DIZERAL AZ M Tablet 10's

Introduction About DIZERAL AZ M TABLET

DIZERAL AZ M TABLET is a combination of Alprazolam and Propranolol which belongs
to the group of medicines called Anxiolytics and Antihypertensive agents
respectively. It is used to manage anxiety and p
used to reduce elevated heart rate and blood pressure associated with anxiety.
It is also capable of reducing tremor (shakiness), restlessness and migraine
headache among the affected patients.

Before taking DIZERAL AZ M TABLET inform your doctor if you have any problems in
your heart, liver or kidneys. You must also inform your doctor if you have
diabetes, muscle weakness, depression with suicidal thoughts, any mental
illnesses, history of alcoholism or drug abuse or thyroid problems as a
precaution. Avoid consum
make you feel more dizzy or drowsy.

Do not take DIZERAL AZ M TABLET without consulting your doctor if you are
pregnant or breastfeeding. The most common side effects of taking this medicine
are depression, headache, dizziness, drowsiness, forgetfulness, constipation,
dry mouth, decreased sex drive, problems in erection, blurred vision, cold hands
and feet, slow heartbeat and problems in sleeping. Consult your doctor if any of
these side effects trouble you.

You must also inform your doctor immediately if you experience suicidal thoughts
or any other unusual changes in behaviour (such as agitation, restlessness,
aggressiveness, irritability, violence or anger).

Uses Of DIZERAL AZ M TABLET

• Reduces anxiety and restlessness
• Manage p
• Reduces chest pain and high blood pressure caused due to anxiety

How DIZERAL AZ M TABLET Works

DIZERAL AZ M TABLET contains two medicines namely alprazolam and propranolol.
Alprazolam is a hypnotic medicine. It suppresses the abnormal electrical
activity within the brain and induces sleep.

Propranolol is a beta-blocker. It reduces the heart rate and force of
contraction of the heart which, therefore reduces abnormal heart signs (such as
racing heartbeat, nervousness and high blood pressure) associated with anxiety.

It can also relax the blood vessels supplying the heart and the brain which
therefore reduces elevated blood pressure, chest pain and migraine.

It also stops the transfer of abnormal nerve signals between the brain and the
muscles which helps in reducing tremors.

How to use DIZERAL AZ M TABLET

Take DIZERAL AZ M TABLET as directed by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and health condition. Do not take this
medicine for more than 4 weeks without consulting your doctor.

Side Effects Of DIZERAL AZ M TABLET

Common

• depression
• headache, dizziness
• drowsiness or sleepiness
• jerky movements or unsteadiness
• forgetfulness
• slurred speech, nervousness
• constipation, dry mouth, loss of appetite
• tiredness, irritability, confusion, disorientation, loss of alertness
• sexual problems, increased or decreased sex drive
• problems in erection
• feeling sluggish
• shakiness or trembling
• double or blurred vision
• nausea
• change in body weight
• fingers and toes may become cold
• slow heartbeat
• signs of Raynaud’s syndrome (numbness and spasm in the fingers followed by warmth and pain)
• sleep disturbances, nightmares

Uncommon

• diarrhea
• abnormally excited
• hallucinations
• urge to urinate
• menstrual cramps (pain in thighs and lower back)
• muscle spasms or weakness

Rare

• dizziness while standing up
• hair loss
• tingling or pricking sensation of body parts
• vision disturbances and dry eyes

Stop taking DIZERAL AZ M TABLET and contact your doctor immediately if you
experience any of the following side effects such as:

• signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
• slow heart rate and low blood pressure causing dizziness, light-headedness, fainting or blurred vision
• changes in behavior (such as feeling agitated, restless, aggressive, irritable, violent or angry, false beliefs, nightmares and hallucinations or other inappropriate behavior)
• memory loss (amnesia)
• yellowing of the skin and the whites of the eye (jaundice)

How To Manage Side Effects

!### Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals.
Drink plenty of fluids. Exercise more regularly. Consult your doctor if this
side effect bothers you.

!### Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Do not consume excessive
alcohol, as it could aggravate your dizziness. Consult your doctor if your
dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

!### Insomnia

Try to have a regular bedtime schedule. Avoid having naps during the daytime.
Limit caffeine intake and reduce watching TV before bedtime. If the symptom does
not improve, consult your doctor.

!### Nausea And Vomiting

Take DIZERAL AZ M TABLET with or just after a meal or a snack. Stick to simple
meals. Avoid eating rich or spicy food. Consult your doctor if your nausea
worsens.

Warning & Precautions

!### Pregnancy

ContraindicatedDIZERAL AZ M TABLET is generally not recommended for use in pregnant women
unless considered necessary by the physician, as it may harm the growing baby.
Therefore, inform your doctor before taking DIZERAL AZ M TABLET if you are
pregnant, think you might be pregnant or planning to have a baby.

!### Breastfeeding

ContraindicatedDIZERAL AZ M TABLET may excrete in breast milk. Therefore, it is not recommended
for use in breastfeeding women. However, consult your doctor for advice before
taking it.

!### Driving and Using Machines

Use with CautionDo not drive or handle any heavy tools or machines if you experience dizziness
or drowsiness after taking DIZERAL AZ M TABLET.

!### Alcohol

Consult your doctorAvoid consum
you feel dizzier and drowsier.

!### Kidney

Use with CautionDIZERAL AZ M TABLET should be used with caution in patients with kidney
problems. Therefore, consult your doctor before taking it.

!### Liver

Consult your doctorDIZERAL AZ M TABLET is not recommended for use in patients with severe liver
problems. It should be used with caution in patients with other mild liver
problems. Therefore, consult your doctor before taking it.

!### Allergy

ContraindicatedDo not take DIZERAL AZ M TABLET if you are allergic to propranolol, alprazolam
or to any other sedative or hypnotic medicines (such as midazolam, nitrazepam,
clonazepam).

!### Lungs

ContraindicatedDIZERAL AZ M TABLET is not recommended for use in patients suffering from
asthma, chronic bronchitis, emphysema, COPD or bronchospasm. Therefore, consult
your doctor before taking it.

!### Heart Disease

Consult your doctorDIZERAL AZ M TABLET is not recommended for use in patients with sinus
bradycardia (slow heart beat due to problems in SA nodes), heart block, severe
hypotension (low blood pressure), congestive heart failure or heart defects. It
should be used with caution in patients with a previous history of heart failure
or other heart problems. Therefore, consult your doctor before taking it.

Others

DIZERAL AZ M TABLET is not recommended for use if you:

• have cardiogenic shock (heart cannot pump blood suddenly)
• have hypertensive emergency crisis (abnormal increase in blood pressure which is severe)
• have an increased acidity of the blood (metabolic acidosis)
• are on a strict fasting diet
• suffer from other forms of angina (Prinzmetal’s angina)
• suffer from myasthenia gravis (severe muscle weakness)
• have sleep apnea (breathing stops and starts during sleep)

Before taking DIZERAL AZ M TABLET, inform your doctor if you:

• have diabetes
• suffer from unstable angina (chest pain that occurs in the absence of any stressful activity)
• are going for glaucoma screening test
• are planning for any major surgery
• have other types of arrhythmias (such as Wolf-Parkinson-White Syndrome)
• have any bleeding problems
• have stroke or any circulatory problems
• have swollen ankles
• have previously experienced depression with thoughts of committing suicide
• have any mental illnesses that required hospitalization
• have a previous experience of drug abuse or alcoholism
• have used any hypnotic medicine earlier

Use in Pediatrics:

DIZERAL AZ M TABLET is not recommended for use in children and adolescents (aged
below 18 years) due to lack of safety data. Therefore, consult your doctor
before taking it.

Use in Geriatrics:

DIZERAL AZ M TABLET should be used with caution in elderly patients (aged above
65 years). Therefore, consult your doctor before taking it.

Interactions

A. Drug - Drug interactions:

Before taking DIZERAL AZ M TABLET, inform your doctor if you are taking any of
the following medicine such as:

• other medicines used to reduce anxiety and to induce sleep (such as midazolam, clonazepam, nitrazepam, nefazodone, fluvoxamine, fluoxetine)
• opioid analgesic medications (such as buprenorphine, morphine, codeine or propoxyphene, pethidine, fentanyl etc.)
• other medicines used to manage psychiatric disorders (such as pimozide, haloperidol, risperidone, thioridazine)
• medicines used to manage epilepsy (such as phenytoin, carbamazepine)
• medicines used to manage allergic reactions (such as azelastine, cyproheptadine, mequitazine)
• medicines used to manage fungal infections (such as ketoconazole)
• oral contrace
• medicines used to manage bacterial infections (such as erythromycin)
• medicines used to manage HIV infection (such as ritonavir, nelfinavir, atazanavir, saquinavir, indinavir)
• general anaesthetic (used to create of loss of consciousness before surgery) such as methoxyflurane and trichloroethylene
• other medicines used in the management of hypertension and other heart problems (Ex. nifedipine, nisoldipine, nicardipine, isradipine, lacidipine, verapamil, diltiazem, hydralazine, clonidine, enalapril, lisinopril, ramipril, disopyramide, quinidine, amiodarone, isoprenaline, dobutamine, propafenone and digoxin)
• alpha blockers (used to manage hypertension and BPH) Ex. prazosin, doxazosin
• reserpine (an antihypertensive from plant source)
• lignocaine (used to locally numb body parts)
• adrenaline (a medicine that can stimulate the heart)
• ibuprofen and indomethacin (medicine used to relieve pain and inflammation)
• medicines used to manage migraine headaches (Ex. ergotamine, dihydroergotamine or rizatriptan)
• cimetidine, aluminium hydroxide gel (medicine used for stomach problems)
• rifampicin (a medicine used to manage tuberculosis infection)
• theophylline (a medicine used to manage asthma)
• fingolimod (a medicine used to manage multiple sclerosis)
• thyroxine (a medicine used to manage thyroid deficiency)

Overdosage:

If you or anyone else accidentally took more DIZERAL AZ M TABLET, consult your
doctor immediately or visit the nearby hospital. Symptoms of overdose might
include slow heartbeat, low blood pressure, drowsiness, confusion, feeling cold,
slurred speech, breathing difficulties with symptoms such as fatigue,
hallucinations, tremors, confusion, nausea, vomiting, body spasms and fainting.

Synopsis

Drug	:	Alprazolam, Propranolol
Pharmacological Category	:	Benzodiazepines, Beta-Blockers
Therapeutic Indication	:	Anxiety, P
Dosage Forms	:	Tablet

More Information

• Keep DIZERAL AZ M TABLET out of reach of children
• Store DIZERAL AZ M TABLET at room temperature

FAQs About DIZERAL AZ M TABLET

Q: What is the use of DIZERAL AZ M TABLET?

A: DIZERAL AZ M TABLET is used to manage anxiety and p
be used to reduce elevated heart rate and blood pressure associated with
anxiety. It is also capable of reducing tremor (shakiness), restlessness and
migraine headache among the affected patients.

Q: How DIZERAL AZ M TABLET works in my body?

A: DIZERAL AZ M TABLET suppresses the abnormal electrical activity within the
brain and induces sleep. It also reduces the heart rate and force of contraction
of the heart which, therefore reduces abnormal heart signs (such as racing
heartbeat, nervousness and high blood pressure) associated with anxiety.

Q: What precautions must be followed while taking DIZERAL AZ M TABLET?

A: Before taking DIZERAL AZ M TABLET inform your doctor if you have any problems
in your heart, liver or kidneys. You must also inform your doctor if you have
diabetes, muscle weakness, depression with suicidal thoughts, any mental
illnesses, history of alcoholism or drug abuse or thyroid problems as a
precaution. Avoid consum
make you feel more dizzy or drowsy. Do not take DIZERAL AZ M TABLET without
consulting your doctor if you are pregnant or breastfeeding. Inform your doctor
immediately if you experience suicidal thoughts or any other unusual changes in
behaviour (such as agitation, restlessness, aggressiveness, irritability,
violence or anger).

Q: Can DIZERAL AZ M TABLET cause weight gain?

A: Yes. Weight gain is one of the common side effects of taking DIZERAL AZ M
TABLET. If this side effect bothers you, contact your doctor.

Q: Will DIZERAL AZ M TABLET reduce my sex drive?

A: Yes. DIZERAL AZ M TABLET may affect your sexual life. It may decrease sex
drive or cause problems in orgasm, ejaculation or erection. Therefore, consult
your doctor if you experience any such symptoms.

Q: Can DIZERAL AZ M TABLET be used in children?

A: DIZERAL AZ M TABLET is not recommended for use in children and adolescents
(aged below 18 years) due to lack of safety data. Therefore, consult your doctor
before taking it.

Q: Can DIZERAL AZ M TABLET be used during pregnancy?

A: DIZERAL AZ M TABLET is generally not recommended for use in pregnant women
unless considered necessary by the physician, as it may harm the growing baby.
Therefore, inform your doctor before taking DIZERAL AZ M TABLET if you are
pregnant, think you might be pregnant or planning to have a baby.

Q: Will the use of DIZERAL AZ M TABLET cause sleepiness?

A: Yes, DIZERAL AZ M TABLET can make your feel sleepy, drowsy or tired.
Therefore, do not drive or handle heavy machines or tool if you feel drowsy or
sleepy. Avoid consum

Q: Can I consume alcohol while taking DIZERAL AZ M TABLET?

A: Avoid consum
feel more dizzy or drowsy.

Q:What to do if I forget to take a dose of DIZERAL AZ M TABLET?

A: If you forget to take a dose of DIZERAL AZ M TABLET, take it as soon as you
remember. However, if it is time to take the next dose, skip the missed dose and
take the next one at regular times. Do not take a double dose of DIZERAL AZ M
TABLET to compensate a missed dose, as it could lead to toxicity.

Q: Will taking a higher dose of DIZERAL AZ M TABLET than the prescribed one be
beneficial?

A: No, taking a higher dose of DIZERAL AZ M TABLET will not be effective rather
it can lead to toxicity. Always take the dose prescribed by your doctor. If the
prescribed dose is not effective for you, consult your doctor for advice. Your
doctor might increase the dose or suggest an alternative therapy.

Q: Can I stop taking DIZERAL AZ M TABLET once my symptoms subside?

A: No. Do not stop taking DIZERAL AZ M TABLET without consulting your doctor
even if you feel better during the mid-way of the therapy. Sudden
discontinuation of therapy may cause withdrawal symptoms such as headaches,
muscle pain, tension, restlessness, confusion, mood changes, difficulty in
sleeping and irritability.

Q: Can DIZERAL AZ M TABLET be taken daily?

A: Yes. DIZERAL AZ M TABLET can be taken daily as per your doctor’s instruction.
However, if you are doubtful, consult your doctor.

Q: How to take DIZERAL AZ M TABLET?

A: Take DIZERAL AZ M TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine.

Q: What are the common side effects of taking DIZERAL AZ M TABLET?

A: The most common side effects of taking this medicine are depression,
headache, dizziness, drowsiness, forgetfulness, constipation, dry mouth,
decreased sex drive, problems in erection, blurred vision, cold hands and feet,
slow heartbeat and problems in sleeping. Consult your doctor if any of these
side effects trouble you.

Q: What happens if I accidentally take more DIZERAL AZ M TABLET?

A: If you or anyone else accidentally took more DIZERAL AZ M TABLET, consult
your doctor immediately or visit the nearby hospital. Symptoms of overdose might
include slow heartbeat, low blood pressure, drowsiness, confusion, feeling cold,
slurred speech, breathing difficulties with symptoms such as fatigue,
hallucinations, tremors, confusion, nausea, vomiting, body spasms and fainting.

Useful Diagnostic Tests

• Kidney Function Test