Dasanat 50mg Tablet 60'S

Introduction About DASANAT 50MG TABLET

DASANAT 50MG TABLET contains Dasatinib which belongs to the group of medicines
called Tyrosine Kinase Inhibitors. It is used to manage cancers of blood and
bone marrow (such as chronic myeloid leukaemia (CML) and philadelphia chromosome
positive (Ph+) acute lymphoblastic leukaemia) in adults, adolescents and in
children (aged 1 year or above).

It is primarily used in patients when management with conventional therapies is
not suitable or fails to provide adequate response.

Leukaemia is the cancer of white blood cells. It is caused due to abnormal
growth and multiplication of blood cells within the bone marrow. It is
characterized by severe tiredness, breathlessness, increased bleeding tendency,
tiredness, anemia, night sweats, fever, chills, frequent infections and weight
loss.

During management with DASANAT 50MG TABLET your doctor will closely monitor your
health condition through several blood tests to avoid the risk of unwanted side
effects. Avoid eating grapefruit or drinking grapefruit juice while taking
DASANAT 50MG TABLET as it may increase the risk of side effects.

Before taking DASANAT 50MG TABLET inform your doctor if you have any liver,
kidney or heart problems. You must also inform your doctor if you have or at
risk of developing hepatitis C infection as a precaution.

Avoid concomitant use of antacids or any stomach medicines along with DASANAT
50MG TABLET. Leave a time gap of at least 2 hours between the medicines. DASANAT
50MG TABLET is not recommended for use in pregnant or breastfeeding women.

Men and women taking DASANAT 50MG TABLET must use a suitable contrace
method to avoid pregnancy while undergoing therapy with DASANAT 50MG TABLET.

The most common side effects of taking DASANAT 50MG TABLET are increased
bleeding tendency, increased infections, feeling tired or weak, nausea,
vomiting, hair loss, mouth ulcers, changes in taste, inflammation of the food
pipe or stomach, muscle pain or spasm, skin rashes, headache, dizziness and
weight loss. Contact your doctor if any of these side effect worsens.

Uses Of DASANAT 50MG TABLET

It is used in adults, adolescents and in children (aged 1 year or above) to
manage:

• Cancers of blood and bone marrow (such as chronic myeloid leukaemia and philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia)

How DASANAT 50MG TABLET Works

DASANAT 50MG TABLET is an anti-cancer medicine. It works by blocking the actions
of certain proteins (such as BCR-ABL, Src kinase, etc.) in the body that
triggers cancer formation. As a result, it reduces abnormal growth and
multiplication of cancer cells in the body.

How to use DASANAT 50MG TABLET

Take DASANAT 50MG TABLET as advised by your physician. It can be taken with or
without meals. Swallow the medicine with a glass of water. Do not crush or chew
the medicine.

Try to take DASANAT 50MG TABLET at the same time each day. Your doctor will
decide the correct dose and duration of therapy for you depending upon your age,
body weight and health condition. Do not stop taking DASANAT 50MG TABLET unless
advised by your doctor.

Side Effects Of DASANAT 50MG TABLET

Common

• increased infections
• nausea, vomiting
• diarrhea, stomach pain, bloating, constipation, heartburn
• lack of appetite, changes in taste
• mouth ulcers, hair loss
• weight loss or weight gain
• headache, tiredness, weakness
• dizziness
• skin rash, itching, dry skin, acne
• increased bleeding tendency
• joint pain, muscle pain or spasms
• increased sweating, flushing
• blurred vision, dry eyes
• depression, sleeplessness
• oedema (swelling of body parts)

Uncommon

• irregular heartbeat, chest pain, breathing difficulties
• stomach ulcers, inflammation of the food pipe
• swollen tummy, anal tears
• anxiety, confusion, mood swings, memory loss
• low sexual drive
• loss of hearing, sensitivity to light
• skin inflammation, nail disorder
• problems in passing urine
• breast enlargement in men, menstrual disorder
• high blood cholesterol levels
• swollen lymph nodes
• increased protein in the urine

Stop taking DASANAT 50MG TABLET and contact your doctor immediately if you
experience any of the following side effects such as:

• signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
• chest pain, cough, breathing difficulties and fainting (signs of fluid retention in lungs)
• unusual bleeding or bruising with fever, tiredness and confusion (signs of blood vessel damage)
• bloody stools/urine/vomit or black tarry stools
• blistering or peeling of skin and mucous membranes with fever and sore throat, mouth ulcers

How To Manage Side Effects

!### Constipation

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and
drink plenty of water. Try doing exercise regularly (going for a daily walk or
run). If this does not help, inform your doctor for receiving alternate
managements for constipation.

!### Diarrhea

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid
taking any medicine on your own to manage diarrhoea and consult your doctor if
the symptom gets worse.

!### Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Consult your doctor if your
dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Consult your doctor if your headache worsens.

!### Mouth Ulcers

Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on
the affected areas of the mouth if required. Consult your doctor if the symptom
did not improve.

!### Nausea And Vomiting

Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea
worsens, consult your doctor for advice.

!### Skin rash Or Itching

Avoid hot showers because hot water can irritate your skin further. Do not
scratch the affected area. Use protective clothing when going outdoors.
Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Warning & Precautions

!### Pregnancy

ContraindicatedDASANAT 50MG TABLET is not recommended for use in pregnant women unless
considered necessary by the physician. Therefore, inform your doctor before
taking DASANAT 50MG TABLET if you are pregnant or think you may be pregnant.
Women of childbearing potential must use a suitable contrace
avoid pregnancy while undergoing therapy with DASANAT 50MG TABLET.

!### Breastfeeding

ContraindicatedDASANAT 50MG TABLET is not recommended for use in breastfeeding women as it may
pass through the breast milk. Therefore, consult your doctor taking it.

!### Driving and Using Machines

Use with CautionDo not drive or operate any heavy tools or machines if you feel dizzy after
taking DASANAT 50MG TABLET.

!### Alcohol

Consult your doctorAvoid consum
you feel dizzier.

!### Kidney

Use with CautionDASANAT 50MG TABLET should be used with caution in patients with kidney
problems. Therefore, consult your doctor before taking it.

Liver

Use with CautionDASANAT 50MG TABLET should be used with caution in patients with liver problems.
Therefore, consult your doctor before taking it.

!### Allergy

Use with CautionDo not take DASANAT 50MG TABLET if you are allergic to Dasatinib.

!### Heart Disease

Use with CautionDASANAT 50MG TABLET should be used with caution in patients with heart problems.
Therefore, consult your doctor before taking it.

!### Use In Pediatrics

ContraindicatedDASANAT 50MG TABLET is not recommended for use in children (aged below 1 year).
Bone growth and development will be closely monitored in children taking this
medicine. Therefore, consult your child’s doctor for advice.

!### Use In Geriatrics

Use with CautionDASANAT 50MG TABLET should be used with caution in elderly patients (aged 65
years or above). Therefore, consult your doctor before taking it.

Others

DASANAT 50MG TABLET is not recommended for use if you:

• have, ever had or at risk of having hepatitis B infection

Interactions

A. Drug-Drug Interactions:

Before taking DASANAT 50MG TABLET, inform your doctor, if you are taking any of
the following medicines such as:

• medicines used for blood thinning (Ex. warfarin)
• ketoconazole, itraconazole (used to manage fungal infection)
• medicines used to manage bacterial infection (such as erythromycin, clarithromycin, telithromycin)
• ritonavir (a medicine used to manage HIV infection)
• medicines used to manage epilepsy (Ex. phenytoin, carbamazepine, phenobarbital)
• rifampicin (a medicine used to manage tuberculosis)
• medicines used to manage stomach ulcers (such as famotidine, omeprazole)
• St. John’s wort (an herbal preparation used to manage depression)
• antacids (used to neutralize stomach acids) Ex. aluminium hydroxide or magnesium hydroxide

B. Drug-Food Interactions:

Avoid eating grapefruit or drinking grapefruit juice while taking DASANAT 50MG
TABLET as it may increase the risk of side effects.

Overdosage:

If you or anyone else accidentally took more DASANAT 50MG TABLET, consult your
doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Dasatinib
Pharmacological Category	:	BCR-ABL Tyrosine Kinase Inhibitor
Therapeutic Indication	:	Chronic Myeloid Leukaemia, Ph+ Acute Lymphoblastic Leukaemia
Dosage Forms	:	Tablet

More Information

• Keep DASANAT 50MG TABLET out of reach of children
• Store DASANAT 50MG TABLET at room temperature

FAQs About DASANAT 50MG TABLET

Q: What is DASANAT 50MG TABLET used for?

A: DASANAT 50MG TABLET is used to manage cancers of blood and bone marrow (such
as chronic myeloid leukaemia (CML) and philadelphia chromosome positive (Ph+)
acute lymphoblastic leukaemia) in adults, adolescents and in children (aged 1
year or above). It is primarily used in patients when management with
conventional therapies is not suitable or fails to provide adequate response.

Q: How DASANAT 50MG TABLET works in my body?

A: DASANAT 50MG TABLET is an anti-cancer medicine. It works by blocking the
actions of certain proteins (such as BCR-ABL, Src kinase, etc.) in the body that
triggers cancer formation. As a result, it reduces abnormal growth and
multiplication of cancer cells in the body.

Q: Can DASANAT 50MG TABLET manage cancer?

A: The success rate of cancer depends upon the severity of the disease. However,
DASANAT 50MG TABLET acts by stopping the abnormal growth and multiplication of
cancer cells in the body, which may help in managing the cancer completely.

Q: Can the use of DASANAT 50MG TABLET cause hair loss?

A: Hair loss is one of the common side effects of taking DASANAT 50MG TABLET. If
it bothers you, consult your doctor for advice.

Q: Can the use of DASANAT 50MG TABLET cause mouth ulcers?

A: Mouth ulcers are one of the common side effects of taking DASANAT 50MG
TABLET. Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving
gel on the affected areas of the mouth if required. Consult your doctor if the
symptom did not improve

Q: Can DASANAT 50MG TABLET be used in children?

A: DASANAT 50MG TABLET can be used in children and adolescents (aged 1 year or
above) if prescribed by the physician. It should not be used in children aged
below 1 year due to increased risk of side effects.

Q: Is DASANAT 50MG TABLET a chemo drug?

A: Yes. DASANAT 50MG TABLET contains a medicine called Dasatinib which is a
chemotherapeutic agent. It stops abnormal growth and multiplication of cancer
cells in the body.

Q: What happens if I forgot to take a dose of DASANAT 50MG TABLET?

A: If you forgot to take a dose of DASANAT 50MG TABLET, take it as soon as you
remember. However, if it is time for the next dose of DASANAT 50MG TABLET, skip
the missed dose and take the next one regularly. Do not take a double dose of
DASANAT 50MG TABLET to compensate the missed ones.

Q: What precautions must be followed while taking DASANAT 50MG TABLET?

A: Before taking DASANAT 50MG TABLET inform your doctor if you have any liver,
kidney or heart problems or if you have or at risk of developing hepatitis C
infection as a precaution. Avoid eating grapefruit or drinking grapefruit juice
while taking DASANAT 50MG TABLET. Leave a time gap of at least 2 hours between
DASANAT 50MG TABLET and stomach medicines. Inform your doctor before taking
DASANAT 50MG TABLET if you are pregnant or breastfeeding women. Men and women
taking DASANAT 50MG TABLET must use a suitable contrace
pregnancy while undergoing therapy with DASANAT 50MG TABLET.

Q: Will taking a higher dose of DASANAT 50MG TABLET be more effective?

A: No, taking a higher dose of DASANAT 50MG TABLET will not be effective rather
it can lead to toxicity. Always take the dose prescribed by your doctor. If the
prescribed dose is not effective for you, consult your doctor for advice. Your
doctor might increase the dose or suggest an alternative therapy

Q: What happens if I stop taking DASANAT 50MG TABLET?

A: No. Do not stop taking DASANAT 50MG TABLET without consulting your doctor as
it may make your symptoms reappear. Therefore, take DASANAT 50MG TABLET as
advised by your doctor for the stipulated duration.

Q: Can DASANAT 50MG TABLET be used during pregnancy?

A: DASANAT 50MG TABLET is not recommended for use in pregnant women unless
considered necessary by the physician. Therefore, inform your doctor before
taking DASANAT 50MG TABLET if you are pregnant or think you may be pregnant.

Q:Can the use of DASANAT 50MG TABLET make me feel tired?

A: Yes. DASANAT 50MG TABLET may make you feel tired easily. This is because, it
reduces the levels of red blood cells in your blood and may make you anaemic.
Consult your doctor if you experience tiredness after taking DASANAT 50MG
TABLET. Tiredness can also occur if you have any pre-existing disease conditions
such as liver or kidney impairment while taking this medicine.

Q:Can I drive a car after takingDASANAT 50MG TABLET?

A: DASANAT 50MG TABLET may make you feel tired or dizzy. Therefore, do not drive
or operate any heavy tools or machines if your ability is affected by DASANAT
50MG TABLET.

Q: How to take DASANAT 50MG TABLET?

A: Take DASANAT 50MG TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine. DASANAT 50MG TABLET
can be taken with or without food.

Q:How to control nausea caused due to DASANAT 50MG TABLET?

A: Generally, anticancer medicines are associated with uncontrollable nausea and
vomiting. To avoid this, your doctor would prescribe a suitable medicine to
control them along with DASANAT 50MG TABLET. If not, consult your doctor for a
suitable anti-emetic medicine. Do not self-manage nausea.

Q: What are the side effects of taking DASANAT 50MG TABLET?

A: The most common side effects of taking DASANAT 50MG TABLET are increased
bleeding tendency, increased infections, feeling tired or weak, nausea,
vomiting, hair loss, mouth ulcers, changes in taste, inflammation of the food
pipe or stomach, muscle pain or spasm, skin rashes, headache, dizziness and
weight loss. Contact your doctor if any of these side effect worsens.

Q: Who should avoid taking DASANAT 50MG TABLET?

A: DASANAT 50MG TABLET is not recommended for use if you are allergic to
dasatinib. It is also not recommended for use in pregnant or breastfeeding women
and in children (aged below 1 year).

Q: IsDASANAT 50MG TABLET safe to use in kidney disease?

A: DASANAT 50MG TABLET should be used with caution in patients with kidney
problems. Your doctor will access your health condition and suggest a suitable
dose for you.

Q:Can the use of DASANAT 50MG TABLET affect the liver?

A: Yes. DASANAT 50MG TABLET may affect the way your liver work. It can elevate
the levels of certain liver enzymes in your body. Therefore, it should be used
with caution in patients with liver problems. Consult your doctor before taking
it.