Consegna 30/70 U200 Injection 3ml

INTRODUCTION ABOUT CONSEGNA 30/70 U200 INJECTION

CONSEGNA 30/70 U200 INJECTION contains Biphasic Isophane Insulin which belongs
to the group of medicines called Antidiabetic agents. It improves glycemic
control in patients with diabetes mellitus (both type I and type II). It helps
your body to make utilize of the circulating blood glucose by transporting the
circulating glucose from the blood into the muscles and fat tissues.

Biphasic Isophane Insulin is a pre-mixed combination of Regular (soluble)
insulin and Isophane (NPH) insulin. It is a fast-acting medicine where it begins
to lower blood sugar levels within 30 minutes. Therefore, inject the medicine 30
minutes before meal and make sure to have your meals within the next 30 minutes.

Talk to your doctor before starting therapy with CONSEGNA 30/70 U200 INJECTION
if you have any liver, kidney or heart problems. You must also inform your
doctor if you have any hormonal problems, made sudden changes to your diet or
perform intense exercise as a precaution. Do not use this medicine if you have
hypoglycemia (low blood sugar levels). Consult your doctor before using this
medicine if you are pregnant or breastfeeding.

The most common side effects of receiving CONSEGNA 30/70 U200 INJECTION are low
blood sugar levels, pain, redness, itching, swelling or thickening at the
injection site, lump formation under the skin and swelling of body parts.
Consult your doctor if any of these side effect troubles you.

USES OF CONSEGNA 30/70 U200 INJECTION

• Improves glycemic control in patients with diabetes mellitus (both type I and type II)

HOW CONSEGNA 30/70 U200 INJECTION WORKS

CONSEGNA 30/70 U200 INJECTION helps your body to make utilize of the circulating
blood glucose. It helps in the transport of glucose from the blood into the
muscles and fat tissues. It also stops the production of glucose by the liver.
As a result, it controls blood sugar levels and improve glycemic control in
patients with diabetes mellitus.

DIRECTIONS FOR USE

Use CONSEGNA 30/70 U200 INJECTION under careful medical supervision. Inject
CONSEGNA 30/70 U200 INJECTION into your thighs, buttocks, upper arm, or abdomen
(i.e., subcutaneously). Do not administer this medicine into the vein or muscle
directly. It should be administered at least 10 minutes before meals. Eat a meal
or snack containing carbohydrates within 20 minutes of the injection to avoid
low blood sugar.

Before administration, roll the vial/cartridge between your hands until the
liquid becomes uniformly white and cloudy. While injecting, keep the needle
under the skin for at least 6 seconds to make sure that the entire dose is
injected.

Prior to the administration, visualize the cartridge/vial for any visible
particulate matter and discoloration. Discard the needle and syringe after use
and do not share your needles with others to avoid the risk of transmission of
infections.

Avoid repeatedly injecting the medicine at the same site to manage skin damage.
Instead, rotate the injection site. Make sure to consult your doctor before
changing the injection site as a precaution.

CONSEGNA 30/70 U200 INJECTION should not be mixed with any other insulins before
use. Do not stop therapy with CONSEGNA 30/70 U200 INJECTION without consulting
your doctor. Your doctor will decide correct dose and frequency of
administration depending upon your age, body weight and health condition.

SIDE EFFECTS OF CONSEGNA 30/70 U200 INJECTION

COMMON

• Injection site reactions (such as pain, redness, itching or swelling)
• Lipodystrophy (shrinkage of fat tissues beneath the skin)
• Lumps under the skin
• Weight gain, swelling of body parts
• Hypoglycemia (Low blood sugar levels)

UNCOMMON

• diabetic retinopathy (eye diseases due to diabetes)
• swelling around the ankles and other joints
• painful neuropathy (pain caused by nerve damage)

RARE

• problem in vision

Consult your doctor immediately if you experience any of the following side
effects:

• allergic reaction (generalized skin rash with itching, sweating, and swelling of layers under the skin, difficulties in breathing, palpitation, vomiting, stomach upset, reduction in blood pressure and fainting /loss of consciousness)
• signs of severe hypoglycemia (such as cold sweats, cool pale skin, headache, rapid heartbeat, nausea, increased hunger, temporary vision changes, drowsiness, tiredness and weakness, nervousness or tremor, anxiety, confusion and difficulty in concentrating)

HOW TO MANAGE SIDE EFFECTS

!### Hypoglycemia

Managing hypoglycemia, or low blood sugar, involves prompt action to raise blood
glucose levels and manage complications. When experiencing hypoglycemia,
individuals should quickly consume a source of rapidly-absorbed carbohydrates,
such as glucose tablets, fruit juice, or regular soda. Waiting for about 15
minutes and rechecking blood sugar levels is crucial to ensure they rise to a
safe range. If hypoglycemia persists, additional carbohydrate intake may be
necessary. Once blood sugar levels stabilize, a small snack containing both
carbohydrates and protein can help sustain them. Regular monitoring and
consultation with a healthcare professional are essential for developing a
personalized plan to manage hypoglycemia effectively. In severe cases, emergency
assistance may be required.

!### Injection Site Reactions

Managing injection site reactions is essential for individuals who regularly
administer injections. To alleviate discomfort and minimize potential issues, it
is crucial to follow proper injection techniques. Rotate injection sites to
manage overuse of a single area, allowing tissues to heal. Use a clean, sterile
needle and syringe for each injection. Apply an ice pack to the injection site
before and after administration to reduce pain and swelling. If redness,
swelling, or irritation persists, consult a healthcare professional for
guidance. It is essential to report any severe or persistent reactions to ensure
appropriate adjustments to the injection routine and to manage potential
complications.

WARNING & PRECAUTIONS

!### PREGNANCY

Monitoring requiredCONSEGNA 30/70 U200 INJECTION can be used during pregnancy if prescribed by the
physician. Therefore, consult your doctor before administration.

!### BREASTFEEDING

SafeCONSEGNA 30/70 U200 INJECTION is considered safe for use during breastfeeding.
However, consult your doctor before administration.

!### DRIVING AND USING MACHINES

Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected
by CONSEGNA 30/70 U200 INJECTION.

!### ALCOHOL

Consult your doctorAvoid consum
your existing disease condition.

!### KIDNEY

Use with CautionCONSEGNA 30/70 U200 INJECTION should be used with caution in patients with
kidney problems. Therefore, consult your doctor before administration.

!### LIVER

Use with CautionCONSEGNA 30/70 U200 INJECTION should be used with caution in patients with liver
problems. Therefore, consult your doctor before administration.

!### ALLERGY

ContraindicatedTalk to your doctor before receiving CONSEGNA 30/70 U200 INJECTION if you are
allergic to Regular insulin, Isophane insulin or to any other Human insulin (Ex.
Lente, ultra-Lente).

!### HEART DISEASE

Use with CautionCONSEGNA 30/70 U200 INJECTION should be taken with caution in patients with
heart disease. Therefore, consult your doctor before administration.

!### USE IN PEDIATRICS

Monitoring requiredCONSEGNA 30/70 U200 INJECTION can be used in children and adolescents (aged
below 18 years) if prescribed by the physician. Therefore, consult your doctor
before administration.

!### USE IN GERIATRICS

Use with CautionCONSEGNA 30/70 U200 INJECTION should be used with caution in elderly patients
(aged 65 years or above). Therefore, consult your doctor before administration.
Proper dose adjustments and careful monitoring of blood glucose levels and
kidney functions are required in such patients.

OTHERS

CONSEGNA 30/70 U200 INJECTION is not recommended for use if you:

• have or at risk of developing hypoglycemia (low blood sugar levels)

Talk to your doctor before receiving CONSEGNA 30/70 U200 INJECTION if you:

• have problems in adrenal, pituitary or thyroid glands
• have recently changed your diet plan and lifestyle
• are exercising more than usual
• recently became ill or had any infections
• are planning to go abroad (as mealtime and injection timings may get changed)

INTERACTIONS

A. Drug-Drug interactions:

Before CONSEGNA 30/70 U200 INJECTION is administered, inform your doctor if you
are taking any of the following medicines such as:

• other antidiabetic agents (Ex. tolbutamide, glibenclamide, glipizide), bigu
• antidepressants (Ex. rasagiline, selegiline, phenelzine)
• Heart medicines (Ex. propranolol, atenolol, nebivolol) or ACE inhibitors (Ex. captopril, enalapril, lisinopril)
• salicylates (used to relieve pain or fever) Ex. aspirin
• anabolic steroids (used to build muscle and improve athlete performance) Ex. testosterone, nandrolone, oxandrolone
• sulfonamide antibiotics (Ex. sulfasalazine, sulfadiazine, sulfamethoxazole)
• oral contrace
• thiazide diuretics (Ex. chlorothiazide, hydrochlorothiazide)
• glucocorticoids (used to manage inflammation) Ex. cortisone, betamethasone, beclomethasone, dexamethasone, budesonide, prednisone
• thyroid hormones (used to manage thyroid deficiency) Ex. thyroxine, triiodothyronine
• sympathomimetic agents (used to manage asthma or other circulatory disorders) Ex. ephedrine, adrenaline, salbutamol, or terbutaline
• growth hormone (a hormone used to increase skeletal and somatic growth in the body)
• danazol (a medicine used for endometriosis)
• octreotide (used to manage diarrhea)
• lanreotide (a medicine used to manage abnormal body growth)

B. Interaction with food or drink:

CONSEGNA 30/70 U200 INJECTION should be administered 30 minutes before a meal.

Overdosage:

If you or anyone else took too much of this medicine, contact your doctor
immediately or go to a hospital straight away as it may cause severe
hypoglycemia. Symptoms of hypoglycemia might include fainting, feel unwell,
sweating, vomiting, difficulty in breathing, fast heartbeat, and dizziness.

SYNOPSIS

Drug	:	Biphasic Isophane Insulin
Pharmacological Category	:	Antidiabetic agents
Therapeutic Indication	:	Diabetes mellitus
Dosage Forms	:	Injection, Cartridge, Pen

MORE INFORMATION

• Keep out of reach of children
• Store the unopened pack in the refrigerator at 2-8°C. Do not freeze
• During use or when carried as a spare, keep it at room temperature
• Always place the vial/cartridge in the outer carton to protect from light

FAQs ABOUT CONSEGNA 30/70 U200 INJECTION

Q: Should CONSEGNA 30/70 U200 INJECTION be refrigerated?

A: Yes. An unopened pack must be stored in the refrigerator (2°C – 8°C). During
use or while carrying as a spare, keep it at room temperature to ensure uniform
resuspension.

Q: Can CONSEGNA 30/70 U200 INJECTION be mixed with other insulins?

A: No. CONSEGNA 30/70 U200 INJECTION is already a pre-mixed combination of
regular insulin and isophane insulin and therefore should not be mixed with
other insulins. For more information regarding the direction of use contact your
doctor.

Q: Is CONSEGNA 30/70 U200 INJECTION safe during pregnancy?

A: Yes. CONSEGNA 30/70 U200 INJECTION can be used during pregnancy if prescribed
by the physician. Therefore, consult your doctor before administration.

Q: How long does it take for CONSEGNA 30/70 U200 INJECTION to start working?

A: CONSEGNA 30/70 U200 INJECTION is a fast-acting medicine where it begins to
lower blood sugar levels about 30 minutes post administration and its effect
would last for about 24 hours.

Q: Can CONSEGNA 30/70 U200 INJECTION be given intravenously?

A: No. CONSEGNA 30/70 U200 INJECTION is meant for subcutaneous use only (i.e.,
thighs, buttocks, abdomen, or upper arms). It should not be directly injected
into the vein or muscle as it may cause severe hypoglycemia.

Q: What is the best area for injecting CONSEGNA 30/70 U200 INJECTION? Should I inject it only at the same site every day?

A: The best place for injecting this medicine is front of your thighs, buttocks,
abdomen, or upper arms. The insulin would work more quickly if it were injected
into the waist (abdomen). Do not repeatedly inject the medicine on the same
site. Instead, rotate the injection sites within the same area to avoid the risk
of developing lumps or skin pitting.

Q: What is CONSEGNA 30/70 U200 INJECTION used for?

A: CONSEGNA 30/70 U200 INJECTION improves glycemic control in patients with
diabetes mellitus (both type I and type II). It helps your body to make utilize
of the circulating blood glucose by transporting the circulating glucose from
the blood into the muscles and fat tissues.

Q: What are the most common side effects of taking CONSEGNA 30/70 U200 INJECTION?

A: The most common side effects of receiving CONSEGNA 30/70 U200 INJECTION are
low blood sugar levels, pain, redness, itching, swelling or thickening at the
injection site, lump formation under the skin and swelling of body parts.
Consult your doctor if any of these side effect troubles you.

Q: Can I stop therapy with CONSEGNA 30/70 U200 INJECTION without consulting your doctor?

A: No. You should not stop therapy with CONSEGNA 30/70 U200 INJECTION without
consulting your doctor because it may lead to reversal of symptoms. If you feel
better after using CONSEGNA 30/70 U200 INJECTION, consult your doctor for
advice.

Q: Will taking a higher dose of CONSEGNA 30/70 U200 INJECTION be more effective?

A: No, taking a higher dose of CONSEGNA 30/70 U200 INJECTION will not be
effective rather it can lead to toxicity. Always take the dose prescribed by
your doctor. If the prescribed dose is not effective for you, consult your
doctor for advice. Your doctor might increase the dose or suggest an alternative
therapy.

Q: Can I take medication for high blood pressure along with CONSEGNA 30/70 U200 INJECTION?

A: It is not advisable to take medicines to control blood pressure while taking
CONSEGNA 30/70 U200 INJECTION without consulting your doctor. Therefore, consult
your doctor before taking any antihypertensive medications along with CONSEGNA
30/70 U200 INJECTION as they have known interactions with CONSEGNA 30/70 U200
INJECTION.

REFERENCES

1. KD. Tripathi. Insulin, Oral Hypoglycemic Drugs and Glucagon. Essentials of
   medical pharmacology. Seventh edition. 2013. Page – 263-264 & 266-269.

2. Jaime A. Davidson, D
Garber, Mariano J. Garcia, Charles B. Kahn, Norman G. Soler, John R. White,
William J. Huster. Effect of Premixed NPH and Regular Insulin on Glucose Control
and Health-Related Quality of Life in Patients with Type 2 Diabetes Mellitus.
AACE Endocrine practice. [Revised in August 1996]. [Accessed on 23rd January
2024]

3. Biocon Ltd. Biphasic Isophane Insulin Injection IP. Insugen-50/50 100 IU
   Refill. [Revised in July 2020]. [Accessed on 23rd January
   2024]

4. Biocon Ltd. Biphasic Isophane Insulin Injection IP. Insugen-30/70
   (Biphasic)100 IU. [Revised in May 2012]. [Accessed on 23rd January
   2024]

5. Novo Nordisk A/S. Mixtard 30 40 IU/ml (international units/ml) suspension for
   injection in vial. European Medical Agency. [Revised in September 2007].
   [Accessed on 23rd January
   2024]

6. Sanofi-Aventis Deutschland GmbH. Biphasic Isophane Insulin Injection I.P.
   [Revised in March 2017]. [Accessed on 23rd January
   2024]

USEFUL DIAGNOSTIC TESTS

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Insulin-Fasting
• medicalslot Diabetic Checkup
• Advance Diabetes Monitoring (Senior Female)
• Jaanch Diabetic Profile Basic