LOXISTAL P Tablet 10's

Introduction About LOXISTAL P TABLET

LOXISTAL P TABLET is a combination of Lornoxicam and Paracetamol which belongs
to the group of medicines called Non-steroidal anti-inflammatory drugs and
Analgesics, respectively. It is used to manage mild to moderate joint pain and
provides relief from inflammation of joints caused by certain types of rheumatic
diseases (autoimmune and inflammatory disease) in affected individuals.

LOXISTAL P TABLET is not recommended for use in patients allergic to Lornoxicam,
Paracetamol, other NSAIDs including acetylsalicylic acid. It is also not
recommended for use in patients suffering from thrombocytopenia (low blood
platelet count that causes increased risk of bleeding/unusual bruising),
gastrointestinal bleeding, rupture and bleeding of blood vessel in brain/other
bleeding disorders. The medicine is also not indicated for use in patients
suffering from active pe
and/or in patients with severe heart/liver/kidney problems.

LOXISTAL P TABLET is not recommended for use in pregnant women especially in
first 6 months and last 3 months of pregnancy. It is also not recommended for
use in breastfeeding women unless it is clearly necessary. LOXISTAL P TABLET is
not recommended for use in children and adolescents (aged below 18 years) which
is advised to be used with caution in elderly patients (aged 60 years and above)
after consulting the doctor. The most common side effects of taking LOXISTAL P
TABLET are mild headache, dizziness, abdominal pain, upset stomach, nausea,
vomiting, and/or diarrhea. Consult your doctor if any of these symptoms worsens.

Uses Of LOXISTAL P TABLET

• Manage mild to moderate joint pain
• Provides relief from inflammation of joints caused by certain types of rheumatic diseases (autoimmune and inflammatory disease) in affected individuals

How LOXISTAL P TABLET Works

LOXISTAL P TABLET provides relief from pain and inflammation from rheumatic
diseases where Lornoxicam and Paracetamol works by blocking the production of
certain chemical messengers in the body that cause inflammation and pain thus
managing and providing relief from acute pain and inflammation caused by certain
rheumatic diseases in affected individuals.

How to use LOXISTAL P TABLET

Take LOXISTAL P TABLET as advised by your physician. Swallow the medicine with a
glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose and duration for you depending upon your age, body weight and
disease condition.

Side Effects Of LOXISTAL P TABLET

Common

• Mild headache and dizziness
• Abdominal pain, upset stomach, nausea, vomiting, diarrhoea

Uncommon

• Weight loss
• Inability to sleep, depression
• Eye discharge, ringing in ears
• Cardiac failure, irregular heartbeat, rapid heart rate
• Feeling blushed
• Constipation, excessive wind, belching, dry mouth, gastritis (inflammation in stomach), pe
• Feeling unwell
• Rash, itching, redness of skin, red itchy welts
• Increased sweating
• Signs of angioedema such a rapid swelling on the face
• Oedema (swelling due to water retention)
• Stuffy nose due to rhinitis
• Hair loss
• Pain in the joints

Rare

• Sore throat
• Anaemia, weakness
• Signs of hypersensitivity reactions such as anaphylactoid reaction (anaphylaxis) associated with facial swelling, flushing, troubled breathing, and/or light-headedness
• Confusion, nervousness, agitation, sleepiness, paraesthesia (tingling sensations), tremors, migraine
• Abnormal sensation of taste
• Visual disturbances
• High blood pressure
• Hot flushing
• Abnormal bleeding/bruising, prolonged bleeding time
• Difficulty in breathing, cough, bronchospasm (constriction of lung muscles)
• Perforated ulcers, blood in vomit, gastrointestinal bleeding, black tarry stools
• Inflammation in the mouth, aphthous stomatitis (ulcers in mouth), oesophagitis (inflammation of the gullet), gastro-oesophageal reflux
• Difficulty in swallowing, inflammation of the tongue
• Bone pain, muscle cramp, muscle pain
• Urinary problems such as nocturnia (increased urination in the night)

Stop taking LOXISTAL P TABLET and contact your doctor if you experience any of
the following side effects:

• Shortness of breath, chest pain, and/or ankle swelling
• Severe/continuous stomach pain/black stools
• Signs of liver problems such as yellowing of skin and eyes (jaundice)
• Signs of allergic reaction such as skin problems (ulcers/blistering), swelling of face, lips, tongue/throat, and/or difficulty in breathing
• Signs of Stevens-Johnson syndrome (serious disorder of skin) such as fever, blistering eru
• Serious infections of skin such as chickenpox
• Signs of allergic reaction such as itchy, lumpy/nettle rash, swelling of hands, feet, ankles, face, lips, and/or throat which may cause difficulty in swallowing/breathing

How To Manage Side Effects

!### Diarrhea

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on
your own to manage diarrhea. Consult and inform your doctor if the symptom
worsens.

!### Dizziness Or Drowsiness

Try to rest and get enough sleep. Try to avoid driving or operating any tools or
machines while you feel dizzy. Limit consum
dizziness. Consult and inform your doctor if the symptom worsens.

Headache

If LOXISTAL P TABLET causes headache, then take rest and drink plenty of fluids.
Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller.
Headaches should usually go away after the first week of taking LOXISTAL P
TABLET. If it lasts more than a week or becomes severe, then consult and inform
your doctor.

!### Nausea And Vomiting

Take LOXISTAL P TABLET with/just after a meal. Stick to simple meals. Avoid
eating oil rich/spicy foods, sugary snacks and drinks. Avoid drinking too much
liquid along with your meals, and drink slowly in between meals. Consult your
doctor if the condition worsens.

Warning & Precautions

!### Pregnancy

ContraindicatedLOXISTAL P TABLET is not recommended for use in pregnant women especially in
first 6 months and last 3 months of pregnancy. It is also not recommended for
use in women planning for pregnancy. Consult your doctor before taking the
medicine.

!### Breastfeeding

Monitoring requiredLOXISTAL P TABLET is not recommended for use in breastfeeding women unless it is
clearly necessary. Consult your doctor before taking the medicine.

!### Driving and Using Machines

Use with CautionLOXISTAL P TABLET is unlikely to affect your ability to drive or operate
machines. Consult your doctor before taking the medicine.

!### Alcohol

Consult your doctorAvoid consum
increase risk of side effects.

!### Kidney

ContraindicatedLOXISTAL P TABLET is not recommended for use in patients with kidney problems
such as severe kidney impairment. Consult your doctor before taking the
medicine.

!### Liver

ContraindicatedLOXISTAL P TABLET is not recommended for use in patients with liver problems
such as severe liver impairment. Consult your doctor before taking the medicine.

!### Allergy

ContraindicatedDo not take LOXISTAL P TABLET if you are allergic to Lornoxicam, Paracetamol,
other NSAIDs including acetylsalicylic acid, and/or any other ingredients of
this medicine.

!### Lungs

Use with CautionLOXISTAL P TABLET should be used with caution in patients with history of
asthma. Consult your doctor before taking the medicine.

!### Heart Disease

ContraindicatedLOXISTAL P TABLET is not recommended for use in patients with heart problems
such as severe heart failure. Consult your doctor before taking the medicine.

!### Use In Pediatrics

ContraindicatedLOXISTAL P TABLET is not recommended for use in children and adolescents (aged
below 18 years). Consult your doctor before administering the medicine.

!### Use In Geriatrics

Use with CautionLOXISTAL P TABLET should be used with caution in elderly patients (aged 60 years
and above). Consult your doctor before taking the medicine.

Others

LOXISTAL P TABLET is not recommended for use if you:

• Suffer from thrombocytopenia (low blood platelet count that causes increased risk of bleeding/unusual bruising)
• Suffer from gastrointestinal bleeding, rupture and bleeding of a blood vessel in the brain, and/or other bleeding disorders
• Suffer from active pe

Before taking LOXISTAL P TABLET, inform your doctor if you:

• Have a history of high blood pressure/heart failure
• Suffer from ulcerative colitis/Crohn’s disease (inflammatory bowel disease)
• Have a history of bleeding tendency
• Have SLE (lupus erythematosus which is a rare immunological disease)
• Suffer from blood coagulation disorder
• Have a history of stroke
• Are at a risk of developing high blood pressure, diabetes, high cholesterol
• Are a smoker

Interactions

A. Drug-Drug Interactions:

Before taking LOXISTAL P TABLET, inform your doctor, if you are taking any of
the following medicine:

• Other NSAIDs (medicines used to manage inflammation) such as COX-2 inhibitors (Ex celecoxib), acetylsalicylic acid/aspirin, ibuprofen
• Cimetidine (medicine used in the management of heartburn and pe
• Anticoagulants (medicines used to manage the formation of blood clots) Ex. heparin, phenprocoumon, warfarin
• Corticosteroids (medicines used to manage pain and inflammation) Ex. dexamethasone
• Methotrexate (medicine used to manage cancer and immunological diseases)
• Lithium (medicine used to manage depression or mood disorders)
• Immunosuppresive agents (medicines used to suppress the immune responses of the body) ciclosporine, tacrolimus
• Medicines used to manage heart problems Ex. digoxin, ACE-inhibitors (captopril), beta-adrenergic blockers (atenolol)
• Diuretics (medicines used to lower blood pressure) Ex. furosemide
• Quinolone antibiotics (medicines used to manage bacterial infections)  Ex. ciprofloxacin
• Anti-platelet agents (medicines used to manage heart attacks and strokes) Ex. clopidogrel, ticagrelor
• Selective Serotonin Reuptake Inhibitors (medicines used to manage depression) Ex. citalopram
• Sulphonylureas (medicines used to manage diabetes) Ex. glibenclamide
• Inducers and inhibitors of CYP2C9-isoenzymes Ex. rifampicin, fluconazole
• Angiotensin II receptor blocker (medicines used to manage high blood pressure, diabetes induced kidney damage, and congestive heart failure) Ex. telmisartan
• Pemetrexed (medicine used to manage certain forms of lung cancer)
• Flucloxacillin (medicine used to manage certain bacterial infections)
• Metoclopramide, domperidone (medicines used to manage nausea and vomiting)
• Colestyramine (medicines used to manage raised cholesterol levels in blood)

B. Drug-Food Interactions:

Avoid taking LOXISTAL P TABLET along with food since it may reduce effectiveness
of the medicine.

Overdosage:

If you or anyone else accidentally takes too much of LOXISTAL P TABLET, consult
your doctor immediately or visit nearby hospital. Symptoms of overdose are
nausea, vomiting, dizziness, disturbed vision, and/or serious liver damage.

Synopsis

Drug	:	Lornoxicam, Paracetamol
Pharmacological Category	:	Non-steroidal anti-inflammatory drug, Analgesics
Therapeutic Indication	:	Joint pain, Inflammation (due to rheumatic disease)
Dosage Forms	:	Tablet

More Information

Storage

• Keep LOXISTAL P TABLET out of reach in children
• Do not store LOXISTAL P TABLET above 30°C

FAQs About LOXISTAL P TABLET

Q: What LOXISTAL P TABLET is used for?

A: LOXISTAL P TABLET is used to manage mild to moderate joint pain which also
provides relief from inflammation of joints caused by certain types of rheumatic
diseases (autoimmune and inflammatory disease) in affected individuals.

Q: What happens if you take more LOXISTAL P TABLET than your required dose?

A: If you or anyone else accidentally takes too much of LOXISTAL P TABLET,
consult your doctor immediately or visit nearby hospital. Symptoms of overdose
are nausea, vomiting, dizziness, disturbed vision, and/or serious liver damage.

Q: What are the side effects of LOXISTAL P TABLET?

A: The most common side effects of taking LOXISTAL P TABLET are mild headache,
dizziness, abdominal pain, upset stomach, nausea, vomiting, and/or diarrhea.
Consult your doctor if any of these symptoms worsens.

Q: Is it safe to drink alcohol while taking LOXISTAL P TABLET?

A: Avoid consum
increase the risk of side effects. Before taking this medicine, inform your
doctor if you have chronic alcoholism.

Q: How LOXISTAL P TABLET works?

A: LOXISTAL P TABLET provides relief from pain and inflammation from rheumatic
diseases where Lornoxicam and Paracetamol works by blocking the production of
certain chemical messengers in the body that cause inflammation and pain thus
managing and providing relief from acute pain and inflammation caused by certain
rheumatic diseases in affected individuals.

Useful Diagnostic Tests

• Complete blood count
• C-reactive protein
• Erythrocyte sedimentation rate (ESR)