Flucofit 150mg Tablet 1'S

Introduction About FLUCOFIT 150MG TABLET

FLUCOFIT 150MG TABLET contains Fluconazole which belongs to the group of
medicines called Anti-fungal agents. It is used to manage various fungal
infections such as systemic candidiasis (fungal infection affecting the blood,
brain, heart, eyes or other parts of the body), mucosal candidiasis (fungal
infection affecting the mouth, throat or denture sore mouth), cryptococcosis
(fungal infection mainly affecting the lungs and brain), vaginal candidiasis
(fungal infection of the vagina and tissues at the opening of vagina (vulva)).

Also, it manages fungal infections in immunocompromised patients considered at
risk as a consequence of HIV infection or low white blood cell count after
cytotoxic chemotherapy, radiotherapy or bone marrow transplant.

Before taking FLUCOFIT 150MG TABLET, inform your doctor if you have liver,
kidney or heart problems, abnormal levels of potassium, calcium, or magnesium in
your blood, are prone to develop severe skin reactions and have a history of
adrenal insufficiency.

FLUCOFIT 150MG TABLET is not recommended for use in pregnant and breast-feeding
women unless clearly advised by the doctor. FLUCOFIT 150MG TABLET should be used
with caution in children and adolescents (from birth to 17 years of age). It
should be used with caution in elderly patients particularly with renal
impairment.

The most common side effects of taking FLUCOFIT 150MG TABLET are headache,
nausea, vomiting diarrhea, abdominal pain, and indigestion. Consult your doctor
if any of the side effect gets worse.

Uses Of FLUCOFIT 150MG TABLET

• Manage various fungal infections (such as systemic candidiasis, mucosal candidiasis, cryptococcosis and vaginal candidiasis)
• Prevents fungal infection in immunocompromised patients

How FLUCOFIT 150MG TABLET Works

FLUCOFIT 150MG TABLET works by stopping the action of an enzyme called
ergosterol, which is an integral part of the fungal cell membrane to increase
its cellular permeability. Thereby, making the cell membrane more permeable and
stops the fungal growth. This type of action is useful in managing and managing
various fungal infections.

How to use FLUCOFIT 150MG TABLET

Take FLUCOFIT 150MG TABLET as advised by your physician. Swallow FLUCOFIT 150MG
TABLET with a glass of water and do not chew or crush the medicine. The correct
dose and duration for you will be decide by the doctor depending upon your age,
body weight and type of infection.

Side Effects Of FLUCOFIT 150MG TABLET

Common

• headache
• nausea, vomiting
• diarrhea
• abdominal pain
• indigestion
• acne

Uncommon

• seizures, dizziness, altered nerve sensation and taste
• skin rash with itching, abnormal odor from skin and dry skin
• abnormal changes in vision
• constipation, flatulence and dry mouth
• thirst, tiredness, body pain and fever
• weakness, general feeling of discomfort, rigor
• pharyngitis, herpes simplex viral infection
• loss of appetite
• back, muscle pain, muscle spasm
• renal pain
• head spinning sensation (vertigo)
• insomnia, and nervousness
• muscle overactivity (hypertonia)
• increased urine output
• abnormal or heavy vaginal bleeding, painful menses, vaginal discharge and disorder, uterine spasm, female sexual dysfunction
• hot flushes, excess sleepiness
• deafness, increased blood pressure, low oxygen levels, intolerance to oral intake, inflamed and sore mouth (in children)

Rare

• allergic reactions
• low white blood cells and platelet count
• hair loss
• damage to liver causing liver failure, hepatitis, and necrosis
• skin reactions (like steven johnson syndrome and toxic epidermal necrolysis)
• shaking
• change in heart rate or rhythm

Stop taking FLUCOFIT 150MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• sudden wheezing, difficulty in breathing or tightness in the chest, swelling of eyelids, face or lips, itching all over the body, reddening of the skin or itchy red spots
• skin rash that causes blistering in mouth and tongue
• signs of liver problems (tiredness, loss of appetite, vomiting and yellowing of the skin or whites of the eyes)
• signs of DRESS syndrome or drug hypersensitivity syndrome (widespread rash, high body temperature and enlarged lymph nodes)

How To Manage Side Effects

Diarrhea:

Drink lot of fluids, such as water or fruit juice to keep yourself hydrated. Do
not take any medicine on your own to manage diarrhea without consulting your
doctor.

Nausea or vomiting:

Stick to simple meals while receiving this medicine. Avoid eating oily rich,
fried or spicy foods. Do not lie down or sleep immediately after eating. Consult
your doctor if the symptom does not improve.

Stomach pain:

Try to take rest and relax. Eat and drink slowly or try to have smaller and
frequent meals. Keep a heat pad on your stomach. If the symptom does not
improve, contact your doctor.

Headache:

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to
be relaxed and stress free. Apply pain relieving balm on your forehead if
necessary. Consult your doctor if the symptom does not improve.

Dizziness:

Lie down until dizziness is gone, then get up slowly. Move slowly and carefully,
do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid
coffee, cigarettes, alcohol, and drugs. Consult your doctor if the symptom gets
worse.

Warning & Precautions

!### Pregnancy

FLUCOFIT 150MG TABLET is not recommended for use during pregnancy unless
considered clearly necessary. Consult your doctor before taking FLUCOFIT 150MG
TABLET.

!### Breastfeeding

FLUCOFIT 150MG TABLET is not recommended for use in breastfeeding women after
repeated use or after high dose of this medicine. You may continue
breast-feeding after single dose of FLUCOFIT 150MG TABLET. Consult your doctor
before taking FLUCOFIT 150MG TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if you experience dizziness or fits after
taking FLUCOFIT 150MG TABLET.

!### Kidney

FLUCOFIT 150MG TABLET should be used with caution in patients with kidney
dysfunction. Consult your doctor before taking FLUCOFIT 150MG TABLET.

!### Liver

FLUCOFIT 150MG TABLET should be used with caution in patients with liver
dysfunction. Consult your doctor before taking FLUCOFIT 150MG TABLET.

!### Allergy

FLUCOFIT 150MG TABLET is not recommended for use if you are allergic to
fluconazole or other azole anti-fungals (such as itraconazole or posaconazole).

!### Heart Disease

FLUCOFIT 150MG TABLET should be used with caution in patients with heart rhythm
problems. Consult your doctor for advice before taking FLUCOFIT 150MG TABLET.

Others

FLUCOFIT 150MG TABLET is not recommended for use if you:

• rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsor

Before taking FLUCOFIT 150MG TABLET, inform your doctor if you:

• have abnormal levels of potassium, calcium, or magnesium in your blood
• are prone to develop severe skin reactions (itching, reddening of the skin or difficulty in breathing)
• have history of adrenal insufficiency
• have no improvement in fungal infection

Use in Pediatrics:

FLUCOFIT 150MG TABLET should be used with caution in children and adolescents
(from birth to 17 years of age). Consult child’s doctor for advice before
administration of FLUCOFIT 150MG TABLET to your child.

Use in Geriatrics:

FLUCOFIT 150MG TABLET should be used with caution in elderly patients
particularly with renal impairment. Your doctor may adjust the dose depending
upon kidney function. Consult your doctor for advice before taking FLUCOFIT
150MG TABLET.

Interactions

A. Drug-Drug Interactions:

Before taking FLUCOFIT 150MG TABLET, inform your doctor, if you are taking any
of the following medicines:

• medicines used to manage diabetes medicines (Ex. glyburide, tolbutamide, glipizide, chlorpropamide)
• medicines used to manage high blood pressure (Ex. hydrochlorothiazide, nifedipine, isradipine, amlodipine, felodipine and losartan)
• medicines used as blood thinners (Ex. warfarin)
• medicines used to use to manage rejection of organ transplants (Ex. cyclosporine, tacrolimus, sirolimus)
• rifampicin or rifabutin (used to manage tuberculosis)
• astemizole, terfenadine (used to manage certain type of allergies)
• medicines used to control seizures /fits (Ex. phenytoin or carbamazepine)
• theophylline (used to control asthma)
• cisapride (used to manage heartburn)
• medicines used to manage heart diseases (Ex. quinidine, amiodarone)
• medicines used to manage depression (Ex. amitriptyline, nortriptyline)
• pimozide (used to control motor or verbal tics)
• amphotericin B, voriconazole (medicine for managing various fungal infections)
• erythromycin (used for managing bacterial infections)
• cyclosphosphamide, medicines used for management of cancer (Ex. vincristine or vinblastine)
• alfent
• halofantrine (for managing malaria)
• medicines used to manage high cholesterol levels (Ex. atorvastatin, simvastatin, and fluvastatin)
• medicines used to manage painful conditions with inflammation (Ex. celecoxib, ibuprofen, and naproxen)
• prednisone (used to manage inflammatory disorders)
• antiviral medications used to manage HIV infection (Ex.  saquinavir, zidovudine)
• tofacitinib (used to manage rheumatoid arthritis)
• ivacaftor (medicine used for managing cystic fibrosis)
• ibrutinib (used for managing blood cancer)
• midazolam, triazolam or similar medicines (used to induce sleep and manages anxiety)
• olaparib (used for managing ovarian cancer)
• methadone (used to manage chronic pain and also opioid dependance)

Overdosage:

If you or anyone else accidentally takes too much of FLUCOFIT 150MG TABLET,
consult your doctor immediately or visit the nearby hospital. Overdosage
symptoms of FLUCOFIT 150MG TABLET are hearing, seeing, feeling and thinking
things that are not real (hallucination and paranoid behaviour).

Synopsis

Drug	:	Fluconazole
Pharmacological Category	:	Triazoles
Therapeutic Indication	:	Prevent and manages various fungal infections
Dosage Forms	:	Tablet, Dispersible tablet, Capsule, Injection, Infusion, Dry syrup, Dusting powder, Gel, Cream, Ear drops, Eye drops, Soap

More Information

• Keep FLUCOFIT 150MG TABLET out of reach of children
• Store at room temperature

FAQs About FLUCOFIT 150MG TABLET

How does FLUCOFIT 150MG TABLET work?

FLUCOFIT 150MG TABLET works by stopping the action of an enzyme called
ergosterol, which is an integral part of the fungal cell membrane to increase
its cellular permeability. Thereby, making the cell membrane more permeable and
stops the fungal growth. This type of action is useful in managing and managing
various fungal infections.

What if I forget to take a dose of FLUCOFIT 150MG TABLET?

If you have missed a dose of FLUCOFIT 150MG TABLET, take it as soon as you
remember. However, if it is almost time for your next dose, skip the missed dose
and take the next scheduled dose. Do not double the dose of FLUCOFIT 150MG
TABLET to make up for the missed one as this may increase the chances of
developing side effects.

What are the common side effects of FLUCOFIT 150MG TABLET?

The common side effects of taking FLUCOFIT 150MG TABLET are headache, nausea,
vomiting, diarrhea, abdominal pain, indigestion and acne. Consult your doctor if
any of the symptom gets worse or does not improve over the time

CanFLUCOFIT 150MG TABLET be used in elderly patients?

FLUCOFIT 150MG TABLET should be used with caution in elderly patients
particularly with renal impairment. Your doctor may adjust the dose depending
upon kidney function. Consult your doctor for advice before taking FLUCOFIT
150MG TABLET.

Is FLUCOFIT 150MG TABLET safe to use during pregnancy?

FLUCOFIT 150MG TABLET is not recommended for use during pregnancy unless clearly
advised by the doctor. Consult your doctor before taking FLUCOFIT 150MG TABLET
if you are pregnant or planning to get pregnant.

Useful Diagnostic Tests

• Complete blood count
• Liver function test