AKT 3 Tablet 5's

Introduction About AKT 3 TABLET

AKT 3 TABLET is a combination of Ethambutol, Isoniazid and Rifampicin which
belongs to the group of medicines called Antituberculosis agents respectively.
It is used for the initial management of tuberculosis. Tuberculosis (TB) is a
bacterial infection which spreads through inhaling tiny droplets from the coughs
or sneezes of an infected person. Symptoms such as persistent cough with sputum
and blood, weight loss, night sweats, high temperature, tiredness and fatigue,
loss of appetite and swelling in the neck.

Your doctor will perform some regular blood tests such as liver function test,
visual acuity, uric acid level to monitor any changes in your body. Avoid
consum
AKT 3 TABLET is not recommended in patients with acute liver disease,
drug-induced liver disease, inflammation of the o
body weight of less than 20 kg. AKT 3 TABLET should be used with caution in
patients with hepatitis and kidney disease, suffer from tingling in the hands
and feet (peripheral neuropathy), HIV infection, hypersensitive to ethionamide
or niacin (nicotinic acid), epilepsy or a history of psychiatric disease and
diabetes or porphyria.

AKT 3 TABLET should be used with caution in pregnant and breastfeeding women.
Contact your doctor before taking AKT 3 TABLET. The most common side effects of
taking AKT 3 TABLET are peripheral neuropathy (sensations of tingling, pricking,
or numbness of the skin, especially in the feet and hands), increased liver
enzymes & uric acid levels in blood, flushing, reddish discoloration of body
fluids such as urine, sputum, tears, saliva and sweat, diarrhoea, abdominal
pain, loss of appetite, nausea, and vomiting or skin reactions. Consult your
physician if you experience any of the above side effects worsen.

Uses Of AKT 3 TABLET

• Used to manage tuberculosis

How AKT 3 TABLET Works

AKT 3 TABLET helps to manage tuberculosis, where Ethambutol has bacteriostatic
properties that inhibits cell wall synthesis. Isoniazid destroys and manages the
growth of bacteria. Rifampicin acts via the inhibition of DNA-dependent RNA
polymerase, leading to a suppression of RNA synthesis and cell death.

How to use AKT 3 TABLET

Take AKT 3 TABLET as advised by your physician. Take the medicine, with a glass
of water. Do not crush or chew the medicine. Your doctor will decide the right
dose depends on your age, body weight and severity of infection.

Side Effects Of AKT 3 TABLET

Common

• sensations of tingling, pricking, or numbness of the skin, especially in the feet and hands
• increased liver enzymes and uric acid levels in blood
• flushing
• reddish discoloration of body fluids such as urine, sputum, tears, saliva and sweat
• gastrointestinal symptoms such as (diarrhoea, abdominal pain, loss of appetite, nausea, and vomiting)
• skin reactions with rash or itching
• disturbances of the menstrual cycle (in women)
• eye problems (ocular redness, permanent discolouration of soft contact lenses, visual disturbances due to the inflammation of the o

Uncommon

• inflammation of the liver (hepatitis)
• epile
• headache
• inflammation of the brain
• personality changes and memory impairment

Rare

• gastritis
• bowel infection
• nephritis (inflammation of the kidney)
• photosensitivity reactions (skin sensitivity to light)
• conjunctivitis

Stop taking AKT 3 TABLET and contact your physician immediately if you
experience any of the following side effects:

• unexplained loss of appetite, nausea, vomiting, dark urine, yellow discoloration of the skin (jaundice), persistent fatigue and abdominal pain and tenderness

How To Manage Side Effects

!### Diarrhea

Consume lots of water and fruit juice which keeps yourself hydrated. Contact
your doctor if diarrhoea worsens.

!### Nausea And Vomiting

Take the medication right before or after eating. Stick to simple meals. Avoid
eating oily or spicy food. If the nausea and vomiting doesn’t improve, consult
your doctor.

!### Stomach Pain

Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on
your stomach. Contact your doctor if the abdominal pain did not improve.

Warning & Precautions

!### Pregnancy

Use with CautionAKT 3 TABLET should be used with caution in pregnant women. Contact your doctor
before taking AKT 3 TABLET.

!### Breastfeeding

Use with CautionAKT 3 TABLET should be used with caution in breastfeeding women. Contact your
doctor before taking AKT 3 TABLET.

!### Driving and Using Machines

Use with CautionDo not drive or operate machines while taking AKT 3 TABLET, may cause visual
disturbances, dizziness and other side effects on the nervous system that can
impair your ability to drive and to use machines.

!### Alcohol

Consult your doctorAvoid consum
damage. Contact your doctor before taking AKT 3 TABLET.

!### Kidney

Use with CautionAKT 3 TABLET should be used with caution in patients with kidney disease.
Contact your doctor before taking AKT 3 TABLET.

!### Liver

Consult your doctorAKT 3 TABLET is not recommended for use in patients with acute liver disease,
drug-induced liver disease. It should be used with caution in patients with
liver disease (hepatitis) and chronic liver disease. Contact your doctor before
taking AKT 3 TABLET.

!### Allergy

ContraindicatedDo not take AKT 3 TABLET if you are allergic to Ethambutol, Isoniazid,
Rifampicin or to other ingredients of this medicine.

!### Use In Pediatrics

Consult your doctorYour doctor will prescribe the right dose depends on your child’s age, body
weight and severity of the infection. Consult your doctor before giving to your
child.

Others

AKT 3 TABLET is not recommended for use if you have:

• inflammation of the o

Before taking AKT 3 TABLET, inform your doctor if you:

• suffer from tingling in the hands and feet (peripheral neuropathy)
• have HIV infection
• have epilepsy
• have a history of psychiatric disorders
• have diabetes
• have porphyria

Interactions

A. Drug-Drug interactions:

Before taking AKT 3 TABLET inform your doctor if you are taking any of the
following medicines:

• antibiotics such as voriconazole, clarithromycin (medicine used to manage fungal infections)
• HIV protease inhibitors (Ex. efavirenz, nevirapine) (drugs used to manage HIV infection)
• aluminium hydroxide (medicine used to manage diseases related to the gastric acid)
• disulfiram (medicine used for the management of chronic alcoholism)
• medicines to manage fungal infections (Ex. ketoconazole, fluconazole)
• quinine (medicine used to manage malaria)
• immunosuppressant drugs (Ex. cyclosporine, tacrolimus)
• medicines to manage heart conditions (Ex. verapamil, digoxin)
• medicines to manage blood lipids (Ex. simvastatin)
• medicines to manage diabetes (Ex. glibenclamide)
• oral contrace
• medicines to manage epile
• medicines used to help you sleep (Ex. diazepam, flurazepam, triazolam, midazolam)
• medicines for the management of certain psychiatric conditions (Ex. chlorpromazine, haloperidol)
• medicines for management of blood clots (Ex. warfarin)
• medicines used at surgery (Ex. alfent
• corticosteroids (Ex. prednisolone, medicines for the management of inflammations and other diseases, such as asthma or rheumatoid arthritis)
• paracetamol (used for pain)

B. Drug-Food interaction:

When taken with cheese or fish, AKT 3 TABLET may cause redness, itching of the
skin, hot feeling, rapid or pounding heartbeat, sweating, chills or clammy
feeling, headache, and/or light-headedness.

Overdosage:

If you or anyone else accidentally takes too much of AKT 3 TABLET, consult your
doctor immediately or visit the nearby hospital. Symptoms of overdose may
develop vomiting, gastrointestinal disturbances, fever, headache, dizziness,
slurring of speech, hallucinations and/or visual disturbances.

Synopsis

Drug	:	Ethambutol, Isoniazid, Rifampicin
Pharmacological Category	:	Antituberculosis agents
Therapeutic Indication	:	Tuberculosis
Dosage Forms	:	Tablet, Combipack, Kit, Kit-Tablet

More Information

• Keep AKT 3 TABLET out of reach of children
• Store AKT 3 TABLET at a room temperature

FAQs About AKT 3 TABLET

Q: What is AKT 3 TABLET used for?

A: AKT 3 TABLET is used for the initial management of tuberculosis. Consult your
doctor before taking AKT 3 TABLET.

Q: Can I drink alcohol while taking AKT 3 TABLET?

A: Avoid consum
damage. Contact your doctor before taking AKT 3 TABLET.

Q: What to do if I forget to take AKT 3 TABLET?

A: If you miss or forget to take a dose, the missed dose should be taken as soon
as possible, unless the next regular dose is scheduled within 6 hours. Skip the
missed dose if it is almost time for the next regular dose. You should not take
a double dose to make up for forgotten individual doses.

Q: What happens if I stop taking AKT 3 TABLET?

A: You should keep taking the AKT 3 TABLET for as long as your doctor has
instructed, even if you are feeling better. If you stop the medicine too soon,
the infection may not be completely managed. You should not stop management
unless your doctor or health care provider says so.

Q: Can I drive after taking AKT 3 TABLET?

A: Do not drive or operate machines while taking AKT 3 TABLET, it may cause
visual disturbances, dizziness and other side effects on the nervous system that
can impair your ability to drive and to use machines.

Useful Diagnostic Tests

• Complete Blood Test
• Erythrocyte Sedimentation Rate
• Mycobacterium Tuberculosis DNA PCR-Qualitative Test
• Peripheral Smear Examination