Joxate O Tablet 10'S

Introduction About JOXATE O TABLET

JOXATE O TABLET is a combination of Flavoxate and Ofloxacin which belongs to the
group of medicines called Antispasmodics and Antibiotics respectively. JOXATE O
TABLET is used to manage or manage urinary tract infections (UTI) and associated
problems such as regulating frequency and control of urination in the urinary
bladder, prostate gland, urethra and ureter infection.

Urinary tract infection (UTI) is an infection in any part of the urinary system,
the bladder, kidneys or urethra. It is more common in women and generally occurs
in the bladder or urethra, but more serious infections involve the kidney. A
bladder infection may cause increased urge to urinate, blood in the urine, pain
with urination and pelvic pain. A kidney infection may cause back pain, fever,
nausea and vomiting.

Before taking JOXATE O TABLET, inform your doctor if you have gastrointestinal
disease, gastrointestinal bleeding, muscular inability to swallow, urinary
retention, myasthenia gravis, glaucoma, epilepsy or tendonitis.

JOXATE O TABLET is not recommended to use among pregnant and breastfeeding
women. This medicine is not suitable for use in children and adolescents (under
18 years of age). JOXATE O TABLET should be used with caution in elderly
patients (aged above 60 years).

The most common side effect of JOXATE O TABLET is nausea. Consult your doctor if
the side effect worsens over the time.

Uses Of JOXATE O TABLET

• Manage urinary tract infections (UTIs) and associated urinary incontinence problems

How JOXATE O TABLET Works

JOXATE O TABLET contains flavoxate and ofloxacin. Flavoxate is an antispasmodic
that works by relaxing muscles of the urinary bladder and managing frequent,
urgent or uncontrolled urination and relieving the associated pain. Ofloxacin is
an antibiotic that acts by killing the bacteria by managing them from
reproducing and repairing themselves.

How to use JOXATE O TABLET

Take JOXATE O TABLET as advised by your physician. Swallow JOXATE O TABLET with
a glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose and duration of JOXATE O TABLET for you depending upon your age,
body weight and disease condition.

Side Effects Of JOXATE O TABLET

Common

• nausea

Uncommon

• sleepiness
• visual impairment
• vomiting, dry mouth, gastric pain and upset stomach (dyspepsia)
• nausea, vomiting, diarrhea or stomach pain
• irritated or burning eyes
• headache, sleep disturbances including difficulty sleeping (insomnia)
• feeling dizzy, having spinning sensations
• agitation, feeling restless
• cough and inflamed sore nose or throat (nasopharyngitis)
• skin rash or itching

Rare

• loss of appetite
• fast heartbeat
• drowsiness
• feeling confused or anxious, seeing, feeling, nightmares or hearing things that are not there, mental illness and depression
• alter in or loss of sense of taste or smell
• shortness of breath or wheezing
• excessive hot flushes and sweating
• lightheadedness or fainting, which may be due to low blood pressure
• rash with pimple
• urinary retention
• fatigue

Stop taking JOXATE O TABLET and contact your doctor immediately if you
experience any of the following side effects:

• severe allergic reactions (such as severe skin rash, swelling of the face, lips, mouth, tongue or throat (angioedema), anaphylactic shock (such as sudden wheezing, swelling of your lips, tongue and throat or body, rash, fainting or difficulties in swallowing
• severe skin rash or allergic reaction
• severe diarrhea (which may be bloody) with stomach pain and fever
• tenderness, pain or restricted movement of the tendons
• blurred, double or altered colour vision
• aortic aneurysm and dissection (symptoms like sudden, severe pain in the abdomen, chest, or back)
• experiencing a rapid onset of shortness of breath, especially when lying down flat in the bed or noticing swelling of ankles, feet or abdomen or new onset of heart palpitations (sensation of rapid or irregular heartbeat)
• sign of pain or inflammation of a tendon (symptoms like ankle, wrist, elbow, shoulder or knee)
• experience symptoms of nerve damage (neuropathy) such as burning, pain, numbness, tingling and/or weakness especially in the feet and legs or hands and arm

How To Manage Side Effects

Nausea or vomiting:

Try to take JOXATE O TABLET with or just after a meal or a snack. Stick to
simple meals. Avoid eating oil rich or spicy food. Consult your doctor if the
symptom gets worse.

Diarrhea:

Drink lot of fluids such as water to keep yourself hydrated. Try to avoid taking
any medicine on your own to manage diarrhoea and consult your doctor if the
symptom gets worse.

Headache:

Take rest and drink plenty of water. Avoid taking alcohol and skipping meals. Do
not strain your eyes by watching screen for long time. Consult your doctor if
the symptom persists for long or gets worsened.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller and frequent
meals. Keep a heating pad on your stomach. If the symptom does not improve,
contact your doctor.

Loss of appetite:

Eat when you are hungry. Eat smaller meals more often than usual. Snack only
when you're hungry. Eat a nutritious snack that is rich in calories and protein
such as dried fruit and nuts.

Warning & Precautions

!### Pregnancy

JOXATE O TABLET is not recommended for use in pregnant women. Consult your
doctor before taking JOXATE O TABLET.

!### Breastfeeding

JOXATE O TABLET is not recommended for use in breastfeeding women. Consult your
doctor before taking JOXATE O TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if you experience sleepiness, dizziness or
blurred vision after taking JOXATE O TABLET.

!### Alcohol

Avoid consum

!### Kidney

JOXATE O TABLET should be used with caution if you have any kidney problems or
impaired kidney function. Consult your doctor before taking JOXATE O TABLET.

!### Liver

JOXATE O TABLET should be used with caution if you have any liver problems.
Consult your doctor before taking JOXATE O TABLET.

!### Allergy

Do not take JOXATE O TABLET if you are allergic to Flavoxate or Ofloxacin.

!### Heart Disease

JOXATE O TABLET should be used with caution in patients with heart disease,
endocarditis (an infection of the heart) leaking heart valves (heart valve
regurgitation), irregular heartbeat, weak heart (heart failure), history of
heart attack and family history of aortic aneurysm or aortic dissection or
congenital heart valve disease and prolonged QT interval. Consult your doctor
before taking JOXATE O TABLET.

Others

JOXATE O TABLET is not recommended for use if you:

• have a gastrointestinal disease that affects the normal passage of food (obstruction)
• have a gastro-intestinal bleeding
• have a muscular inability to swallow (achalasia)
• are not able to completely empty your bladder (urinary retention)
• have glaucoma
• myasthenia gravis (disease which causes general weakness and fatigability of the muscles)
• suffer from epilepsy or are at risk of fits
• have a history of inflammation and swelling of the tendons (tendonitis) (after management with a quinolone antibiotic such as ciprofloxacin or norfloxacin)
• have a family history of glucose-6-phosphate dehydrogenase deficiency

Before taking JOXATE O TABLET, inform your doctor if you:

• have aortic aneurysm or large vessel peripheral aneurysm(enlargement or bulge of a large blood vessel)
• experienced a previous episode of aortic dissection (a tear in the aorta wall)
• connective tissue disorders (Marfan syndrome or Ehlers- Danlos syndrome, Turner syndrome)
• Sjogren’s syndrome (an inflammatory autoimmune disease)
• vascular disorders (such as takayasu arteritis, giant cell arteritis)
• high blood pressure or atherosclerosis
• rheumatoid arthritis (disease of the joints)
• ever had a history of mental illness
• salt imbalance in the blood (particularly low levels of potassium or magnesium in the blood)
• are diabetic or suffer from low blood sugar

Use in pediatrics:

JOXATE O TABLET is not suitable for use in children and adolescents (under 18
years of age). Consult your child’s doctor for advice.

Use in geriatrics:

JOXATE O TABLET should be used with caution in elderly patients (aged above 60
years). Consult your doctor before taking JOXATE O TABLET.

Interactions

A. Drug-Drug interactions:

Before taking JOXATE O TABLET, inform your doctor, if you are taking any of the
following medicines:

• medicines used to manage arrhythmias (Ex. hydroquinidine, quinidine, disopyramide, amiodarone, dofetilide, sotalol, ibutilide)
• medicine used to manage depression (Ex. tricyclic antidepressants such as clomipramine and amitriptyline)
• antimicrobials (Ex. macrolides such as erythromycin, clarithromycin, azithromycin, fluoroquinolone such as ciprofloxacin, norfloxacin)
• medicines used to manage some mental health conditions such as schizophrenia and bipolar disorder (Ex. aripiprazole, olanzapine)
• medicines or dietary supplements that contain iron (for anemia) or zinc
• medicine used for stomach ulcers and indigestion (Ex. antacids that contain magnesium or aluminum, sucralfate and cimetidine)
• medicine used to manage inflammation and swelling or over-active immune system (Ex. corticosteroids such as prednisone)
• medicines used as painkillers called non-steroidal anti-inflammatory drugs (NSAIDs) (Ex. ibuprofen or diclofenac)
• medicine used to manage asthma or chronic obstructive pulmonary disease (Ex. theophylline)
• medicine used to manage control blood sugar (Ex. glibenclamide)
• medicine used to manage gout (Ex. probenecid)
• medicines used to manage rheumatism (Ex. methotrexate)
• medicines used to thin blood (Ex. warfarin)
• medicine used to manage HIV infection (Ex. didanosine)
• medicines used as diuretics such as furosemide (used to manage fluid retention)

Overdosage:

If you or anyone else accidentally take too much of this medicine, consult your
doctor immediately or visit the nearby hospital. Overdosage symptoms of JOXATE O
TABLET are confusion, dizziness or loss of consciousness, nausea, seizures or
fits.

Synopsis

Drug	:	Flavoxate, Ofloxacin
Pharmacological Category	:	Anticholinergics, Fluoroquinolone antibiotics
Therapeutic Indication	:	Urinary tract infections (UTI) and its symptoms
Dosage Forms	:	Tablet

More Information

• Keep JOXATE O TABLET out of reach of children
• Store JOXATE O TABLET at room temperature

FAQs About JOXATE O TABLET

Q: What precaution to be taken if an overdose of JOXATE O TABLET is taken?A: If you or anyone else accidentally take too much of JOXATE O TABLET,
consult your doctor immediately or visit the nearby hospital. Overdosage
symptoms of JOXATE O TABLET are confusion, dizziness or loss of consciousness,
nausea, seizures or fits.

Q: Can I stop JOXATE O TABLET if my condition improves?A: Do not stop taking JOXATE O TABLET without consulting with your doctor,
even if you feel your condition is improved. Stopping may worsen the condition
or increase the chance of recurrence.

Q: How does JOXATE O TABLET work?A: JOXATE O TABLET contains flavoxate and ofloxacin. Flavoxate is an
antispasmodic that works by relaxing muscles of the urinary bladder and managing
frequent, urgent or uncontrolled urination and relieving the associated pain.
Ofloxacin is an antibiotic that acts by killing the bacteria by managing them
from reproducing and repairing themselves.

Q: Is JOXATE O TABLET safe to use in patients with kidney problems?A: JOXATE O TABLET should be used with caution if you have any kidney
problems or impaired kidney function. Your doctor may monitor your kidney
function test during or after management to manage the risk of any unusual
effects. Consult your doctor before taking JOXATE O TABLET.

Q: What happens if I forget to take a dose of JOXATE O TABLET?A: If you miss a dose of JOXATE O TABLET, take it as soon as possible.
However, if it is almost time for your next dose, skip the missed dose and go
back to your regular schedule. Do not double the dose to match up for the missed
dose.

Useful Diagnostic Tests

• Urine routine and culture tests