Corpril AM 5/2.5mg Capsule 10'S

Introduction About CORPRIL AM 5/2.5MG CAPSULE

CORPRIL AM 5/2.5MG CAPSULE is a combination of Amlodipine and Ramipril which
belongs to the group of medicines called Antihypertensive agents. It is used to
manage hypertension (high blood pressure) and certain type of angina (chest
pain) called as Prinzmetal or variant angina. It can also be used to manage
heart failure and reduce the chances of hospitalization among the heart
patients.

It also protects the function of kidneys particularly in patients who have both
hypertension and type II diabetes mellitus.

Before taking CORPRIL AM 5/2.5MG CAPSULE inform your doctor if you have any
liver or kidney problems. You must also inform your doctor if you have any other
heart problems apart from hypertension, angina and heart failure (such as
cardiogenic shock or narrowing of heart valves).

Talk to your doctor if you are on a low salt diet or have diabetes or are
severely dehydrated due to any recent sickness (such as vomiting or diarrhea)
before taking CORPRIL AM 5/2.5MG CAPSULE as a precaution.

CORPRIL AM 5/2.5MG CAPSULE is not recommended for use in patients with severe
hypotension (low blood pressure). It is also not suitable for use in women who
are pregnant or breastfeeding due to increased risk of side effects.

The most common side effects of taking CORPRIL AM 5/2.5MG CAPSULE are dizziness,
swelling of ankles or other body parts, headache, sleepiness, tiredness, racing
heartbeat, indigestion, constipation and muscle cramps. Contact your doctor if
any of these side effects trouble you.

Uses Of CORPRIL AM 5/2.5MG CAPSULE

It is used to:

• Manage hypertension and angina
• Prevent heart failure
• Protects kidney functions in patients with hypertension and diabetes

How CORPRIL AM 5/2.5MG CAPSULE Works

CORPRIL AM 5/2.5MG CAPSULE is a vasodilator. It relaxes the blood vessels
supplying the heart and other organs (such as kidneys). This improves blood flow
and oxygen supply to the heart muscles which reduces strain on the heart.

It also allows blood to flow more smoothly across the blood vessels with less
pressure. It can improve blood supply to the kidneys which helps in delaying the
worsening of kidney functions in diabetic patients. As a result, it reduces
blood pressure and improves the functions of the heart and the kidneys.

How to use CORPRIL AM 5/2.5MG CAPSULE

Take CORPRIL AM 5/2.5MG CAPSULE as advised by your physician. Swallow the
medicines with a glass of water. Do not crush or chew the medicine. CORPRIL AM
5/2.5MG CAPSULE can be taken with or without food.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition.

Continue to take CORPRIL AM 5/2.5MG CAPSULE for the stipulated duration
instructed by your doctor to achieve better results.

Side Effects Of CORPRIL AM 5/2.5MG CAPSULE

Common

• edema (swelling of the ankles or other body parts)
• headache, dizziness, sleepiness
• palpitations (fast heartbeat)
• flushing (redness and warmth of the skin)
• stomach pain, nausea, diarrhea, constipation, indigestion
• changes in bowel habit
• tiredness, weakness
• blurred vision, double vision
• muscle pains
• dry cough, sinus inflammation
• increased potassium levels in blood

Uncommon

• anxiety, depression
• insomnia (sleeplessness)
• changes in taste
• tingling sensation in limbs, loss of pain sensation
• ringing in the ears
• increased sweating
• increased urination at night
• inability to obtain an erection, enlargement of the breasts in men
• joint pain, back pain

Rare

• confusion
• red, swollen tongue
• loosening or separation of a nail from its bed
• skin rash, itching, redness
• red, itchy, swollen or watery eyes
• low RBC, WBC and platelet counts

Stop taking CORPRIL AM 5/2.5MG CAPSULE and contact your doctor immediately if
you experience any of the following side effects:

• signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
• severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
• chest pain, shortness of breath (signs of heart attack)
• inflammation of pancreas (causing severe stomach pain that radiates to the back side of the body)
• sever stomach pain due to obstruction of the gut or inflammation of pancreas
• dizziness, fainting or lightheadedness, excessive sweating following an exercise or after regular activities (signs of low RBC count in blood)
• signs of liver problems (such as fever, muscle pain, rashes, itching, stomach pain, diarrhea, discoloration of eyes, skin and urine)
• increased bleeding or bruising

How To Manage Side Effects

Nausea and vomiting:

Take CORPRIL AM 5/2.5MG CAPSULE with or just after a meal or a snack. Stick to
simple meals. Avoid eating rich or spicy food. Consult your doctor if your
nausea worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Do not consume excessive
alcohol, as it could aggravate your dizziness. Consult your doctor if your
dizziness worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals.
Drink plenty of fluids. Exercise more regularly. Consult your doctor if this
side effect bothers you.

Warning & Precautions

!### Pregnancy

CORPRIL AM 5/2.5MG CAPSULE is not recommended for use in pregnant women as it
may cause serious harm to the growing fetus. Therefore, inform your doctor
before taking this medicine if you are pregnant, think you may be pregnant or
planning to have a baby. If you accidentally become pregnant while undergoing
therapy with CORPRIL AM 5/2.5MG CAPSULE, inform your doctor immediately.

!### Breastfeeding

CORPRIL AM 5/2.5MG CAPSULE is not recommended for use in breast-feeding women.
Therefore, consult your doctor before taking it.

!### Driving and Using Machines

Do not drive or operate any heavy tools or machines if you feel dizzy after
taking CORPRIL AM 5/2.5MG CAPSULE.

!### Alcohol

Avoid consum
severely decrease your blood pressure and make you feel dizzier or faint.

!### Kidney

CORPRIL AM 5/2.5MG CAPSULE is not recommended for use in patients with severe
kidney impairment (including dialysis or narrowing or renal arteries). It should
be used with caution in patients with other kidney problems (including kidney
transplantation). Therefore, consult your doctor before taking it.

!### Liver

CORPRIL AM 5/2.5MG CAPSULE should be used with caution in patients with liver
problems. Therefore, consult your doctor before taking it.

!### Allergy

Do not take CORPRIL AM 5/2.5MG CAPSULE if you are allergic to Amlodipine,
Ramipril or to any other calcium antagonists (such as nifedipine, diltiazem) or
ACE inhibitors (such as captopril, lisinopril, enalapril).

!### Heart Disease

CORPRIL AM 5/2.5MG CAPSULE is not recommended for use in patients with severe
heart problems such as heart failure, aortic stenosis (narrowing of arteries) or
cardiogenic shock (inability of heart to pump blood). It should be used with
caution in patients having a history of recent heart attack or heart failure.
Therefore, consult your doctor before taking it.

Others

CORPRIL AM 5/2.5MG CAPSULE is not recommended for use if you:

• have severe low blood pressure (hypotension)
• have diabetes with impaired kidney functions

Before taking CORPRIL AM 5/2.5MG CAPSULE, inform your doctor if you have:

• severe uncontrollable increase in blood pressure (hypertensive crisis)
• have problems in the blood vessels supplying the brain
• are on a salt-restricted diet
• are severely dehydrated due to any recent sickness such as vomiting or diarrhea
• have low WBC, RBC and platelet count in the blood
• have diabetes
• have any autoimmune disease that affects the skin or collagen (Ex. lupus erythematosus, rheumatoid arthritis or scleroderma)
• are scheduled for any upcoming surgery
• have any desensitization management (used to reduce the effect of an allergy to bee or wasp stings)
• have high blood potassium levels

Use inPaediatrics:

CORPRIL AM 5/2.5MG CAPSULE is not recommended for use in children and
adolescents (aged below 18 years) due to lack of safety data. Therefore, consult
your doctor before consum

Use inGeriatrics:

CORPRIL AM 5/2.5MG CAPSULE should be used with caution in elderly patients.
Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking CORPRIL AM 5/2.5MG CAPSULE, inform your doctor if you are taking
any of the following medicines such as:

• racecadotril (a medicine used to manage diarrhea)
• medicines that supplement potassium to the body (Ex. spironolactone, triamterene or amiloride)
• trimethoprim containing antibiotics (used for infections)
• medicines used to manage organ transplant rejection (Ex. ciclosporin, temsirolimus, sirolimus, everolimus)
• heparin (used to manage blood clots)
• medicines used for heart conditions such as hypertension, chest pain, irregular heartbeats or heart failure (Ex. atenolol, propranolol, furosemide, bumet
• lithium (a medicine used in some types of mental illness)
• medicines used to relieve pain (Ex. morphine, aspirin, ibuprofen, celecoxib, valdecoxib)
• anti-diabetic medicines and insulin (used to lower the blood glucose level) Ex. vildagli
• corticosteroids (used to relieve pain and inflammation) Ex. prednisone
• allopurinol (a medicine used to manage gout)
• other medicines used to manage high blood pressure or angina (Ex. diltiazem, verapamil)
• ketoconazole, itraconazole (used to manage fungal infections)
• ritonavir, indinavir, nelfinavir (used in management of HIV infections)
• rifampicin, erythromycin, clarithromycin (used to manage bacterial infections)
• dantrolene (a medicine used to manage muscle spasms)
• medicines used to control elevated cholesterol levels (Ex. simvastatin)
• St. John’s wort (an herbal medicine used to manage depression)

B. Drug - Food interaction:

Avoid drinking grapefruit juice while taking CORPRIL AM 5/2.5MG CAPSULE, as it
could reduce your blood pressure to an abnormal level.

Overdosage:

If you or anyone else accidentally took more CORPRIL AM 5/2.5MG CAPSULE, consult
your doctor immediately or visit the nearby hospital. Symptoms of overdosage
might include dizziness, fainting, light-headedness, weakness, shock, cool or
clampy skin, fast heartbeat, anxiety, cough and shortness of breath.

Synopsis

Drug	:	Amlodipine, Ramipril
Pharmacological Category	:	Calcium Channel Blockers, ACE inhibitors
Therapeutic Indication	:	Hypertension, Angina, Heart Failure, Kidney Failure
Dosage Forms	:	Tablet, Capsule

More Information

• Keep CORPRIL AM 5/2.5MG CAPSULE out of the sight and reach of children
• Store CORPRIL AM 5/2.5MG CAPSULE at room temperature

FAQs About CORPRIL AM 5/2.5MG CAPSULE

What are the uses of CORPRIL AM 5/2.5MG CAPSULE?

CORPRIL AM 5/2.5MG CAPSULE is used to manage hypertension (high blood pressure)
and certain type of angina (chest pain). It can also be used to manage heart
failure and reduce the chances of hospitalization among the heart patients. It
also protects the function of kidneys particularly in patients who have both
hypertension and type II diabetes mellitus.

How CORPRIL AM 5/2.5MG CAPSULE works?

CORPRIL AM 5/2.5MG CAPSULE is a vasodilator. It relaxes the blood vessels
supplying the heart and other organs. This improves blood flow and oxygen supply
to the heart muscles which reduces strain on the heart. It also allows blood to
flow more smoothly across the blood vessels with less pressure.  It can improve
blood supply to the kidneys which helps in delaying the worsening of kidney
functions in diabetic patients. As a result, it reduces blood pressure and
improves the functions of the heart and the kidneys.

What happens when I stop taking CORPRIL AM 5/2.5MG CAPSULE?

Do not stop taking CORPRIL AM 5/2.5MG CAPSULE without consulting your doctor as
your symptoms may re-appear once again. Make sure to take CORPRIL AM 5/2.5MG
CAPSULE for the stipulated duration recommended by your doctor to achieve
maximum results.

What is the best time to take CORPRIL AM 5/2.5MG CAPSULE?

CORPRIL AM 5/2.5MG CAPSULE can be taken with or without meals. Your doctor will
decide the best time for you to take CORPRIL AM 5/2.5MG CAPSULE based on your
age, body weight and disease condition.

What to do if I forgot to take a dose of CORPRIL AM 5/2.5MG CAPSULE?

If you have missed a dose of CORPRIL AM 5/2.5MG CAPSULE, take it as soon as you
remember. However, if it is time for the next dose of CORPRIL AM 5/2.5MG
CAPSULE, skip the missed dose and take the next one regularly. Do not take a
double dose of CORPRIL AM 5/2.5MG CAPSULE to compensate the missed ones.

What precautions should be followed while taking CORPRIL AM 5/2.5MG CAPSULE?

Before taking CORPRIL AM 5/2.5MG CAPSULE, inform your doctor if you have any
liver or kidney problems. You must also inform your doctor if you have severe
high or low blood pressure or other heart problems (such as narrowing of the
arteries, cardiogenic shock or a recent heart attack). Do not take CORPRIL AM
5/2.5MG CAPSULE if you are pregnant or breastfeeding. Regularly visit your
doctor and take all the necessary blood tests recommended by your doctor without
fail.

Can I consume alcohol while taking CORPRIL AM 5/2.5MG CAPSULE?

Avoid consum
make you feel dizzier and drowsier.

What happens if I accidentally take more CORPRIL AM 5/2.5MG CAPSULE?

If you or anyone else accidentally took more CORPRIL AM 5/2.5MG CAPSULE, consult
your doctor immediately. Symptoms of overdosage might include dizziness,
fainting, light-headedness, weakness, shock, cool or clampy skin fast heartbeat,
anxiety, cough and shortness of breath.

Can I take CORPRIL AM 5/2.5MG CAPSULE daily?

Take CORPRIL AM 5/2.5MG CAPSULE as advised by your physician. Your doctor will
evaluate your health condition and suggests whether can you take CORPRIL AM
5/2.5MG CAPSULE every day or not.

Can CORPRIL AM 5/2.5MG CAPSULE cause ankle swelling?

CORPRIL AM 5/2.5MG CAPSULE may cause edema or swelling of ankles in few
patients. If you experience ankle swelling, keep your legs on a table or
slightly elevated from the ground level. If this symptom bothers you, contact
your doctor.

What are the side effects of CORPRIL AM 5/2.5MG CAPSULE?

The most common side effects of taking CORPRIL AM 5/2.5MG CAPSULE are dizziness,
swelling of ankles or other body parts, headache, sleepiness, tiredness, racing
heartbeat, indigestion, constipation and muscle cramps. Contact your doctor if
any of these side effects trouble you.

Can I stop taking CORPRIL AM 5/2.5MG CAPSULE once my symptoms subside?

No. Do not stop taking CORPRIL AM 5/2.5MG CAPSULE without consulting your
doctor. As hypertension is a chronic condition, long term management may be
necessary to control its symptoms. Therefore, take CORPRIL AM 5/2.5MG CAPSULE as
advised by your doctor for the stipulated duration. Sudden withdrawal of the
therapy may increase your blood pressure once again.

Can the use of CORPRIL AM 5/2.5MG CAPSULE affect the liver?

Yes. CORPRIL AM 5/2.5MG CAPSULE may affect the way your liver work. Therefore,
it should be used with caution in patients with liver problems. Consult your
doctor before taking it.

Can CORPRIL AM 5/2.5MG CAPSULE cause erectile dysfunction?

CORPRIL AM 5/2.5MG CAPSULE may cause problems in erection in few individuals.
Consult your doctor if it bothers you.

Is CORPRIL AM 5/2.5MG CAPSULE safe to use in diabetic patients?

CORPRIL AM 5/2.5MG CAPSULE may alter the blood sugar levels in your body. It can
also hide the symptoms of low blood sugar. Therefore, it is necessary to inform
your doctor if you have diabetes before taking CORPRIL AM 5/2.5MG CAPSULE as a
precaution. Your doctor will closely monitor your blood sugar levels to avoid
the risk of side effects. Also, inform your doctor if you experience any unusual
tiredness, hunger or thirst while undergoing therapy with CORPRIL AM 5/2.5MG
CAPSULE.

Can CORPRIL AM 5/2.5MG CAPSULE be used during pregnancy?

CORPRIL AM 5/2.5MG CAPSULE is not recommended for use in pregnant women as it
may cause serious harm to the growing foetus. Therefore, inform your doctor
before taking CORPRIL AM 5/2.5MG CAPSULE if you are pregnant, think you may be
pregnant or planning to have a baby.

What kind of foods should be avoided while takingCORPRIL AM 5/2.5MG
CAPSULE?

CORPRIL AM 5/2.5MG CAPSULE has the capacity to increase blood potassium level
which can lead to irregular heartbeat. To manage any such occurrence, it is
advisable to avoid potassium rich foods such as bananas, oranges, green leafy
vegetables and potassium containing supplements while taking CORPRIL AM 5/2.5MG
CAPSULE.

Useful Diagnostic Tests

• Kidney Function Test