DIOF Suspension 60ml

Introduction About DIOF SUSPENSION

DIOF SUSPENSION is a combination of Metronidazole and Ofloxacin, which belong to
the group of medicines called Antibiotics. DIOF SUSPENSION is used to manage
different kinds of bacterial and parasitic infections (caused by different kinds
of bacteria or parasites), diarrhea (loose, watery stools that occur more often
than usual) and systemic infection (an infection that is in the bloodstream).

DIOF SUSPENSION should be used with caution in patients with liver problems,
kidney problems and heart disease. DIOF SUSPENSION is not recommended for use by
pregnant or breastfeeding women. Consult your doctor before taking it.

The most common side effects of DIOF SUSPENSION are nausea, headache,
sleeplessness, genital itching in women, dizziness, vaginal inflammation,
diarrhoea and vomiting. Consult your doctor if any of the symptoms worsen.

Uses Of DIOF SUSPENSION

• Manage bacterial and parasitic infections
• Manage diarrhea
• Manage systemic infection (an infection that is in the bloodstream)

How DIOF SUSPENSION Works

DIOF SUSPENSION helps to reduce infections caused by different bacteria or
parasites, whereas Metronidazole works by inhibiting the protein synthesis in
the cells of various bacteria and parasites, which gradually leads to cell
death. Ofloxacin works by managing bacterial growth (DNA replication), which
leads to cell death.

How to use DIOF SUSPENSION

Always use DIOF SUSPENSION as directed by your physician. Shake well before use.
Do not stop using DIOF SUSPENSION without informing your doctor.

Side Effects Of DIOF SUSPENSION

Common

• nausea
• headache
• sleeplessness
• genital itching in women
• dizziness
• vaginal inflammation
• diarrhoea
• vomiting

Rare

Stop using DIOF SUSPENSION and contact your doctor immediately if you have:

• allergic reaction with symptoms such as swelling of the face, lips, throat or tongue, itching, difficulty breathing, difficulty swallowing
• skin rashes with blistering, peeling or bleeding of the skin around the lips, eyes, mouth, nose and genitals
• serious but very rare side effect is a brain disease (encephalopathy)
• blistering or bleeding of the skin around the eyes, mouth, lips, nose and genitals
• red, scaly widespread rash with bumps under the skin and blisters accomp
• steven johnson syndrome - severe blistering rash where layers of the skin may peel off

How To Manage Side Effects

Nausea / Vomiting:

Take this medicine with or just after meals. Stick to simple meals. Avoid eating
oil-rich or spicy foods. Consult your doctor if the symptom does not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the head if required. Do not consume alcohol. Consult
your doctor if the symptom does not improve.

Dizziness:

If you feel dizzy, keep your eyes closed sit or lie down. Do not drive or
operate machinery. Consult your doctor if the symptom does not improve.

Diarrhea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated.
Avoid taking any medicine on your own for managing diarrhoea. Consult your
doctor if the symptom does not improve.

Warning & Precautions

!### Pregnancy

DIOF SUSPENSION is not recommended for use in pregnant women. Consult your
doctor before using it.

!### Breastfeeding

DIOF SUSPENSION is not recommended for use in breastfeeding women. Consult your
doctor before using it.

!### Driving and Using Machines

Do not drive or operate any machines if you feel sleepy or dizzy or could affect
your eyesight after using DIOF SUSPENSION. Consult your doctor before using it.

!### Alcohol

Avoid consum
unpleasant side effects such as nausea, vomiting, hot flushes, stomach pain,
very fast or uneven heartbeat and headache. Consult your doctor before using it.

!### Kidney

DIOF SUSPENSION should be used with caution in patients with kidney problems and
patients undergoing kidney dialysis. Consult your doctor before using it.

!### Liver

DIOF SUSPENSION should be used with caution in patients with liver problems.
Consult your doctor before using it.

!### Allergy

Do not take DIOF SUSPENSION if you are allergic to metronidazole, ofloxacin,
other quinolone antibiotics such as ciprofloxacin or norfloxacin or any of the
other ingredients in this medicine. Consult your doctor before using it.

!### Lungs

DIOF SUSPENSION should be used with caution in patients with a lung transplant.
Consult your doctor before using it.

!### Heart Disease

DIOF SUSPENSION should be used with caution in patients with heart disease.
Consult your doctor before using it.

Others

Before using DIOF SUSPENSION, inform your doctor if you:

• have a disease of the nervous system
• are on hemodialysis
• have a history of joint problems or rheumatoid arthritis
• are suffering from Alzheimer’s disease, seizures, stroke
• have decreased in blood minerals

Use in Pediatrics:

DIOF SUSPENSION should be used with caution in children. Consult your doctor
before using it.

Use in Geriatrics:

DIOF SUSPENSION should be used with caution. Consult your doctor before using
it.

Interactions

A. Drug-Drug interactions:

Before taking DIOF SUSPENSION, inform your doctor if you are taking any of these
medicines:

• warfarin (anticoagulants)
• lithium (used to manage mental illness)
• phenytoin, carbamazepine, phenobarbitone (used to manage epilepsy)
• 5 fluorouracil, busulfan (used to manage cancer)
• ciclosporin (immunosuppressant)
• disulfiram

Overdosage:

If you or anyone else accidentally receive too much of DIOF SUSPENSION, consult
your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Metronidazole, Ofloxacin
Pharmacological Category	:	Nitroimidazole antibiotic, Quinolone antibiotic
Therapeutic Indication	:	Bacterial and parasitic infections, diarrhea, systemic infection
Dosage Forms	:	Tablet, Syrup, Suspension, Oral Suspension

More Information

• Keep DIOF SUSPENSION out of reach from children
• Store at room temperature

FAQs About DIOF SUSPENSION

Can I drive after taking DIOF SUSPENSION?

Do not drive or operate any machines if you feel sleepy or dizzy or if it could
affect your eyesight after taking DIOF SUSPENSION. Since DIOF SUSPENSION is an
antibiotic, it will affect the body’s normal functioning. So, it is advised not
to drive or operate any machinery after taking DIOF SUSPENSION.

Can breast-feeding women take DIOF SUSPENSION?

A few clinical trial studies show that DIOF SUSPENSION passes through the breast
milk from mother to infant while breastfeeding. So, DIOF SUSPENSION is not
recommended for breastfeeding women. Consult your doctor before taking it.

I am presently undergoing kidney dialysis. Can I take DIOF SUSPENSION?

DIOF SUSPENSION should be used with caution in dialysis patients. Since dialysis
purifies intoxicants and other materials in the blood, DIOF SUSPENSION can also
be removed. So, the effect of DIOF SUSPENSION might be reduced. It is better to
inform your doctor if you are on dialysis and you are taking DIOF SUSPENSION.

Does DIOF SUSPENSION cause vomiting?

Since vomiting is the most common side effect observed for DIOF SUSPENSION, it
may cause vomiting. So, eat simple meals and avoid oily or spicy foods and take
this medicine with or just after meals. Consult your doctor if the symptom does
not improve.

How many doses of DIOF SUSPENSION can I take in a day?

Take DIOF SUSPENSION as advised by your physician. Do not crush or chew the
medicine. Swallow the medicine with a glass of water. Your doctor will determine
the correct dose and duration for you depending on your age, body weight and
disease condition.

Does DIOF SUSPENSION cause sleeplessness?

Yes, the use of DIOF SUSPENSION may cause sleeplessness. DIOF SUSPENSION may
influence the normal sleep cycle, resulting in reduced sleep compared to normal.
So, it is better to make your surroundings comfortable, which can have a
positive influence on sleep (like the room light being dimmed or minimizing
external noises).