LEFDAY 10 Tablet 10's

Introduction About LEFDAY 10 TABLET

LEFDAY 10 TABLET contains Leflunomide which belongs to the group of medicines
called Anti-rheumatics. It is used for the management of active rheumatoid
arthritis or with active psoriatic arthritis. Rheumatoid arthritis is an
auto-immune chronic inflammatory disorder which affects many joints including
those in the hands and feet. Symptoms include inflammation of joints, swelling,
difficulty moving and pain, loss of appetite, fever, loss of energy and anaemia
(lack of red blood cells). Active psoriatic arthritis refers to a condition
where psoriasis, a skin condition is present along with arthritis. Symptoms
include inflammation of joints, swelling, difficulty in moving, pain and patches
of red and scaly skin (skin lesions).

Before starting management with LEFDAY 10 TABLET, your doctor might ask you to
take a few blood tests to understand the existing condition and to use this
medicine safely. LEFDAY 10 TABLET is not recommended for use in patients having
liver or moderate to severe kidney disease, any problem which affects the immune
system (like AIDS), bone marrow problems, serious infections, severely low
levels of proteins in the blood (hypoproteinaemia) and reduced levels of white
or red blood cells and platelet count. LEFDAY 10 TABLET should be used with
caution in patients who have interstitial lung disease, tuberculosis or if you
are a male who wishes to father a child and chronic diarrhoea. Avoid consum
of alcohol during management with this medicine as it may increase the risk of
liver damage.

LEFDAY 10 TABLET is not recommended for use in pregnant women or women who
become pregnant during management with this medicine and it is not recommended
for use in breastfeeding women. LEFDAY 10 TABLET is not recommended for use in
children and adolescents (below 18 years of age). The most common side effects
of taking LEFDAY 10 TABLET are loss of appetite, tiredness, headache, dizziness,
diarrhoea, nausea, vomiting, inflammation of the mouth or mouth ulcers,
abdominal pain and increased hair loss. Consult your doctor if any of the side
effects worsen.

Uses Of LEFDAY 10 TABLET

It is used to manage:

• active rheumatoid arthritis
• active psoriatic arthritis

How LEFDAY 10 TABLET Works

LEFDAY 10 TABLET acts by inhibiting an enzyme which results in stopping the
activated and autoimmune white blood cells. This inhibition leads to
anti-inflammatory and immunomodulatory effects, reducing inflammation due to
arthritis.

How to use LEFDAY 10 TABLET

Take LEFDAY 10 TABLET as advised by your doctor. Swallow the medicine with a
glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose and duration for you depending upon your age, body weight and
disease condition.

Side Effects Of LEFDAY 10 TABLET

Common

• mild allergic reactions
• loss of appetite
• weight loss
• tiredness
• headache
• dizziness
• abnormal skin sensations like tingling (paraesthesia)
• mild increase in blood pressure
• diarrhoea
• inflammation of the colon
• nausea
• vomiting
• mouth ulcers or swelling of the mouth
• abdominal pain
• increased hair loss
• eczema, dry skin, rash, itching
• tendonitis (pain in feet or hands caused by inflammation in the membrane surrounding the tendons)
• problems affecting the nerves of the arms or legs

Uncommon

• anxiety
• taste disturbances
• urticaria (nettle rash)
• tendon rupture

Rare

• severe increase in blood pressure
• inflammation of the lung (interstitial lung disease)
• hepatitis and jaundice (yellowing of the skin or white of the eyes)
• sepsis (severe infection)

Stop taking LEFDAY 10 TABLET and contact your doctor immediately if you
experience any of the following side effects:

• serious allergic reaction (signs include weakness, light-headedness or dizziness or have difficulty breathing)
• skin rash and ulcers in the mouth (Drug Reaction with Eosinophilia and Systematic Symptoms (DRESS), stevens-johnson syndrome and toxic epidermal necrolysis)
• blood disorders (signs include pale skin, tiredness, bruising)
• signs of liver failure (signs include tiredness, abdominal pain and jaundice)
• signs of infection (signs include cough, fever and sore throat)
• coughing or breathing problems (signs include interstitial lung disease or pulmonary hypertension)
• signs of peripheral neuropathy (unusual tingling, weakness or pain in the hands or feet)

How To Manage Side Effects

!### Diarrhea

Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating
high-fat or spicy foods. Try to avoid taking any medicine on your own to manage
diarrhoea and consult your doctor if the symptom gets worse.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to
be relaxed and stress-free. Apply pain relieving balm on your forehead if
necessary. Consult your doctor if the symptom does not improve.

!### Loss Of Appetite

Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only
when you're hungry. Eat a nutritious snack which is rich in calories and
protein, such as dried fruits and nuts. Consult your doctor if the symptom does
not improve.

!### Nausea And Vomiting

Stick to simple meals while taking this medicine. Avoid eating oily rich, fried
or spicy foods. Do not lie down or sleep immediately after eating. Consult your
doctor if the symptom does not improve.

!### Stomach Pain

Try to rest and relax. Eat and drink slowly or try to have smaller meals more
frequently. Keep a heating pad on your stomach. If the symptom does not improve,
consult your doctor.

Warning & Precautions

!### Pregnancy

ContraindicatedLEFDAY 10 TABLET is not recommended for use in pregnant women or women who
become pregnant during management with this medicine, as it may increase the
risk of serious birth defects in the baby. Women of childbearing potential
should not take LEFDAY 10 TABLET without using reliable contrace
If you plan to become pregnant after stopping management with this medicine and
it is necessary to ensure that all traces of the medicine have left your body,
this may take up to 2 years. Consult your doctor before taking LEFDAY 10 TABLET.

!### Breastfeeding

ContraindicatedLEFDAY 10 TABLET is not recommended for use in breastfeeding women as it passes
through the breast milk. Consult your doctor before taking LEFDAY 10 TABLET.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you feel dizzy after taking LEFDAY 10
TABLET.

!### Alcohol

Consult your doctorAvoid consum
the chances of liver damage.

!### Kidney

ContraindicatedLEFDAY 10 TABLET is not recommended for use in patients with moderate to severe
kidney problems. Consult your doctor before taking LEFDAY 10 TABLET.

!### Liver

ContraindicatedLEFDAY 10 TABLET is not recommended for use in patients with any liver problems.
Consult your doctor before taking LEFDAY 10 TABLET.

!### Allergy

ContraindicatedDo not take LEFDAY 10 TABLET if you are allergic to Leflunomide or any other
ingredients of this medicine.

!### Lungs

Use with CautionLEFDAY 10 TABLET should be used with caution in patients who have suffered with
interstitial lung disease or if you ever had tuberculosis. Consult your doctor
before taking LEFDAY 10 TABLET.

!### Use In Pediatrics

ContraindicatedLEFDAY 10 TABLET is not recommended for use in children and adolescents (below
18 years of age). Consult your child’s doctor for advice.

Others

LEFDAY 10 TABLET is not recommended for use if you:

• have any problem which affects the immune system (like AIDS)
• have bone marrow problems or reduced white blood or red blood cells and platelets
• have serious infections
• have hypoproteinaemia (severely low levels of proteins in the blood)

Before taking LEFDAY 10 TABLET, inform your doctor if you:

• are a male who wishes to father a child
• are due to have a specific blood test (calcium test)
• unexplained chronic diarrhoea

Interactions

A. Drug-Drug Interactions:

Before taking LEFDAY 10 TABLET, inform your doctor if you are taking any of the
following medicines:

• other medicines for rheumatoid arthritis (Ex. sulfasalazine), antimalarials (Ex. chloroquine and hydroxychloroquine), intramuscular or oral gold, D-penicillamine
• medicines used as immunosuppressants (Ex. azathioprine, methotrexate)
• medicines used as blood thinners (Ex. warfarin)
• medicines used to manage multiple sclerosis (Ex. teriflunomide)
• medicines used for the management of diabetes (repaglinide, pioglitazone, nateglinide, rosiglitazone)
• medicines used in the management of cancer (daunorubicin, doxorubicin, paclitaxel, topotecan)
• medicine used for depression, urinary incontinence or in kidney disease in diabetics (Ex. duloxetine)
• medicines used for the management of severe diarrhoea (Ex alosetron)
• medicines used to manage asthma (Ex. theophylline)
• medicines used as a muscle relaxant (Ex. tiz
• oral contrace
• medicines used for infections (Ex. cefaclor, benzylpenicillin, ciprofloxacin)
• medicines used for the management of pain or inflammation (Ex. indomethacin, ketoprofen)
• diuretics for heart disease (Ex. furosemide)
• medicines used in the management of HIV infection (Ex. zidovudine)
• medicines used in the management of high cholesterol (Ex. rosuvastatin, simvastatin, atorvastatin, colestyramine, pravastatin)
• activated charcoal (used to manage certain kinds of poisoning)

Overdosage:

If you or anyone else accidentally takes too much of LEFDAY 10 TABLET, consult
your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Leflunomide
Pharmacological Category	:	Disease-Modifying Antirheumatic Drug (DMARD)
Therapeutic Indication	:	Rheumatoid Arthritis, Active psoriatic arthritis
Dosage Forms	:	Tablet

More Information

Storage

• Keep LEFDAY 10 TABLET out of reach of children
• Store at room temperature

FAQs About LEFDAY 10 TABLET

Q: What is LEFDAY 10 TABLET and why it is given?

A: LEFDAY 10 TABLET contains Leflunomide which belongs to the group of medicines
called Anti-rheumatic medicines. It is used to manage active rheumatoid
arthritis and active psoriatic arthritis. Consult your doctor before taking
LEFDAY 10 TABLET.

Q: What type of drug is LEFDAY 10 TABLET?

A: LEFDAY 10 TABLET has leflunomide as the active agent which is a
disease-modifying antirheumatic drug (DMARDs). It acts by slowing the
progression of the condition and decreasing the inflammation which aids in
improving the physical activity of the people affected with rheumatoid
arthritis.

Q: Can LEFDAY 10 TABLET be taken by pregnant women?

A: LEFDAY 10 TABLET is not recommended for use in pregnant women or women who
become pregnant during management with this medicine, as it may increase the
risk of serious birth defects in the baby. Women of childbearing potential
should not take LEFDAY 10 TABLET without using reliable contrace
If you plan to become pregnant after stopping management with this medicine and
it is necessary to ensure that all traces of the medicine have left your body,
this may take up to 2 years. Consult your doctor before taking LEFDAY 10 TABLET.

Q: Does LEFDAY 10 TABLET affects the liver?

A: LEFDAY 10 TABLET is not recommended for use in patients who have liver
diseases. Inform your doctor if you notice any signs of liver injury (which
includes itching, yellowing of eyes or skin, loss of appetite, dark urine or
light-coloured stools). Your doctor may monitor your liver function test before
and during management with LEFDAY 10 TABLET to manage the risk of liver damage.
Consult your doctor before taking LEFDAY 10 TABLET.

Q: Does LEFDAY 10 TABLET has any effect on male fertility?

A: LEFDAY 10 TABLET should be used with caution in a male who wishes to father a
child because it may pass into the semen. Effective contrace
exercised while on the course of LEFDAY 10 TABLET. If you wish to father a child
and you are taking LEFDAY 10 TABLET, ask for your doctor’s advice as he may
advise you to stop taking this medicine and take certain medications to remove
this medicine rapidly from the body. Consult your doctor for advice.

Useful Diagnostic Tests

• X-rays
• Complete Blood Count
• Liver Function Test
• Kidney Function Test