Detrusitol SR 4mg Capsule 7'S

Introduction About DETRUSITOL SR 4MG CAPSULE

DETRUSITOL SR 4MG CAPSULE contains Tolterodine which belongs to a group of
medicines called Antimuscarinics. DETRUSITOL SR 4MG CAPSULE is used to manage
the symptoms of overactive bladder syndrome which occur as an inability to
control urination, need to rush to the toilet with no advance warning and/or to
go to the toilet more frequently. Overactive bladder syndrome is a condition
associated with the bladder function that causes frequent and sudden urge to
urinate which may be difficult to control.

Tolterodine is an antimuscarinic which works by inhibiting the bladder
contraction that causes relaxation of the muscles of the urinary bladder
resulting in the management of frequent, urgent or controlled urination thus
providing relief from the symptoms of overactive bladder syndrome.

Avoid taking DETRUSITOL SR 4MG CAPSULE, if you suffer from urinary retention
(inability to pass urine), from the bladder, uncontrolled narrow-angle glaucoma
(high pressure in the eyes with loss of eyesight), myasthenia gravis (excessive
weakness of the muscles), severe ulcerative colitis (ulceration and inflammation
of the colon). Before taking DETRUSITOL SR 4MG CAPSULE, inform your doctor if
you have difficulties in passing urine, hiatal hernia (a condition marked by the
bulging of the upper part of stomach), and/or have heart, kidney, and liver
disease. DETRUSITOL SR 4MG CAPSULE is not recommended for use in pregnant and
breastfeeding women. The medicine is also not recommended for use in children
and adolescents (below 18years). The most common symptoms of taking DETRUSITOL
SR 4MG CAPSULE are dry mouth, dizziness, sleepiness, headache, dry eyes, and
blurred vision. Consult your doctor if any of these symptoms gets worse.

Uses Of DETRUSITOL SR 4MG CAPSULE

• It is used to manage the symptoms of overactive bladder syndrome (a disorder marked by frequent and sudden urge to urinate that may be difficult to control)

How DETRUSITOL SR 4MG CAPSULE Works

DETRUSITOL SR 4MG CAPSULE works by inhibiting the bladder contraction that
causes relaxation of the muscles of the urinary bladder resulting in the
management of frequent, urgent, or controlled urination thus providing relief
from the symptoms of overactive bladder syndrome.

How to use DETRUSITOL SR 4MG CAPSULE

Take DETRUSITOL SR 4MG CAPSULE as advised by your physician. Swallow DETRUSITOL
SR 4MG CAPSULE with a glass of water and do not chew or crush the medicine. Your
doctor will decide the correct dose and duration for you depending upon your
age, body weight and disease condition.

Side Effects Of DETRUSITOL SR 4MG CAPSULE

Common

• dry mouth
• bronchitis (inflammation of airways)
• sinusitis (inflammation of sinuses)
• dizziness
• sleepiness
• headache
• sensation of tingling or prickling in the fingers and toes
• dry eyes
• blurred vision
• vertigo (spinning sensation)
• palpitations
• indigestion
• constipation
• abdominal pain
• excessive air or gas in the stomach or the intestine
• vomiting
• dry skin
• painful or difficult urination
• inability to empty the bladder
• tiredness
• chest pain
• extra fluid in the body causing swelling (Ex. in the ankles)
• increased weight
• diarrhea

Uncommon

• allergic reactions
• nervousness
• increased heart rate
• signs of heart failure such as shortness of breath with activity, weakness, and swelling in the legs, ankles and feet
• irregular heartbeat
• heartburn
• memory impairment

Rare

Stop taking DETRUSITOL SR 4MG CAPSULE and contact your doctor if you experience
any of the following side effects:

• signs of angiodema (painless swelling under the skin) such as swollen face, tongue or pharynx, difficulty to swallow, itchy skin rash and difficulty in breathing
• signs of hypersensitivity allergic reaction such as skin rash, itching, and difficulty in breathing
• signs of heart failure such as chest pain, difficulty breathing or getting tired easily (even at rest), difficulty breathing at night, and swelling of the legs

How To Manage Side Effects

!### Constipation

Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals, and
drink plenty of water. Try doing exercise regularly (going for a daily walk or
run). If this does not help, inform your doctor for receiving alternate
managements for constipation.

!### Diarrhea

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid
taking any medicine on your own to manage diarrhea and consult your doctor if
the symptom gets worse.

!### Dizziness Or Drowsiness

Try to rest and relax and get enough sleep. Try to avoid driving or operating
any tools or machines while you are feeling dizzy. Limit your consum
alcohol, as it can aggravate your dizziness. Consult and inform your doctor if
the symptom does not improve.

!### Dry Mouth

Try to drink plenty of cold water. Sip on cold unsweetened drinks and use lip
balm if your lips are dry. Try to brush your teeth twice a day and use
mouthwash. Consult your doctor if the symptom gets worse.

Headache

If DETRUSITOL SR 4MG CAPSULE causes headache, then take rest and drink plenty of
fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a
painkiller. Paracetamol is safe to be taken with DETRUSITOL SR 4MG CAPSULE.
Headaches should usually go away after the first week of taking DETRUSITOL SR
4MG CAPSULE. If headaches last more than a week or severe, inform your doctor.

!### Indigestion

Try to have smaller and more frequent meals and eat and drink slowly. Try to
reduce consum
obese. Avoid smoking and don’t have rich, spicy, or fatty foods. Consult and
inform your doctor if the symptom does not improve.

!### Nausea And Vomiting

Try to take DETRUSITOL SR 4MG CAPSULE with or just after a meal or a snack.
Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if
the symptom gets worse.

!### Tiredness

Make sure you take rest and drink plenty of fluids. Avoid or limit the
consum
can sit down (or lie down) when the symptoms are at their worst. Try not to
drive or use tools or machinery until you feel well.

Warning & Precautions

!### Pregnancy

ContraindicatedDETRUSITOL SR 4MG CAPSULE is not recommended for use in pregnant women.  Consult
your doctor before taking DETRUSITOL SR 4MG CAPSULE.

!### Breastfeeding

ContraindicatedDETRUSITOL SR 4MG CAPSULE is not recommended for use in breastfeeding women.
Consult your doctor before taking DETRUSITOL SR 4MG CAPSULE.

!### Driving and Using Machines

Use with CautionDETRUSITOL SR 4MG CAPSULE might cause dizziness, tiredness, or affect your
sight. If you experience these side effects, do not drive, or operate machines.
Consult your doctor before taking DETRUSITOL SR 4MG CAPSULE.

!### Alcohol

Consult your doctorAvoid consum
might make side effects worse.

!### Kidney

Use with CautionDETRUSITOL SR 4MG CAPSULE should be used with caution in patients with kidney
problems. Consult your doctor for advice before taking DETRUSITOL SR 4MG
CAPSULE.

!### Liver

Use with CautionDETRUSITOL SR 4MG CAPSULE should be used with caution in patients with liver
conditions. Consult your doctor for advice before taking DETRUSITOL SR 4MG
CAPSULE.

!### Allergy

ContraindicatedDETRUSITOL SR 4MG CAPSULE is not recommended for use if you are allergic to
Tolterodine or any of the other ingredients.

!### Heart Disease

Use with CautionDETRUSITOL SR 4MG CAPSULE should be used with caution in patients with heart
problems such as slow heartrate, weak heart muscle, reduced blood flow to the
heart; irregular heartbeat and heart failure.Consult your doctor before taking
DETRUSITOL SR 4MG CAPSULE.

!### Use In Pediatrics

ContraindicatedDETRUSITOL SR 4MG CAPSULE is not recommended for use in children and adolescents
(below 18 years). Consult your doctor before taking DETRUSITOL SR 4MG CAPSULE.

!### Use In Geriatrics

Use with CautionDETRUSITOL SR 4MG CAPSULE is used with caution in elderly patients (aged 65
years or above). Consult your doctor before taking DETRUSITOL SR 4MG CAPSULE.

Others

DETRUSITOL SR 4MG CAPSULE is not recommended for use if you:

• inability to pass urine from the bladder (urinary retention)
• have an uncontrolled narrow-angle glaucoma (high pressure in the eyes with loss of eyesight)
• suffer from myasthenia gravis (excessive weakness of the muscles)
• suffer from severe ulcerative colitis (inflammation and ulceration of the colon)
• suffer from a toxic megacolon (a type of severe colon disease)

Before taking DETRUSITOL SR 4MG CAPSULE, inform your doctor if you:

• have difficulty while passing urine
• have a gastro-intestinal disease that affects the passage and/or digestion of food
• suffer from neurological disorders that affect your blood pressure, bowel or sexual function
• have a hiatal hernia (condition marked by the bulging of upper part of stomach)
• have decreased bowel movements or suffer from severe constipation
• intolerant to certain sugars
• hypokalaemia (condition of low levels of potassium in blood)
• hypocalcaemia (condition of low levels of calcium in blood)
• hypomagnesaemia (condition of low levels of magnesium in blood)

Interactions

A. Drug-Drug Interactions:

Before taking DETRUSITOL SR 4MG CAPSULE, inform your doctor, if you are taking
any of the following medicine:

• antibiotics (medicines used to manage bacterial infections) Ex. erythromycin, clarithromycin
• ketoconazole, itraconazole (medicines used for fungal infections)
• medicines used in the management of HIV (Ex. indinavir, nelfinavir, ritonavir)
• medicines that affect the passage of food (Ex. metoclopramide and cisapride)
• medicines used to manage irregular heartbeat (Ex. amiodarone, sotalol, quinidine, procainamide)
• other antimuscarinic agents (medicines used to manage post operative nausea and vomiting) Ex. scopolamine
• medicines used to block the action of a neurotransmitter (chemicals that enable the brain to provide a variety of functions) Ex. clidinium, darifenacin, dicyclomine

Overdosage:

If you or anyone else accidentally takes too much of DETRUSITOL SR 4MG CAPSULE,
consult your doctor immediately or visit the nearby hospital. Symptoms of
overdose are dry mouth and severe central anticholinergic effects such as
confusion, restlessness.

Synopsis

Drug	:	Tolterodine
Pharmacological Category	:	Antimuscarinic
Therapeutic Indication	:	Overactive bladder syndrome
Dosage Forms	:	Tablet, Capsule

More Information

• Keep the medicine out of reach in children
• Store DETRUSITOL SR 4MG CAPSULE at room temperature

FAQs About DETRUSITOL SR 4MG CAPSULE

Q: What DETRUSITOL SR 4MG CAPSULE is used for?

A: DETRUSITOL SR 4MG CAPSULE is used to manage the symptoms of overactive
bladder syndrome which occur as an inability to control urination, need to rush
to the toilet with no advance warning and/or to go to the toilet more
frequently.

Q: How should I take DETRUSITOL SR 4MG CAPSULE?Can I crush DETRUSITOL SR 4MG
CAPSULE and then take it?

A: No, do not chew or crush DETRUSITOL SR 4MG CAPSULE. Swallow the medicine with
a glass of water. Take the medicine as advised by your physician. Your doctor
will decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Q: Can DETRUSITOL SR 4MG CAPSULE be used in children?

A: No, DETRUSITOL SR 4MG CAPSULE is not recommended for use in children and
adolescents (below 18 years). DETRUSITOL SR 4MG CAPSULE is accidentally ingested
by a child or adolescent, go to the hospital immediately and consult the doctor
for further management.

Q: What happens if you forget to take DETRUSITOL SR 4MG CAPSULE?

A: If you forget to take DETRUSITOL SR 4MG CAPSULE at the usual time, take it as
soon as you remember unless it is almost time for your next dose. In that case,
omit the forgotten dose and follow the normal dose schedule. Do not take double
dose to make up for a forgotten one. If you have doubts on missed dosage,
consult your doctor before taking the missed dose of DETRUSITOL SR 4MG CAPSULE.

Q: Is it safe to drive after taking DETRUSITOL SR 4MG CAPSULE?

A: DETRUSITOL SR 4MG CAPSULE might cause dizziness, tiredness, or affect your
sight. If you experience these side effects, do not drive, or operate machines.
Consult your doctor before taking DETRUSITOL SR 4MG CAPSULE.

Useful Diagnostic Tests

• Urine analysis test
• Cystometry test