients with liver disease?

A: NINTIB 150 CAPSULE should be taken with caution in patients with liver
problems. Your doctor may monitor your liver function before and during
management with NINTIB 150 CAPSULE to assess the risk of liver damage or any
unusual effects. Consult your doctor before taking NINTIB 150 CAPSULE.

Useful Diagnostic Tests

• Liver function tests
• Pulmonary function tests