ANGIDIL SR Tablet 15's

Introduction About ANGIDIL SR TABLET

ANGIDIL SR TABLET contains Ranolazine which belongs to the group of medicines
called Antianginals. It is used to manage chronic angina.

Angina pectoris can be defined as a sudden, sharp and severe chest pain that
originates from the apex of the heart and radiates to the left shoulder. It can
be characterized by the presence of severe and crushing pain along with a
feeling of pressure and suffocation, especially behind the breastbone.

ANGIDIL SR TABLET is not recommended for use in patients with severe kidney
disease, moderate to severe liver disease. Contact your doctor before taking.

ANGIDIL SR TABLET should be used with caution in patients with mild to moderate
kidney disease, mild liver disease and moderate to severe heart failure,
abnormal ECG changes like like QT prolongation or long QT syndrome. Contact your
doctor before taking.

ANGIDIL SR TABLET is generally not recommended for use in pregnant women unless
considered clearly necessary. Contact your doctor before taking. ANGIDIL SR
TABLET is not recommended for use in breastfeeding women as it is not known
whether it may pass through the breast milk. Contact your doctor before taking
it.

ANGIDIL SR TABLET is not recommended for use in children and adolescents under
18 years of age. Contact your doctor before taking.

ANGIDIL SR TABLET should be used with caution in elderly patients aged 65 years
or above. Contact your doctor before taking.

Avoid drinking grapefruit juice as it may lead to unwanted effects. The most
common side effects of taking ANGIDIL SR TABLET are nausea, vomiting,
constipation, dizziness headache and weakness. Contact your doctor if any of the
above side effects worsen.

Uses Of ANGIDIL SR TABLET

• Used to manage chronic angina

How ANGIDIL SR TABLET Works

ANGIDIL SR TABLET works by inhibiting the entry of sodium and potassium into the
heart cells, thereby managing the calcium influx causing vasodilation and
reduces ventricular tension, myocardial oxygen demand. Thus, relieving angina
symptoms.

How to use ANGIDIL SR TABLET

Take ANGIDIL SR TABLET as advised by your physician. Swallow the medicine with a
glass of water. Do not crush or chew the medicine. Your physician will decide
the correct dose and duration for you depending upon your age, body weight and
disease condition.

Side Effects Of ANGIDIL SR TABLET

Common

• nausea, vomiting
• constipation
• dizziness
• headache
• weakness

Uncommon

• altered sensation
• anxiety
• difficulty sleeping
• confusion
• hallucination
• blurred vision, visual disturbance
• changes in sensation (touch or taste)
• tremors
• feeling tired or sluggish
• sleepiness or drowsiness
• fainting
• dark urine, blood in urine, difficulty in urination
• difficulty in breathing
• cough, nose bleed
• excessive sweating, itching
• feeling swollen or bloated
• hot flushes, low blood pressure
• increase in creatinine
• increase in urea in blood
• increase in blood platelets count and white blood cells
• changes in ECG heart tracing
• joint swelling, pain in extremity
• loss of appetite and/or weight loss
• muscle cramp or weakness
• ringing in the ears or spinning sensation
• stomach pain, discomfort, indigestion
• dry mouth

Rare

• paraesthesia in mouth and lips
• rashes
• problems with coordination
• decrease in blood pressure upon standing
• disorientation
• coldness in hands and legs
• hives, allergic skin reaction
• impotence
• inability to walk due to imbalance
• inflammation of pancreas or intestine
• loss of memory
• throat tightness
• low sodium levels in the blood (hyponatremia) causing tiredness, confusion, muscle twitching, cramps

Stop taking ANGIDIL SR TABLET and contact your doctor immediately if you
experience any of the following side effects:

• symptoms of angioedema or allergic reaction such as hives, swelling of the face, tongue or throat causing difficulty in breathing or swallowing

How To Manage Side Effects

Headache:

Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a
pain-relieving balm on the head if necessary. Do not consume alcohol. Contact
your doctor if the symptom did not improve.

Nausea and Vomiting:

Take the medicine, with or just after a meal. Stick to simple meals. Avoid
eating oily or spicy food.

Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals.
Drink plenty of water and exercise more regularly.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operate any machines
while you are feeling dizzy. Do not consume alcohol, as it can aggravate your
dizziness. Contact your doctor if the symptom did not improve.

Warning & Precautions

!### Pregnancy

ANGIDIL SR TABLET is not recommended for use in pregnant women unless considered
clearly necessary. Contact your doctor before taking ANGIDIL SR TABLET.

!### Breastfeeding

ANGIDIL SR TABLET is not recommended for use in breastfeeding women as it is not
known whether it may pass through the breast milk. Contact your doctor before
taking ANGIDIL SR TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if you feel dizziness, lightheadedness,
faintness, blurred vision, confusion, hallucination, double vision and
coordination problems after taking ANGIDIL SR TABLET.

!### Kidney

ANGIDIL SR TABLET is not recommended for use in patients with severe kidney
disease and should be used with caution in mild to moderate kidney disease.
Contact your doctor before taking ANGIDIL SR TABLET.

!### Liver

ANGIDIL SR TABLET is not recommended for use in patients with moderate to severe
liver disease and should be used with caution in mild liver disease. Contact
your doctor before taking ANGIDIL SR TABLET.

!### Allergy

Do not take ANGIDIL SR TABLET if you are allergic to Ranolazine or to lactose or
other sugars or to any other ingredients of this medicine.

!### Heart Disease

ANGIDIL SR TABLET should be used with caution in patients with moderate to
severe heart failure, abnormal ECG changes like QT prolongation or long QT
syndrome. Contact your doctor before taking ANGIDIL SR TABLET.

Others

ANGIDIL SR TABLET is not recommended for use if you have:

• rare hereditary problems like galactose intolerance, the Lapp lactase deficiency and glucose-galactose malabsor

Use in pediatrics:

ANGIDIL SR TABLET is not recommended for use in children and adolescents under
18 years of age. Contact your doctor before taking ANGIDIL SR TABLET.

Use in geriatrics:

ANGIDIL SR TABLET should be used with caution in elderly patients aged 65 years
or above. Contact your doctor before taking ANGIDIL SR TABLET.

Interactions

A. Drug - Drug interactions:

Before taking ANGIDIL SR TABLET, inform your doctor if you are taking any of the
following medicine:

• medicines used to manage bacterial infections (Ex. clarithromycin, telithromycin, erythromycin)
• medicines used to manage fungal infections (Ex. itraconazole, ketoconazole, fluconazole, voriconazole, posaconazole)
• medicines used to manage HIV infection (atazanavir, nelfinavir, ritonavir, indinavir, saquinavir tenofovir disoproxil and efavirenz)
• nefazodone (used for depression)
• medicines used to manage heart problems or heart rhythm disorders (Ex. quinidine, dofetilide, sotalol, metoprolol, diltiazem, verapamil, procainamide, disopyramide)
• medicine used to manage rejection of a transplanted organ (cyclosporine, tacrolimus, sirolimus, everolimus)
• medicines used to manage epilepsy (Ex. phenytoin, carbamazepine or phenobarbital)
• medicines used to manage tuberculosis (Ex. rifampicin, rifampin, rifabutin, rifapentine)
• St. John's Wort (herbal medicine used for depression)
• digoxin (medicines used for heart failure)
• medicines used to manage allergies (Ex. terfenadine, astemizole, mizolastine)
• medicines to manage psychoses (Ex. bupropion, imipramine, doxepin, amitriptyline, paroxetine)
• medicines used to manage cancer (Ex. cyclophosphamide)
• medicines to manage elevated cholesterol levels in the blood (Ex. simvastatin, lovastatin, atorvastatin)
• cimetidine (medicine used for stomach ulcers)
• metformin (medicines used to manage diabetes mellitus)

B. Drug - Food interaction:

Avoid drinking grapefruit juice with this medicine as it may lead to unwanted
effects. Consult your doctor for advice.

Overdosage:

If you or anyone else accidentally takes too much of ANGIDIL SR TABLET, consult
your doctor immediately or visit the nearby hospital. Symptoms of overdose are
dizziness, nausea and vomiting.

Synopsis

Drug	:	Ranolzine
Pharmacological Category	:	Antianginals
Therapeutic Indication	:	Chronic angina
Dosage Forms	:	Tablet

More Information

• Keep ANGIDIL SR TABLET out of the sight and reach of children
• Store ANGIDIL SR TABLET below 25°C

FAQs About ANGIDIL SR TABLET

Who should avoid taking ANGIDIL SR TABLET?

ANGIDIL SR TABLET is not recommended for use in patients with allergic history
to Ranolazine or lactose or rare hereditary problems like galactose intolerance,
the Lapp lactase deficiency and glucose-galactose malabsor
disease, moderate to severe liver disease. Contact your doctor before taking
ANGIDIL SR TABLET.

How ANGIDIL SR TABLET works?

ANGIDIL SR TABLET works by inhibiting the entry of sodium and potassium into the
heart cells, thereby managing the calcium influx causing vasodilation and
reduces ventricular tension, myocardial oxygen demand. Thus, relieving angina
symptoms.

What are the side effects of taking ANGIDIL SR TABLET?

The most common side effects of taking ANGIDIL SR TABLET are nausea, vomiting,
constipation, dizziness headache and feeling weak. Contact your doctor if any of
the symptoms worsen.

Does ANGIDIL SR TABLET cause hyponatremia?

Yes. ANGIDIL SR TABLET may cause hyponatremia. Contact your doctor if you
experience any unusual symptoms like tiredness, confusion, muscle twitching,
cramps.

Can I take grapefruit juice while taking ANGIDIL SR TABLET?

No. Avoid drinking grapefruit juice with this medicine as it may lead to
unwanted effects. Contact your doctor before taking.