COLJOY 0.5mg Tablet 10's

Introduction About COLJOY 0.5MG TABLET

COLJOY 0.5MG TABLET contains Colchicine which belongs to a group of medicines
called Antigout agents. COLJOY 0.5MG TABLET is used in adults, in the short-term
management of gout attacks and to manage gout recurrence. It is also indicated
in familial mediterranean fever (FMF) to manage fever attacks and amyloidosis (a
rare protein disorder that interferes with normal functioning of organs). Gout
is a common and complex form of arthritis (joint pain) which is characterized by
sudden, severe attacks of pain, swelling, redness and tenderness in one or more
joints which most often occurs in the big toe. Familial mediterranean fever is a
genetic disorder that causes recurrent fevers and painful inflammation of the
abdomen, chest and joints.

Colchicine is an antigout agent which works by lessening the buildup of hard
uric acid crystals in the joints by reducing the uric acid level in the blood
which are needed for the formation of hard uric acid crystals that cause pain in
joints resulting in the decreased swelling and relief from pain in the joints.
It also works by managing the occurrence of pain in the abdomen, chest or joints
in patients suffering from familial mediterranean fever by decreasing the
production of amyloid protein which is an abnormal protein that forms due to a
rare protein disease called amyloidosis which causes interference in the normal
functioning of an organ. Along with this management, your doctor might advise
regular blood tests to check for any occurence of blood disorders.

Before taking COLJOY 0.5MG TABLET, inform your doctor if you are allergic to
Colchicine, and or have blood disorders, heart, kidney, or liver disease which
is not recommended for use in patients with severe liver or kidney disease.
COLJOY 0.5MG TABLET is not recommended for use in pregnant women when indicated
for gout management and used with caution in familial mediterranean fever (FMF)
only if it’s clearly necessary in pregnant and childbearing potential women who
should use effective contrace
the termination of management with COLJOY 0.5MG TABLET when indicated for gout
management. COLJOY 0.5MG TABLET is not recommended for use to manage gout in
children and adolescents (below 18 years of age) which is indicated for use in
children less than 5 years of age and adolescents (from 10 to 18 years of age)
in the management of familial mediterranean fever (FMF) after consulting the
doctor for an advice. The most common side effects of taking COLJOY 0.5MG TABLET
are nausea, vomiting, abdominal cramps and diarrhea. Contact your doctor if any
of the symptoms worsen.

Uses Of COLJOY 0.5MG TABLET

• To manage gout attacks for short-term and to manage recurrence of gout
• Manage familial mediterranean fever to manage fever attacks and amyloidosis

How COLJOY 0.5MG TABLET Works

COLJOY 0.5MG TABLET is an antigout agent which works by lessening the buildup of
hard uric acid crystals in the joints by reducing the uric acid level in the
blood. In familial mediterranean fever it works by decreasing the production of
amyloid protein which is an abnormal protein that forms due to a rare protein
disease called amyloidosis which causes interference in the normal functioning
of an organ.

How to use COLJOY 0.5MG TABLET

Take COLJOY 0.5MG TABLET as advised by your physician. Swallow COLJOY 0.5MG
TABLET with a glass of water and do not chew or crush the medicine. Your doctor
will decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Side Effects Of COLJOY 0.5MG TABLET

Common

• Nausea
• vomiting
• abdominal cramps
• diarrhea

Rare

Stop taking COLJOY 0.5MG TABLET and contact your doctor if you experience any of
the following side effects:

• weakness of the muscles, red to brown discoloration of urine, pain in muscle, and fatigue
• infection with symptoms such as high fever, severe throat ache, sore mouth and aplastic anemia (serious form of anemia)

How To Manage Side Effects

!### Diarrhea

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid
taking any medicine on your own to manage diarrhea and consult your doctor if
the symptom gets worse.

!### Nausea And Vomiting

Try to take COLJOY 0.5MG TABLET with or just after a meal or a snack. Stick to
simple meals. Avoid eating rich or spicy food. Consult your doctor if the
symptom gets worse.

Warning & Precautions

!### Pregnancy

Monitoring requiredCOLJOY 0.5MG TABLET is not recommended for use in pregnant women when indicated
for gout management and is used with caution in familial mediterranean fever
(FMF) only if it’s clearly necessary in pregnant and childbearing potential
women. Women with childbearing potential should use effective contrace
during and for at least 3 months following the termination of management with
COLJOY 0.5MG TABLET when indicated for gout management who should consult doctor
before taking COLJOY 0.5MG TABLET.

!### Breastfeeding

Monitoring requiredCOLJOY 0.5MG TABLET is not recommended for use in breastfeeding women when
indicated for the management of gout which is advised to be used with caution
for familial mediterranean fever (FMF) only if it is clearly necessary. Consult
your doctor before taking COLJOY 0.5MG TABLET.

!### Driving and Using Machines

Use with CautionCOLJOY 0.5MG TABLET may cause drowsiness and dizziness which could affect your
ability to drive or operate machines. Consult your doctor before taking COLJOY
0.5MG TABLET.

!### Alcohol

Consult your doctorAvoid consum
doctor before taking COLJOY 0.5MG TABLET.

!### Kidney

Consult your doctorCOLJOY 0.5MG TABLET should be used with caution in patients with kidney problems
which would be carefully monitored by your doctor.  It is not recommended for
use in patients with severe renal impairment. Consult your doctor for advice
before taking COLJOY 0.5MG TABLET.

!### Liver

Consult your doctorCOLJOY 0.5MG TABLET should be used with caution in patients with liver problems
which would be carefully monitored by your doctor. It is not recommended for use
in patients with severely impaired liver disease or severe liver impairment.
Consult your doctor for advice before taking COLJOY 0.5MG TABLET.

!### Allergy

ContraindicatedCOLJOY 0.5MG TABLET is not recommended for use if you are allergic to colchicine
or any of the other ingredients of this medicine.

!### Heart Disease

Use with CautionCOLJOY 0.5MG TABLET should be used with caution in patients with heart or
vascular disease. Consult your doctor before taking COLJOY 0.5MG TABLET.

!### Use In Pediatrics

Consult your doctorCOLJOY 0.5MG TABLET is not recommended for use to manage gout in children and
adolescents (below 18 years of age). COLJOY 0.5MG TABLET is used when indicated
for familial mediterranean fever (FMF) in children less than 5 years of age and
adolescents (from 10 to 18 years of age) after consulting the doctor for an
advice.

!### Use In Geriatrics

Use with CautionCOLJOY 0.5MG TABLET should be used with caution in elderly patients (aged 70
years or above) especially when you are weak after careful assessment of
potential benefits and consequences of therapy. Consult your doctor before
taking COLJOY 0.5MG TABLET.

Others

COLJOY 0.5MG TABLET is not recommended for use if you:

• have a severe blood disorder

Before taking COLJOY 0.5MG TABLET, inform your doctor if you:

• have problems with your digestive tract
• have blood disorders

Interactions

A. Drug-Drug Interactions:

Before taking COLJOY 0.5MG TABLET, inform your doctor, if you are taking any of
the following medicine:

• erythromycin, telithromycin, clarithromycin and azithromycin (antibiotics used to manage bacterial infections)
• ketoconazole, itraconazole, voriconazole (medicines used to manage fungal infections)
• ritonavir, atazanavir, amprenavir, saquinavir, nelfinavir, fosamprenavir and indinavir (medicines used to manage HIV infection)
• verapamil, quinidine, and diltiazem (medicines used to manage heart disease)
• ciclosporin (medicine used to reduce the body’s resistance to infection by suppressing the immune system)
• Statins such as simvastatin, fluvastatin or pravastatin (medicines used to lower cholesterol)
• fibrates (medicines used to lower cholesterol and some fats in the blood)
• digoxin (medicine used to manage heart failure and irregular heart rate)
• cimetidine (medicine used to reduce intestinal or gastric ulcers)
• tolbutamide (medicine used to lower blood sugar)
• vitamin B12 (medicine used in the management of anemia)

B. Drug-Food Interactions:

COLJOY 0.5MG TABLET should not be taken with grapefruit juice.

Overdosage:

If you or anyone else accidentally takes too much of COLJOY 0.5MG TABLET,
contact your doctor immediately or go to a hospital straight away. Early
symptoms of overdose are burning sensation in the throat, stomach and skin,
nausea and vomiting, abdominal cramps, bloody diarrhea, dehydration, and
lowering of blood pressure and shock. Overdosage symptoms after 24 – 72 hours
can result in life-threatening complications such as consciousness disorder with
possible delusions, coma, symptoms of paralysis, respiratory depression, fluid
retention in the lungs, kidney damage, shortage of blood and cardiac arrest.

Synopsis

Drug	:	Colchicine
Pharmacological Category	:	Antigout agents
Therapeutic Indication	:	Gout attacks and Familial Mediterranean Fever (FMF)
Dosage Forms	:	Tablet

More Information

• Keep COLJOY 0.5MG TABLET out of reach in children
• Store COLJOY 0.5MG TABLET at room temperature

FAQs About COLJOY 0.5MG TABLET

Q: What COLJOY 0.5MG TABLET is used for?

A: COLJOY 0.5MG TABLET is used in adults, in the short-term management of gout
attacks and to manage gout recurrence. It is also indicated in familial
mediterranean fever (FMF) to manage fever attacks and amyloidosis (a rare
protein disorder that interferes with normal functioning of organs). Gout is a
common and complex form of arthritis (joint pain) which is characterized by
sudden, severe attacks of pain, swelling, redness and tenderness in one or more
joints which most often occurs in the big toe. Familial mediterranean fever is a
genetic disorder that causes recurrent fevers and painful inflammation of the
abdomen, chest and joints.

Q: What happens if you forget to take COLJOY 0.5MG TABLET?

A: If you forget to take COLJOY 0.5MG TABLET, take another dose as soon as you
remember. If it is almost time for your next dose, do not take the missed dose
at all and continue as per your prescribed dosing regime. Consult your doctor if
you are not sure about the missed dose.

Q: What happens if you take more COLJOY 0.5MG TABLET than your required
dose?

A: If you or anyone else accidentally takes too much of COLJOY 0.5MG TABLET,
contact your doctor immediately or go to a hospital straight away. Early
symptoms of overdose are burning sensation in the throat, stomach and skin,
nausea and vomiting, abdominal cramps, bloody diarrhea, dehydration, and
lowering of blood pressure and shock.

Q: Can COLJOY 0.5MG TABLET be taken with grapefruit juice?

A: No, COLJOY 0.5MG TABLET should not be taken with grapefruit juice since it
may increase the risks of side effects and lead to some unwanted complications.
Consult your doctor before taking COLJOY 0.5MG TABLET.

Q: Is COLJOY 0.5MG TABLET safe to use in children?

A: COLJOY 0.5MG TABLET is not recommended for use to manage gout in children and
adolescents (below 18 years of age). It is used when indicated for familial
mediterranean fever (FMF) in children less than 5 years of age and adolescents
(from 10 to 18 years of age) after consulting the doctor for an advice.

Useful Diagnostic Tests

• Kidney function test
• Liver function test
• Uric acid test