FRUCIX 40 Tablet 10's

Introduction About FRUCIX 40 TABLET

FRUCIX 40 TABLET contains frusemide (furosemide) which belongs to the group of
medicines called Diuretics. It is used to manage edema (fluid retention) due to
problems with your heart, lungs, kidneys, liver, blood vessels or high blood
pressure. Generally, accumulation of excess fluid in the body adds extra
pressure on your heart, blood vessels, lungs, kidneys or liver and can cause
swelling of the ankles, breathing difficulties or even make you feel more tired
than usual.

During the course of management with FRUCIX 40 TABLET, your doctor will
recommend you take several blood tests to monitor your blood sugar and uric acid
levels as a precaution to avoid unwanted side effects. They may also monitor
your blood potassium and sodium levels carefully, especially if you have
vomiting or diarrhea.

Before taking this medicine, inform your doctor if you have any kidney, liver or
heart problems. FRUCIX 40 TABLET is not recommended for use in pregnant and
breast-feeding women. FRUCIX 40 TABLET should be used with caution in children
over 12 years of age. Also, it should be used with caution in elderly patients.
The most common side effects of taking FRUCIX 40 TABLET are dehydration,
electrolyte imbalance and decreased blood volume. Consult your doctor if any of
the side effect worsens or persist for a long period of time.

Uses Of FRUCIX 40 TABLET

• Manage edema (fluid retention)

How FRUCIX 40 TABLET Works

FRUCIX 40 TABLET contains frusemide which is a loop diuretic. It works by
inhibiting the reabsor
tubules and in the thick ascending loop of Henle by inhibiting the
sodium-chloride cotransport system. As a result, it promotes diuresis (urine
output) by enhancing the excretion of water along with sodium, chloride,
magnesium and calcium.

How to use FRUCIX 40 TABLET

Take FRUCIX 40 TABLET as directed by your physician. Swallow FRUCIX 40 TABLET as
whole with a sip of water. Do not crush or chew the medicine. Your doctor will
decide the correct dose and duration for you depending upon your age, body
weight and disease condition. Continue to take FRUCIX 40 TABLET, as long as your
doctor tells you to do so, to obtain better results.

Side Effects Of FRUCIX 40 TABLET

Common

• Signs of dehydration, altered fluid and electrolyte balance in the body (such as nausea, vomiting, dry mouth, weakness, drowsiness, fits, restlessness, muscle pain, low blood pressure, difficulty in urination or irregular heartbeat)

Uncommon

• Anaemia (causing tiredness, breathlessness, unusual bleeding or bruising)
• Gout
• Changes in vision including blurred or yellow vision
• Light-headedness, sensations of pressure in the head, headache, drowsiness, weakness, dizziness when standing
• Irregular heartbeat
• Muscle cramps or weakness
• Changes in the amount or need to urinate
• Tiredness
• Dry mouth, thirst
• Nausea or vomiting
• Changes in bowel movements including diarrhoea and constipation
• Deafness

Rare

• Delusions, hallucinations, disorg
• Tingling or prickling sensation often in arms or legs
• Confusion, headache
• Generally feeling unwell, fever
• Ringing in the ears and loss of hearing
• Symptoms of shock (such as changes in heart rate, breathlessness, cool clammy skin)
• Inflammation of the pancreas (causing pains in your abdomen or back and nausea)
• Changes in the liver causing yellowing of the skin or whites of the eyes
• Skin rashes

Stop taking FRUCIX 40 TABLET and consult your doctor immediately if you
experience any of the following side effects:

• Severe allergic reactions (such as skin rash, itching, photosensitivity, skin peeling, swelling of the lips, face, tongue or throat or difficulty in breathing or swallowing)
• Symptoms of stevens-johnson syndrome (such as blistering or peeling of the skin around the eyes, nose, mouth or genital, with fever or flu-like symptoms)
• Vasculitis (inflammation of blood vessels)
• Signs of kidney inflammation (such as pain in lower back, blood in the urine, fever, feeling drowsy)
• Blood clot in the legs with pain and swelling

How To Manage Side Effects

!### Dry Mouth

Sip water regularly and other sugar free liquids. Do not use mouthwashes that
contain alcohol because they can make your mouth dry, use mouthwash that is used
only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco
products. Consult your doctor if the symptom does not improve.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to
be relaxed and stress free. Apply pain relieving balm on your forehead if
necessary. Consult your doctor if the symptom does not improve.

!### Nausea And Vomiting

Stick to simple meals while taking FRUCIX 40 TABLET. Avoid eating oily rich,
fried or spicy foods. Do not lie down or sleep immediately after eating. Consult
your doctor if the symptom does not improve.

!### Skin rash Or Itching

Avoid hot showers because hot water can irritate the skin further. Do not rub or
scratch the affected area. Use sunscreen and protective clothing when going
outdoor. Regularly use moisturizers to soothe and hydrate the affected area. If
the symptom still persists, consult your doctor.

Warning & Precautions

!### Pregnancy

ContraindicatedFRUCIX 40 TABLET is not recommended for use in pregnant women. If you become
pregnant while taking this medicine talk to your doctor to check the growth of
the baby. Consult your doctor before taking FRUCIX 40 TABLET.

!### Breastfeeding

ContraindicatedFRUCIX 40 TABLET is not recommended for use in breast-feeding women. Consult
your doctor before taking FRUCIX 40 TABLET.

!### Driving and Using Machines

Use with CautionDo not drive or operate any tools or machines if you experience drowsiness,
dizziness or blurred vision after taking FRUCIX 40 TABLET.

!### Alcohol

Consult your doctorAvoid consum
for advice.

!### Kidney

Consult your doctorFRUCIX 40 TABLET is not recommended for use in patients having anuria (failure
of the kidneys to produce urine), severe kidney damage, kidney failure or
impaired kidney function due to poisoning by nephrotoxic agents. It should be
used with caution in patients with kidney problems. Consult your doctor before
taking FRUCIX 40 TABLET.

!### Liver

Consult your doctorFRUCIX 40 TABLET is not recommended for use in patients with liver cirrhosis and
liver encephalopathy. It should be used with caution in patients with liver
congestion (slowed blood flow through the vessels) or other liver problems.
Consult your doctor before taking FRUCIX 40 TABLET.

!### Allergy

ContraindicatedDo not take FRUCIX 40 TABLET if you are allergic to frusemide (furosemide) or
sulphonamide antibiotics (such as sulfamethoxazole).

!### Heart Disease

Use with CautionFRUCIX 40 TABLET should be taken with caution in patients with low blood
pressure. Consult your doctor before taking FRUCIX 40 TABLET.

!### Use In Pediatrics

Use with CautionFRUCIX 40 TABLET should be used with caution in children over 12 years of age. A
suitable dosage form is used in children under 12 years of age. Consult your
child’s doctor for advice.

!### Use In Geriatrics

Use with CautionFRUCIX 40 TABLET should be used with caution in elderly patients. Consult your
doctor before taking FRUCIX 40 TABLET.

Others

FRUCIX 40 TABLET is not recommended for use if you:

• Are dehydrated
• Have low levels of sodium, potassium or other electrolytes in the blood
• Have low blood volume
• Have addison’s disease
• Have digitalis poisoning

Before taking FRUCIX 40 TABLET, inform your doctor if you:

• Have hypovolaemia (low blood volume)
• Have hypoproteinemia (low levels of proteins in blood) due to kidney damage
• Have prostate trouble or difficulty in passing urine
• Have diabetes
• Have gout (painful or inflamed joints)
• Have an abnormal blood condition
• Are going to undergo any blood or urine test

Interactions

A. Drug-Drug Interactions:

Before taking FRUCIX 40 TABLET, inform your doctor if you are taking any of the
following medicines:

• Medicines used to reduce high blood pressure such as ACE inhibitors (Ex. ramipril, enalapril, perindopril), angiotensin II-receptor blockers (Ex. losartan, candesartan, irbesartan), alpha-blockers (Ex. prazosin), thiazide diuretics (Ex. bendroflumethiazide) and potassium sparging diuretics (Ex. amiloride, spironolactone, acetazolamide and metolazone)
• Medicines used to manage irregular heartbeat (Ex. digoxin, amiodarone, sotalol, disopyramide, flecainide, lidocaine, mexiletine dofetilide and ibutilide)
• Medicines used to manage angina (Ex. nitroglycerin or isosorbide dinitrate)
• Medicines used to reduce high cholesterol levels in blood (Ex. clofibrate, colestyramine and colestipol)
• Medicines used to manage diabetes (Ex. insulin and metformin)
• Non-steroidal anti-inflammatory medicines (Ex. aspirin, ibuprofen, ketoprofen or indomethacin)
• Corticosteroids (used to manage pain or inflammation) Ex. dexamethasone, prednisolone
• Medicines used to manage stomach ulcers (Ex. sucralfate or carbenoxolone)
• Medicines used to manage epilepsy (Ex. phenytoin, carbamazepine or phenobarbital)
• Antibiotics (used to manage bacterial infections) such as gentamicin, amikacin, neomycin, netilmicin, tobramycin, vancomycin or cephalosporins such as cefixime
• Medicines used to manage asthma (Ex. terbutaline, salbutamol, salmeterol, formoterol or bambuterol)
• Medicines used to manage nasal congestion (Ex. xylometazoline or ephedrine)
• Medicines used to manage mental problems (Ex. lithium, chlorpromazine, risperidone, amisulpride, sertindole or pimozide)
• Medicines used to manage depression (Ex. reboxetine, amitriptyline and phenelzine)
• Laxatives (used to manage constipation) Ex. lactulose, polyethylene glycol, bisacodyl
• Skeletal muscle relaxants given during operations (Ex. tubocurarine, curarine derivates and succinylcholine)
• Chloral hydrate (a medicine used to induce sleep)
• Theophylline (a medicine used to manage breathing difficulties)
• Immunosuppressants (used to suppress immune system and manage graft rejection) Ex. tacrolimus, ciclosporin or aldesleukin
• Radiocontrast agent (used before X-ray examinations)
• Probenecid (used to manage gout)
• Cisplatin (used to manage certain type of cancers)
• Methotrexate (used to manage severe arthritis or some forms of cancer)
• Aminoglutethimide (used to manage breast cancer or cushing´s syndrome)
• Amphotericin B (used to manage fungal infections)
• Atomoxetine (used for attention deficit hyperactivity disorder)
• Muscle relaxants (Ex. baclofen and tiz
• Antihistamines (used to manage allergies) Ex. cetirizine
• Alprostadil (a medicine used to manage male impotence)
• Oral contrace
• Liquorice (used to manage cough)
• Moxisylyte (a medicine used for raynaud's syndrome)
• Levodopa (used to manage parkinson’s disease)

Overdosage:

If you or anyone else accidentally takes too much of FRUCIX 40 TABLET, consult
your doctor immediately or visit the nearby hospital. Overdosage symptoms of
FRUCIX 40 TABLET includes dehydration and changes in the levels of certain
chemicals in the blood.

Synopsis

Drug	:	Frusemide (furosemide)
Pharmacological Category	:	Diuretics
Therapeutic Indication	:	Fluid retention (edema)
Dosage Forms	:	Injection, Tablet, Oral Solution

More Information

Storage

• Keep FRUCIX 40 TABLET out of reach of children
• Do not store FRUCIX 40 TABLET above 25°C

FAQs About FRUCIX 40 TABLET

Q: What is FRUCIX 40 TABLET and why is it prescribed?

A: FRUCIX 40 TABLET contains frusemide (furosemide) which belongs to the group
of medicines called Diuretics. It is used to manage edema (fluid retention) due
to problems with your heart, lungs, kidneys, liver, blood vessels or high blood
pressure.

Q: Will FRUCIX 40 TABLET make me feel tired?

A: FRUCIX 40 TABLET may cause hypotension (decrease in blood pressure) in some
individuals and feeling of extreme tiredness or fainting can be attributed to
this. Consult your doctor if you experience any unusual symptoms after taking
FRUCIX 40 TABLET.

Q: Is FRUCIX 40 TABLET safe to use in patients with kidney problems?

A: FRUCIX 40 TABLET is not recommended for use in patients having anuria
(failure of the kidneys to produce urine), severe kidney damage, kidney failure
or impaired kidney function due to poisoning by nephrotoxic agents. FRUCIX 40
TABLET should be used with caution in patients with kidney problems. Consult
your doctor before taking FRUCIX 40 TABLET.

Q: Will FRUCIX 40 TABLET increase the urge to pass urine?

A: No, although FRUCIX 40 TABLET acts by increasing urine output, it only
increases the frequency of urine output and not the urge to pass urine. Consult
your doctor if you experience any symptoms of urinary incontinence or if you
have any bladder problems.

Q: Can FRUCIX 40 TABLET be used in pregnant women?

A: FRUCIX 40 TABLET is not recommended for use in pregnant women. If you become
pregnant while taking FRUCIX 40 TABLET talk to your doctor to check the growth
of the baby. Consult your doctor before taking FRUCIX 40 TABLET.

Q: How does FRUCIX 40 TABLET work?

A: FRUCIX 40 TABLET contains frusemide which is a loop diuretic. It works by
inhibiting the reabsor
tubules and in the thick ascending loop of Henle by inhibiting the
sodium-chloride cotransport system. As a result, it promotes diuresis (urine
output) by enhancing the excretion of water along with sodium, chloride,
magnesium and calcium.

Useful Diagnostic Tests

• Kidney Function Test