Doripen 500mg Injection 1'S

Introduction About DORIPEN 500MG INJECTION

DORIPEN 500MG INJECTION contains Doripenem which belong to the group of
medicines called Antibiotics. It is used in adults to manage serious bacterial
infections of the respiratory tract (Ex. pneumonia), urinary tract (Ex.
pyelonephritis), stomach and blood (Ex. sepsis).

DORIPEN 500MG INJECTION should be used under careful medical supervision. It
will be given to you only by a doctor or a nurse into the vein. Make sure to
receive therapy with DORIPEN 500MG INJECTION for the stipulated duration
instructed by your doctor. Stopping therapy or skipping doses in between therapy
may not control infection effectively.

Before receiving DORIPEN 500MG INJECTION inform your doctor if you have any
kidney problems. You must also inform your doctor if you previously experienced
diarrhea after taking any antibiotics or have a previous history of stroke or
fits as a precaution.

Inform your doctor before receiving DORIPEN 500MG INJECTION if you are pregnant,
think you may be pregnant or planning to have a baby or breastfeeding. The most
common side effects of receiving DORIPEN 500MG INJECTION are stomach pain,
nausea, vomiting, diarrhoea, headache, skin rash and pain or inflammation at the
site of injection. Consult your doctor if any of these side effect worsens.

Uses Of DORIPEN 500MG INJECTION

It is used in adults to manage the following serious bacterial infections:

• Pneumonia that is acquired in the hospital setting
• Complicated Urinary tract infections (Ex. kidney infections (pyelonephritis))
• Complicated intra-abdominal infections (infections of areas around the stomach)
• Blood infections (Ex. sepsis)

How DORIPEN 500MG INJECTION Works

DORIPEN 500MG INJECTION is a powerful antibiotic. It kills the susce
bacteria by interfering with the bacterial cell wall synthesis. It is effective
against a wide range of bacteria (including both gram-positive and gram-negative
bacteria). As a result, it destroys the susce
further growth and multiplication and reduces the severity of the infection.

How to use DORIPEN 500MG INJECTION

DORIPEN 500MG INJECTION will be given to you only by a doctor or a nurse into
the vein (intravenously).

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and severity of infection. Do not stop
therapy or skip doses in between the therapy to achieve better control over
infection.

Side Effects Of DORIPEN 500MG INJECTION

Common

• nausea, vomiting
• diarrhoea
• headache
• skin rash, itchy skin
• injection site reactions (pain and inflammation)
• fungal infections of mouth or vagina
• increased liver enzymes

Uncommon

• increased numbers of WBC and platelets
• fits

Rare

Contact your doctor immediately if you experience any of the following side
effects:

• signs of severe allergic reactions (such as skin rash, itching, swelling of the face, lips, throat or tongue causing difficulty in breathing or swallowing)
• severe skin reactions (such as widespread skin rash, blistering, peeling or bleeding on any part of the skin with fever, chills, enlarged lymph nodes and malaise or pink or reddish skin lesions on palms or soles)
• severe bloody diarrhea

How To Manage Side Effects

!### Diarrhea

Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated.
Consuming ORS can also be beneficial. Do not consume any medicine on your own
without consulting your doctor. If your diarrhea worsens, contact your doctor
immediately.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

!### Injection Site Reactions

Place an ice pack at the site of injection. Do not move the affected area.
Consult your doctor if the symptom worsens.

!### Nausea And Vomiting

Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if
nausea worsens.

!### Skin rash Or Itching

Avoid hot showers because hot water can irritate your skin further. Do not
scratch the affected area. Use protective clothing when going outdoors.
Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Warning & Precautions

!### Pregnancy

Use with CautionDORIPEN 500MG INJECTION should be used in pregnant women only if considered
necessary by the physician. Therefore, consult your doctor before receiving it.

!### Breastfeeding

Monitoring requiredDORIPEN 500MG INJECTION may pass through the breast milk. Therefore, it should
be used in breastfeeding women only if considered necessary by the physician.

!### Driving and Using Machines

Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected
by DORIPEN 500MG INJECTION.

!### Kidney

Use with CautionDORIPEN 500MG INJECTION should be used with caution in patients with kidney
problems. Therefore, consult your doctor before receiving it.

!### Allergy

ContraindicatedTalk to doctor before receiving DORIPEN 500MG INJECTION if you are allergic to
Doripenem or to any other antibiotics (such as cephalosporins, penicillin
antibiotics etc).

!### Use In Pediatrics

ContraindicatedDORIPEN 500MG INJECTION is not recommended for use in children and adolescents
(aged below 18 years) due to lack of safety data. Therefore, consult your doctor
before receiving it.

!### Use In Geriatrics

Consult your doctorThere is no evidence of effects of DORIPEN 500MG INJECTION on geriatric patients
over the age of 65 years. Therefore, contact your doctor before receiving.

Others

Before receiving DORIPEN 500MG INJECTION inform your doctor if you:

• previously experienced diarrhea after taking an antibiotic
• have ulcerative colitis (inflammation of gut)
• have a previous history of stroke
• have a previous history of fits

Interactions

A. Drug-Drug Interactions:

Before receiving DORIPEN 500MG INJECTION, inform your doctor if you are taking
any of the following medicine:

• Probenecid (medicine used to manage gout)
• Valproic acid, sodium valproate, valpromide (medicines used to manage epilepsy)

Overdosage:

DORIPEN 500MG INJECTION will be given to you only by a doctor or nurse in a
hospital, and so it is unlikely to receive an overdose. However, contact your
doctor if you experience any unusual side effects.

Synopsis

Drug	:	Doripenem
Pharmacological Category	:	Carbapenems
Therapeutic Indication	:	Serious Bacterial Infection
Dosage Forms	:	Injection

More Information

• Keep DORIPEN 500MG INJECTION out of the sight and reach of children
• Store DORIPEN 500MG INJECTION at room temperature or in a refrigerator (2-8°C) based on the instructions given in the product label

FAQs About DORIPEN 500MG INJECTION

Q: What is the use of DORIPEN 500MG INJECTION?

A: DORIPEN 500MG INJECTION is used to manage pneumonia acquired in the hospital
setting, complicated stomach and urinary tract infections and blood infections.

Q: How DORIPEN 500MG INJECTION works in my body?

A: DORIPEN 500MG INJECTION kills the susce
the bacterial cell wall synthesis. It is effective against a wide range of
bacteria (including both gram-positive and gram-negative bacteria).

Q: Can [GBNKEYWORD] be used in patients with kidney problems?

A: DORIPEN 500MG INJECTION should be used with caution in patients with kidney
problems. Therefore, consult your doctor before receiving it.

Q: How DORIPEN 500MG INJECTION is administered?

A: DORIPEN 500MG INJECTION will be given to you only by a doctor or a nurse into
the vein (intravenously).

Q: For how long should I take DORIPEN 500MG INJECTION?

A: TakeDORIPEN 500MG INJECTION for the stipulated duration as prescribed by your
doctor. Do not skip the medicine or stop receiving it on your own as it may
cause the infection to become severe.

Q: Can DORIPEN 500MG INJECTION be given to pregnant women?

A: DORIPEN 500MG INJECTION should be used in pregnant women only if considered
necessary by the physician. Therefore, consult your doctor before receiving it.

Q: What precautions should I follow while receiving DORIPEN 500MG INJECTION?

A: Before receiving DORIPEN 500MG INJECTION inform your doctor if you have any
kidney problems. You must also inform your doctor if you previously experienced
diarrhea after taking any antibiotics or have a previous history of stroke or
fits or if you are pregnant or breastfeeding as a precaution.

Q: What arethe common side effects of receiving DORIPEN 500MG
INJECTION?

A: The most common side effects of receiving DORIPEN 500MG INJECTION are stomach
pain, nausea, vomiting, diarrhoea, headache, skin rash and pain or inflammation
at the site of injection. Consult your doctor if any of these side effect
worsens.

Q: Can I stop receiving DORIPEN 500MG INJECTION once my symptoms subside?

A: Do not stop receiving DORIPEN 500MG INJECTION once your symptoms subside. It
is important to take the full course of DORIPEN 500MG INJECTION to achieve
better results. Failing to complete the full course of the therapy or skipping
doses in between the therapy may not result in adequate infection control. It
may also cause your symptoms to reappear.

Q: Can the use of DORIPEN 500MG INJECTION cause diarrhea?

A: DORIPEN 500MG INJECTION may cause diarrhea in some individuals. If you
experience diarrhea, drink plenty of fluids, such as water or fruit juice to
keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any
medicine on your own without consulting your doctor. If your diarrhea worsens
contact your doctor immediately.

Q: What kind of infections that DORIPEN 500MG INJECTION can manage?

A: DORIPEN 500MG INJECTION is an antibiotic. It is used to manage infections
caused by bacteria. It kills harmful bacteria by binding to the bacterial cell
and interfering with cell wall synthesis. It can manage bacterial infections of
the respiratory tract, urinary tract, stomach and blood.

Q: Is DORIPEN 500MG INJECTION a steroid?

A: No. DORIPEN 500MG INJECTION is an antibiotic and not a steroid medicine.

Q: Can DORIPEN 500MG INJECTION manage viral infections?

A: No. DORIPEN 500MG INJECTION cannot manage viral infections. It manages only
bacterial infections. It acts by killing the susce
responsible for causing infections, and therefore not effective against any
viral infections.

Useful Diagnostic Tests

• Complete Blood Count (CBC)
• Renal Function Tests (RFT)
• Liver Function Tests (LFT)