CINZINE PLUS Tablet 10's

Introduction About CINZINE PLUS TABLET

CINZINE PLUS TABLET is a combination of Cinnarizine and Dimenhydrinate which
belongs to the group of medicines called Antihistamines & Calcium channel
blockers respectively. It is used for the short-term, symptomatic management of
vertigo associated with Benign Paroxysmal positional vertigo (BPPV) and migraine
in adults, who have not responded to alternative managements.

CINZINE PLUS TABLET is not recommended for use in patients having severe kidney
and liver problems. Contact your doctor before taking.

Before taking CINZINE PLUS TABLET inform your doctor if you have severe heart
disease, lung diseases such as asthma or emphysema.

CINZINE PLUS TABLET is not recommended for use in pregnancy. Contact your doctor
before taking. CINZINE PLUS TABLET is not recommended for use in breast feeding
women as it may pass through the breast milk. Contact your doctor before taking.

CINZINE PLUS TABLET is not recommended for use in children and adolescents under
18 years of age. Contact your doctor before taking.

[GBNEYWORD] should be used with caution in elderly patients aged (65 years or
above). Contact your doctor before taking.

The most common side effects of this medicine are drowsiness, dry mouth,
headache and stomach pain. Contact your doctor if any of the symptoms worsen.

Uses Of CINZINE PLUS TABLET

• Used to manage vertigo

How CINZINE PLUS TABLET Works

CINZINE PLUS TABLET helps to manage vertigo, where Cinnarizine blocks the
calcium channels, inhibiting smooth muscle contraction and improves
microcirculation to inner ear and relieves vertigo or spinning sensation.
Dimenhydrinate inhibits histamine H1 receptors and also acts on the
chemoreceptor triggering zone in the brain and manages vomiting. Thus, reducing
symptoms of vertigo (feeling of dizziness or spinning sensation associated with
nausea and vomiting).

How to use CINZINE PLUS TABLET

Take this medicine as advised by your physician. Swallow this medicine as whole
with a glass of water and do not crush or chew the medicine. Your doctor will
decide the right dose depends on your age, body’s weight and disease condition.

Side Effects Of CINZINE PLUS TABLET

Common

• drowsiness
• dry mouth
• headache
• stomach pain

Uncommon

• sweating
• reddening of the skin
• indigestion
• nausea
• diarrhoea
• nervousness, forgetfulness
• cramps
• tinnitus (ringing in the ear)
• paraesthesia or tingling sensation of the hands or feet, tremors

Rare

• tremors (shaking)
• impaired vision
• allergic reactions (skin reactions)
• light sensitivity
• difficulty in urinating

Stop taking CINZINE PLUS TABLET and contact your doctor immediately if you
experience any of the following side effects:

• chest tightness
• yellowish discolouration of skin or whites of the eyes
• increased pressure inside the eye or severe eye pain
• unusual excitement
• convulsions or fitting, uncontrollable movements of the body or face, trembling and shaking of the hands and fingers, twisting movement of the body, muscle stiffness with difficulty walking, stiffness of the arms or legs and severe feeling of restlessness and desire to keep moving
• rash, itching, hives on the skin, swelling of the face, lips, tongue or other parts of the body causing wheezing, difficulty breathing or shortness of breath and severe skin reactions

How To Manage Side Effects

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a
pain-relieving balm on the head if necessary. Do not consume alcohol. Contact
your doctor if the symptom did not improve.

Nausea or Vomiting:

Take this medicine with, or just after meals. Stick to simple meals. Avoid
eating oily or spicy foods.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not
take any medicine on your own for managing diarrhea. Contact your doctor if the
symptom did not improve.

Stomach pain:

Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on
your stomach. Contact your doctor if the symptom did not improve.

Warning & Precautions

!### Pregnancy

CINZINE PLUS TABLET is not recommended for use in pregnant women. Contact your
doctor before taking.

!### Breastfeeding

CINZINE PLUS TABLET is generally not recommended for use in breastfeeding women
as it may pass through the breast milk. Consult your doctor before taking it.

!### Driving and Using Machines

Do not drive or operate any machines if you feel dizziness, drowsiness or sleepy
after taking [GBNEYWORD].

!### Alcohol

Avoid consum
make you tired or sleepy.

!### Kidney

CINZINE PLUS TABLET is not recommended for use in patients with severe kidney
disease. Contact your doctor before taking.

!### Liver

CINZINE PLUS TABLET is not recommended for use in patients with severe liver
disease. Contact your doctor before taking.

!### Allergy

Do not take CINZINE PLUS TABLET if you are allergic to Cinnarizine,
Dimenhydrinate or any other ingredients of this medicine.

!### Lungs

CINZINE PLUS TABLET should be used with caution in patients with lung diseases
such as asthma or emphysema. Contact your doctor before taking.

!### Heart Disease

CINZINE PLUS TABLET should be used with caution in patients with severe heart
diseases. Contact your doctor before taking.

Others

CINZINE PLUS TABLET is not recommended for use if you have:

• angle-closure glaucoma
• convulsions
• increased pressure in the brain
• urine retention due to prostate problems

Before taking CINZINE PLUS TABLET, inform your doctor if you have:

• low or high blood pressure
• raised pressure in the eye
• obstruction in the bowels or pyloroduodenal obstruction
• an enlarged prostate
• an overactive thyroid
• Parkinson’s disease or tremor
• depression
• porphyria

Use in pediatrics:

CINZINE PLUS TABLET is not recommended for use in children and adolescents under
18 years of age. Consult your doctor before taking.

Use in geriatrics:

CINZINE PLUS TABLET should be used with caution in elderly patients (aged 65
years above). Contact your doctor before taking.

Interactions

A. Drug-Drug interactions:

Inform your physician if you are taking any of the following medicine:

• medicines used to manage depression and anxiety (amitriptyline, nortriptyline)
• medicines used to examine eye (Ex. atropine)
• medicines used to manage cough or blocked nose (Ex. ephedrine)
• medicines used to manage cancer (Ex. procarbazine)
• medicines taken to lower blood pressure (Ex. atenolol, propranolol, diltiazem, verapamil)
• medicines used to manage bacterial infections (gentamicin, vancomycin)
• medicines used to manage heart rhythm disorders (Ex. quinidine, procainamide, sotalol)
• medicines used to manage seizures (phenobarbital, methylphenobarbital)
• medicines used to manage severe pain (morphine and codeine)
• medicines used to manage allergies (Ex. cetirizine, levocetirizine)
• medicines used to manage depression and anxiety (chlorpromazine, haloperidol and monoamine oxidase inhibitors like selegiline, rasagiline, selective serotonin reuptake inhibitors like fluoxetine, paroxetine)
• belladonna alkaloids (used for stomach cramps)
• medicines used to manage Parkinson's disease (benztropine and trihexyphenidyl)
• omeprazole (medicine used for stomach ulcers)
• medicine used to manage pregnancy (Ex. oral contrace
• olanzapine (medicine used to manage psychotic disorders)
• betahistine (medicine used to manage meniere’s disease)

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your
doctor immediately. Symptoms of overdose are tiredness, dizzy and shaky,
dilation of pupils and unable to urinate, dry mouth, facial flushing, faster
heart rate, fever, sweating and headache.

Synopsis

Drug	:	Cinnarizine, Dimenhydrinate
Pharmacological Category	:	Antihistamines & Calcium channel blockers
Therapeutic Indication	:	Vertigo
Dosage Forms	:	Tablet

More Information

• Keep out of reach of children
• Store CINZINE PLUS TABLET at normal temperature

FAQs About CINZINE PLUS TABLET

Q: How CINZINE PLUS TABLET works?

A: CINZINE PLUS TABLET helps to manage vertigo, where Cinnarizine blocks the
calcium channels, inhibiting smooth muscle contraction and improves
microcirculation to inner ear and relieves vertigo or spinning sensation.
Dimenhydrinate inhibits histamine H1 receptors and also acts on the
chemoreceptor triggering zone in the brain and manages vomiting. Thus, reducing
symptoms of vertigo (feeling of dizziness or spinning sensation associated with
nausea and vomiting).

Q: Can I use CINZINE PLUS TABLET in children?

A: No. CINZINE PLUS TABLET is not recommended for use in children and
adolescents below 18 years of age. Consult your doctor before taking.

Q: What are the possible common side effects of taking CINZINE PLUS TABLET?

A: The most common side effects of this medicine are drowsiness, dry mouth,
headache and stomach pain. Contact your doctor if any of the symptoms worsen.

Q: Can I consume alcohol while using CINZINE PLUS TABLET?

A: No. Avoid consum
may make you tired or sleepy.

Q: Can I use CINZINE PLUS TABLET in enlarged prostate?

A: No. CINZINE PLUS TABLET is not recommended for use in patients with enlarged
prostate as it may cause difficulty in urination. Contact your doctor before
taking.

Q: Does CINZINE PLUS TABLET cause depression?

A: Yes. CINZINE PLUS TABLET may cause depression in some individuals and it
should be used with caution in patients with history of depression. Contact your
doctor before taking.